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Avocado oil supplement combined with exercise improves joint function in osteoarthritis over traditional treatments like NSAIDS and multivitamins with exercise.
In this study, 90 osteoarthritis patients were randomly sorted into three groups for different treatments: one group took multivitamins associated with exercise, the second group took NSAIDS, and the third, avocado oil combined with strengthening exercises. The pain and knee functionality of each participant were measured using the Visual Analogue Scale and Oxford Knee score respectively.
Throughout the three-month treatment course, the group that used avocado oil alongside exercises outperformed the others. They had the highest Oxford Knee scores, indicating better knee functionality, and also had higher average Pain Threshold scores from the Visual Analogue Scale. Hence, this study postulates that avocado oil, coupled with muscle exercises, offers a more effective solution for managing osteoarthritis over NSAIDS and multivitamins.
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PIASCLEDINE-ExpASU®, a type of avocado/soybean unsaponifiable product, displays superior pharmacological activity due to its unique composition, including a high inhibitory effect on pro-inflammatory factors.
2022 Frontiers in Pharmacology Composition Analysis and Pharmacological Activity of Avocado/Soybean Unsaponifiable Products Used in the Treatment of Osteoarthritis Lambert C, Bellemère G, Boyer G, Ponelle F, Bauer T, Legeny MC, et al.
Experimental Study Avocado-Soybean Unsaponifiables Osteoarthritis
The study began with the characterisation of the lipid content of seven different avocado/soybean unsaponifiable (ASU) products through gas chromatography analysis performed on a VARIAN 3400 chromatograph. In parallel, the effects of these products were tested on human osteoarthritis chondrocytes (cartilage cells) cultured in alginate beads. The researchers focused on the effects of these ASU products on aggrecan, key interleukins, and matrix metalloproteases.
In terms of results, PIASCLEDINE-ExpASU® stood out due to a specific profile involving unique chromatographic peaks and the presence of specific compounds like alkyl furan fraction, alkyl triols, and squalene. Remarkably, this product showed heightened efficacy in inhibiting production of nitric oxide, interleukins, and catabolic factors. Meanwhile, excepting two products, the remaining ASUs showed varied capacity in increasing aggrecan production, a positive factor in the context of osteoarthritis treatment.
Pomegranate has been confirmed to improve clinical features and reduce inflammatory, oxidative stress, and apoptosis markers in osteoarthritis.
2021 Health Promotion Perspectives Systematic review of the effects of pomegranate (Punica granatum) on osteoarthritis Malek Mahdavi A, Javadivala Z
Systematic Review Osteoarthritis Pomegranate
In the methodology, a systematic review was conducted using established databases like Scopus, PubMed, Embase, WOS, ProQuest, and Google Scholar up until February 2021. Both MESH and non-MESH keyword searches were performed in the title, abstract, and keywords. The review considered full-text clinical, animal, and in vitro studies in all languages and specifically excluded review articles, book chapters, conference abstracts, and research related to pomegranate in health problems other than osteoarthritis. A manual search was performed to examine the references or citations of eligible papers as well as grey literature to discover potential researches.
The results of the systematic review included twenty-three articles which all showed the beneficial impact of pomegranate across human, animal, and in vitro studies. These showed improvements in clinical presentations and reductions in inflammatory, oxidative stress, and apoptosis markers in osteoarthritis. This demonstrated the therapeutic potential of pomegranate for easing the effects of osteoarthritis.
Avocado/soy unsaponifiables effectively treat osteoarthritis by controlling the balance between oxidant and antioxidant molecular markers.
2021 Journal of Complementary and Integrative Medicine Avocado/soy unsaponifiables can redress the balance between serum antioxidant and oxidant levels in patients with osteoarthritis: a double-blind, randomized, placebo-controlled, cross-over study Jangravi Z, Basereh S, Zaree Mahmoudabadi A, Saberi M, Alishiri GH, Korani M
Randomised Controlled Trial Antioxidant Avocado Avocado Unsaponifiable
The methodology used in this study was a double-blind, randomized, placebo-controlled, cross-over trial. Forty osteoarthritis patients were classified into two groups: one received avocado/soy unsaponifiables (ASU) for three months followed by three months of placebo, and the other group received a placebo first for three months followed by three months of ASU. The patients' oxidant status was evaluated by measuring their serum malonldialdehyde (MDA). Other measures such as total antioxidant capacity, reduced glutathione, and antioxidant enzymes like superoxide dismutase and catalase were also assessed.
After three months of treatment, all patients who were given avocado/soy unsaponifiables exhibited a significant decrease in their serum MDA levels, indicating lower oxidative stress. In comparison, these levels were higher at baseline and after placebo treatment. Furthermore, the treatment with avocado/soy unsaponifiables resulted in positive changes in the patients' antioxidant levels. Analysis also showed that the effect of avocado/soy unsaponifiables was consistent, regardless of the sequence in which the medication was received. These findings demonstrate that avocado/soy unsaponifiables can contribute effectively to the treatment of osteoarthritis by regulating the balance between oxidant and antioxidant molecular markers.
Green tea and its compounds, especially catechins, may potentially prevent and treat osteoarthritis due to their potent antioxidant and anti-inflammatory properties.
2020 Longhua Chinese Medicine The possible role of green tea on osteoarthritis: a narrative report Barbalho SM, Goulart RA, Buglio DS, Araujo AC, Guiguer EL
Review Article Anti-Inflammatory Antioxidant Green Tea
The researchers performed an extensive review exploring the potential impact of green tea and its bioactive compounds, chiefly catechins, on osteoarthritis management. Their focus was on the anti-inflammatory and antioxidant abilities of these compounds. Based on the review, such compounds can quell inflammation by blocking various signaling pathways interconnected with inflammatory processes. Specifically, they have the potential to suppress the expression of several cytokines and enzymes related to inflammation.
In addition, green tea was noted for its property to neutralize free radicals, thus averting the formation of harmful reactive oxygen species and countering oxidative stress. While many conventional, non-surgical osteoarthritis therapies can lead to numerous adverse effects, the current review suggests that green tea could serve as a safer alternative. It may be a promising direction in the prevention and management of this chronic, painful, and inflammatory condition, which touches a significant number of people globally.
Green tea catechins potentially contribute to maintaining joint and skeletal muscle health, mitigating symptoms of osteoarthritis and sarcopenia.
2020 Antioxidants Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition Luk HY, Appell C, Chyu MC, Chen CH, Wang CY, Yang RS, et al.
Review Article Arthritis Green Tea Green Tea Catechin
The research begins by providing an understanding of osteoarthritis, a degenerative inflammatory disorder of articular cartilage, and sarcopenia, a condition characterized by loss of muscle mass and strength. It explores their prevalence, causes such as excessive inflammation and oxidative stress, mitochondrial dysfunction, and diminished autophagy. It then delves into the role of green tea catechins in joint health, including their influence on inflammatory signaling agents, anabolic mediators, and miRNAs expression.
This leads to a decrease in chondrocyte death and collagen degradation, thereby offering cartilage protection. The investigation also examines the effects of green tea catechins on skeletal muscle health. It highlights their role in maintaining an equilibrium between protein synthesis and degradation, and enhancing the synthesis of mitochondrial energy metabolism.
The review thus suggests a positive impact of green tea catechins on joint and muscle health, helping to maintain favorable muscle homeostasis and reduce muscle atrophy associated with aging. It ends by pointing out the limitations of the current study and proposing future research directions.
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