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Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
2022 Journal of Asian Multicultural Research for Medical and Health Science Study Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia A A, Astuti A, Leli L, Saad R
Randomised Controlled Trial Anaemia Haemoglobin
This quasi-experimental study with a pretest-posttest design involved 30 pregnant women divided into two groups: one receiving Fe (Control Group) and the other Honey + Fe (Intervention Group) for 60 days. Blood and urine analyses revealed a remarkable increase in hemoglobin levels in the Honey + Fe group (2.80 ± 0.26 g/dl), surpassing the Fe control group (0.80 ± 0.13 g/dl). Moreover, the Intervention Group demonstrated a notable decrease in 8-Ohdg levels (-4.23 ± 1.32 nmol/ml, p = 0.031), indicating reduced oxidative stress, while the Fe control group exhibited less significant changes (2.98 ± 1.30 nmol/ml, p = 0.322). Independent T Test confirmed the Honey + Fe group's superior effectiveness in increasing hemoglobin levels and decreasing 8-Ohdg levels in anemic pregnant women (p = 0.001 and p = 0.002, respectively).
The study underscores the synergistic benefits of honey and iron supplementation in enhancing hemoglobin levels and mitigating oxidative stress among anemic pregnant women. The robust findings, supported by statistical significance, emphasize the potential clinical relevance of incorporating honey into anemia management strategies, offering a more effective approach compared to iron supplementation alone.
The date palm enhances both male and female fertility parameters through its nutritional attributes and antioxidant functionality.
2021 Metabolites Therapeutic Potential of Date Palm against Human Infertility: A Review Shehzad M, Rasheed H, Naqvi SA, Al-Khayri JM, Lorenzo JM, Alaghbari MA, et al.
Review Article Date Fruit Ovarian Function Sperm Quality
The research conducted a thorough review of the role of date palm in treating infertility. The health benefits of date palm and its varied components were explored, with a focus on their effects on reproductive parameters in both sexes. The comprehensive review shed light on how the substantial nutrients and antioxidant features of date palm can be beneficial for people dealing with infertility.
In men, the study found direct links between consumption of date palm and improved hormonal levels alongside notable enhancements in seminal vesicle parameters and sperm quality. For women, this natural remedy showed a positive impact on the process of oogenesis, hormone regulation, and improving pregnancy outcomes. The focus was on the potential of date fruit as a natural enhancer of fertility, downplaying the role of any synthetic or invasive medical interventions. The study thus testifies to the innovative use of a widely available natural resource in addressing a pressing health issue.
Endometriosis and Adenomyosis can have impact on miscarriage risk in pregnancy.
2020 BioMed Research International Miscarriage on Endometriosis and Adenomyosis in Women by Assisted Reproductive Technology or with Spontaneous Conception: A Systematic Review and Meta-Analysis Yangxue Huang, Xianhong Zhao, Yiyuan Chen, Jie Wang, Weilin Zheng, Lixing Cao
Systematic Review
The study analyzed 39 publications involving 697,984 women to assess the impact of endometriosis (EMS) and adenomyosis (AD) on miscarriage risk. Women with EMS showed increased miscarriage risk in spontaneous conception (SC), but similar risk in assisted reproductive technology (ART) compared to tubal infertility. AD was associated with higher miscarriage risk in ART. Sensitivity analyses supported these conclusions. EMS staging did not significantly alter miscarriage risk. Early-stage EMS showed higher early abortion risk. No significant associations were found between EMS and low birthweight, placental abruption, intrauterine growth restriction, or preeclampsia. EMS correlated with higher odds of antepartum hemorrhage, postpartum hemorrhage, preterm birth, placenta praevia, and stillbirth. SUP and DIE were linked to increased miscarriage risk, while OMA showed no significant association. The findings suggest the need for closer monitoring and follow-up for pregnant women with EMS or AD, particularly in early pregnancy. Standardized recording of EMS types, stages, and miscarriage timing is recommended for future studies.
Clinical trials categorize botanical parts of date palm as being most effective in eight different areas such as obstetrics, oncology, and endocrinology.
2020 Complementary Therapies in Medicine Clinical effects of date palm (Phoenix dactylifera L.): A systematic review on clinical trials Bagherzadeh karimi A, Elmi A, Zargaran A, Mirghafourvand M, Fazljou SMB, araj-Khodaei M, et al.
Systematic Review Anticancer
In the study, a comprehensive review was conducted on all types of clinical trials (including randomized, pilot, quasi-experimental, cross-over, and non-randomized) assessing the clinical impacts of date palm for the period between 2000 to August 2019. These trials were sourced from both English and Persian language papers. The methodological quality of these trials was scrutinized based on the risk of bias assessment laid out by the Cochrane handbook of systematic reviews and subsequently, results were reported via the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement.
The study saw twenty-six research works fitting the criteria set for inclusion. These studies spanned across eight categories based on the varied botanical derivatives of the date palm. These categories consisted of fields like obstetrics, gynecology, oncology, dermatology, hematology, gastroenterology, endocrinology, metabolism, and infertility. However, there were concerns raised regarding existing biases in trial conduction, with about 80% of the studies indicating performance and detection bias, roughly half indicating selection bias, and about 20% indicating attrition and reporting bias. Regardless, these clinical trials provide useful insights into the possible health benefits of various date palm components.
Acupuncture was a feasible intervention and reduced threatened miscarriage symptoms when compared to a touch intervention.
2016 BMC Pregnancy and Childbirth Does acupuncture have a role in the treatment of threatened miscarriage? Findings from a feasibility randomised trial and semi-structured participant interviews Betts D, Smith CA, Dahlen HG.
Randomised Controlled Trial
Threatened miscarriage is a common complication of early pregnancy increasing the risk of miscarriage or premature labour. Currently there is limited evidence to recommend any biomedical pharmacological or self-care management, resulting in a ‘watchful waiting’ approach. The objective of this study was to examine the feasibility of offering acupuncture as a therapeutic treatment for women presenting with threatened miscarriage.
Acupuncture was a feasible intervention and reduced threatened miscarriage symptoms when compared to a touch intervention. Further research is required to further explore acupuncture use for this common complication and whether it can reduce the incidence of miscarriage.
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