Glucose Metabolism

Presentation Slides

Chinese Medicine Research Hub

Review Article

Ziziphus jujuba and its main components, lupeol and betulinic acid, show promise in treating complications of metabolic syndrome, including diabetes, obesity, and hypertension.

2024 Current Nutrition Reports Ziziphus jujuba (Jujube) in Metabolic Syndrome: From Traditional Medicine to Scientific Validation
Ghasemzadeh Rahbardar M, Fazeli Kakhki H, Hosseinzadeh H

Chinese Medicine Research Hub

Systematic Review

Consumption of sesame seeds and its products positively influences human glucose metabolism, potentially making it a beneficial addition to glucose-lowering diets.

2022 Phytotherapy Research Consumption of sesame seeds and sesame products has favorable effects on blood glucose levels but not on insulin resistance: A systematic review and meta‐analysis of controlled clinical trials
Sohouli MH, Haghshenas N, Hernández‐Ruiz , Shidfar F

Chinese Medicine Research Hub

Systematic Review

Acupuncture could improve body mass index, waist-to-hip ratio as well as insulin resistance (HOMA-IR) in patients with PCOS.

2021 Evidence-Based Complementary and Alternative Medicine The Effect of Acupuncture on Glucose Metabolism and Lipid Profiles in Patients with PCOS: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Ruqun Zheng, Peng Qing, Mei Han, Jinlong Song, Min Hu, Hongxia Ma, Juan Li

Chinese Medicine Research Hub

Systematic Review

Coffee consumption, in the long term, improves glucose metabolism but may cause unfavourable acute effects.

2019 Journal of Traditional and Complementary Medicine Effects of coffee consumption on glucose metabolism: A systematic review of clinical trials
Reis CEG, Dórea JG, da Costa THM

Chinese Medicine Research Hub

Systematic Review

Cocoa consumption has strong beneficial impacts on cardiovascular health, reducing blood pressure, improving vascular function, and modulating lipid and glucose metabolism.

2017 Frontiers in Nutrition Cocoa, Blood Pressure, and Vascular Function
Ludovici V, Barthelmes J, Nägele MP, Enseleit F, Ferri C, Flammer AJ, Ruschitzka F, Sudano I

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Glucose Metabolism" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Glucose Metabolism" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Glucose Metabolism" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2024 in the journal Current Nutrition Reports found that Ziziphus jujuba and its main components, lupeol and betulinic acid, show promise in treating complications of metabolic syndrome, including diabetes, obesity, and hypertension. The research assessed the properties of Ziziphus jujuba and its main bioactive agents, lupeol and betulinic acid, in relation to metabolic syndrome. Investigations focussed on their potential roles in glucose uptake enhancement, hepatic glucose synthesis reduction, insulin sensitivity improvement, and lipid profile modulation. Studies involved identifying the influence of these substances on key signaling pathways and insulin signaling proteins, as well as evaluating their anti-adipogenic effects and capacity to improve endothelial function. Ziziphus jujuba and its constituents exhibited potential therapeutic benefits for metabolic syndrome by facilitating glucose uptake, reducing glucose synthesis, and improving insulin sensitivity. They also showed potential in moderating lipid synthesis and fat accumulation, demonstrating anti-fatty effects and a capacity to influence adipogenic enzymes and transcription factors. Moreover, these substances demonstrated enhanced endothelial function, reflecting positively on vascular health. These accumulative findings suggest promising potential for Z. jujuba, lupeol, and betulinic acid as natural treatments for metabolic syndrome complications.

A Systematic Review published in 2022 in the journal Phytotherapy Research found that Consumption of sesame seeds and its products positively influences human glucose metabolism, potentially making it a beneficial addition to glucose-lowering diets. The methodology involved conducting a systematic review and meta-analysis on the effect of sesame seeds consumption on blood glucose and insulin resistance in adults. The researchers gathered data from recognized academic resources like PubMed/MEDLINE, SCOPUS, Web of Science, Google Scholar, and EMBASE, which included controlled clinical trials up until February 2021. The sesame products in these trials ranged from sesame oil, sesamin, and tahini, with the intervention period lasting from 45 days to 9 weeks. The results illustrate that the intake of sesame and its products significantly improved fasting blood glucose and Hemoglobin A1c levels. Nonetheless, the results regarding fasting serum insulin and the homeostatic model assessment for insulin resistance were not found to have any significant relation. Hence, the consumption of sesame might be a beneficial supplement for managing glucose levels in humans.

A Systematic Review published in 2021 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture could improve body mass index, waist-to-hip ratio as well as insulin resistance (HOMA-IR) in patients with PCOS. Overall, we found that acupuncture was closely associated with decreased BMI, WHR, FPG, and HOMA-IR and that acupuncture could significantly improve HOMA-IR and the level of fasting glucose in patients with PCOS, which confirms previous reports. It is also reported that acupuncture can decrease BMI and WHR. FINS, 2hFPG, and 2hFINS were reduced in the acupuncture groups, but these differences were not significantly different. The results of the lipid profile were reported in a few studies, and we found that acupuncture significantly improved triglycerides levels, while the differences in total cholesterol, LDL-C, and HDL-C were not significant. Acupuncture seems to be associated with a few adverse events, and the reported adverse events, such as bleeding, were mild and transient, demonstrating that acupuncture is safe and reliable. Thus, we conclude that acupuncture, compared with standard therapy, is more effective and safer in improving glucose metabolism and insulin sensitivity in patients with PCOS.

A Systematic Review published in 2019 in the journal Journal of Traditional and Complementary Medicine found that Coffee consumption, in the long term, improves glucose metabolism but may cause unfavourable acute effects. Researchers undertook a systematic review to evaluate the impact of coffee consumption on glucose metabolism. They scanned two electronic databases, PubMed and Web of Science, for relevant studies published till September 2017. After thorough scrutiny, eight clinical trials involving 247 participants were earmarked for analysis. These trials were divided into short-term (1-3 hours) and long-term (2-16 weeks) studies for distinct evaluation. The participants' characteristics, major discoveries, and study quality were all meticulously noted and analysed. The initial short-term studies revealed that consumption of caffeinated coffee might lead to an escalation in the area under the curve for the glucose response, an immediate effect. Conversely, long-term studies suggested that caffeinated coffee might contribute to the enhancement of glycaemic metabolism over time by reducing the glucose curve and bolstering the insulin response. Despite the immediate short-term effects, an overall positive long-term impact on glucose metabolism was reported.

A Systematic Review published in 2017 in the journal Frontiers in Nutrition found that Cocoa consumption has strong beneficial impacts on cardiovascular health, reducing blood pressure, improving vascular function, and modulating lipid and glucose metabolism. In the study's methodology, the link between the consumption of natural polyphenol-rich foods, specifically cocoa, and a decreased risk of cardiovascular diseases was explored. The process involved evaluating cocoa's influence on various aspects, such as blood pressure reduction, vascular function improvement, lipid and glucose metabolism modulation, and reduction of platelet aggregation. This evaluation was performed in varying demographic groups, including healthy individuals, individuals with risk factors such as diabetes and arterial hypertension, and individuals with established coronary heart diseases or heart failure. The study's findings indicate that cocoa's consumption has a significant and positive effect on cardiovascular health. Notably, it was found to reduce blood pressure, enhance vascular function, and modulate lipid and glucose metabolism. These beneficial effects were observed in all the subjects irrespective of their health status - healthy, at risk, or with established cardiovascular diseases. The results hypothesize several potential mechanisms through which cocoa exerts these positive effects, including the activation of nitric oxide synthase, increased availability of nitric oxide, and inherent antioxidant and anti-inflammatory properties.

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