Insights & Discussion
In 2004, polyphenols were isolated from mung bean sprouts, which exert antibacterial activity against Helicobacter pylori, one of the most common causative organisms in gastrointestinal disorders.
The utility of bioactive compounds from food legumes as natural antimicrobial agents are commonly known as biocides. Mung bean sprouts have potent antiviral and prophylactic activities against respiratory syncytial virus and Herpes Simplex virus −1, and these activities were comparable with Acyclovir. The underlying mechanism was attributed to active components of mung bean sprouts potentially induce antiviral cytokines in human cells and thereby nullify the actions on viral proliferation. Similarly, antifungal and antiviral potency of two beans proteins, designated alpha (28 kDa) and beta (28 kDa) proteins were isolated and were capable of inhibiting human immunodeficiency virus reverse transcriptase and glycohydrolases associated with HIV infection. Further, antifungal peptides (7.3 kDa, 9.03 kDa) were isolated from beans, which exerted an antifungal effects and inhibited mycelial growth in Fusarium oxysporum, F. solani, Pythium aphanidermatum, Sclerotium rolfsii, Mycosphaerella arachidicola, and antibacterial effects on Staphylococcus aureus. In addition, two proteins, Mungin (18-kDa) and chitinase (30.8 kDa) isolated from mung bean seeds possess antifungal activity against Rhizoctonia solani, Coprinus comatus, Mycosphaerella arachidicola, Botrytis cinerea, and Fusarium oxysporum. Mungin and chitinase exert an inhibitory activity against α- and β-glucosidases, suppressing [3H] thymidine in the corporation by mouse splenocytes. In 2004, polyphenols were isolated from mung bean sprouts, which exert antibacterial activity against Helicobacter pylori, one of the most common causative organisms in gastrointestinal disorders. Furthermore, several in vitro and in vivo studies have also been reported that mung bean seeds are protective against sepsis.
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Gold kiwifruit extracts contained different bioactive materials which showed selective cytotoxic activity against human oral tumor cells and displayed anti-HIV, antioxidant, and antibacterial activities.
2023 Journal of Ethnopharmacology Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts Motohashi N, Shirataki Y, Kawase M, Tani S, Sakagami H, Satoh K, et al.
Network Pharmacology Antibacterial Antioxidant Kiwifruit
The methodology involved stepwise extraction of gold kiwifruit with hexane, acetone, methanol, and 70% methanol; the extracts were then fractionated using silica gel and ODS column chromatographies to examine their biological activities. Different fractions like H1, H2 (from the hexane extract), A1, A2 (from the acetone extract), and M2 (from the methanol extract) were tested, as well as more hydrophilic fractions from the 70% methanol extract.
In the discussion of the results, fractions H1, H2, A1, A2 and M2 displayed notable cytotoxic activity against human oral tumor cell lines, with these showing more sensitivity compared to human gingival fibroblasts. The hydrophilic fractions from the 70% methanol extract demonstrated higher anti-HIV activity, radical generation, and oxygen scavenging activity. However, the antibacterial activity of these fractions was generally lower than that of the more lipophilic (hexane, acetone, methanol) extracts, indicating no distinct antimicrobial action. Interestingly, all fractions were inactive against Helicobacter pylori.
Fresh raw wildflower honey, particularly at concentrations of 10–30%, exhibit comparable efficacy to manuka honey in inhibiting antibiotic-resistant "superbugs" implicated in wound infections, offering a potentially cost-effective alternative for wound care in the United States.
2022 Antibiotics Both Manuka and Non-Manuka Honey Types Inhibit Antibiotic Resistant Wound-Infecting Bacteria Hewett SR, Crabtrey SD, Dodson EE, Rieth CA, Tarkka RM, Naylor K
Network Pharmacology Antibacterial Antimicrobial Honey
Postoperative infections, a significant concern in US hospitals, often involve drug-resistant wound-infecting bacteria, contributing to life-threatening complications. Manuka honey, FDA-approved for wound treatment, has demonstrated antibacterial efficacy. This study sought alternative honey types for wound infections. Using a honey-plate method, it identified fresh raw Arkansas wildflower honeys as effective against antibiotic-resistant bacteria, mirroring manuka honey's inhibition. Concentrations of 10–30% honey proved effective against critical "superbugs," indicating potential cost-effective alternatives for wound care in the US, where manuka honey accessibility and antibiotic resistance are challenges.
The study presents a promising revelation: fresh raw Arkansas wildflower honeys, akin to manuka honey, exhibit substantial efficacy against antibiotic-resistant bacteria implicated in wound infections. The demonstrated effectiveness at concentrations of 10–30% suggests a feasible and cost-effective alternative for wound care in the US, addressing challenges associated with manuka honey availability and antibiotic resistance. These findings have the potential to reshape wound treatment practices, providing accessible and efficient solutions to combat infections caused by drug-resistant bacteria.
Adzuki beans' high lysine content, antioxidative, antibacterial, and anti-inflammatory properties highlight their dual-use as a nutritious food source and a therapeutic agent for various diseases.
2022 Molecules Nutritional Composition, Efficacy, and Processing of Vigna angularis (Adzuki Bean) for the Human Diet: An Overview Wang Y, Yao X, Shen H, Zhao R, Li Z, Shen X, et al.
Review Article Adzuki Bean Antibacterial Lysine
The study methodology involved comprehensive analysis of the nutritional profile and health benefits offered by adzuki beans. Different varieties of the beans were tested to assess disparities in the contents and compositions of starch, protein, fat, polysaccharides, and polyphenols. The processing characteristic components such as isolated protein and heated flavor were also examined to aid in the development of adzuki bean-based food products.
The results showed that adzuki beans have diverse benefits both in terms of nutrition and health. Their proteins were found to be rich in lysine, an essential amino acid, compensating for its shortage in the everyday diet typically containing cereals. The antioxidant, antibacterial, and anti-inflammatory properties are capable of enhancing human health in multiple ways. Adzuki beans and their extracts were found to hold potential in preventing and treating conditions like diabetes, kidney disease, obesity, and even cognitive decline from a high-fat diet. This discovery highlighted the usefulness of adzuki beans as not just food but also a practical ingredient in medicinal treatments.
The underutilized pomegranate peel, full of abundant bioactive substances, could be repurposed for its potential health benefits like anti-inflammatory, anti-cancer, cardiovascular protection, and antibacterial activities.
2022 Frontiers in Nutrition Pomegranate Peel as a Source of Bioactive Compounds: A Mini Review on Their Physiological Functions Mo Y, Ma J, Gao W, Zhang L, Li J, Li J, et al.
Review Article Anti-Inflammatory Antibacterial Anticancer
This paper conducts a miniature review of the characterization and physiological functions of the key bioactive compounds present in pomegranate peel. The exploration underscores the main phenolic compounds in the peel, illustrating substances such as tannins, flavonoids, phenolic acids, dietary fibers, alkaloids, minerals, and vitamins. A deep understanding of these components and their potential benefits is vital to the study and future applications.
The research finds that these core components essentially function as antioxidants, either enhancing oxidative biomarkers or proactively neutralizing reactive oxygen species. By establishing these key functions, it essentially links these activities to a broader context of benefits, including but not limited to anti-inflammatory, anti-cancer, cardiovascular protection, and antibacterial attributes, thereby indicating a potential for substantial health benefits. With comprehensive understanding and appropriate application of these substances, the pomegranate peels, often classified as waste, could find a new life as robust health-enhancing elements.
Jujube nutrients may offer potential therapeutic benefits including antioxidant, antibacterial, anti-inflammatory functions, and improving sleep quality and learning.
2022 Journal of Agricultural and Food Chemistry Wild Jujube (Ziziphus jujuba var. spinosa): A Review of Its Phytonutrients, Health Benefits, Metabolism, and Applications Hua Y, Xu X, Guo S, Xie H, Yan H, Ma X, et al.
Review Article Anti-Inflammatory Antibacterial Antioxidant
The methodology used for this study involves a comprehensive review of existing research about Wild jujube, giving particular focus on its phytonutrients, biological functions, metabolism of bioactive compounds, and applications. The study does not seem to detail a specific experimental procedure, but instead bases its conclusions on existing literature. Various parts of the wild jujube plant, such as the fruits, seeds and leaves, were examined for their potential role as food, medicine, or health care aids.
The results from the review suggest that the different parts of the wild jujube plant play many roles. The fruits have been noted for their antioxidant, antibacterial, and anti-inflammatory properties, and as ingredients preventing aging. The mature seeds have been found to have potential beneficial effects on central nervous system diseases, particularly in the treatment of insomnia and the enhancement of learning and memory.
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