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Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
2022 Jun The American Journal of Clinical Nutrition Sesso HD, Manson JAE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, et al.
Randomised Controlled Trial Cardiovascular Disease CocoaCocoa extract supplementation in older adults reduced cardiovascular disease related death rates, but did not significantly lessen total cardiovascular events.
Beneficial role of Avocado oil orally used in Osteoarthritis: experience in a tertiary care hospital of Bihar, India
2019 May 23 International Journal of Basic & Clinical Pharmacology Chandra A, Kumar A, Kumar M, Kumar M, Dikshit H
Randomised Controlled Trial Avocado Oil OsteoarthritisAvocado oil supplement combined with exercise improves joint function in osteoarthritis over traditional treatments like NSAIDS and multivitamins with exercise.
Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease
2018 Jul Circulation: Cardiovascular Quality and Outcomes Kim J, Choi J, Kwon SY, McEvoy JW, Blaha MJ, Blumenthal RS, et al.
Our meta-analysis of clinical trials and prospective cohort studies demonstrates that MVM supplementation does not improve cardiovascular outcomes in the general population.
Systematic Review Meta-Analysis MultivitaminResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Cocoa extract supplementation in older adults reduced cardiovascular disease related death rates, but did not significantly lessen total cardiovascular events.
2022 The American Journal of Clinical Nutrition Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial Sesso HD, Manson JAE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, et al.
Randomised Controlled Trial Cardiovascular Disease Cocoa
A randomized, double-blind, placebo-controlled trial was conducted on 21,442 US adults aged 60 or over, all of who were free of major cardiovascular disease and recently diagnosed cancer. The participants were assigned to either a cocoa extract supplement, which included 500 mg flavanols per day, or a placebo. The intervention phase ran from June 2015 to December 2020. The primary outcome was focused on the number of total cardiovascular events, including myocardial infarction, stroke, and cardiovascular death among others.
The results showed that during a median follow-up of 3.6 years, there were 410 participants taking cocoa extract and 456 under placebo who had confirmed total cardiovascular events. Secondary endpoints showed reduced death due to cardiovascular disease for the cocoa extract supplement users. However, there was no significant impact on the incidence of total cardiovascular events. Conversely, a lower risk of total cardiovascular events was supported when analyses were censored at nonadherence. Overall, no safety concerns were raised during the trial.
Avocado oil supplement combined with exercise improves joint function in osteoarthritis over traditional treatments like NSAIDS and multivitamins with exercise.
2019 International Journal of Basic & Clinical Pharmacology Beneficial role of Avocado oil orally used in Osteoarthritis: experience in a tertiary care hospital of Bihar, India Chandra A, Kumar A, Kumar M, Kumar M, Dikshit H
Randomised Controlled Trial Avocado Oil Osteoarthritis
In this study, 90 osteoarthritis patients were randomly sorted into three groups for different treatments: one group took multivitamins associated with exercise, the second group took NSAIDS, and the third, avocado oil combined with strengthening exercises. The pain and knee functionality of each participant were measured using the Visual Analogue Scale and Oxford Knee score respectively.
Throughout the three-month treatment course, the group that used avocado oil alongside exercises outperformed the others. They had the highest Oxford Knee scores, indicating better knee functionality, and also had higher average Pain Threshold scores from the Visual Analogue Scale. Hence, this study postulates that avocado oil, coupled with muscle exercises, offers a more effective solution for managing osteoarthritis over NSAIDS and multivitamins.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
2022 Jun The American Journal of Clinical Nutrition Sesso HD, Manson JAE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, et al.
Randomised Controlled Trial Cardiovascular Disease CocoaCocoa extract supplementation in older adults reduced cardiovascular disease related death rates, but did not significantly lessen total cardiovascular events.
Beneficial role of Avocado oil orally used in Osteoarthritis: experience in a tertiary care hospital of Bihar, India
2019 May 23 International Journal of Basic & Clinical Pharmacology Chandra A, Kumar A, Kumar M, Kumar M, Dikshit H
Randomised Controlled Trial Avocado Oil OsteoarthritisAvocado oil supplement combined with exercise improves joint function in osteoarthritis over traditional treatments like NSAIDS and multivitamins with exercise.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Randomised Controlled Trial
Cocoa extract supplementation in older adults reduced cardiovascular disease related death rates, but did not significantly lessen total cardiovascular events.
Sesso HD, Manson JAE, Aragaki AK, Rist PM, Johnson LG, Friedenberg G, Copeland T, Clar A, Mora S, Moorthy MV, Sarkissian A, Carrick WR, Anderson GL
Randomised Controlled Trial
Avocado oil supplement combined with exercise improves joint function in osteoarthritis over traditional treatments like NSAIDS and multivitamins with exercise.
Chandra A, Kumar A, Kumar M, Kumar M, Dikshit H
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Multivitamin" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Multivitamin" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Multivitamin" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Randomised Controlled Trial published in 2022 in the journal The American Journal of Clinical Nutrition found that Cocoa extract supplementation in older adults reduced cardiovascular disease related death rates, but did not significantly lessen total cardiovascular events. A randomized, double-blind, placebo-controlled trial was conducted on 21,442 US adults aged 60 or over, all of who were free of major cardiovascular disease and recently diagnosed cancer. The participants were assigned to either a cocoa extract supplement, which included 500 mg flavanols per day, or a placebo. The intervention phase ran from June 2015 to December 2020. The primary outcome was focused on the number of total cardiovascular events, including myocardial infarction, stroke, and cardiovascular death among others. The results showed that during a median follow-up of 3.6 years, there were 410 participants taking cocoa extract and 456 under placebo who had confirmed total cardiovascular events. Secondary endpoints showed reduced death due to cardiovascular disease for the cocoa extract supplement users. However, there was no significant impact on the incidence of total cardiovascular events. Conversely, a lower risk of total cardiovascular events was supported when analyses were censored at nonadherence. Overall, no safety concerns were raised during the trial.
A Randomised Controlled Trial published in 2019 in the journal International Journal of Basic & Clinical Pharmacology found that Avocado oil supplement combined with exercise improves joint function in osteoarthritis over traditional treatments like NSAIDS and multivitamins with exercise. In this study, 90 osteoarthritis patients were randomly sorted into three groups for different treatments: one group took multivitamins associated with exercise, the second group took NSAIDS, and the third, avocado oil combined with strengthening exercises. The pain and knee functionality of each participant were measured using the Visual Analogue Scale and Oxford Knee score respectively. Throughout the three-month treatment course, the group that used avocado oil alongside exercises outperformed the others. They had the highest Oxford Knee scores, indicating better knee functionality, and also had higher average Pain Threshold scores from the Visual Analogue Scale. Hence, this study postulates that avocado oil, coupled with muscle exercises, offers a more effective solution for managing osteoarthritis over NSAIDS and multivitamins.
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