Insights & Discussion
Cinnamon supplementation significantly decreases inflammation and oxidative stress levels, serving as a potential additive for cardiometabolic health improvement.
The systematic review and meta-analysis followed the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines. A comprehensive search for appropriate clinical trials was performed across multiple databases including PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, Embase, and Google Scholar until January 2020. After duplicates were removed, 1145 studies were found eligible and 12 studies were finally included in the meta-analysis, investigating the impact of cinnamon supplementation dosages ranging between 1.5 to 4 grams per day.
The results of the meta-analysis revealed that cinnamon supplementation led to a significant reduction in inflammation markers, C-reactive protein and interleukin-6, alongside a decrease in malondialdehyde, an oxidative stress marker. Concurrently, an increase was observed in the total antioxidant capacity following the supplementation, implying an enhancement in the body's defensive ability against oxidative damage. Nevertheless, no significant change was identified in the levels of intercellular adhesion molecule-1 after the cinnamon supplementation.
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Bananas and plantains contain compounds with anti-inflammatory, anti-apoptotic, and antioxidative properties that hold promise for potentially reversing neurological disorders.
2022 Foods Suitability of Banana and Plantain Fruits in Modulating Neurodegenerative Diseases: Implicating the In Vitro and In Vivo Evidence from Neuroactive Narratives of Constituent Biomolecules Oyeyinka BO, Afolayan AJ
Anti-Apoptotic Anti-Inflammatory Antioxidant
The methodology of the study revolved around scrutinizing the bioactive properties found in bananas and plantains. Researchers pinpointed various neuroprotective mechanisms within commonly consumed fruits, specifically bananas and plantains. The study examined protein expression regulation and targeted specific gene pathways, including nuclear and tumor necrosis factors, extracellular signal-regulated and mitogen-activated protein kinases, activator protein-1, and the glial fibrillary acidic protein. In their investigations, they also considered the underutilized peel components of these fruits.
The results suggest that the multitude of bioactive compounds found in both the pulp and peels of bananas and plantains perform a variety of beneficial neuroprotective activities. These range from acting as antioxidants, preventing cell death (anti-apoptotic), and reducing inflammation (anti-inflammatory), to directly influencing the functionality of the nervous system (neuromodulatory). This discovery implicates plant-based foods, specifically bananas and plantains, as potentially significant substances in combating, halting, or mitigating the pathological mechanisms underlying neurodegenerative disorders.
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
2022 Pharmacological Research - Modern Chinese Medicine Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Ai Ye Anti-Inflammatory Antioxidant
The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19.
Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.
Cherries and blueberries, rich in phenolic compounds, can be effectively used in pharmaceutical products, smart foods, functional beverages, and nutraceuticals to prevent or treat diseases.
2022 Molecules Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties Gonçalves AC, Nunes AR, Flores-Félix JD, Alves G, Silva LR
Review Article Anti-Diabetic Anti-Inflammatory Antioxidant
The research primarily studied the health-promoting potential of cherries and blueberries, given their high nutritional density and substantial phenolic compounds. The focus was on their ability to counteract oxidative stress markers and suppress pro-inflammatory responses, which are significant factors in chronic diseases such as diabetes. The researchers analyzed these fruits for their potential incorporation into various products such as pharmaceutical preparations, smart foods, functional beverages, and nutraceuticals.
In the discussion of the results, it was emphasized how cherries and blueberries exhibit significant biological potential. They were not only seen as effective in combatting oxidative stress and inflammation but also as potential immune boosters. The conclusions underscored the fruits' potential role as functional foods and their relevance to the burgeoning popularity of functional beverages, hinting at their promise for inclusion in a variety of health-related products.
Walnut seed skin extract demonstrates potential hepato-renal protective effects, inhibiting inflammatory responses, oxidative stress and apoptosis, in kidney-damaged Sprague-Dawley rats.
2022 Cytokine The hepato-renal protective potential of walnut seed skin extract against acute renal ischemia/reperfusion damage Askin S, Askin H, Dursun E, Palabiyik E, Uguz H, Cakmak , et al.
Animal Study Acute Kidney Injury Acute Renal Ischemia Anti-Inflammatory
In the methodology, Sprague-Dawley rats in acute kidney injury state were divided into three groups: a healthy control, a group induced with renal ischemia/reperfusion (IR), and another group induced with renal IR and treated with walnut seed skin (WSS) extract. Blood, liver and kidney tissues were collected for serum evaluations of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, urea, and creatinine. Histopathological studies were performed on liver and kidney tissues, and gene markers related to anti-oxidant, anti-inflammatory, and apoptotic effects were measured.
The results showed an improvement in deteriorated serum parameters in rats with renal ischemia pre-treated with WSS extract. Histopathological analysis revealed a protective effect of WSS on kidney and liver tissues. Though gene expression studies yielded diverse results for liver and kidney tissues, the consensus was that WSS had a pronounced protective impact on the liver. It was inferred that WSS's healing potential in renal and hepatic tissues seems to work via inhibiting inflammatory response, oxidative stress, and apoptosis.
Jujube nutrients may offer potential therapeutic benefits including antioxidant, antibacterial, anti-inflammatory functions, and improving sleep quality and learning.
2022 Journal of Agricultural and Food Chemistry Wild Jujube (Ziziphus jujuba var. spinosa): A Review of Its Phytonutrients, Health Benefits, Metabolism, and Applications Hua Y, Xu X, Guo S, Xie H, Yan H, Ma X, et al.
Review Article Anti-Inflammatory Antibacterial Antioxidant
The methodology used for this study involves a comprehensive review of existing research about Wild jujube, giving particular focus on its phytonutrients, biological functions, metabolism of bioactive compounds, and applications. The study does not seem to detail a specific experimental procedure, but instead bases its conclusions on existing literature. Various parts of the wild jujube plant, such as the fruits, seeds and leaves, were examined for their potential role as food, medicine, or health care aids.
The results from the review suggest that the different parts of the wild jujube plant play many roles. The fruits have been noted for their antioxidant, antibacterial, and anti-inflammatory properties, and as ingredients preventing aging. The mature seeds have been found to have potential beneficial effects on central nervous system diseases, particularly in the treatment of insomnia and the enhancement of learning and memory.
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