Ovarian Cancer

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Chinese Medicine Research Hub

Cohort Study

Moderate consumption of carrots is associated with a lower incidence of colorectal cancer, implying a potential cancer prevention effect in a certain dose-range.

2022 Frontiers in Nutrition Association of Dietary Carrot/Carotene Intakes With Colorectal Cancer Incidence and Mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Jiang Z, Chen H, Li M, Wang W, Fan C, Long F

Chinese Medicine Research Hub

Systematic Review

The literature overall supports an inverse association between green tea and cardiovascular disease-related health outcomes, while the included meta-analyses generally suggested an inverse association between green tea and BMI-related and blood pressure outcomes.

2020 European Journal of Clinical Nutrition Green tea and cancer and cardiometabolic diseases: a review of the current epidemiological evidence
Abe SK, Inoue M

Chinese Medicine Research Hub

Animal Study

Blueberries can reduce the proliferation of ovarian cancer cells by downregulating the levels of specific biomarkers, exhibiting potential for non-pharmaceutical therapy.

2017 Oncology Letters Blueberries inhibit cyclooxygenase-1 and cyclooxygenase-2 activity in human epithelial ovarian cancer
Lin W, Li Z

Chinese Medicine Research Hub

Experimental Study

Adzuki bean exhibited the strongest antiproliferative properties in a dose-dependent manner against all digestive system cancer cell lines, ovary cancer cell SK-OV-3 and breast cancer cell MCF-7 among all legumes tested.

2012 Food Chemistry Comparative study on antiproliferation properties and cellular antioxidant activities of commonly consumed food legumes against nine human cancer cell lines
Xu B, Chang SKC

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Ovarian Cancer" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Ovarian Cancer" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Ovarian Cancer" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Cohort Study published in 2022 in the journal Frontiers in Nutrition found that Moderate consumption of carrots is associated with a lower incidence of colorectal cancer, implying a potential cancer prevention effect in a certain dose-range. The research analysed the dietary intake of carrots/carotene and their relationship to colorectal cancer incidence and mortality in a cohort from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening. The study involved 101,680 participants who joined the cohort between November 1993 and July 2001. The hazard ratios were estimated through multivariable Cox regression analyses. Additionally, subgroup analyses and interaction tests were conducted to check for potential effect modifiers. A generalised additive model was used to examine the non-linear trend of the exposure to cancer-related outcomes. In total, the study documented 1,100 colorectal cancer cases and 443 cancer-related deaths. It was discovered that dietary carrot intake was linked to a 21% lower risk of colorectal cancer incidence for those in the 4th quintile group compared to the lowest quintile group. Increase in carrot intakes, on a per standard deviation, did not reveal any statistically significant associations with the disease incidence. There were no significant associations found between dietary α-, and β-carotene intake and colorectal cancer incidence, nor were there any associations between carrot/carotene intakes and cancer mortality. They also observed no non-linear dose-response relationships between dietary carrot, α-, and β-carotene intake and colorectal cancer incidence and mortality. Notably, the study found that smoking status could potentially modify the association of dietary carrot intake with incidence of colorectal cancer, but not mortality.

A Systematic Review published in 2020 in the journal European Journal of Clinical Nutrition found that The literature overall supports an inverse association between green tea and cardiovascular disease-related health outcomes, while the included meta-analyses generally suggested an inverse association between green tea and BMI-related and blood pressure outcomes. The evidence on green tea consumption and health outcomes presented in this review suggests green tea may be favorable for cardiovascular disease, particularly stroke, and certain cancers such as endometrial, esophageal, lung, non-Hodgkins lymphoma, oral, and ovarian cancer. More evidence is needed to assess the impact of green tea on breast, gastric, and liver cancer risk. Additional studies could also help clarify the suggested null association with certain cancer sites: colorectal, pancreatic, and prostate cancer. Possible minor adverse events on health from green tea consumption were reported in one study, however these must be interpreted cautiously within the study context and possible finer dose-response implications. The findings for green tea and diabetes risk were inconclusive. For BMI the current evidence suggests a possible weak association, while the evidence is stronger supporting a decrease in blood pressure from green tea. More studies investigating a possible association between green tea consumption and other health outcomes such as cognition, injuries, respiratory disease would be informative to more completely assess the impact of green tea on human health. In conclusion, our review suggests green tea may have health benefits especially for cardiovascular disease and certain cancer sites.

A Animal Study published in 2017 in the journal Oncology Letters found that Blueberries can reduce the proliferation of ovarian cancer cells by downregulating the levels of specific biomarkers, exhibiting potential for non-pharmaceutical therapy. The research method involved the overexpression or silencing of cyclooxygenase (COX)-1 and COX-2, known biomarkers of ovarian cancer, in SKOV3 ovarian cancer cells. The effect of blueberries on the cells' viability was then measured utilizing a colorimetric assay known as an MTT test. Additionally, a mouse model for ovarian cancer was established to further this investigation. The results revealed that the administration of blueberries led to the inhibition of ovarian cancer cell proliferation, primarily through decreased levels of COX-1 and COX-2. Furthermore, regular consumption of blueberries greatly reduced the tumor size in the ovarian cancer mouse model compared to the control without blueberry treatment. This indicates that blueberries might have considerable potential as a natural therapy for ovarian cancer due to fewer side effects and high effectiveness.

A Experimental Study published in 2012 in the journal Food Chemistry found that Adzuki bean exhibited the strongest antiproliferative properties in a dose-dependent manner against all digestive system cancer cell lines, ovary cancer cell SK-OV-3 and breast cancer cell MCF-7 among all legumes tested. This research involved comparing the health-promoting effects of various food legumes. The Cellular Antioxidant Activity (CAA) was assessed using a fluorescence microplate reader and in vitro animal cell cultivation. The antiproliferative properties against cancer cells were evaluated through the MTT method in an in vitro cell culture system. Additionally, the study quantified phytochemicals (total phenolic, procyanidin, saponin, and phytic acid) and chemical antioxidant activities (DPPH free radical scavenging activity, oxygen radical absorbing capacity, peroxyl radical scavenging capacity). The results indicated significant variations in phytochemical and antioxidant activities among different legumes. Notably, adzuki bean demonstrated the strongest dose-dependent antiproliferative effects against various cancer cell lines, including those from the digestive system, ovary, and breast. Meanwhile, black soybean showed the highest levels of saponin, phytic acid, and the strongest cellular antioxidant activities. These findings suggest that food legumes, particularly adzuki beans and black soybeans, are promising as natural antioxidants for health promotion and cancer prevention.

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