Pancreatic Cancer

Presentation Slides

Chinese Medicine Research Hub

Cohort Study

Regular consumption of raw carrots is associated with a significant, dose-dependent reduction in lung cancer incidence, suggesting a potential cancer-protective effect attributed to polyacetylenic compounds, particularly falcarinol and falcarindiol, present in raw carrots.

2023 Nutrients Carrot Intake and Risk of Developing Cancer: A Prospective Cohort Study
Deding U, Baatrup G, Kaalby L, Kobaek-Larsen M

Chinese Medicine Research Hub

Review Article

Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer.

2023 Journal of the Science of Food and Agriculture Carrot and carotene and multiple health outcomes: an umbrella review of the evidence
Yi X, Li J, Liao D, Peng G, Zheng X, Xu H, Zhang T, Ai J

Chinese Medicine Research Hub

Coix seed extract could augment the efficacy of gemcitabine therapy in pancreatic cancer cells at least partly due to the alteration of ABC transporter-mediated drug efflux function.

2019 International Journal of Molecular Sciences Coix Seed Extract Enhances the Anti-Pancreatic Cancer Efficacy of Gemcitabine through Regulating ABCB1- and ABCG2-Mediated Drug Efflux: A Bioluminescent Pharmacokinetic and Pharmacodynamic Study
Qian, Y.; Xiong, Y.; Feng, D.; Wu, Y.; Zhang, X.; Chen, L.; Gu, M.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Pancreatic Cancer" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Pancreatic Cancer" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Pancreatic Cancer" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Cohort Study published in 2023 in the journal Nutrients found that Regular consumption of raw carrots is associated with a significant, dose-dependent reduction in lung cancer incidence, suggesting a potential cancer-protective effect attributed to polyacetylenic compounds, particularly falcarinol and falcarindiol, present in raw carrots. This research involved a long-term study of 55,756 Danish citizens over a period of more than 25 years. The focus was on investigating the relationship between regular consumption of raw carrots and the development of various cancers, predominantly adenocarcinomas and leukemia. The study assessed whether the frequency of carrot consumption influenced the incidence of lung, pancreatic, breast, prostate cancer, and leukemia. Additionally, it compared the effects of eating raw versus processed carrots. The study found that eating raw carrots regularly was associated with a reduced occurrence of lung cancer. This link was less clear for pancreatic cancer and non-existent for breast and prostate cancer. The research suggested that the cancer-preventive properties of raw carrots could be attributed to specific compounds, namely falcarinol and falcarindiol. These compounds are not present in cooked carrots. This significant finding points towards the potential of raw carrots in cancer prevention, particularly for lung cancer.

A Review Article published in 2023 in the journal Journal of the Science of Food and Agriculture found that Carrot and carotene consumption could diminish the risk of a wide range of negative health consequences, including multiple types of cancer. An umbrella review methodology was adopted to identify connections between carrot and carotene intake and various health outcomes. We turned to databases such as Web of Science, PubMed, and Embase to find the needed data. The analysis included the collected evidence from both interventional and observational studies that focused on carrots, carotene, and any related health impact. To estimate the summary effect size for each correlation, both random and fixed effects models were employed. The study reviewed a total of 1329 studies and utilized the data from 30 meta-analyses with 26 health outcomes that fit the eligibility requirements. These featured outcomes related to various types of cancer, fractures, age-related cataract, sunburn, and Alzheimer's disease. The associations were analyzed between the health outcomes and the intake of carrots, intake of carotene, and serum carotene levels.

A published in 2019 in the journal International Journal of Molecular Sciences found that Coix seed extract could augment the efficacy of gemcitabine therapy in pancreatic cancer cells at least partly due to the alteration of ABC transporter-mediated drug efflux function. Results showed that coix seed extract could synergistically enhance the anti-cancer efficacy of gemcitabine. Meanwhile coix seed extract alone or in combination with gemcitabine could significantly increase the AUCluc while decreasing the Kluc. Western blot and immunohistochemistry assay demonstrated that coix seed extract could significantly mitigate gemcitabine-induced upregulation of ABCB1 and ABCG2 protein. The Pearson correlation analysis demonstrated that the bioluminescent pharmacokinetic parameters and pharmacodynamic index have strong association in vitro and in vivo. In conclusion coix seed extract could augment the efficacy of gemcitabine therapy in pancreatic cancer cells may at least partly due to the alteration of ABC transporter-mediated drug efflux function.

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