Anti-Depressant

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Chinese Medicine Research Hub

Review Article

Depression, a prevalent and debilitating disorder, necessitates novel treatments beyond conventional drugs. Stingless bee honey, rich in antioxidants, emerges as a potential antidepressant candidate, explored comprehensively through monoamine, inflammatory, and neurotrophin hypotheses.

2022 Molecules Pathophysiology of Depression: Stingless Bee Honey Promising as an Antidepressant
Zakaria FH, Samhani I, Mustafa MZ, Shafin N

Chinese Medicine Research Hub

Experimental Study

Saffron and its bioactive molecules, notably crocins, have been found to be as effective as common antidepressants in treating depression disorders.

2022 Molecules Anti-Depressant Properties of Crocin Molecules in Saffron
Siddiqui SA, Ali Redha A, Snoeck ER, Singh S, Simal-Gandara J, Ibrahim SA, Jafari SM

Chinese Medicine Research Hub

Experimental Study

Chrysanthemum morifolium, Naringenin and Apigenin can alleviate depression-like behavior by interfering with specific metabolic pathways.

2020 Artificial Cells, Nanomedicine, and Biotechnology A metabolomic study on the anti-depressive effects of two active components from Chrysanthemum morifolium
Liu T, Zhou N, Xu R, Cao Y, Zhang Y, Liu Z, Zheng X, Feng W

Chinese Medicine Research Hub

Randomised Controlled Trial

Shiatsu is a safe and potentially useful alternative approach for refractory headache.

2017 Neurological Sciences Single-blind, randomized, pilot study combining shiatsu and amitriptyline in refractory primary headaches
Villani V, Prosperini L, Palombini F, Orzi F, Sette G.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Anti-Depressant" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Anti-Depressant" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Anti-Depressant" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2022 in the journal Molecules found that Depression, a prevalent and debilitating disorder, necessitates novel treatments beyond conventional drugs. Stingless bee honey, rich in antioxidants, emerges as a potential antidepressant candidate, explored comprehensively through monoamine, inflammatory, and neurotrophin hypotheses. This comprehensive review delves into the urgent need for safer and more effective depression treatments, considering the limitations of conventional drugs. The focus is on Stingless Bee Honey (SBH), recognized for its high antioxidant content, and its potential as an antidepressant is explored through the lenses of the monoamine, inflammatory, and neurotrophin hypotheses. Stingless bee honey's potential as an antidepressant is examined in the context of its antioxidant richness, offering a new avenue for addressing depression beyond conventional drug approaches. The review highlights the importance of exploring alternative medicines, such as SBH, for safer and more efficacious depression treatments.

A Experimental Study published in 2022 in the journal Molecules found that Saffron and its bioactive molecules, notably crocins, have been found to be as effective as common antidepressants in treating depression disorders. The methodology of the research centered on the incredible therapeutic properties of saffron, more specifically its bioactive molecules known as crocins. These molecules were singled out as they have shown a capacity to inhibit monoamine oxidase type A and B. The researchers also conducted experiments with saffron petal extracts, observing their impact on contractile response in electrical field stimulation. There were further investigations into saffron's ability to inhibit the reuptake of monoamines, display -methyl-d-aspartate antagonism, and enhance brain-derived neurotrophic factor signaling. The discussion of the results highlighted the effectiveness of saffron and its crocins in treating depressive disorders. From several experimental studies, it became apparent that saffron and crocins might perform similarly to fluoxetine and imipramine, both widely accepted antidepressant drugs. As such, the paper suggests that these natural elements found in saffron could offer an alternative treatment method for depression. The limitations, however, as highlighted in the study, were issues surrounding stability and delivery of the herbal treatment.

A Experimental Study published in 2020 in the journal Artificial Cells, Nanomedicine, and Biotechnology found that Chrysanthemum morifolium, Naringenin and Apigenin can alleviate depression-like behavior by interfering with specific metabolic pathways. In this study, the researchers decided to evaluate the impact of Chrysanthemum morifolium, Naringenin, and Apigenin on depression-like behaviors instigated specifically by corticosterone. These substances, which are the primary active ingredients in the aqueous extract of C. morifolium and are used in Traditional Chinese Medicine, were analyzed regarding their therapeutic properties for depression. Researchers analyzed behavior and biochemical indicators tied to depression to understand the effects of these substances on a modeled depression scenario. In the discussion of results, the authors highlight that these substances demonstrated antidepressant properties through their interference with certain metabolic pathways. These pathways include tryptophan metabolism, arginine and proline metabolism, citrate cycle, niacin and niacinamide metabolism, phenylalanine metabolism, and alanine, aspartate and glutamate metabolism. The effects were further explained on the basis of material and energy metabolism. Moreover, it was noted that Naringenin could potentially be used as a replacement for Chrysanthemum morifolium with similar beneficial outcomes; while Apigenin paralleled the function of other positive drugs targeting depression.

A Randomised Controlled Trial published in 2017 in the journal Neurological Sciences found that Shiatsu is a safe and potentially useful alternative approach for refractory headache. Although all the three groups improved in terms of headache frequency, visual analogue scale score, and number of pain killers, there was no between-group difference in primary endpoint. Shiatsu (alone or in combination) was superior to amitriptyline in reducing the number of pain killers taken per month. Seven (19%) subjects reported adverse events, all attributable to amitriptyline, while no side effects were related with shiatsu treatment. Shiatsu is a safe and potentially useful alternative approach for refractory headache. However, there is no evidence of an additive or synergistic effect of combining shiatsu and amitriptyline. These findings are only preliminary and should be interpreted cautiously due to the small sample size of the population included in our study.

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