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Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Benefit" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Benefit" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Benefit" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Systematic Review published in 2024 in the journal Food Science & Nutrition found that Eating plums, especially dried plums, significantly lowers LDL levels and total cholesterol levels, particularly in adults with existing health issues. The researchers conducted a systematic review and meta-analysis using keyword searches on databases such as PubMed, Scopus, and ISI Web of Science up to a specified date. They were on a mission to find eligible trials that would help ascertain the benefits of plum consumption on adult lipid profiles. In their observation of the collected data, they concluded that plum, specifically dried plum consumption, had a noteworthy impact on LDL levels, mainly when the subjects were in an unhealthy state. This consumption led to a significant decrease in total cholesterol levels in the unhealthy subjects. Nevertheless, the study couldn't establish major changes in triglycerides and HDL concentrations as a result of the plum consumption.

A Review Article published in 2024 in the journal The Natural Products Journal found that Pumpkin seeds are recognised for their medicinal, nutritional, and cosmetic benefits, including anti-diabetic, heart disease prevention, anti-cancer, and antioxidant qualities. The review article undertakes a comprehensive exploration of the nutraceutical importance of pumpkin seeds. The methodology includes an examination of the various known substances in the seeds, such as phytoestrogens, unsaturated fatty acids, and vitamin E. The study then delves into the different benefits and therapeutic uses of these components stretching from medicinal to nutritional to cosmetic applications. The results of this research are diverse and impressive, with implications for several major health sectors. Their potential anti-diabetic and hypoglycemic properties could suggest a significant role in the management and prevention of diabetes. Meanwhile, the seeds' potential in cardiovascular disease prevention could help to address one of the most pressing global health issues. Moreover, potential anti-cancer properties imply that these seeds could even have a part to play in cancer prevention. The review also described potential additional qualities, such as antidepressant, anti-helminthic (parasite-removing), and antioxidant effects.

A Review Article published in 2024 in the journal Pharmaceuticals found that Lemongrass essential oil can effectively treat periodontitis, gingivitis, oral malodour, skin aging, and dandruff, and it is comparable to certain established treatments. The methodology used in the research followed a scoping review design, which was aimed at identifying, summarizing, and synthesizing existing literature related to the clinical applications of lemongrass essential oil. Three databases, namely PubMed, Web of Science, and Scopus, were utilized, following the PRISMA-ScR guidelines, to find articles published within approximately a 10-year timeframe. The results of the review suggest that patients have received noticeable therapeutic benefits from treatments that were primarily administered oromucosally and topically. It can be deduced that the efficacy of lemongrass essential oil in treating periodontitis, gingivitis, and oral malodour is similar to that of chlorhexidine and doxycycline. Moreover, the oil has demonstrated potential in treating skin conditions such as pityriasis versicolor, preventing skin aging, and having anti-dandruff effects. The diverse range of applications of the oil and its efficacy when compared to established treatments highlight its potential for clinical applications.

A Randomised Controlled Trial published in 2023 in the journal Nutrients found that Consumption of unripe avocado extract in the diet may lower postprandial insulin levels in overweight adults with previously elevated insulin levels. In this study, a double-blinded, randomised controlled trial was performed on 60 non-diabetic adults (with a majority of 47 being women, average age 48 years, BMI 34.0 kg/m). The participants were stratified by sex and randomised into two groups. One group daily consumed an extract from unripe avocado (10 g finely ground, freeze-dried unripe avocado), while the other took a placebo (10 g finely ground cornmeal supplemented with 5% spinach powder) over a period of 12 weeks. The primary outcome measured was the change in glucose area under the curve (AUC) in response to a 75 g oral glucose tolerance test. The results showed no significant differences between both groups in terms of glucose AUC, insulin AUC, or cardiovascular outcomes. However, in a subgroup analysis focusing on participants with above median baseline postprandial insulin levels, there was a notable reduction in insulin AUC in those who consumed the avocado extract compared to the placebo. This suggests that the daily consumption of an unripe avocado extract, enriched in MH, might not significantly impact glucose tolerance or insulin sensitivity in obese non-diabetic adults. Nonetheless, there seems to be a potential benefit of this intervention on postprandial insulin levels in individuals with initially elevated insulin responses.

A Systematic Review published in 2023 in the journal Phytotherapy Research found that Pomegranate can significantly enhance women's health during and after menopause by reducing hot flashes severity and other menopause symptoms. The study aimed at understanding the impacts of pomegranate on women's health through and following menopause. To gather data, a rigorous search was conducted on various academic platforms, including PubMed, Web of Science, Cochrane, Scopus, and Google Scholar, up to the end of 2022. All forms of clinical research studies, from randomized clinical trials to case series, were considered for review. The material was evaluated using the Cochrane RoB 2.0 tool specifically for quality assessment of randomized clinical trials. To quantify the effects of the pomegranate intervention, standardized mean differences were calculated using a random effect model. It was found that pomegranate significantly reduces the severity of hot flashes in menopausal women, improves their high-density lipoprotein levels, and reduces the Follicle-Stimulating Hormone (FSH). However, no significant improvement was noticed in the low-density lipoprotein, body mass index, and body weight. Despite these findings, the study recognized that the results' conclusiveness was hampered due to small sample sizes and the lack of study design elements such as blinding and randomization.

A Review Article published in 2023 in the journal Nutrire found that Almond consumption has beneficial impacts on cardiovascular diseases, diabetes, obesity, and it can improve cognitive performance and protect against skin aging. The methodology employed in this study included analyzing a range of clinical studies centered on the health benefits linked to the consumption of sweet almond nuts. Various health outcomes correlated with almond consumption were investigated such as body weight, food intake, blood pressure, blood lipid composition, glucose and insulin levels, oxidative status, liver enzymes, and some inflammation biomarkers. The discussion of the results reveals that almond consumption has been found to create favorable alteration in aspects like body weight, food intake, blood pressure, blood lipid composition, glucose, and insulin levels, as well as oxidative status, liver enzymes, and inflammation biomarkers. These findings highlight the beneficial impact of almonds on multiple health issues including cardiovascular diseases, diabetes, and obesity. Additionally, the consumption of almonds has been associated with improved cognitive performance and protection against skin photodamage and aging.

A Cohort Study published in 2023 in the journal Nutrients found that Long-term consumption of green tea can potentially lessen the risk of depression in postmenopausal women by decreasing inflammation and boosting estradiol levels. In the study, researchers performed an analysis on a tea-producing village, incorporating 386 postmenopausal women in the investigation, who participated either as green tea consumers or non-drinkers (control group). The level of estradiol, inflammation markers, sleep quality, and depression symptoms were measured to uncover any correlations. The results reflected significant disparities between the tea-drinking and control groups in terms of depression and insomnia levels, BMI, inflammation levels, and estradiol quantities. By appraising these outcomes, it was found that green tea intake could quell the likelihood of depression via its impact on sleep, inflammation, and estradiol levels. The risk of depression was consequently seen as reduced among postmenopausal women engaging in regular consumption of green tea.

A Systematic Review published in 2023 in the journal Chinese Journal of Integrative Medicine found that Acupuncture may have a positive impact on clinical pregnancy rate and live birth rate in women undergoing in vitro fertilization (IVF), although the results are limited by the heterogeneity of the current evidence. This study aimed to assess the efficacy of acupuncture on embryo transfer in women undergoing in vitro fertilization (IVF). A total of 49 randomized controlled trials (RCTs) involving 9422 women were analyzed. The results indicated that acupuncture had a significant positive impact on the clinical pregnancy rate (CPR) and live birth rate (LBR) compared to the control groups (odds ratio [OR]=1.65 for CPR, 1.34 for LBR). Subgroup analyses showed that traditional acupuncture was more beneficial for women aged < 35 years, those receiving ≥ 3 sessions, and those with lower baseline CPR rates in the control group. However, significant heterogeneity was observed among the studies. In conclusion, while there were some benefits of acupuncture in improving CPR and LBR in IVF, the results should be interpreted with caution due to the variability in the current evidence.

A Review Article published in 2023 in the journal PharmaNutrition found that Soy protein, bioactive peptides, and isoflavones are generally safe for consumption and may help reduce the risk of several significant health conditions. Methodology: This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. It began with a sophisticated multi-database search, featuring resources like Google Scholar, Scopus, and others. This search targeted articles published from 2017 to March 2023 and used specific keywords for accuracy. Forty-three articles were handpicked from this process after excluding reviews, conference reports, duplicates, inaccessible texts, and any non-English publications. Discussion of Results: A thorough examination of the chosen articles resulted in the conclusion that soy proteins, soy bioactive peptides, and soy isoflavones are typically safe for human consumption. Furthermore, it was found that the consumption of these compounds may have beneficial effects, potentially lowering risk factors for ailments such as osteoporosis, various cancers, hypertension, atherosclerosis, and more.

A Review Article published in 2023 in the journal Journal of Microbiology and Biotechnology found that Soybean intake can potentially reduce risks of several cancers, type 2 diabetes, osteoporosis, and hot flashes, and it may negatively impact some drug treatments and cause allergies. This research primarily involves review and analysis of current clinical studies focusing on the benefits and risks of soybean ingredients. The method appears to be a systematic review of various epidemiological studies which were investigating the correlation between soybean consumption and the risk of developing multiple types of cancers including breast, prostate, colorectal, ovarian, and lung cancers. Besides cancer, other common diseases such as type 2 diabetes, osteoporosis, and menopausal symptoms like hot flashes were also investigated. Moreover, any potential adverse effects of soybean, including its possible detrimental impact on certain drug treatments and its allergenicity, were also factors of study in these clinical evidences. In the discussion of results, the researchers found a significant inverse association between soybean intake and cancer risks, wherein an increase in the consumption of soybean foods was associated with a reduced likelihood of cancer. Besides showing potential anticancer properties, soybean consumption was found inversely correlated with risks of type 2 diabetes. Soy isoflavones, compounds present in soybeans, also showed potential benefits in the management of osteoporosis and hot flashes. On the other hand, the adverse effects of soybean, including interference with certain drug therapies and causing allergies, were also duly noted. Therefore, the research concludes that while soybean promises several significant health benefits, caution should be exercised for individuals under specific drug treatments or with allergies to soy.

A Review Article published in 2023 in the journal International Journal of Food Properties found that Plums, which are rich in bioactive compounds, antioxidants, and vitamins, can help maintain blood glucose level, bone health, heart health and even treat certain cancers. The research explored the health benefits and medicinal effects of plums, a common fruit belonging to the Prunus genus. The study focused not only on their consumption as a food source but also their uses in beverages. Special attention was given to the polyphenolic compounds, bioactive compounds, and antioxidants inherent in plums, such as phenolic acids, anthocyanins, carotenoids, and various organic acids, alongside an array of necessary minerals and vitamins. Apart from detailing traditional nutritional components, the study analyzed the unique constituents of plums like caffeic acid, chlorogenic acid and other phenolic compounds which contribute to its antioxidant property. The broader health benefits provided by these compounds spanning bone health, cardiovascular health, blood glucose stabilization, and potential impacts on gastrointestinal diseases were studied, with a particular emphasis on their possible role in the prevention and treatment of heart disease and specific kinds of cancer: lung and oral. The role of plums' low fat and high dietary fibre content in heart disease prevention was of special focus.

A Review Article published in 2023 in the journal Critical Reviews in Food Science and Nutrition found that Theabrownins, a major ingredient in dark tea, significantly contribute to multiple health benefits by modulating lipid metabolism, reducing weight gain, and preventing diseases, surpassing other tea types. The research focuses on theabrownins, macromolecular pigments found in dark tea, believed to have numerous health benefits. These pigments derive from the oxidative polymerization of tea polyphenols and are observed to have a reddish-brown color and a mellow taste. One of the primary aspects of the research is the method of generation of theabrownins, which is mainly through microbial fermentation. This method seemingly enhances the health-promoting qualities of dark tea, especially its hypolipidemic effect, compared to other tea variants. The results of the study affirm the host of health benefits provided by theabrownins - including the modulation of lipid metabolism, reduction in body weight gain, attenuation of diabetes, mitigation of NAFLD, scavenging ROS, and prevention of tumors. Particular attention was given to the role that theabrownins play in influencing the gut microbiota, leading to significant health benefits. Despite some limitations, these factual conclusions advocate the potential of dark tea in fostering human health, premised upon its theabrownins content.

A Systematic Review published in 2023 in the journal Nutrients found that Natural calcium-rich mineral waters offer a bioavailable calcium source, beneficial for bone health, cardiovascular function, weight management, and overall well-being. This systematic review analyzed peer-reviewed articles, clinical trials, and experimental studies from the past decade. It focused on the health benefits of calcium-rich mineral waters, especially for individuals with lactose intolerance or on plant-based diets. The review process assessed the contribution of these waters to daily calcium intake and their bioavailability compared to other calcium sources. The review found that natural mineral waters high in calcium can significantly enhance calcium intake, with improved absorption rates. These waters show promise in promoting bone health and cardiovascular function, including potential reductions in blood pressure and cardiovascular disease risk. Some evidence suggests benefits in weight management. However, the review highlighted the need for further research on interactions with other dietary components, effects on specific health conditions, and long-term consumption impacts. Despite these gaps, calcium-rich mineral waters are recognized as a valuable dietary calcium source for a diverse population.

A Systematic Review published in 2023 in the journal Current Sleep Medicine Reports found that There is evidence to support significant improvements to total sleep time and sleep efficiency with the ingestion of tart cherries. We identified a total of 277 unique records, from which 8 studies of low-moderate methodological quality were included in the systematic review. Meta-analysis of subjectively recalled sleep efficiency (SE) and total sleep time (TST) were not significant. Objective SE, however, was significantly higher in the cherry cohort when compared to placebo with an effect size of 0.63 (95% CI 0.29–0.97, P < 0.01). There was low associated heterogeneity (I2 = 0%). Objective TST was significantly higher in the cherry cohorts, with a pooled effect size of 1.21 (95% CI 0.83–1.58, P < 0.01). There was high associated heterogeneity (I2 = 81.5%).

A Animal Study published in 2023 in the journal Food Research International found that Fermented soy milk significantly improves lipid profiles and fertility in a model of premenopausal mice, due to increased bioavailability and action of beneficial compounds. In this study, non-fermented soy beverage (SB) and soy beverage fermented with Bifidobacterium pseudocatenulatum INIA P815 (FSB) were tested on both cyclic and acyclic C57BL/6J aged female mice which mimic premenopause and menopause conditions respectively. Over a period of 36 days, the beverages were given to the mice and the variables measured included body weight, lipid and inflammatory profile and fertility. In addition, hepatic gene expressions were examined and the faecal microbiota composition was assessed to further understand the effects of the two beverages. In the results, FSB displayed a higher concentration of the aglycones daidzein and genistein as well as increased antioxidant activity due to the fermentation process. The cyclic mice that were given FSB experienced a significant rise in the number of oocytes and zygotes retrieved. It was also noticed that the triglycerides were lower in the groups that were given FSB compared to the SB groups. However, it was found that neither of the treatments significantly influenced the inflammatory profile or caused a major shift in intestinal microbiota or hepatic gene expressions in either of the groups. Still, it was observed that FSB had more health benefits than SB with regards to the lipid profile and fertility in the cyclic mice, likely due to the increased bioavailability and bioactivity of compounds due to fermentation.

A Review Article published in 2023 in the journal Antioxidants found that Pomegranate and its components could offer considerable potential as dietary supplements or supports in treatment for cardiovascular and non-cardiovascular diseases. The review examines a myriad of recent preclinical and clinical studies focusing on pomegranate. To harness the health benefits of pomegranate, different components were extracted and studied. These include juice from the fruit's edible arils, oil from the seeds, and bioactive products from the typically discarded peel. The research also considers advances in encapsulation and green extraction techniques to optimize the use of waste pomegranate products. The studies suggest promising beneficial effects of pomegranate in diverse areas. Though challenges remain, such as limited oral bioavailability and uncertainty concerning the role of active metabolites, the collective findings offer crucial insight into the significant potential of pomegranate as a dietary supplement or co-therapy for a range of diseases, especially cardiovascular and non-cardiovascular ones.

A Review Article published in 2023 in the journal Frontiers in Nutrition found that Sardines, being an affordable source of Omega-3 and other cardioprotective nutrients, can potentially reduce the need for Omega-3 supplementation and manage cardiometabolic diseases. The abstract primarily acknowledges the importance of Omega-3 polyunsaturated fatty acids with respect to managing diseases related to heart health and metabolism, for instance, type 2 diabetes, hypertension, hypertriglyceridaemia, and fatty liver disease. However, these fatty acids are not the sole beneficial component of sardines. Minerals including but not limited to calcium, potassium, and magnesium as well as substances like taurine and arginine found in sardines have a significant role in controlling mild inflammation and oxidative stress which are usually present in cardiovascular diseases and hemodynamic dysfunction. The results discussed in the abstract suggest a positive correlation between consumption of sardines and potential cardiometabolic benefits. By considering the dose-response relationship effects, a pragmatic approach towards consumption of nutrients was suggested. The intake of sardines was seen not only as a means of Omega-3 supplementation but also as a comprehensive approach to enhancing cardiovascular health. The abstract concludes with an emphasis on the many beneficial nutrients found in sardines besides Omega-3, underlining the need to shift the focus from synthetic supplementation to natural dietary improvement.

A Review Article published in 2023 in the journal Nutrients found that Vitamin D deficiency could accelerate depressive symptoms and suicide risks, and vitamin D supplementation may mitigate these effects. The paper examines the links between vitamin D deficiency, depression, and suicide from various studies. It hypothesizes that vitamin D could enhance serotonin synthesis and modulate proinflammatory cytokines, both factors in depression and suicide. The paper reviews this hypothesis in the context of the broader health issue of suicide, which is among the leading causes of death worldwide. This paper then discusses the potential benefits of vitamin D supplementation. Drawing upon indirect evidence suggesting that vitamin D deficiencies may be a risk factor for depression—one of the most common factors in suicide attempts—the paper postulates that vitamin D supplementation could play a role in helping to reduce the risk of depression and thus suicide. The beneficial mechanisms of vitamin D, such as enhancing serotonin synthesis and modulating proinflammatory cytokines, which are associated with depression and suicide, stand as the central contributing factors in this hypothesis.

A Animal Study published in 2023 in the journal Behavioural Neurology found that Pumpkin seeds have been shown to provide neuropharmacological benefits such as reducing anxiety and depression, and improving memory. The study evaluated the effects of pumpkin seeds on four areas - anxiety, depression, memory, and motor coordination. Anxiety was tested using models like light and dark apparatus, elevated plus maze, head dip, and open field test, while depression was assessed by the forced swim test and tail suspension test. Memory and learning abilities were gauged through the passive avoidance test, stationary rod apparatus, and Morris's water maze test. The effect on motor skilled learning was assessed by stationary rod and rotarod apparatus. Finally, the levels of brain biogenic amines were determined using reversed phase high-pressure liquid chromatography. In the results evaluation, it was found that pumpkin seeds exhibit properties that help reduce anxiety and alleviate depression, while also enhancing memory. However, they showed no significant effects on motor coordination. An elevated level of norepinephrine was observed, possibly contributing to its antidepressant effects. Furthermore, a reduction in the weight of the animal was observed after chronic administration. These benefits are probably due to the seeds' secondary metabolites like cucurbitacin, beta-sitosterol, polyphenolic compounds, citrulline, kaempferol, arginine, beta-carotene, quercetin, and other antioxidants.

A Review Article published in 2023 in the journal Food Reviews International found that Australian native plums contain phytochemicals that exhibit health benefits such as cardiovascular and liver protection. The research review examined five varieties of Australian native plums: Terminalia ferdinandiana (Kakadu Plum), Davidsonia jerseyana (Davidsons Plum), Podocarpus elatus (Illawarra Plum), Pleiogynium timorense (Burdekin Plum) and Parinari nonda (Nonda Plum). The paper explored each plum variety in terms of their ideal growing conditions, their phytochemical composition, their sensory properties, and their potential applications. Extracts from different parts of the fruit including the peel, pulp, and seeds were analyzed for their capabilities to interact with cell signaling pathways, scavenge free radicals, and inhibit harmful microorganisms such as bacteria, fungi, and viruses. The findings suggest that Australian native plums not only have substantial nutritional value - being high in dietary fiber and low in fat - but they also offer a multitude of health benefits. Notably, these fruits exhibit cardiovascular and liver-protective properties. Moreover, aside from their nutritional and health value, these native plums also display impressive economic potential. For instance, the pulp of these plums could be incorporated into food and beverage creation while their wood could be utilized for furniture making.

A Randomised Controlled Trial published in 2023 in the journal Frontiers in Public Health found that Acupuncture can improve both perimenopausal depression and insomnia with short-medium term effects while being a safe treatment. The experiment involved seventy eligible participants who were randomly assigned to either a real-acupuncture (RA) or a sham-acupuncture (SA) group. They were given 17 sessions of either RA or SA treatments over an 8-week timeframe. The primary outcomes for mood and sleep were evaluated using the 17-item Hamilton Depression Rating Scale and the Pittsburgh Sleep Quality Index scores. Secondary outcomes included an evaluation of anxiety symptoms, perimenopausal symptoms, and quality of life. Also, participants' experiences and overall satisfaction with treatment were assessed. Blood samples were collected as well to measure reproductive hormone levels. Reports indicate that 65 participants completed all treatment sessions while 54 and 41 participants completed the 8-week and 16-week follow-ups respectively. The results showed the RA group to have a bigger reduction of Pittsburgh Sleep Quality Index scores at post-treatment and 8-week follow-up compared to the sham-acupuncture group. Although, the change in the Hamilton Depression Rating Scale scores for the RA group wasn’t significantly different from the sham group. There were no significant mean differences for the Hamilton Depression Rating Scale or the Pittsburgh Sleep Quality Index between the two groups from the beginning to the 16th-week follow-up, nor were any differences noted in serum reproductive hormone levels among the groups. No major adverse events were reported.

A Review Article published in 2023 in the journal Frontiers in Aging Neuroscience found that Honey exhibits multifaceted benefits for brain health, acting as a memory booster, neuroprotective agent, anti-stress, and anti-nociceptive substance, fostering potential therapeutic applications to enhance overall cognitive well-being. This review scrutinizes 34 original articles exploring the impact of honey on brain health. Honey, traditionally known as a natural sweetener, emerges as a versatile substance with applications in nutrition, health supplementation, and brain health enhancement. The analysis identifies four key benefits: memory enhancement, neuroprotection, stress reduction, and pain alleviation. The review emphasizes the growing interest in understanding the mechanisms that underlie these effects, paving the way for potential therapeutic roles of honey in promoting cognitive well-being. The literature review underscores the significant role of honey in brain health research, shedding light on its diverse benefits, including memory improvement, neuroprotection, stress mitigation, and pain relief. The emphasis on unraveling the underlying mechanisms reflects a broader interest in establishing honey's therapeutic potential for enhancing overall brain health. This comprehensive exploration of honey's effects on cognition opens avenues for developing novel therapeutic strategies harnessing honey's natural properties.

A Review Article published in 2023 in the journal Reference Series in Phytochemistry found that Through innovative refinement, nanocurcumin, evolved from turmeric's primary component curcumin, has improved characteristics and pharmaceutical potential, particularly in drug delivery systems. The methodology of the research involved analyzing the cultivation, storage, and surrounding environmental factors crucial to turmeric production, such as soil condition and climate. This was intertwined with investigations into the chemical composition of turmeric, focusing mainly on curcumin, its main component. Moving forward, the study then evaluated curcumin analogs and formulations, leading to a deep dive into the relatively new development of nanocurcumin. The discussion of the research results revealed several interesting findings. Firstly, turmeric exhibited a variety of useful properties, highlighting its role in traditional medicine and livelihood in Indian tribes. Most importantly, the research concluded the impressive potential of nanocurcumin. This altered form of curcumin showed not only enhanced characteristics but also possible applications in the pharmaceutical field, specifically for drug delivery systems.

A Review Article published in 2023 in the journal Pharmacological Research found that Consumption of tea and coffee may possibly provide anti-inflammatory effects, contributing to reduced cardiovascular risk and mortality. The methodology of this narrative review examined the potential anti-inflammatory properties of consuming tea and coffee as a factor in reducing the risk of cardiovascular disease. This was done by analyzing a plethora of studies and meta-analyses that explored the impact of diet on inflammation, with a keen focus on the consumption of these beverages. The studies looked at a variety of risk factors for atherosclerotic cardiovascular disease, including inflammation biomarkers such as C-reactive protein, along with the impact of modern lipid-lowering treatments. In discussing the results, it was noticed that inconsistent findings were produced from the analysed studies which made a conclusive determination challenging. However, a trend was observed where drinking tea and coffee seemed to raise adiponectin levels, reduce reactive oxygen species and lower low-density lipoprotein cholesterol levels. Despite these potential anti-inflammatory properties of tea and coffee being somewhat uncertain due to various confounding factors, their consumption is still recommended as part of a healthy diet.

A Systematic Review published in 2022 in the journal Research in Nursing & Health found that Acupuncture, either in isolation or as an adjunct to pharmacological treatment, has clinical benefits and can be considered a safe option for managing depression. A review of 22 trials involving 2,391 participants found that acupuncture can reduce depression severity. Combining acupuncture with antidepressants was more effective than using antidepressants alone or waitlist. However, acupuncture alone or with antidepressants didn't show significant benefits compared to sham acupuncture. Sham acupuncture might have stronger effects than other placebos. Differences in treatment sessions and cultural backgrounds between China and Western countries affect outcomes. Lack of standardization in acupuncture regimens hinders research. Mild adverse events were reported but need better documentation.

A Animal Study published in 2022 in the journal Nutraceuticals found that A. lappa (burdock root) benefits diabetic rodents by reducing blood glucose and improving lipids, but human effects are uncertain This study analyzed the effects of A. lappa (burdock root) and related compounds on diabetic rodents. Results showed that these substances can lower blood glucose levels and improve triglyceride and cholesterol levels in these animals, depending on factors like the type of diabetes model used. However, it's essential to remember that these findings are based on animal studies, and we need more research to know if they apply to humans and prolonged use may have adverse effects.

A Systematic Review published in 2022 in the journal Dermatologic Therapy found that Long Dan Xie Gan formula used as an adjuvant therapy may hasten skin healing, relieve pain symptoms, and prevent persistent pain in acute herpes zoster patients. For the methodology, multiple databases such as PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journal Database, and Wanfang were searched by two independent authors for relevant randomized controlled trials (RCT) until July 31, 2021. The chosen studies analysed the additive effects of LDXG formula, in different forms such as decoction, capsule, or pill, for acute herpes zoster management. Nine RCTs fitting the criteria were selected, totaling 821 patients for the meta-analysis. Concerning the results, statistical analysis using a random effect model revealed that adding LDXG formula to conventional therapy noticeably shortened the time of blister resolution, crust formation, and pain resolution. It also reduced the pain intensity and incidence of lingering pain for those with acute herpes zoster in comparison to conventional treatment alone. Yet, this evidence was assessed as being of very low to moderate certainty, indicating interpretation of these results should be cautious due to statistical heterogeneity and/or an unclear risk of bias existing.

A Systematic Review published in 2022 in the journal Evidence-Based Complementary and Alternative Medicine found that HuoXiang ZhengQi (HQXXD) may be a safe and effective treatment for Chronic Cough Variant Asthma (CVA), improving clinical efficacy and airway responsiveness while reducing recurrence rates. HuoXiang ZhengQi (HQXXD) for Chronic Cough Variant Asthma (CVA) was systematically evaluated. The HQXXD group showed significantly higher total effective rates of clinical efficacy and airway responsiveness compared to the control group, while the recurrence rate was lower. Adverse reactions were not reported in HQXXD treatment, indicating its safety for CVA patients.

A Review Article published in 2022 in the journal Molecules found that Adzuki beans' high lysine content, antioxidative, antibacterial, and anti-inflammatory properties highlight their dual-use as a nutritious food source and a therapeutic agent for various diseases. The study methodology involved comprehensive analysis of the nutritional profile and health benefits offered by adzuki beans. Different varieties of the beans were tested to assess disparities in the contents and compositions of starch, protein, fat, polysaccharides, and polyphenols. The processing characteristic components such as isolated protein and heated flavor were also examined to aid in the development of adzuki bean-based food products. The results showed that adzuki beans have diverse benefits both in terms of nutrition and health. Their proteins were found to be rich in lysine, an essential amino acid, compensating for its shortage in the everyday diet typically containing cereals. The antioxidant, antibacterial, and anti-inflammatory properties are capable of enhancing human health in multiple ways. Adzuki beans and their extracts were found to hold potential in preventing and treating conditions like diabetes, kidney disease, obesity, and even cognitive decline from a high-fat diet. This discovery highlighted the usefulness of adzuki beans as not just food but also a practical ingredient in medicinal treatments.

A Review Article published in 2022 in the journal Comprehensive Reviews in Food Science and Food Safety found that Pumpkin seed oil, with its phytochemical content, shows beneficial properties against cardiovascular problems in menopausal women and hormone imbalances. The study focused on gathering scientific information that highlights the potential of pumpkin seed oil as a health-benefiting food ingredient. Its focus is on the oil’s chemical composition, phytochemical content, biological activity, safety measures alongside the various production processes. The researchers examined major phytochemicals found in the oil, including polyphenols, phytoestrogens, and fatty acids, while also noting the potential health benefits of carotenoids, squalene, tocopherols, and minerals present in it. In terms of methodology, most studies within this review were conducted in vitro to validate the oil's antioxidant and antimicrobial activities. Furthermore, there were clinical studies undertaken specifically to observe the effect of the oil in addressing cardiovascular challenges in menopausal women and conditions related to sex hormone imbalances. The comprehensive overview covers a wide array of data on the composition and potential uses of pumpkin seed oil.

A Review Article published in 2022 in the journal Nutrients found that Bee pollen, enriched with multiple nutrients, serves as a protective shield against a variety of ailments such as diabetes, allergies, and cancers, and potentially useful in cosmetic applications. The methodology employed involved a detailed review of clinical trials and patents related to the use of bee pollen. The researchers critically analyzed cases where bee pollen has been applied, particularly focusing on its use in treating allergies, prostate illnesses, cancer, and skin issues. Insights were also gained from the various patents and health recipes that utilize bee pollen to treat chronic health problems. In discussion of the results, it was found that bee pollen stands out for its multiple health benefits. Its impressive nutritional profile makes it a strong agent against diseases like diabetes, cancer, and cardiovascular conditions. Furthermore, the research indicated that bee pollen could be effectively utilized as a supplementary food given its nutrient richness. It was also observed that bee pollen holds a significant potential for usage in cosmetic applications, posing it as a natural and cost-effective choice for skincare and beauty industry.

A Systematic Review published in 2022 in the journal Critical Reviews in Food Science and Nutrition found that Vitamin D supplementation, particularly in doses greater than 2,000 IU/day, can help reduce depressive symptoms in adults. In the methodology, a comprehensive database search (including Medline, PsycINFO, CINAHL and The Cochrane Library) was performed to identify English language articles relating to the impact of Vitamin D on depression in adults, published before April 2022. This meta-analysis considered both general and clinical populations and also included studies of individuals suffering from systemic diseases, but excluded studies involving light therapy, co-supplementation (except calcium), and bipolar disorder. During the assessment of the work, the Cochrane risk-of-bias tool (RoB 2) and GRADE standards were employed to appraise the validity of each study. The results revealed a positive effect of Vitamin D on alleviating depressive symptoms. Despite the presence of high heterogeneity within included studies and with the majority having concerns related to risk of bias, it was found overall that Vitamin D supplementation, particularly when administered at doses about 2,000 IU/day, could serve as a valuable solution in reducing depressive conditions. This offers an interesting angle for mental health treatment, suggesting the supplement could be a useful addition to standard therapeutic procedures for clinical depression.

A Systematic Review published in 2022 in the journal Reproductive BioMedicine Online found that The potential of acupuncture as a non-pharmacological intervention to alleviate IVF-related state anxiety. This systematic review and meta-analysis focused on acupuncture's impact on IVF-related state anxiety. Eight trials involving 2253 participants were analyzed, with 1785 completing anxiety assessments. Results indicated a small yet significant reduction in state anxiety through acupuncture versus various controls, as measured by different scales after embryo transfer or oocyte retrieval. The standardized mean difference was -0.21, but evidence certainty was low due to limited studies and potential bias. Acupuncture emerges as a safe, drug-free option for alleviating IVF-related anxiety, although further research is needed to establish its efficacy amidst trial heterogeneity.

A Review Article published in 2022 in the journal Journal of Agricultural and Food Chemistry found that Jujube nutrients may offer potential therapeutic benefits including antioxidant, antibacterial, anti-inflammatory functions, and improving sleep quality and learning. The methodology used for this study involves a comprehensive review of existing research about Wild jujube, giving particular focus on its phytonutrients, biological functions, metabolism of bioactive compounds, and applications. The study does not seem to detail a specific experimental procedure, but instead bases its conclusions on existing literature. Various parts of the wild jujube plant, such as the fruits, seeds and leaves, were examined for their potential role as food, medicine, or health care aids. The results from the review suggest that the different parts of the wild jujube plant play many roles. The fruits have been noted for their antioxidant, antibacterial, and anti-inflammatory properties, and as ingredients preventing aging. The mature seeds have been found to have potential beneficial effects on central nervous system diseases, particularly in the treatment of insomnia and the enhancement of learning and memory.

A Randomised Controlled Trial published in 2022 in the journal Annals of the Rheumatic Diseases found that Fasting followed by a plant-based diet positively impacts disease activity and cardiovascular risk factors in rheumatoid arthritis patients. In the pilot study, patients with rheumatoid arthritis (RA) were split into two groups: one underwent a 7-day fast (consuming no more than 250 calories per day), followed by 11 weeks of a plant-based diet; the other was provided with conventional nutritional counseling according to the recommendations of the German Society for Nutrition for a total of 12 weeks. Disease activity and treatment responses were evaluated at the beginning of the experiment, day 7, week 6, and week 12. The results showed improvements in disease activity in both the fasting and conventional nutritional counseling groups. Noteworthy was the fact that the fasting group started showing improvements by day 7 as opposed to week 6 in the conventional group. Additionally, cardiovascular risk factors, such as weight and total cholesterol levels, showed more marked improvement in the fasting group compared to the conventional group. These improvements were found to be independent of any antibody status, intervention delivery method, or previous eating habits.

A Review Article published in 2022 in the journal Molecules found that Cherries and blueberries, rich in phenolic compounds, can be effectively used in pharmaceutical products, smart foods, functional beverages, and nutraceuticals to prevent or treat diseases. The research primarily studied the health-promoting potential of cherries and blueberries, given their high nutritional density and substantial phenolic compounds. The focus was on their ability to counteract oxidative stress markers and suppress pro-inflammatory responses, which are significant factors in chronic diseases such as diabetes. The researchers analyzed these fruits for their potential incorporation into various products such as pharmaceutical preparations, smart foods, functional beverages, and nutraceuticals. In the discussion of the results, it was emphasized how cherries and blueberries exhibit significant biological potential. They were not only seen as effective in combatting oxidative stress and inflammation but also as potential immune boosters. The conclusions underscored the fruits' potential role as functional foods and their relevance to the burgeoning popularity of functional beverages, hinting at their promise for inclusion in a variety of health-related products.

A Systematic Review published in 2022 in the journal Frontiers in Neurology found that Acupuncture shows potential benefits in stroke rehabilitation, particularly for shoulder-hand syndrome post-stroke. Systematic review papers evaluating the effectiveness of any stroke rehabilitation intervention were identified by comprehensive searches across PubMed, EMBASE, CDSR, six Korean databases, and two Chinese databases, as performed up until October 2021. Specific quality assessment tools (AMSTAR 2) were employed to determine the fitness of systematic reviews for inclusion. Furthermore, graphic representations like bubble plots were utilized to effectively visualize and organize scientific evidence on different clinical topics, number of articles, patient inclusion, confidence, and demonstrated effectiveness of interventions. The research paper scrutinizes 48 carefully-selected systematic reviews, performed between 2015 and 2021. These reviews either concentrate on post-stroke cognitive impairment (four systematic reviews) or primarily address post-stroke motor function (forty-four systematic reviews). 19 different interventions from traditional Chinese medicine, with acupuncture being the most prevalent, are methodically inspected. The study notes that the quality of the selected systematic reviews was overall low or very low. Despite this, most reviews did indicate that traditional Chinese medicine interventions, such as acupuncture, appear to possess potential benefits for stroke rehabilitation, particularly with shoulder-hand syndrome.

A Systematic Review published in 2022 in the journal Frontiers in Psychiatry found that Acupuncture can be a safe and effective alternative therapy to conventional drugs for improving sleep quality and relieving symptoms in patients with active depression. The research methodology involved a systematic review of randomized controlled trials focusing on the effect of acupuncture on depression-related insomnia. These studies were identified from seven different databases, dating up until December 2021. The papers included compared acupuncture to controls (waiting list or placebo/sham acupuncture) and conventional treatments (Western pharmacotherapy and/or cognitive-behavioral therapy) either alone or in combination with acupuncture. The analysis followed Cochrane criteria and encompassed a total of 21 trials, including 1,571 participants. Regarding results, it was found that acupuncture significantly reduced severity metrics of sleep quality and depression for patients who have active depression, compared with placebo-acupuncture. When contrasted with standard care (antidepressants and/or sleeping aids), acupuncture led to improvements in sleep quality and depressive symptom scores. However, for those suffering from the lingering symptoms of past or partially treated depression, the therapeutic benefits of acupuncture were minor and not statistically noteworthy. Unfortunately, no studies were found to review acupuncture's efficacy compared to cognitive-behavioral therapy or its potential synergistic effect when used concurrently.

A Review Article published in 2022 in the journal Journal of Traditional Chinese Medical Sciences found that Pu-erh tea possesses therapeutic mechanisms potentially beneficial for metabolic diseases due to its interaction with liver and gut microbiome. The methodology of this research involved reviewing and summarising the processing elements and bioactive components of pu-erh tea. Extensive study of relative human and animal trials was conducted, and the potential therapeutic mechanisms of this tea were examined and extrapolated. In discussing the results, it was discovered that pu-erh tea evidently has beneficial effects on metabolic diseases, such as hypocholesterolemic and hypolipidemic effects. The research points to the conclusion that the tea's interaction with the liver and gut microbiome is the major contributing factor to these health benefits. It helps regulate tea biotransformation and endogenous metabolism, underlining the tea's potential use in therapeutic interventions.

A Review Article published in 2022 in the journal Applied Sciences found that Purple carrot roots, rich in bioactive compounds like anthocyanin, may be effective in preventing metabolic syndrome and cancer by reducing inflammation and metabolic changes. The methodology employed in the research deeply studies the role of purple carrot’s main bioactive compounds against metabolic syndrome and cancer. The main focus lies on anthocyanin, a phenolic compound present in purple carrot roots. This natural food source was shifted towards as a healthier nutritional approach instead of dietary supplements. The research leans on the effectiveness of these compounds in evading or delaying the onset of cardiovascular diseases, obesity, diabetes, and cancer by inhibiting inflammatory effects. The discussion primarily surrounds the role of bioactive compounds found in purple carrots, specifically anthocyanin, in their potential prevention of metabolic syndrome and cancer. The study focused on how these components could disrupt the onset of cardiovascular disease, obesity, diabetes, and similar health issues. The results suggest that these compounds were successful in decreasing metabolic changes and inflammation. It has been suggested that purple carrots' inherent components might serve as a major tool in the prevention and treatment of metabolic syndrome and cancer.

A Review Article published in 2022 in the journal Journal of Nutrition and Metabolism found that Pomegranate juice, due to its unique bioactive compounds, could potentially alleviate complications related to SARS-CoV-2 infections, especially in patients with pre-existing chronic diseases. The methodology employed in this research involved reviewing and discussing currently available published evidence of the beneficial effects of pomegranate juice during conditions of viral infections. The team exploited databases such as PubMed and Scopus to access relevant references. They centered their investigation around the hypothesis that the bioactive compounds in fresh pomegranate juice are advantageous in various chronic diseased conditions, thereby making the juice potentially beneficial for SARS-CoV-2 infected patients. In the discussion of results, the researchers found compelling evidence supporting the idea that pomegranate juice can be helpful in the contexts of SARS-CoV-2 infections, particularly for those patients who have a clinical history of chronic diseases like hypertension, cardiovascular disease, diabetes, and cancer. Notably, they point out that it is the unique bioactive compounds in the juice that make it beneficial for such situations.

A Systematic Review published in 2022 in the journal Evidence-Based Complementary and Alternative Medicine found that Traditional Chinese medicine, including acupuncture, can provide superior pain relief and faster recovery for HIV-related Herpes Zoster compared to regular drugs. The review began by searching nine electronic databases for randomized controlled trials focused on the use of traditional Chinese medicine in treating HIV-associated Herpes Zoster. Two independent authors extracted data on interventions and outcomes, and the Cochrane risk-of-bias tool was used to evaluate the quality of the trials. Meta-analyses were subsequently performed using specific software. Results of the review showed that in general, the use of Chinese herbal medicine resulted in lower pain intensity and shorter herpes-related pain duration. Additionally, patients treated with this type of medicine and combined treatments recorded lower incidences of postherpetic neuralgia. The cure rate, defined as the complete absence of pain and herpes, also significantly improved with acupuncture and Chinese herbal medicine, compared to regular drugs. Notably, four trials reported on side effects, and no severe adverse events were mentioned.

A Review Article published in 2022 in the journal Nutrients found that Apple juice consumed in moderation has been found to positively impact markers of cardiovascular health, potentially influencing risk of cancer and neurodegenerative diseases. The methodology of this review involved examining 67 studies focused on the health implications of apple juice consumption, with special attention given to 20 interventional studies conducted on humans. The bulk of the examined studies looked at potential effects relating to oxidative stress markers, with some also looking at effects on inflammatory markers, lipid profile, and diabetes markers. The analysis of the results highlighted a noticeable association between the consumption of cloudy apple juice and markers revealing good cardiovascular health. The positive effects were especially significant in relation to oxidative stress. In addition, apple juice also exhibited beneficial influence on other health indicators like inflammation, lipid profile, and diabetes.

A Systematic Review published in 2022 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture appears to have positive effects on live birth rates, clinical pregnancies, and other outcomes in female infertility, but more robust studies are required to establish its true efficacy and safety. This study evaluated acupuncture's efficacy for female infertility through a systematic review of 27 randomized controlled trials involving 7676 participants. The intervention group receiving acupuncture showed significantly higher rates of live births, clinical pregnancies, biochemical pregnancies, ongoing pregnancies, adverse events, and implantation rates compared to the control group. However, no significant difference was found in oocytes retrieved, good-quality embryo rate, miscarriages, and ectopic pregnancy rate. While the study suggests potential benefits of acupuncture, further high-quality research is needed to confirm these findings.

A Review Article published in 2022 in the journal International Journal of Innovative Research in Engineering & Management found that Carrots, rich in carotenoids, flavonoids, and vitamins, have numerous health benefits including antioxidants, immune enhancement, and anti-cancer properties. The paper provides an insightful review of carrots and their biochemical properties and wide-ranging health benefits. It presents carrots as a tuber crop rich in elements like carotenoids, vitamins, and soluble fiber, which contribute to their wellness properties. The consumption of carrots is increasing owing to their recognized value as a natural source of antioxidants with anti-cancer properties. The review also discusses the various uses of carrots and its by-products, carrot pomace, in food processing to boost the nutritional content of various products. The carrots are used in diverse culinary preparations from salads & curries to nutritionally rich processed goods like juices, dry powder, candy, pickle, and gazrailla. Furthermore, carrot pomace which is abundant in beta-carotene is used to improve products such as bakery goods and also to create a range of useful products.

A Review Article published in 2022 in the journal Reference Series in Phytochemistry found that The flower of Chrysanthemum morifolium, widespread in Asia, has been discovered as a treatment for diverse diseases, including obesity, heart disease, and cancer, due to its beneficial phytoconstituents. Methodology: A comprehensive examination of Chrysanthemum morifolium was conducted to shed light on its medicinal uses and health benefits. The studies focused on its use in traditional medicine, which includes treatment for excessive internal heat, eye inflammation, fever, migraines, and hypertension. The biological properties of the flower, such as flavonoids, polyphenols, volatile oils, terpenoids, and polysaccharides were analyzed, and their antioxidant, anti-inflammatory, anti-obesity, cardioprotective, neuroprotective, anticancer, and antidiabetic effects taken into account. Discussion of results: The examination of Chrysanthemum morifolium validated the flower's antioxidant, anti-inflammatory, and anticancer properties, among others. It also indicated potential applications in preventing and treating obesity, cardiovascular diseases, neurodegenerative diseases, and diabetes. Moreover, its medicinal efficacy and safety in treating health conditions were backed by clinical studies.

A Review Article published in 2022 in the journal Reference Series in Phytochemistry found that Coconut water possesses unique compound profiles that imbue it with a broad spectrum of medical properties, incorporating aspects of nutrition, pharmacology, and disease prevention. The study utilized comprehensive analysis to assess the chemical profile of coconut water, identifying a range of components including phytohormones, enzymes, antioxidant compounds, vitamins, minerals, and phenolic compounds. These components are known to contribute to the water's biological activity and pharmacological effects, thereby enabling a raft of medicinal properties inherent to coconut water. The water was found to feature anti-microbial, anti-bacterial, anti-inflammatory, anti-hypertensive, rejuvenating, hepatoprotective, hypolipidemic, and diuretic properties. An examination of the therapeutic effects of coconut water revealed a significant impact on gastric dysfunction, dysentery, and child malnutrition alongside notable capabilities to manage hypertension. The water was found to promote exercise performance, reduce swelling, dissolve kidney stones, improve kidney function, improve digestion, relieve constipation, reduce the risk of heart disease, lower high blood pressure, and improve cholesterol levels. Consumption of tender coconut water was specifically found to reduce the risk of heart disease, help prevent Alzheimer’s disease pathologies and prevent osteoporosis in experimental animals. The unique nutritional profile of coconut water was also found to provide it with the capacity to balance body chemistry and fight cancer.

A Review Article published in 2022 in the journal Brazilian Journal of Pharmaceutical Sciences found that High doses of vitamin C, vitamin D supplementation and natural honey can potentially decrease fatalities and support the management of COVID-19. The team undertook a systematic analysis of existing literature and pertinent clinical trials to evaluate the potential of vitamin C, vitamin D, and natural honey intervention during the progression of the COVID-19 pandemic. This assessment aimed to determine the impact of these substances upon the outcomes of COVID-19, particularly in reducing respiratory damage and potentially improving patient immunity. The research revealed that substantial doses of vitamin C illustrated to lower lung damage and reduce intensive care stay duration for COVID-19 patients. It was observed that vitamin D deficiency is common among individuals living in institutions, and having supplements could aid in defending against respiratory infections. Natural honey, due to its antiviral effects and immune-enhancement capacities, also displayed promising results in treating COVID-19. The acquired evidence drove the belief that administering vitamin C, vitamin D, and natural honey, along with the existing treatment protocols, could potentially be a compelling method to decrease fatalities associated with COVID-19.

A Theoretical Article published in 2022 in the journal Traditional Medicine Research found that The jujube tree bears fruit endowed with substantial nutritional value and contains numerous phytochemical components with reported antioxidant, anti-cancer and neuroprotective properties. The research implemented an analysis of the jujube tree, its fruit, and its long history of usage in traditional medicine, focusing primarily on its use in traditional Persian and Chinese medicines. The varied geographical distribution of the tree was studied, especially its presence in tropical and subtropical regions across Europe and Asia. Researchers took into account the tree’s resilience to soil salinity and alkalinity as part of its general characteristics. The core of the study involved an in-depth investigation into the nutritional composition and pharmacological properties of the jujube fruit. The fruit's contents were categorized into proteins, minerals, vitamins, organic acids, and carbohydrates. Furthermore, a range of phytochemical components such as polyphenols, flavonoids, terpenoids, anthocyanins, alkaloids, and carotenoids were identified. Research noted both the fruit's nutraceutical and cosmeceutical potential. It also explored the medicinal properties of all elements of the plant, not just the fruit. The physiological impacts of the jujube were also evaluated across various medical contexts, seeking to understand its impact on different organs and tissues, as well as its influence on various health conditions and concerns. Culminating in the identification of antioxidant, anti-cancer, antimicrobial, neuroprotective, cardioprotective, hepatoprotective properties. Noteworthy, are also its health-promoting effects, with strong references to anti-aging properties.

A Systematic Review published in 2022 in the journal The American Journal of Chinese Medicine found that Fresh and dried ginger displays key botanical, phytochemical and ethnopharmacological differences, which are fundamental for their specific clinical uses in treating gastrointestinal issues. The methodology used in the research involved a retrospective comparison between Sheng Jiang (SJ, meaning fresh ginger) and Gan Jiang (GJ, meaning dried ginger), two traditional Chinese herbs. The comparison was undertaken specifically considering aspects of botany, phytochemistry, and ethnopharmacology. The research also delved into exploring the traditionally attributed use of ginger, in both its fresh and dried forms, for the treatment of gastrointestinal disorders, and its relationship with human gut microbiota - an aspect that hasn't been considered extensively previously. The results displayed notable differences between fresh and dried ginger in terms of botany, phytochemical, and ethnopharmacological properties. Fresh and dried ginger are cultivated differently and display distinct physical appearances. This research proposed that these differences lay the foundation for how these two forms of ginger are applied clinically. Furthermore, discussing the pharmacology of gut microbiota-related gastrointestinal benefits, it is suggested that fresh and dried ginger could present innovative and potent avenues for preventing and treating gastrointestinal disorders.

A Cohort Study published in 2021 in the journal Muhammadiyah International Public Health and Medicine Proceeding found that Consumption of sardines can effectively prevent type 2 diabetes mellitus and hypertension, particularly in senior citizens, due to their high omega 3, EPA, and DHA content. For the methodology, the researchers carried out a literature study to delve into the research topic. They exclusively used already available research and data for their study rather than new, hands-on investigations. They explored extensively into the health benefits and properties of sardines and how it contributes to preventing type 2 diabetes and hypertension. In their discussion of the results, it was determined that sardines have multiple beneficial properties. They discovered that sardines have anti-inflammatory and antioxidant roles, they enhance membrane fluidity and increase insulin receptors and action. Furthermore, sardines also possess hypoglycemic and hypotensive qualities. The multitude of these properties thus shows the capability of sardines to effectively prevent and lower hypertension and type 2 diabetes, especially among senior citizens.

A Cohort Study published in 2021 in the journal Muhammadiyah International Public Health and Medicine Proceeding found that Sardines are highly proven to be able to effectively prevent type 2 diabetes, prevent hypertension, and lower blood pressure, especially for senior citizens. Sardines contain anti-inflammatory, and antioxidant roles, boost cell membrane fluidity, boost the number of insulin receptors and insulin action, and also contain hypotensive and hypoglycemic effects.

A Review Article published in 2021 in the journal Journal of Food Composition and Analysis found that Cocoa, including its often discarded shell, has promising potential in providing benefits to human health due to its high content of health-boosting phytochemicals. Cocoa, extracted from the seeds of Theobroma cacao L., contains a wide range of phytochemicals, with polyphenols being the most predominant. These compounds contribute to a variety of beneficial biological properties such as antioxidant, anti-inflammatory properties, among others. Furthermore, the cocoa bean shell, usually seen as a by-product, has started to attract attention for its own significant phytochemical content, emphasizing the potential health benefits it could also provide. The review gathered and examined existing literature investigating these health benefits. While the benefits of cocoa have been explored in relation to various health conditions like heart diseases and nervous system disorders, the focus of the review was to assess the role of cocoa and its potential therapeutic capacity in the context of cancer. Without revealing specifics, the review not only outlined the potential health benefits that cocoa and its shells can offer, but also delved into the potential mechanisms that enable such benefits, thus presenting a holistic view on the topic.

A Review Article published in 2021 in the journal Critical Reviews in Food Science and Nutrition found that Coffee consumption may contribute to the prevention of several inflammatory diseases and types of cancer, with reduced mortality risk deemed safe up to 400mg of caffeine per day. The methodology used in this scholarly review was based on an extensive literature review using the PubMed/Medline database. As the primary research tool, this database facilitated the authors' collation and analysis of relevant studies concerning the impact of coffee consumption on health outcomes. The focus was to determine both the positive and negative aspects of coffee consumption, with an additional aim of providing dosage recommendations. The data collated from these studies was then summarised and analysed through a narrative approach, making the findings more digestible and interpretable. The findings suggested that coffee consumption may play a significant role in preventing inflammatory and oxidative stress-related diseases such as obesity, metabolic syndrome and type 2 diabetes. In addition, findings indicated that coffee consumption also seemed to have an association with a lower incidence of several types of cancer and a reduction in the risk of all-cause mortality. However, notable is the need for a time gap between coffee consumption and the intake of some drugs to avoid potential interactions. It was also concluded that the consumption of up to 400mg/day of caffeine was generally found to be safe for the average person.

A Review Article published in 2021 in the journal Food Chemistry found that Pu-erh tea, with its complex components, interacts greatly with gut microbiomes and holds significant potential for healthcare applications. Pu-erh tea undergoes a post-fermentation process involving various microorganisms, leading to highly complex components. This tea has its potential benefit due to its rich interactions with the gut microbiomes; the structure and the homeostasis of which are deeply connected to human wellness and progress of various diseases. This study provides a systemic review of the current findings pertaining to the bioactive components of Pu-erh tea and their interactions with gut microbiomes. For the discussion of results, the beneficial effects of Pu-erh tea on gut microbiomes may establish its role in healthcare. These benefits are due to the tea's bioactive components' impacts on the structure of the gut microbiomes, and subsequent health improvements. Additionally, the establishment of "components-function-indicators" clues can propel the standardisation of the tea's fermentation process and development of functional tea-related products.

A Randomised Controlled Trial published in 2021 in the journal Genes & Nutrition found that Consumption of blueberry supplement did not show significant improvement in metabolic health markers, however, it induced changes in gene expression, indicating a potential longer-term effect. The methodology of the study involved a randomized double-blind placebo-controlled intervention trial conducted with adults at risk of developing Metabolic Syndrome (MetS). Participants, consisting of 49 individuals, were asked to consume 50 grams daily of either a freeze-dried highbush blueberry powder or a placebo powder for a duration of 8 weeks. Metabolic Syndrome phenotypes were evaluated at the beginning, 4 weeks in, and at the end of the trial. To assess any metabolic changes, fasting blood gene expression profiles and plasma metabolomic profiles were observed at the start and the end of the 8 weeks. In examining the results, while significant change was reported for plasma triglyceride levels, the findings did not remain significant after adjusting for age, sex, BMI, and baseline values. Furthermore, no significant difference was observed with respect to body weight, blood pressure, fasting plasma lipid, insulin and glucose levels, insulin sensitivity, or glycated hemoglobin concentrations when comparing the blueberry supplement with the placebo. The distinctive findings were in gene expressions and the presence of certain metabolites. The blueberry supplement caused significant changes in 49 gene expressions and the abundance of 35 metabolites, and these differentially regulated genes largely belonged to immune-related pathways.

A Systematic Review published in 2021 in the journal Journal of Aging and Physical Activity found that High-quality evidence suggests that Tai Chi is an effective intervention for preventing falls in community settings, and through its benefits on cognitive functioning. Tai Chi can be highly effective for preventing falls. Tai Chi is a safe and accessible form of exercise. Indeed, over 500 trials and 120 systematic reviews have been conducted on the health benefits of Tai Chi and no studies have found that Tai Chi worsens a condition (Huston & McFarlane, 2016). In addition, a systematic review of adverse event reporting from Tai Chi trials found Tai Chi is unlikely to result in serious adverse events but may result in minor musculoskeletal aches and pains (Wayne, Berkowitz, Litrownik, Buring, & Yeh, 2014). For older adults with osteoporosis with vertebral fractures, it is recommended that they first receive advice on spine sparing techniques and that they avoid repetitive, weighted, or rapid end range flexion or extension of the spine (Skelton & Mavroeidi, 2018). Frailer older adults, those with a high falls risk or multiple comorbid conditions affecting balance or strength, are recommended to only practice Tai Chi under the supervision of an instructor trained in adapting and tailoring the exercise prescription (Skelton & Mavroeidi, 2018).

A Randomised Controlled Trial published in 2021 in the journal Reproductive BioMedicine & Society Online found that Women receiving IVF perceived that acupuncture or sham acupuncture gave them a psychological advantage through increased relaxation, reduced psychological stress, and enhanced well-being and self-efficacy. In this qualitative study, participants reported that compassionate care and an opportunity to rest during IVF, and especially following embryo transfer, had an emotionally important effect. All women in the trial underwent the same procedural practices which involved bed rest during needling, among other comforts. Some women described benefitting purely from this opportunity to rest quietly in a supportive environment amidst the maelstrom of IVF. There was also recognition that this ‘oasis’, albeit brief, was an important time for allowing the meaning of having an embryo transferred to ‘soak in’, and presented an oppportunity to ‘be in the moment’.

A Review Article published in 2021 in the journal Frontiers in Pharmacology found that Chinese herbal medicines may improve treatment for those with chronic kidney disease, due to their anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated, and antifibrotic effects. The methodology of the research entailed a comprehensive review of peer-reviewed English-language journals that focus on the potential benefits of Chinese herbal medicines (CHMs) in treating kidney disease. The primary factors investigated were the anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated, and antifibrotic properties of CHMs that are commonly used in managing kidney disease. The review also incorporated newly published clinical trials and meta-analyses within this field. The results of the review found that CHMs have multiple beneficial effects, such as anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated, and antifibrotic properties. This, backed by well-structured randomized controlled trials and meta-analyses, highlighted that the incorporation of CHMs as an auxiliary with conventional medicines could assist patients suffering from chronic kidney disease. The results, however, noted the limitations on the development of CHMs, like unknown active ingredients, inferior quality, and limited sample sizes of some clinical trials, and questions on CHMs' safety.

A Review Article published in 2021 in the journal Foods found that Fermented soybean products alleviate and possibly prevent neurodegenerative conditions, including Parkinson's and Alzheimer's diseases. The study involved the fermentation of cooked soybeans with specified bacteria and fungi species, a process known to produce a range of bioactive compounds. These unique compounds, which are most often beneficial to health, are contained in fermented soybean products that are a staple in East Asian diets. In analyzing the results, the focus was on the potential of these fermented soy foods and their components in managing neurodegenerative diseases. Notably, the findings suggested a significant preventive and curative effect of these products on such ailments as Alzheimer's and Parkinson's diseases. The paper, therefore, presents fermented soy foods as potentially reliable natural solutions to these neurodegenerative conditions.

A Review Article published in 2021 in the journal Anesthesiology and Pain Medicine found that Acupuncture is shown to be a beneficial supplementary treatment for chronic abdominal pain, improving patients' quality of life and cutting healthcare costs. The research explores the utilization of acupuncture to treat chronic abdominal pain, a condition widespread and chiefly affected by Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD). This type of pain is defined by three episodes of severe abdominal pain over a span of three months. While its causes are still being looked into, it is believed to be an outcome of the chronicity of acute pain or chronic pain syndromes. A wide array of treatments for these conditions exist but often fall short of fully controlling the symptoms. Acupuncture, a form of traditional Chinese medicine based on the concept of rebalancing the patient's Qi, or Ying/Yang balance, is being investigated as a complementary method. In terms of results, acupuncture has proven effective in providing additional alleviation of symptoms, leading to improved quality of life and reduced disability for patients affected by chronic abdominal pain. While it's not a curative solution, it aids in minimizing symptoms and enhancing overall life quality. It is also considered a safe and inexpensive alternative that may result in significant healthcare savings. Notably, it's not recommended for all patients; its benefits seem to be more pronounced in a select group.

A Review Article published in 2021 in the journal Anesthesiology and Pain Medicine found that Acupuncture has shown promise as a complementary approach in treating chronic abdominal pain, providing symptom relief and improving quality of life. The methodology revolves around applying acupuncture, a form of integrative medicine from traditional Chinese medicine, to patients suffering from chronic abdominal pain. This pain is defined as having three severe abdominal pain instances over three months, often caused by chronic acute pain or chronic pain syndromes, primarily IBS and IBD. Despite existing treatments, these often fail to control the symptoms completely, leaving room for complementary methods like acupuncture. This practice is based on rebalancing a patient's Qi, or Ying/Yang balance, previously shown effective in treating various conditions. The results reveal that acupuncture can serve as a crucial adjunct in managing chronic abdominal pain. It is not a cure, but it significantly aids in symptom reduction and quality of life improvement. Particularly for those affected by IBS and IBD, acupuncture offers extra relief from lingering symptoms, thereby improving quality of life, decreasing disability, and potentially contributing to healthcare cost savings. Acupuncture has emerged as a safe, inexpensive, and beneficial approach for selected patients suffering from chronic abdominal pain.

A Review Article published in 2021 in the journal Journal of Food Biochemistry found that Pomegranate demonstrates anti-proliferative, anti-oxidant, anti-inflammatory properties that can effectively control the progression of various respiratory diseases. The research methodology involved both in vivo and in vitro studies to examine the potential effects of pomegranate fruit, juice, extract, peel powder, and oil on a variety of respiratory disorders such as asthma, lung cancer, and chronic obstructive pulmonary disease. The focus was to understand the properties of pomegranates that led to its anti-proliferative, anti-oxidant, anti-microbial, anti-inflammatory, anti-cancer, and anti-tumorigenic effects, and how these qualities could potentially attenuate these diseases through modulation of various signaling pathways. The discussion of results revealed that pomegranate was effective in controlling the progression of diverse respiratory diseases, suggesting it could be a key therapeutic target. These results not only demonstrated the potential medical benefits of pomegranate against lung-based diseases but also highlighted its possible role in influencing the lung fibrinolytic system. The findings from both preclinical and clinical studies underscored the influence of pomegranate in tackling lung diseases.

A Systematic Review published in 2021 in the journal Cureus Journal of Medical Science found that A systematic analysis indicates that ginger has a higher safety profile than NSAIDs for pain relief, with a smaller number of gastric side effects and fewer kidney risks. The use of ginger is very useful and effective as NSAIDs because of the increasing trend in the use of traditional medicine and herbal medicine, particularly for people who do not want to use chemical drugs with more side effects.

A Systematic Review published in 2021 in the journal Cureus Journal of Medical Science found that Based on beneficial effects and minimal side effects, ginger may be a potential adjunct treatment for primary dysmenorrhea. This review has shown that ginger can minimize pain in one or two periods. The present analysis provides compelling proof of the impact of ginger on relieving menstrual pain. The finding in this study has verified the possibility of ginger efficacy in the treatment of primary dysmenorrhea, though no/small side effects have been identified and its use is associated with health benefits. Ginger is easily accessible due to its low cost. It can also be commonly used in the treatment of primary dysmenorrhea. The use of ginger is very useful and effective as NSAIDs because of the increasing trend in the use of traditional medicine and herbal medicine, particularly for people who do not want to use chemical drugs with more side effects. We strongly recommend that further research be performed with a greater number of patients regarding the effectiveness and protection of various doses of ginger.

A Review Article published in 2021 in the journal Journal of Acupuncture Research found that Acupuncture, in its various forms, shows significant potential in alleviating pain and improving shoulder function in patients with rotator cuff disorders. The participating researchers examined a multitude of sources, involving 12 electronic databases and 3 trial registries until November 2019, poring over any applicable randomized trial regardless of its language or date of publication. The research primarily focused on pain symptoms, the functionality of the shoulder, and the ratio of participants showing improvement within 12 weeks since the initiation of the trial. They adopted the Grading of Recommendations Assessment, Development and Evaluation approach to assess the certainty of evidence, while the included studies' bias risks were evaluated using the Cochrane risk of bias tool. Various types of acupuncture were evaluated, including manual acupuncture, dry needling, electroacupuncture, acupotomy, warm needle acupuncture and fire needle acupuncture, extracted from a total of 28 randomized trials involving 2,216 participants. The results gleaned from these trials suggest that acupuncture could indeed have a significant impact on the relief of pain and the enhancement of shoulder function for patients suffering from rotator cuff diseases. However, discrepancies between the trials resulted in considerable heterogeneity. Despite this, no significant harm was observed amongst the patients. However, due to the level of uncertainty associated with the data and the partialness of the reports, the safety of acupuncture is still up for debate.

A Review Article published in 2021 in the journal Molecules found that Green tea, coffee, wine, and curry have beneficial health effects due to the polyphenols they contain, which possess both antioxidant and pro-oxidant properties. The research leverages epidemiological studies, clinical trials, cell-based studies and animal tests to examine the effects of green tea, coffee, wine, and curry -- and their key polyphenols -- on human health. The polyphenols investigated include epigallocatechin gallate in green tea, chlorogenic acid in coffee, resveratrol in wine, and curcumin in curry. The study concentrates on the workings of these polyphenols, primarily focusing on reactive oxygen species (ROS), and how they perform both anti- and pro-oxidant functions, fundamentally influencing different enzymes and factors with health contributions. In the discussion of the results, it is mentioned that the anti-oxidative actions of these polyphenols assist in the scavenging of ROS and the downregulation of the nuclear factor-κB, yielding beneficial anti-inflammatory effects. Conversely, their pro-oxidant actions appear to elevate ROS production, encouraging the activation of 5'-AMP-activated protein kinase that regulates different enzymes and factors for health improvement. However, the exact mechanism of how these polyphenols exhibit either pro- or anti-oxidant effects remains unclear. Also, the research underscores that while many studies note their health benefits, some others show no positive effects on health conditions such as obesity, suggesting that outcomes could be influenced by various study factors.

A Randomised Controlled Trial published in 2021 in the journal Arthritis & Rheumatology found that Intensive electroacupuncture appears to reduce pain and improve function in knee osteoarthritis patients more effectively than sham acupuncture. In this multicenter research, individuals suffering from knee osteoarthritis were randomly selected to receive one of three treatments thrice weekly, over an eight-week period: electroacupuncture, manual acupuncture, or sham acupuncture. A double-blind model was enforced where participants, outcome assessors, and statisticians remained unaware of the specific treatment group allocations. The primary benchmark of success was the response rate, which gauged the ratio of participants who noted a minimum clinically important improvement in both pain and function by the eighth week. In the study involving 480 participants, 442 were evaluated for the effectiveness of treatment. The response rates varied among the groups at week 8: with electroacupuncture and manual acupuncture groups reporting higher rates of improvement compared to the sham acupuncture group. On continued assessment at weeks 16 and 26, these higher response rates were sustained in both the electroacupuncture and manual acupuncture groups. Among the patients, those who received intensive electroacupuncture reported less pain and better function at week 8 compared to those who received sham acupuncture, and these effects persisted through week 26. Whereas, intensive manual acupuncture did not show any significant benefits at week 8 but showed improvement in the follow-up period.

A Review Article published in 2021 in the journal International Review of Neurobiology found that Goji berries have significant potential as a natural medicine in anticancer efforts due to their high content of active compounds. The research involved extraction and analysis of various fractions from goji berries to ascertain their impact on different types of cancer. These fractions included polysaccharides, polyphenols, flavonoids, carotenoids and their derivatives, and they were tested against particular types of cancer cells, such as those of breast carcinoma. The effect of these extracts on normal human cells, however, has not been explored. Two distinct stages were mapped out: one with a pectin-free fraction of goji berry extract used to inhibit the growth of two breast cancer cell types, and another phase involving an ethanol extract inhibiting a different breast cancer cell line. In the discussion of results, the study revealed that various extracts from goji berries exhibit antiproliferative properties against different types of cancer cells. Evidence shows that a certain pectin-free fraction of the goji extract inhibited the growth of specific types of breast cancer cells, while an ethanol extract curtailed the proliferation of another type in a time- and dose-dependent manner. The study also found that goji polysaccharides not only influence estrogen metabolism but also activate certain cellular signaling pathways and increase the expression of a certain protein.

A Experimental Study published in 2021 in the journal JBRA Assisted Reproduction found that Pomegranate seed oil, rich in conjugated linolenic acid, potentially acts as a cytotoxic agent on tissue tumor cells, reducing polycystic ovary syndrome manifestations. First, data for this study was collected from several databases including the Cochran library, Medline, PubMed, SID, and Science Direct. Keyword searches incorporating phrases such as "medicinal plants", "polycystic ovary syndrome", "plant", "pomegranate extract", and "menstrual irregularities" were used to uncover relevant articles spanning from 1985 to 2021. The focus of the research was to investigate the impact of pomegranate seed oil, particularly its conjugated linolenic acid (CLN) content, on polycystic ovary syndrome, a prevalent endocrine disorder among women. The results revealed that CLN, found abundantly in pomegranate seed oil, had been previously reported to exert a potent cytotoxic effect on tumor tissue cells within the body. This characteristic placed CLN as a potential agent in predenting cancer, lowering LDL cholesterol in the blood, reducing triacylglycerol accumulation in the liver, and importantly, mitigating the effects of polycystic ovary syndrome. Alongside this, the research also underscored the beneficial effects of conjugated linoleic acid (CLA), another group of linoleic acid isomers, in cancer growth inhibition, risk reduction of atherosclerosis, and body fat decrease.

A Review Article published in 2020 in the journal Molecules found that Shaded gardening of Japanese matcha creates high-quality tea with unique compounds that can boost physical and mental health. This study reviewed and compiled health benefits of matcha tea, a type of powdered green tea grown traditionally in Japan with plants shaded during growth. This shading process promotes the synthesis and accumulation of unique biologically active compounds, which includes theanine, caffeine, chlorophyll, and a variety of catechins, with matcha offering a condensed source of these elements. The review indicated that matcha is considered the highest quality tea due to its distinctive chemical composition and prized flavor. In discussing the results, a major conclusion reached was that matcha tea has effective health-promoting attributes due to the tea's high content of antioxidant and anti-inflammatory substances. Such benefits have largely been credited to its significant proportion of catechins - a type of phenolic compound beneficial to human health. The high antioxidant potential of the tea and its subsequent ability to help prevent various diseases and support cognitive function underscores the value in regular consumption of matcha for not only physical health, but also mental health.

A Review Article published in 2020 in the journal Journal of Functional Foods found that Jujube fruits contain a high amount of various bioactive compounds exerting antioxidant, anti-inflammatory, antiobesity, anti-cardiovascular disease, hepatoprotective, antidiabetic, anti-microbial, anticancer, and gastrointestinal-protective effects. The scientific evidence has shown that jujube fruits contain a high amount of various bioactive compounds, including ascorbic acid, triterpenic acids, phenolic acids, amino acids, saponins, cerebrosides, flavonoids, polysaccharides, and mineral constituents. These phytoconstituents play important roles to suppress different diseases, exerting the antioxidant, anti-inflammatory, antiobesity, anti-cardiovascular disease, hepatoprotective, antidiabetic, anti-microbial, anticancer, and gastrointestinal-protective effects.

A Review Article published in 2020 in the journal Frontiers in Pharmacology found that Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production. Jujube promotes erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, possesses potential capacity in recycling heme iron during erythrophagocytosis, exhibits bidirectional role in regulating immune response under different conditions, contains numerous minerals including iron.

A Review Article published in 2020 in the journal Frontiers in Pharmacology found that Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties. Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response. Thus, the blood-nourishing function of jujube is being proposed here. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Taken together, these findings provide several lines of evidence for further development of jujube as supplementary products for prevention and/or treatment of anemia.

A Review Article published in 2020 in the journal Scientific African found that Pumpkin seeds carry bioactive compounds with potential benefits such as antidiabetic, antidepressant, antioxidant, antitumor, and cytoprotective activities, also aiding in microbiological infections and specific organ disorders. The methodology utilised an in-depth literature review, compiling evidence-based data from various electronic databases such as ScienceDirect, ResearchGate, PubMed, Scopus and Google Scholar up until January 2020. The focus of the gathered literature was the potential use of pumpkin seeds as a functional food ingredient and assessing the associated biological mechanisms of the bioactive compounds within the seeds. Pumpkin seeds, despite being small, are rich in a wide variety of beneficial nutrients such as amino acids, phytosterols, unsaturated fatty acids, phenolic compounds, tocopherols, cucurbitacins and valuable minerals. The bioactive compounds found within these seeds have shown multiple promising activities. They possess anthelmintic, antidiabetic, antidepressant, antioxidant, antitumor and cytoprotective properties. Additionally, they demonstrate potentials for addressing microbiological infections and specific disorders related to liver and prostate. The compiled literature strongly suggests that pumpkin seeds can be used as both a traditional and functional food ingredient due to the wide array of health benefits they offer.

A Review Article published in 2020 in the journal The Journal of Nutritional Biochemistry found that Catechin-rich green tea extract (GTE) exercised anti-inflammatory activities can be beneficial in managing Nonalcoholic fatty liver disease (NAFLD) by reducing liver injury and gut-derived endotoxins. The research is built around the study of the anti-inflammatory properties of catechin-rich green tea extract (GTE). The primary analytical interest is its effects on inflammatory responses that contribute to Nonalcoholic fatty liver disease (NAFLD), specifically nonalcoholic steatohepatitis (NASH). The extraction focuses on inhibiting the activation of the hepatic nuclear factor kappa-B, which is known to exacerbate liver injury. The results have shown positive contributions of GTE to management of NAFLD. Itn was observed that the extract limits the activation of the hepatic nuclear factor kappa-B and in turn, reduces NASH-associated liver injury. Additionally, green tea extract was found to contain hepatic-level benefits that attenuate intracellular redox distress and pro-inflammatory signaling. It was also found to improve the gut barrier function, limit the translocation of gut-derived endotoxins, and exercise prebiotic and antimicrobial effects on the gut microbial ecosystem. These results can potentially contribute to managing NAFLD-associated morbidity.

A Review Article published in 2020 in the journal Antioxidants found that Green tea catechins potentially contribute to maintaining joint and skeletal muscle health, mitigating symptoms of osteoarthritis and sarcopenia. The research begins by providing an understanding of osteoarthritis, a degenerative inflammatory disorder of articular cartilage, and sarcopenia, a condition characterized by loss of muscle mass and strength. It explores their prevalence, causes such as excessive inflammation and oxidative stress, mitochondrial dysfunction, and diminished autophagy. It then delves into the role of green tea catechins in joint health, including their influence on inflammatory signaling agents, anabolic mediators, and miRNAs expression. This leads to a decrease in chondrocyte death and collagen degradation, thereby offering cartilage protection. The investigation also examines the effects of green tea catechins on skeletal muscle health. It highlights their role in maintaining an equilibrium between protein synthesis and degradation, and enhancing the synthesis of mitochondrial energy metabolism. The review thus suggests a positive impact of green tea catechins on joint and muscle health, helping to maintain favorable muscle homeostasis and reduce muscle atrophy associated with aging. It ends by pointing out the limitations of the current study and proposing future research directions.

A Review Article published in 2020 in the journal Applied Sciences found that Pomegranate possesses significant biological and nutraceutical value with potential applications against a wide spectrum of diseases due to its rich phytochemical composition. The methodology used in the reported research was primarily a review and analysis of the biological composition of pomegranates. The composition was analyzed closely with attention given to flavonoids, ellagitannins, proanthocyanidins, mineral salts, vitamins, lipids, and organic acids to gauge their nutraceutical value and potential health benefits. In regards to discussion of results, in-depth studies of pomegranate's biological and functional properties provided insight into its potential applications against a wide spectrum of diseases. These include not just neoplastic, cardiovascular and viral diseases but also inflammatory, metabolic, microbial, intestinal, reproductive and skin diseases. The wide health-promoting properties of pomegranate and its bioactive compounds demonstrate its considerable scientific and commercial potential in the field of nutraceuticals.

A Systematic Review published in 2020 in the journal Current Rheumatology Reports found that The majority of studies concluded the superiority of short-term analgesic effects over various controls and suggested that acupuncture may be efficacious for chronic musculoskeletal pain. We examined 16 review articles and 11 randomized controlled trials published in the last 5 years on the clinical efficacy of acupuncture in adults with CMP conditions. The available evidence suggests that acupuncture does have short-term pain relief benefits for patients with symptomatic knee osteoarthritis and chronic low back pain and is a safe and reasonable referral option. Acupuncture may also have a beneficial role for fibromyalgia. However, the available evidence does not support the use of acupuncture for treating hip osteoarthritis and rheumatoid arthritis.

A Systematic Review published in 2020 in the journal Amazonian Journal of Plant Research found that The most important tremella mushroom benefits are anti-aging, anti-inflammatory, lower cholesterol, combat obesity, protect nerves and may fight cancer. The most powerful nutritional constituents of Tremella are amino acids, vitamins, minerals, polysaccharides, Glucurmomannan 1,3-alpha-glucan, Epitope 9beta-D- glucuronosyl), Glucuronic acid, Glucurmic acid, Glucuronoxylomannan, N-acetylglucosamine, Flavonoids, Polyphenols, Alkaloids and Organic acids. Functional foods are making inroads into Chinese diets with their promises to improve health and nutrition. Chinese consumers should choose nutritional and healthy food to maintain general health and reduce the risk of health problems. Nutrition therapy on the basis of traditional Chinese medicine such tremella is quite effective at treating common diseases.

A Systematic Review published in 2020 in the journal European Journal of Clinical Nutrition found that The literature overall supports an inverse association between green tea and cardiovascular disease-related health outcomes, while the included meta-analyses generally suggested an inverse association between green tea and BMI-related and blood pressure outcomes. The evidence on green tea consumption and health outcomes presented in this review suggests green tea may be favorable for cardiovascular disease, particularly stroke, and certain cancers such as endometrial, esophageal, lung, non-Hodgkins lymphoma, oral, and ovarian cancer. More evidence is needed to assess the impact of green tea on breast, gastric, and liver cancer risk. Additional studies could also help clarify the suggested null association with certain cancer sites: colorectal, pancreatic, and prostate cancer. Possible minor adverse events on health from green tea consumption were reported in one study, however these must be interpreted cautiously within the study context and possible finer dose-response implications. The findings for green tea and diabetes risk were inconclusive. For BMI the current evidence suggests a possible weak association, while the evidence is stronger supporting a decrease in blood pressure from green tea. More studies investigating a possible association between green tea consumption and other health outcomes such as cognition, injuries, respiratory disease would be informative to more completely assess the impact of green tea on human health. In conclusion, our review suggests green tea may have health benefits especially for cardiovascular disease and certain cancer sites.

A Systematic Review published in 2020 in the journal Journal of Gastrointestinal and Liver Diseases found that Higher consumption of coffee correlates with a significant decrease in the risk of liver cancer or hepatocellular carcinoma. In the methodology, a systematic review and meta-analysis was performed on original articles, published in English from 1996 to June 2019, that linked coffee consumption with liver cancer or hepatocellular carcinoma. Numerous databases, including PubMed/MEDLINE/EMBASE/Ovid/Google Scholar, were searched for relevant case-control, cohort or prospective studies. The Relative Risk (RR) for these conditions was calculated for coffee drinking, further stratified by the increments of one cup of coffee per day. The final analysis involved 20 studies, analysed using random effects models, with heterogeneity between studies calculated by Cochrane Q and the I2 statistics. The results indicated that the overall Relative Risk (RR) displayed significant heterogeneity among the studies. A subgroup analysis was performed to evaluate the impact of additional coffee intake, and it was discerned that higher coffee consumption was associated with a substantial drop in the risk of developing hepatocellular carcinoma(HCC) or liver cancer. Additionally, there was no indication of significant publication bias observed in the funnel plot.

A Review Article published in 2020 in the journal The Journal of Nutritional Biochemistry found that Honey, with its variable composition based on botanical origin, exhibits antioxidant and anti-inflammatory properties, suggesting its potential efficacy in managing obesity-related dysfunctions, including neurodegeneration, through improved glycemic control and lipid profile. The review explores honey's therapeutic potential, emphasizing its diverse bioactive compounds. The focus is on its effects in combating obesity-related dysfunctions, supported by experimental evidence from animal studies. Experimental findings indicate that honey can enhance glycemic control and lipid profile, offering protection against endothelial dysfunction and neurodegeneration in obesity. The role of honey's key constituents, particularly polyphenols, is highlighted, underscoring the need for further human studies to confirm these health benefits.

A Network Pharmacology published in 2020 in the journal Foods found that Seasonal variations influence the nutrient composition of European sardines, with lipid levels peaking from July to September and amino acid content highest during winter. The methodology consisted of analyzing the proximate composition of European sardines from the Adriatic Sea over a period of one year. The nutritional profiles, focusing on free amino acid and fatty acid, were quantified monthly to discern any seasonal variations. The study paid special attention to quantities of bioactive lipids such as omega-3 fatty acids, and essential amino acids, as these are crucial for determining the nourishing value of the sardines for both industrial processing and for health benefits to consumers. The findings revealed that the nutritional content in sardines displays seasonal variation. The lipid content topped out from July to September, whereas the highest total amino acid content occurred during the winter, from January to March, with histidine, arginine, and threonine being most present. Interestingly, the study noted significant quantities of essential free amino acids throughout the year, with particular surges in March and dips in May. The fatty acid profile predominantly consisted of omega-3 fatty acids, with sardines showcasing high concentrations of eicosapentaenoic and docosahexaenoic acids, which were especially abundant from July to September.

A published in 2020 in the journal Nutrients found that Cocoa polyphenols promote gut health by favorably altering gut microbiota composition and producing secondary bioactive metabolites with antioxidant and anti-inflammatory properties. The study revolves around observing the effects of dietary intake of cocoa polyphenols, bioactive compounds with antioxidant and anti-inflammatory properties, on gut microbiota. These polyphenols have poor absorption in the gut and hence, rarely enter the systemic circulation in their natural forms. Instead, through a bidirectional interaction with the gut microbiota, they stimulate the proliferation of beneficial bacteria and inhibit the growth of harmful ones, thereby acting as a prebiotic. The resulting metabolites from this interaction are bioavailable, and these enter the circulation to reach target organs. The metabolites exhibit substantial antioxidant and anti-inflammatory activities, which improve gut health. These actions augment immunity and reduce the risk of many diseases, documenting a notable health-protective potential of cocoa polyphenols, routed via modulation of gut microbiota composition.

A Review Article published in 2020 in the journal Frontiers in Nutrition found that Incorporating avocados into the Mediterranean diet may enhance its benefits, offering greater health flexibility and adaptability for non-Mediterranean residents. The research approach starts with an evaluation of the nutritional value of a Mediterranean diet, which is traditionally rich in fruits, vegetables, and oleic-acid-rich olive oil. This diet has been associated with lower risks of several chronic diseases. Simultaneously the paper introduces the subject of rising obesity rates globally. The study then evaluates the potential benefits of modifying the Mediterranean diet to include non-traditional fruits and vegetables that could provide more variety in food choices and greater adaptability for those living outside the Mediterranean region. The avocado, a fruit native to the Mediterranean climate and rich in beneficial nutrients like oleic acid and fiber, is proposed as a potential addition. Discussion of the study reveals an interesting proposition: including avocado in the traditional Mediterranean diet, which is not commonly done. The avocado's health benefits and nutritional value are then analysed in depth, drawing from existing research studies, to substantiate the recommendation for incorporating this fruit into the Mediterranean dietary pattern. The discussion concludes by highlighting the potential enhanced health benefits that can result from this inclusion, thereby presenting a compelling case for the suggested adjustment.

A Experimental Study published in 2020 in the journal Nutrients found that Unpasteurised milk and dairy products intake could potentially alter gut microbiome composition which may influence psychological functioning. In this observational study, the impact of dietary change involving unpasteurized dairy consumption on gut microbiota and psychological state was observed among participants of a 12-week residential cookery course on an organic farm. Twenty-four participants, who primarily consumed food from the farm including unpasteurised milk and dairy products, provided faecal samples at the beginning and end of the course. Concurrently, they completed self-report questionnaires touching on mood, anxiety, and sleep aspects and nutrient intake was monitored via a food frequency questionnaire. Gut microbiota analysis was carried out using 16S rRNA gene sequencing and measurement of faecal short chain fatty acids. Post-course, there was a significant growth in the relative abundance of a specific bacterial genus in the gut, associated with unpasteurised milk and dairy product intake. Furthermore, an increase in a particular faecal short chain fatty acid, valerate, was observed together with an elevation in the functional richness of the microbiome profile. The latter was determined by measuring the predicted neuroactive potential using a unique gut-brain module approach. Despite safety concerns, the consumption of unpasteurised milk and dairy products seemed to promote the growth of probiotic bacterial genus, known to be beneficial for various physical and mental health outcomes.

A Systematic Review published in 2020 in the journal International Urogynecology Journal found that Antenatal perineal massage reduces severe perineal trauma and postpartum complications. This meta-analysis of 11 randomized controlled trials involving 3467 patients found that antenatal perineal massage significantly reduces the risk of perineal tears and episiotomy, especially severe tears. Additionally, it leads to shorter second-stage labor, less postpartum perineal pain, and improved wound healing. While some heterogeneity and publication bias were noted, this study supports the routine recommendation of antenatal perineal massage for labor preparation, emphasizing its benefits in reducing perineal trauma and improving obstetric outcomes. Further research with larger sample sizes is encouraged to confirm these findings and explore additional benefits, such as postpartum sexual satisfaction and incontinence reduction.

A Review Article published in 2020 in the journal Food Bioscience found that Different varieties of dates pose impressive nutritional profiles and exhibit multiple health benefits, including anti-cancer, anti-inflammatory, and cholesterol lowering potential. The study embarked on a systematic literature review, utilizing the Scopus, Centre for Agriculture and Bioscience International, Google Scholar and Web of Science databases to assess works published from 1971 to 2017, resulting in 270 relevant articles. The focus was to evaluate the nutritional profile and nutraceutical attributes of different date varieties worldwide, particularly from their cultivation hotspots in West Asia and North Africa. The findings indicate that date fruit is a rich, affordable source of numerous nutrients, including carbohydrates, proteins, amino acids, dietary minerals, vitamins, and various health-promoting compounds such as polyphenols, anthocyanins, tannins and flavones. The fruit's constituents, particularly beta-glucan, show a vast array of beneficial effects on health, functioning as antioxidant, anti-tumor, immune-modulating, anti-diabetic, and cholesterol-lowering agents, as well as promoting beneficial gut microflora growth. Preclinical studies also underline the beneficial effects of date fruit in protecting against a range of health conditions like cardiovascular disease, diabetes, and various forms of cancer. The positive health impacts were observed in different parts of the fruit, namely the flesh, peel, and pits.

A Systematic Review published in 2020 in the journal Postgraduate Medical Journal found that Acupuncture is an effective therapy for simple obesity rather than a placebo effect. The results of this meta-analysis demonstrated that acupuncture could improve body mass index, body weight and waist circumference, suggesting that acupuncture is effective compared with sham acupuncture for the treatment of obesity. However, due to the small number of included studies and limited sample size, our conclusions remain to be confirmed by further high-quality RCTs.

A Cohort Study published in 2020 in the journal Journal of Traditional and Complementary Medicine found that Chinese herbal medicine usage in children with asthma can reduce their risk of hospitalization. The study used data from one million individuals randomly selected from the National Health Insurance Research Database's Registry of Beneficiaries. Children under 18 years old diagnosed with asthma were followed from the year 2000 to 2012. These patients were classified into two groups: the Chinese Herbal Medicine (CHM) group and the non-CHM group. The Kaplan-Meier survival curve and Cox proportional hazard regression model were utilized to estimate the adjusted hazard ratio of the two groups and to determine the correlation between the number of cumulative days the CHM was used and consequent hospitalizations due to asthma. After adjusting for variables such as gender, age, comorbidities, and the total numbers of asthma medications taken, it was found that users of CHM had a reduced risk of hospitalization due to asthma compared to non-CHM users. Children older than six years who used CHM therapy for more than 180 days demonstrated a significant reduction in the risk of subsequent hospitalization for asthma.

A Systematic Review published in 2020 in the journal Nutrients found that These reports suggest the benefits of a walnut-enriched diet in brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation in these diseases. Walnuts contain several components that have antioxidant and anti-inflammatory effects. Animal and human studies from our and other groups suggest that supplementation with walnuts in the diet may improve cognition and reduce the risk and/or progression of mild cognitive impairment and Alzheimer's disease. Furthermore, several animal and human studies have suggested that walnuts may also decrease the risk or progression of other brain disorders such as Parkinson’s disease, stroke, and depression, as well as of cardiovascular disease and type 2 diabetes. Together, these reports suggest the benefits of a walnut-enriched diet in brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation in these diseases.

A Randomised Controlled Trial published in 2020 in the journal International Journal of Psychophysiology found that Daily avocado consumption improves attentional inhibition and increases serum lutein concentrations, irrespective of changes in lutein status, in adults with obesity. The study involved a randomized-controlled trial with 84 adults aged 25-45 years suffering from overweight or obesity. The participants were divided into a treatment group and a control group. Those in the treatment group consumed a daily meal with fresh Hass avocado for 12 weeks while the control group was given an isocaloric meal. The xanthophyll status was evaluated by measuring serum lutein and macular pigment optical density, and cognitive functions such as attention and inhibition were evaluated using the Flanker, Oddball, and Nogo tasks. Regarding the results, the treatment group showed improved serum lutein concentrations and better performance in the Flanker task demonstrating improved attentional inhibition. However, they found no correlation between improvements in performance and changes in lutein status and no significant changes in macular pigment optical density. Therefore, it suggests that the cognitive benefits from avocado intake were not due to changes in lutein status but may involve other unknown mechanisms.

A Review Article published in 2020 in the journal Food Reviews International found that Bioactive compounds found in avocado waste products exhibit various biological properties, with potential applications in the food and pharmaceutical industries. In this study, we delved into the archived scientific research concerning bioactive compounds and their sources, particularly focusing on avocado waste products such as leaves, peels, and seeds. We identified the primary compounds found in these parts to include carotenoids, tocopherols, phytosterols and a group of natural organic structures known as polyphenols. In the results discussion, we found that the compounds discovered in avocado waste products have credible biological activities that have distinct health implications. The wastes extracts demonstrated antimicrobial properties, along with anti-inflammatory characteristics. Additionally, they showed potential anticancer, antidiabetic and antihypertensive capabilities. These findings infer that the bioactive compounds from avocado wastes may be successfully used in the food and pharmaceutical industries.

A Review Article published in 2020 in the journal Nutrients found that Omega 3 fatty acids can counter muscle lipotoxicity and prevent comorbidities in patients with rheumatoid arthritis, supporting muscle health and reducing cardiometabolic disease risk. The research explores the connection between Rheumatoid arthritis, a chronic inflammatory disease, and a set of comorbidities such as cardiovascular disorders, insulin resistance, metabolic syndrome, and sarcopenia, hypothesizing that these could possibly be associated with alterations in lipid metabolism. Patients with rheumatoid arthritis are observed to have lower cholesterol levels paradoxically coupled with an increased risk of cardiovascular disorders. The study also discusses the accumulation of toxic lipid mediators in skeletal muscles which can lead to mitochondrial dysfunctions and insulin resistance, both key factors of cardiovascular disorders and sarcopenia. Through multiple research studies, it was observed that Omega 3 fatty acids could potentially inhibit the development of rheumatoid arthritis and improve muscle metabolism, consequently reducing muscle atrophy in patients with obesity and insulin resistance. Thus, dietary supplementation with Omega 3 fatty acids was suggested as a promising strategy to limit the lipotoxicity in muscles and prevent associated health risks in patients dealing with rheumatoid arthritis.

A Network Pharmacology published in 2020 in the journal Nutrients found that Ganpu tea, derived from Pu-erh tea and the pericarp of Chachi, enhances antioxidant capacities and modulates gut microbiota beneficially more than Pu-erh tea alone. A thorough chemical analysis was conducted on hot-water extracts of Ganpu tea using ultra-high performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry, which identified a total of 92 constituents. Considering the antioxidant properties of Ganpu tea, an experiment was designed and carried out where rats were fed with Ganpu tea over a long period. The same experiment was done using Pu-erh tea and the pericarp of Chachi separately, allowing for comparisons of antioxidant capacities between them and Ganpu tea. The results showed that Ganpu tea had a substantial impact on improving the activities of superoxide dismutase and glutathione peroxidase, both essential antioxidants, more than Pu-erh tea. This indicated a superior antioxidant capacity of Ganpu tea. Further, it significantly increased the abundance of specific gut bacteria, offering a suggestion of the potential benefits of Ganpu tea in human gut microbiota modulation. The results underscore the health benefits of Ganpu tea in enhancing antioxidant activities and promoting beneficial gut microbiota.

A Systematic Review published in 2020 in the journal Nutrition found that Regular dietary intake of olive oil reduces the levels of certain inflammation markers, making it a beneficial alternative dietary fat, especially for managing IL-6. The methodology of this review involved summarising data from randomized controlled trials to investigate the impact of regular dietary intake of olive oil on three specific inflammatory markers: C-reactive protein, interleukin-6, and tumor necrosis factor-alpha. These studies looked at how regular usage of olive oil as part of the diet can affect these markers and provide benefits to individuals who implement it in their dietary routine. The trials focused primarily on the Mediterranean diet, which is known for its high usage of olive oil as a main fat source. The results indicate that olive oil, when consumed on a consistent basis, can reduce the levels of inflammatory markers. It has been observed to be particularly effective in managing levels of interleukin-6. The results obtained from the review of these trials suggest that olive oil can indeed be a beneficial supplement to diet with potential impacts on managing inflammation and related diseases. They hint at potential effectiveness of olive oil as a nutritious factor in mitigating the adverse impacts of a diet high in unhealthy fats, by providing it as a healthier alternative.

A Review Article published in 2020 in the journal International Review of Neurobiology found that The date fruit contains compounds such as flavonoids that can protect tissues from harm and reduce risks of illnesses like cardiovascular disease and cancer. The research focused on the properties of the date palm fruit (Phoenix dactylifera), known to be rich in bioactive compounds such as polyphenols. A particular interest was given to flavonoids, a group of phytochemicals renowned for their high antioxidant capacity, and other useful traits. The study investigated the fruit's capability in protecting tissues against harmful effects, examining the interference with enzymes that prompt the formation of damaging free radicals. In the discussions, it was indicated that the date fruits were not only appreciated for their organoleptic properties but also for their biological activities. The protective properties of the fruit against harmful effects arose from flavonoids and their ability to inhibit the formation of free radicals. Flavonoid-rich date fruit consumption was suggested to correlate to a decreased risk of various diseases, including cardiovascular diseases and cancer. This aspect uplifts date fruit as a prized option for consumers seeking health benefits from their diet.

A Review Article published in 2020 in the journal Journal of Pharmacognosy and Phytochemistry found that Peppermint's extensive applications, especially its antimicrobial and antioxidant features, and potential health benefits can significantly increase its market value in various industries. The study assembled and examined various research papers concerning the drying methods of peppermint. The focus was on how different drying methods affect the drying time, rate and enhancement of quality in terms of color and physical properties. As peppermint is a highly perishable and seasonal plant, efficient drying is important to extend its shelf life, decrease packaging and transportation costs, and generally ensure its availability all year round. In the analysis of the results, the health benefits of peppermint were reviewed in depth, highlighting its anti-viral, anti-bacterial, anti-inflammatory, and anti-fungal properties, among others. Other beneficial advantages such as its anti-asthmatic, allopathic, spasmolytic, anti-headache, anti-septic, and radioactive properties were also in the spotlight, implying the enormous potential of peppermint in not just the food and cosmetic industries, but the medical and biotechnological area as well. This suggests that the plant can be leveraged more for wider human prosperity.

A Review Article published in 2020 in the journal Antioxidants in Fruits: Properties and Health Benefits found that Avocado, particularly the Hass variety, has substantial health benefits due to its rich contents of nutrients, fiber, and bioactive constituents including antioxidants. The methodology of the paper involves a comprehensive overview of avocado, focusing on the extensively cultivated Hass variety. The research explored various components of the avocado which include not only the fruit, but also the seeds, leaves, and skin. These parts were analyzed for their nutritional and bioactive constituents such as phytochemicals, phytosterols, vitamins and minerals. Furthermore, the use of avocado leaves in traditional medicine, the rich composition of the peel and seeds, and the potential health benefits of avocado oil were investigated. The discussion of results revealed that avocados, particularly Hass avocados, are a substantial source of beneficial nutrients, fiber, and bioactive components. It was found that leaves of the avocado have antioxidant properties and are used in traditional medicine. The peel and seeds showed a rich content of phenolic compounds, starch, and fiber. The research also determined that avocado oil presents health advantages and can be used as a good alternative substitute for olive oil. Avocados are largely consumed as a vegetable, often in combination with other ingredients.

A Randomised Controlled Trial published in 2019 in the journal Nutrients found that Consuming walnuts daily can reduce cardiovascular risk factors in chronic kidney disease patients without altering significant physiological levels. In this prospective, randomized, crossover, pilot clinical trial, 13 patients suffering from chronic kidney disease were selected as subjects. They were randomly divided into two groups, one of which was assigned a diet including 30 grams of walnuts each day while the other followed a control diet. After a duration of 30 days, a washout period of an additional 30 days was allowed, following which the groups were switched to the alternate diet. Key markers such as urinary and serum levels of phosphorous and potassium, multiple vascular risk factors, and urinary inositol phosphates were measured before initiating the trial and post the intervention period. The study indicated that a dietary supplement of walnuts resulted in reduced blood pressure, lower LDL cholesterol, and decreased albumin excretion. Interestingly, despite these changes, it had no impact on the physiological levels of phosphorous, potassium, parathyroid hormone, and fibroblast growth factor 23. This indicates that daily consumption of walnuts, when incorporated in a sodium, protein, phosphate, and potassium controlled diet, has the potential to be an effective strategy in reducing cardiovascular risk among chronic kidney disease patients without perturbing key physiological levels.

A Review Article published in 2019 in the journal Journal of Diabetes Research found that Traditional Chinese medicine, especially Zuo Gui Wan, red raspberry leaves, and Orthosiphon stamineus, seems to control gestational diabetes effectively without reported toxicity. The study initiated a systematic search across PubMed, Web of Science, and Embase databases to pinpoint research discussing the impact of traditional Chinese medicine on pregnancy. The results were then further narrowed down to focus on any correlation with all forms of diabetes mellitus. The primary thread that emerged was the beneficial effect of three main herbal remedies: Zuo Gui Wan, red raspberry leaves, and Orthosiphon stamineus. Based off of the results from this search, a focal review of these herbal elements and their associations with type 2 diabetes mellitus was undertaken. Across the board, these remedies demonstrated positive effects on metabolic health, especially among women dealing with gestational diabetes. No experimental models reported any toxicity or harmful side effects associated with these herbal treatments. The report calls out that current studies on both conventional and alternative interventions for gestational diabetes are immensely lacking, emphasizing the need for a standardized protocol to evaluate the efficacy of these herbal medicines.

A Review Article published in 2019 in the journal Antioxidants found that Avocado's nutritional and therapeutic properties show potential for novel drug discovery in prevention and treatment of prevalent diseases such as cancer, diabetes, and cardiovascular issues. The methodology utilized in this review was an extensive summary and assessment of research conducted in recent decades with emphasis on avocado's nutritional and therapeutic properties, along with its unique biochemical profile. Special focus was given to the major metabolites of avocado, their antioxidant properties, as well as their bioavailability and pharmacokinetic features. The discussion of results involved highlighting the potential of avocado in novel drug discovery for the prevention and treatment of a variety of diseases like cancer, microbial, inflammatory, diabetes, and cardiovascular diseases. Emanating from the unique bioactive compounds and antioxidant contents of avocado, it’s clear that the fruit has much more to offer in terms of medicinal value than is currently explored today.

A Review Article published in 2019 in the journal Evidence-Based Complementary and Alternative Medicine found that Honey can protect the bone via its antioxidant and anti-inflammatory properties, primarily through its polyphenol content that acts upon several signalling pathways, leading to bone anabolic and antiresorptive effects. This review aims to summarize the current evidence on the effects of honey on bone health. The evidence reported so far indicates a skeletal-beneficial effect of honey in animal models of osteoporosis. However, the number of studies on humans is limited. The literature shows that honey has promising skeletal-beneficial effects in preventing osteoporosis. Many types of honey have been shown to prevent bone loss in various animal models via its high antioxidant and anti-inflammatory properties. Nevertheless, the efficacy of honey seems to be dose-dependent, whereby very high or low dosage will not produce desirable results on the skeleton.

A Review Article published in 2019 in the journal Agricultural Reviews found that Cocoa and cocoa products, enriched with polyphenols, have potential health benefits including enhanced vascular function, cancer prevention, and improvement in learning and memory. The authors carried out an extensive review of the nutritional profile of cocoa beans, focusing on the high content of carbohydrates, protein, fat, fiber, and minerals. Significantly, they pinpointed bioactive compounds, especially polyphenols (flavonoids and nonflavonoids), as key constituents, attributing to cocoa its antioxidant and anti-inflammatory properties. Emphasis was placed on the consumption of flavonoid-rich chocolates and its potential health benefits. The findings of the research underscore multiple health benefits from cocoa's flavonoids. These include an improvement in peripheral vascular function and a suppression of molecular processes linked with cancer. Notably, the flavonoids have been observed to heighten insulin sensitivity and reduce oxidative damage. They also seem to concentrate in brain areas associated with learning and memory. These insights collectively support the integration of cocoa and its products as a part of a nutritious and balanced diet.

A Review Article published in 2019 in the journal Applied Ecology and Environmental Research found that Chrysanthemum, rich in unique chemical compounds, offers significant health benefits such as stress relief, cardio protection, immunity boost, improved eye health, and osteoporosis risk reduction. The study primarily focuses on evaluating the most important chemical extracts of chrysanthemum. These include flavonoids, betaine, choline, and vitamin B1. Further, the researchers identified thirteen compounds unique to chrysanthemum flowers. These were extracted and analyzed to unveil their potential health benefits. In the discussion of results, the authors highlight chrysanthemum's impressive range of health benefits stemming from its chemical composition. It is revealed that chrysanthemum can potentially alleviate stress and anxiety while improving cardiovascular health. It also has properties to guard against oxidative damage and inflammation, support a healthy immune function, enhance eye health, and lessen the risk of osteoporosis. Interestingly, the herb's beneficial traits align with its traditional use in Chinese medicine, underscoring chrysanthemum's potential in promoting holistic, organic health.

A Randomised Controlled Trial published in 2019 in the journal Aging found that Our study offers the first evidence of the positive contribution of tea drinking to brain structure and suggests a protective effect on age-related decline in brain organisation. Our study comprehensively investigated the effects of tea drinking on brain connectivity at both global and regional scales using multi-modal imaging data (i.e., functional and structural imaging) and provided the first compelling evidence that tea drinking positively contributes to brain structure making network organization more efficient. Our study suggests that tea drinking is effective in preventing (slowing) or ameliorating cognitive decline and that tea drinking might be a simple lifestyle choice that benefits brain health.

A Systematic Review published in 2019 in the journal Nutrients found that The mung bean has been documented to ameliorate hyperglycemia, hyperlipemia, and hypertension, and prevent cancer and melanogenesis, as well as possess hepatoprotective and immunomodulatory activities. The mung bean has been documented to ameliorate hyperglycemia, hyperlipemia, and hypertension, and prevent cancer and melanogenesis, as well as possess hepatoprotective and immunomodulatory activities. These health benefits derive primarily from the concentration and properties of those active compounds present in the mung bean. Vitexin and isovitexin are identified as the major polyphenols, and peptides containing hydrophobic amino acid residues with small molecular weight show higher bioactivity in the mung bean.

A Systematic Review published in 2019 in the journal Journal of Functional Foods found that Consumption of virgin avocado oil, rich in monounsaturated fatty acids and bioactive components, may help manage chronic diseases like hypertension, diabetes, and lower cardiometabolic risk. The research paper is a review that explores various extraction methods developed for producing virgin avocado oil (VAO) and the oil yields for these methods. It additionally details the physicochemical composition of VAO, focusing specifically on its high concentration of monounsaturated fatty acids and bioactive components, such as α-tocopherol and β-sitosterol. The results discussed indicate that VAO, which is mainly composed of oleic, palmitic, and linoleic acids, can be utilized as a functional oil offering potential health benefits. In particular, the intake of avocado oil could aid in managing conditions like hypercholesterolemia, hypertension, diabetes, and fatty liver disease, taking advantage of its rich composition. Furthermore, it was noted that the oil could also reduce cardiometabolic risks and exhibit properties that can combat microbial activity.

A Systematic Review published in 2019 in the journal Oxidative Medicine and Cellular Longevity found that The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation. Goji berries are a high antioxidant potential fruits which alleviate oxidative stress to confer many health protective benefits such as preventing free radicals from damaging DNA, lipids, and proteins. There is a better protection through synergistic and additive effects in fruits and herbal products from a complex mixture of phytochemicals than from a single phytochemical. The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.

A Systematic Review published in 2019 in the journal Oxidative Medicine and Cellular Longevity found that Goji berries, rich in antioxidants, confer health benefits including protection against aging, cancer, and radiation, as well as enhancing immunity and blood production. The methodology of the study focused on a thorough review of the bioactive compounds and pharmacological properties of goji berries, particularly targeting their molecular mechanisms of action. This involved looking at the different ways these fruits are consumed, such as in soups, herbal teas, tinctures, wine, and juice, and how these methods influence the antioxidants present in the fruits. Goji berries were found to offer a range of health benefits due to their ability to alleviate oxidative stress. These benefits include enhancing hemopoiesis (blood formation), offering antiradiation and antiaging properties, inhibiting cancer, improving immunity, and providing antioxidation. Furthermore, the study emphasized that the complex mixture of phytochemicals found in fruits and herbal products like goji berries provide a cumulative protective effect, which proves more beneficial compared to extracting and using one single phytochemical.

A Systematic Review published in 2019 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture has some effects on asthma, especially as an adjunctive therapy. Acupuncture has been applied to treat asthma for thousands of years in China. Asthma was listed as an indication for acupuncture in 1979 by the WHO; however, despite its use for millennia, no strong evidence has demonstrated the beneficial efficiency of conventional treatments plus acupuncture compared with conventional treatments alone. Previous research has indicated that acupuncture downregulates the expression of proinflammatory proteins and upregulates the expression of anti-inflammatory proteins. To the best of our knowledge, this is the first meta-analysis that has systematically estimated the effectiveness of conventional treatments plus acupuncture compared with conventional treatments alone. Conventional treatments plus acupuncture did not show any beneficial effects on pulmonary function in asthmatic patients over conventional treatments alone. However, conventional treatments plus acupuncture did show a clinically and statistically significant improvement in the symptom response rate and the IL-6 level when compared with conventional treatments alone.

A Review Article published in 2019 in the journal Therapeutic Advances in Musculoskeletal Disease found that Cherries and their products have antioxidant properties, the capacity to inhibit the acute inflammatory response to urate crystals, and the ability to decrease bone resorption that is characteristic of gouty bone erosions. Phenolics, and more specifically, the anthocyanins found abundantly in cherries, have been linked to the inhibition of IL-6, TNF-α, IL-1β, IL-8, COX-I and COX-II, as well as the downregulation of NFkB-mediated osteoclastogenesis, suggesting that cherries may have the ability to reduce both acute and chronic inflammation that play a role in recurrent gout flares and chronic destructive arthropathy. Additionally, cyanidin-3-glucoside enhanced genes related to osteoblast differentiation, suggesting that anthocyanins may also play a role in bone formation.

A Theoretical Article published in 2019 in the journal Applied Ecology and Environmental Research found that Chrysanthemum, a plant primarily grown in China and Japan, offers significant health benefits including stress reduction, cardiovascular improvement, and lowering osteoporosis risk. The study focused on Chrysanthemum, a notable plant in the ornamental industry and traditional Chinese medicine, mainly grown in China and Japan. The researchers identified its crucial chemical extracts such as flavonoids, betaine, choline, and vitamin B1. They additionally pinpointed thirteen significant compounds of chrysanthemum flowers, including acacetin-7-0-beta- D-glucopyranoside, luteolin, acaciin, and boscialin, among others. The findings revealed that chrysanthemum tea exhibits considerable health advantages. It eases stress and anxiety, enhances cardiovascular health, protects against oxidative damage, inhibits inflammation, supports healthy immune function, ameliorates eye health, and decreases the risk for osteoporosis. In traditional Chinese medicine, chrysanthemum is considered a cold herb that dispels pathogenic heat, aids the liver, improves eyesight, and promotes detoxification. The study, therefore, endorsed the treatment with natural Chinese herbal medicine, especially chrysanthemum, over synthetic drugs for a more organic life.

A Systematic Review published in 2018 in the journal MOJ Food Processing & Technology found that Chili pepper has preventive and therapeutic properties for many ailments such as different types of cancer, rheumatism, stiff joints, bronchitis and chest colds with cough and headache, arthritis, heart arrhythmias and used as stomachic. A vanilloid receptor known as VR1 which was later found to be member of the family TRP and was called TRPV1 (transient receptor potential vanilloid subtype 1) is the receptor for capsaicin and is universally distributed in the brain, sensory nerves, dorsal root ganglia, bladder, gut, and blood vessels. Capsaicin is activate and then desensitize or block VR1 and was found to be powerful drug in animal models of human disease. Capsaicin plays a potential role in cardiometabolic protection through the activation of TRPV1 in different target organs or tissues, which suggests that TRPV1 may be a promising target for the management of cardiometabolic diseases such as obesity, hypertension, dyslipidemia, diabetes and atherosclerosis. However, association between the dosage of dietary capsaicin and the effect on cardiometabolic protection need to be clarified for determining the daily usage or intake of capsaicin or its derivatives. The activation of VR1 by capsaicin make it possible to be involved in various human disease states ranging from genetic pain insensitivity to chronic pain syndromes. In addition to that VR1 has much broader clinical benefits than mere pain case. Chili pepper has preventive and therapeutic properties for many ailments such as different types of cancer, rheumatism, stiff joints, bronchitis and chest colds with cough and headache, arthritis, heart arrhythmias and used as stomachic. Chili preparations for treating ailments can be standard capsaicin, pharmaceutically prepared gels, creams and plasters, essential oils distilled from pods, powder prepared by crashing pods and extracts by soaking pods in water or ethanol.

A published in 2018 in the journal Nutrients found that The consumption of epicatechin, plentiful in foods like cocoa, positively influences memory, executive function, and processing speed, particularly in older adults. Methodology: The research design for this paper was anchored on the use of intervention studies. These are intensive studies purposed to test breakthrough methodologies or practices on a select group of participants. In this case, the intervention was the ingestion of epicatechin, a compound found largely in cocoa. The subjects monitored were mostly from a more mature demographic, aged 50 years and above. The studies selected for review were those that lasted a minimum of 28 days to ensure an adequate examination period and only those which had a daily epicatechin dose exceeding 50 mg. Discussion of Results: The paper notes an appreciable improvement in the cognitive performance in those subjects who consumed diets high in epicatechin. More specifically, there was an enhancement in memory, executive function, and processing speed. Trends showed that these benefits were more conspicuous in studies which offered more than 50 mg of epicatechin daily, and ran for at least 28 days. The results were particularly noteworthy in the elderly population, where all participants showed cognitive improvement. The impact of epicatechin on cerebral blood flow, however, could not be definitively proved and the results suggest its role requires further exploration. Additionally, the synergistic effects of epicatechin with other dietary elements also complicated the ability to attribute the cognitive improvement to this compound alone.

A Review Article published in 2018 in the journal Food Reviews International found that Pumpkin seed oil appears effective for improving men's health conditions such as enlarged prostate, overactive bladder, and hair loss due to its anti-inflammatory properties and radical scavenging. The study methodology entailed the review of various clinical trials that examined the impacts of pumpkin seed oil on different health conditions common in men. These conditions included Benign Prostatic Hyperplasia (a non-cancerous enlargement of the prostate gland), overactive bladder, and androgenic alopecia (a hair loss condition). The decision to focus on these conditions was based on the potential therapeutic value of the biochemical components of the oil, such as its rich contents of essential, highly unsaturated fatty acids and phytosterols. In discussing the results, it was observed that the beneficial effects of pumpkin seed oil in treating the examined health conditions are potentially linked to the oil's contents of phytoestrogens and unsaturated fatty acids. It was suggested that these compounds may inhibit the enzyme 5-alpha reductase, which is an important factor in the enlargement of the prostate and hair loss. Additionally, the oil's anti-inflammatory properties and its capacity to scavenge free radicals might contribute to its therapeutic advantages. Furthermore, it is postulated that the oil may also have a relaxation effect on the bladder sphincter, thereby aiding patients with urination difficulties.

A Systematic Review published in 2018 in the journal Cochrane Database of Systematic Reviews found that In people with hip osteoarthritis, at close to 8 weeks, acupuncture plus routine primary physician care may improve pain and function compared to routine primary physician care alone. Because acupuncture has previously been documented to have a low risk of adverse effects, and because arthritis patients seem to be accepting of acupuncture (Rao 1999), there seem to be few drawbacks to hip OA patients electing to receive acupuncture, other than the additional costs incurred. While some private health insurance plans cover much of the costs of acupuncture, it is not typically covered by governmental health plans, with some exceptions (NICE 2009). Thus, the out‐of‐pocket costs of the acupuncture will vary depending on an individual's health plan. Given the potential disability caused by OA of the hip and the few available treatments, acupuncture may be considered one treatment option, particularly among patients who are not yet ready for a joint replacement or who are unable to tolerate oral NSAIDs. However, patients should be informed that acupuncture probably has little or no effect in reducing pain or improving function relative to sham acupuncture. . Because there are currently no registered ongoing RCTs, this evidence base is unlikely to substantially change in the near future.

A Systematic Review published in 2018 in the journal Food Science and Human Wellness found that The consumption of mung beans and sprouts in regular basis are not only providing nutrients, but also maintains the microbial flora in the gut, reduces the absorption of toxic compounds, decreases the menace of obesity, hypercholesterolemia, and cardiovascular diseases, and also prevents cancer and diabetes. Based on the high constituents and efficacy of the bioactive compounds, mung beans are playing a greater role in radical scavenging activities, detoxification, and also exhibits chemo-preventive effects. These compounds have the potential health benefit as a complementary and alternative medicine which is exerted for its antioxidant, hepatoprotective, antibacterial, antifungal, antiviral, cardioprotective, anti-inflammatory, antidiabetic, anticancer, anti-obesity, hypolipidemic, and potent chemopreventive properties.

A published in 2018 in the journal Pain Medicine found that Acupuncture therapy offered in the group setting was effective in reducing pain severity, pain interference, and depression in patients with chronic neck, back, or shoulder pain or osteoarthritis. Subjects received eight weekly acupuncture therapy sessions in a group setting. Acupuncture therapy included a combination of palpation, acupuncture needling, Tui na, Gua sha, and auricular treatment. Baseline pain levels were established in a two- to four-week run-in; assessment of the intervention impact on pain intensity, mood, and functional status were made at the end of the treatment period (eight weeks) and 16 weeks after completion of intervention (24 weeks). Of the total 113 participants recruited for the trial, 96 completed the 24-week protocol. We found a statistically and clinically significant decrease in pain severity, pain interference, and depression in our study population. There were no serious adverse events. Acupuncture therapy offered in the group setting was effective in reducing pain severity, pain interference, and depression in patients with chronic neck, back, or shoulder pain or osteoarthritis. Benefit persisted through the 24-week measure despite no additional treatment. This finding has potentially important implications for improving access to effective acupuncture treatment for patients with limited financial resources.

A Systematic Review published in 2018 in the journal Sleep Medicine Reviews found that The results showed that even fragile populations such as the elderly and dialysis patients can benefit from acupressure to improve sleep quality. Thirty-two eligible randomized controlled trials of moderate to high quality which employed polysomnography, actigraphy, or self-assessment sleep quality tools were included. We conducted a meta-analysis using a random effects model with the Pittsburgh sleep quality index (PSQI) as the primary outcome measure (968 adult patients, 13 trials) for trials investigating the effects of traditional Chinese medicine acupressure compared with standard and sham treatments. We performed subgroup analyses to detect sources of heterogeneity, identify the use of acupoints in different populations and explore the contributions of PSQI domains to the total score change. Comparison with the sham group (7 trials with 385 patients) yielded low heterogeneity and an overall effect of 13%–19% improvement in the PSQI score. Based on data from four trials (n = 250), sleep latency and sleep duration were most affected. No adverse effects were reported in any of the reviewed trials.

A Systematic Review published in 2018 in the journal The Journal of Alternative and Complementary Medicine found that Evidence supports the use of acupuncture for menopause symptoms as an adjunctive or stand-alone treatment for reducing vasomotor symptoms and improving health-related quality of life outcomes. Evidence from RCTs supports the use of acupuncture as an adjunctive or stand-alone treatment for reducing VMSs and improving HRQOL outcomes, with the caveat that observed clinical benefit associated with acupuncture may be due, in part, or in whole to nonspecific effects. The safety of acupuncture in the treatment of VMSs has not been rigorously examined, but there is no clear signal for a significant potential for harm.

A Systematic Review published in 2018 in the journal Beverages found that Among the health benefits of green tea are: anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties, and benefits in cardiovascular disease and oral health. Green tea catechins have proved to be very versatile in providing health benefits. This means that there are potential health benefits for everyone in the consumption of green tea. Even moderate amounts of consumption (drinking 1–2 cups of tea per day) may have benefits. It is a very good thing that it is the second most popular beverage worldwide, as the differences in health in a world without green tea might be significant. There is fortunately a wide variety of research being performed using green tea catechins, and we are starting to see many studies performed using human subjects, as it is extremely important that we are able to show the direct benefits to humans. The expansive repertoire of green tea activity in health is important, especially to those people who live where medical assistance is not generally available or affordable.

A Review Article published in 2018 in the journal Oxidative Medicine and Cellular Longevity found that Honey may be used as a potential antidiabetic agent that has the potential to reduce the complications of diabetes. Considerable evidence from experimental studies shows that the honey may provide benefits in the management of diabetes mellitus. The benefits could be a better control of the hyperglycemic state, limiting other metabolic disorders and diminishing the deleterious effects on different organs that may produce diabetic complications. Anyway, there are some data and literature with contrary discussions regarding the use of honey in diabetic diseases. Long-term studies using honey as an alternative or a complementary therapy in human subjects suffering from type 2 diabetes mellitus are needed, with a larger number of patients, randomized clinical trials set up with different levels of diabetes, treated with different doses of honey, following both short-term and long-term treatment.

A Review Article published in 2018 in the journal Journal of Pharmacy And Bioallied Sciences found that Saffron possesses major bioactive compounds such as safranal, crocin, and picrocrocin that are hypothesized to be integral to its antidepressant effects. In this research, a chemical analysis was undertaken on the saffron plant, a perennial herb native to various mountainous regions, ranging from Asia Minor to India. During this in-depth analysis, the researchers identified and elucidated almost 150 volatile and nonvolatile compounds from the plant. A key focus of the analysis was the three major bioactive compounds - safranal, crocin, and picrocrocin, believed to be the primary factors behind saffron's aroma and bitter taste. On the subject of the findings, it was concluded that these major bioactive compounds are likely playing a pivotal role in the medicinal potential of the saffron plant. Specifically, the plant's well-documented antidepressant properties could largely be attributed to these compounds. The study also focused on the pharmacokinetic and pharmacodynamic properties of the plant, indicating that saffron could have efficacious and safe potential for use. It was inferred that this potential mainly pertains to its antidepressant effects, spurring increased interest in further exploration of its assorted bioactive compounds.

A Review Article published in 2017 in the journal PLOS One found that Traditional Chinese Medicine offers potential benefits like pain relief and functional improvement for knee osteoarthritis with few adverse events. Five electronic databases were searched up until April 2016 to study the efficacy and safety of Traditional Chinese Medicine (TCM) for treating knee osteoarthritis. The methodological quality of the included studies was evaluated using the Assessment of Multiple Systematic Reviews (AMSTAR) and the Risk of Bias in Systematic reviews (ROBIS) tools. The quality of evidence was determined using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The findings indicate that TCM potentially benefits patients with knee osteoarthritis through pain relief, functional improvement, and few adverse effects. However, deficiencies were found in the methodological quality of the reviews, such as the absence of an a-priori protocol or protocol registration, and an incomplete literature search. Furthermore, none of the studies offered a list of excluded studies. Overall, the quality of evidence in the systematic reviews was deemed poor, ranging from 'very low' to 'low'. This shortcoming was primarily due to a substantial risk of bias in the original trials, inconsistencies, and imprecision in the outcomes. Though TCM generally appears to be effective for knee osteoarthritis treatment, the evidence is not strong enough due to methodological flaws. Therefore, these findings should be approached cautiously in a clinical setting.

A Systematic Review published in 2017 in the journal Cochrane Database of Systematic Reviews found that Acupuncture and acupressure show potential for improving cervical readiness and certain birthing outcomes, their impact on reducing caesarean section rates remains inconclusive. The study evaluates the efficacy and safety of acupuncture and acupressure for third-trimester cervical ripening or labor induction. Of the 22 trials analyzed, acupuncture's effect on caesarean sections remains inconclusive, while electro-acupuncture appears to influence birthing outcomes like cesarean section rates, instrumental vaginal birth, and spontaneous vaginal birth. The quality of evidence varies, and more comprehensive trials are required to establish their effectiveness and potential safety.

A Systematic Review published in 2017 in the journal Phytomedicine found that Green tea consumption was shown to reduce psychopathological symptoms like anxiety and was also shown to effect cognition, with noted benefits for memory and attention. Green tea was also linked with the activation of working memory as seen in functional MRI. The effects of green tea cannot be attributed to a single constituent of the beverage. This is exemplified in the finding that beneficial green tea effects on cognition are observed under the combined influence of both caffeine and l-theanine, whereas separate administration of either substance was found to have a lesser impact.

A Clinical Study published in 2017 in the journal Mindfulness found that iRest Yoga Nidra combined with acupuncture significantly improves psychological health in veterans compared to using acupuncture alone. The study employed iRest Yoga Nidra, a mindfulness approach that promotes relaxation and focused attention, along with acupuncture. Initially developed for military use, iRest was combined with acupuncture in this exploratory study to determine its effectiveness. Specifically, this was tested on veterans with a view to improving their psychological health. Throughout the study, the participants were exposed to principles such as non-judgment and observation of opposing feelings and emotions, along with the inclusion of these principles into their everyday life. The analysis of results showed that the combined therapy using iRest and acupuncture had a marked effect on psychological health. There were significant improvements in areas such as depression, psychological symptom severity, depression or tension as a result of pain, and the emotional interference with activities of daily life. Conversely, the group that had only undergone acupuncture treatment showed no significant benefits in these areas. Also significant was that the comfort shown by the treatment group was a moderate to high degree in contrast to the low comfort experienced by the group receiving only acupuncture. The overall treatment condition demonstrated considerable changes, with veterans reporting substantive decreases in the levels of mild, moderate, and severe depression. Additionally, it was indicated that the benefits of the combined treatment did not differ across factors such as age, gender, or race.

A Systematic Review published in 2017 in the journal Sleep Medicine Reviews found that The severity of primary restless legs syndrome symptoms can be significantly ameliorated by acupuncture. Complementary and alternative therapies have been found to be effective in both primary and secondary restless legs syndrome (RLS). The severity of primary RLS symptoms can be significantly ameliorated by exercise training, transcutaneous spinal direct current stimulation, pneumatic compression devices, light therapy, repetitive transcranial magnetic stimulation, and acupuncture. Pneumatic compression devices and yoga also improve RLS-related disorders. Exercise training is highly efficacious in the reduction of symptom severity in uremic RLS and related effects such as poor quality of life. Endovenous laser ablation may be a good choice for patients with concurrent RLS and superficial venous insufficiency.

A Systematic Review published in 2017 in the journal Archives of Physical Medicine and Rehabilitation found that Electroacupuncture combined with conventional routine care has the potential of reducing spasticity in the upper and lower limbs and improving overall and lower extremity motor function and activities of daily living for patients with spasticity, within 180 days poststroke. EA combined with conventional routine care has the potential of reducing spasticity in the upper and lower limbs and improving overall and lower extremity motor function and activities of daily living for patients with spasticity, within 180 days poststroke. Further studies of high methodological and reporting quality are needed to confirm the effects and safety of EA, and to explore the adequate and optimal protocol of EA for poststroke spasticity, incorporating a group of comprehensive outcome measures in different populations.

A Review Article published in 2017 in the journal Nutrition Today found that Fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. Taken together, the outcomes from human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. However, larger, adequately powered, randomized, placebo-controlled, double-blind trials examining multiple measures of carbohydrate and lipid metabolism and insulin homeostasis are needed.

A Review Article published in 2017 in the journal Trends in Food Science & Technology found that The claimed health benefits of coix include anti-oxidation, anti-cancer, anti-inflammation, anti-allergy, enhancing immunological activity, regulating endocrine functions, anti-obesity, anti-diabetes, gastroprotection, hypolipidemia, and modulating gut microbiota. Coix seeds contain a range of bioactive components including polysaccharides, proteins, lipids, polyphenols, phytosterols, carotenoids, spiroenone and lactams. The chemical constituents of coix contribute to a range of medical and nutritional benefits. These claimed health benefits include anti-oxidation, anti-cancer, anti-inflammation, anti-allergy, enhancing immunological activity, regulating endocrine functions, anti-obesity, anti-diabetes, gastroprotection, hypolipidemia, and modulating gut microbiota. The bioactivity of coix depends on the varieties as well as the sample preparation methods such as the solvent type. Coix seed is rich in starch and has similar processing properties of other cereals for food formulation. Coix can be further developed as a healthy grain for human consumption.

A Review Article published in 2017 in the journal Current Opinion in Clinical Nutrition and Metabolic Care found that Recent studies have shown that chronic L-citrulline supplementation increases nitric oxide synthesis, decreases blood pressure, and may increase peripheral blood flow. L-Citrulline, either synthetic or in watermelon, may improve vascular function through increased L-arginine bioavailability and nitric oxide synthesis. There is clear evidence that acute L-citrulline ingestion increases plasma L-arginine, the substrate for endothelial nitric oxide synthesis. However, the subsequent acute improvement in nitric oxide production and mediated vasodilation is inconsistent, which likely explains the inability of acute L-citrulline or watermelon to improve exercise tolerance. Recent studies have shown that chronic L-citrulline supplementation increases nitric oxide synthesis, decreases blood pressure, and may increase peripheral blood flow. These changes are paralleled by improvements in skeletal muscle oxygenation and performance during endurance exercise. The antihypertensive effect of L-citrulline/watermelon supplementation is evident in adults with prehypertension or hypertension, but not in normotensives. However, L-citrulline supplementation may attenuate the blood pressure response to exercise in normotensive men. The beneficial vascular effects of L-citrulline/watermelon supplementation may stem from improvements in the L-arginine/nitric oxide pathway. Reductions in resting blood pressure with L-citrulline/watermelon supplementation may have major implications for individuals with prehypertension and hypertension. L-Citrulline supplementation, but not acute ingestion, have shown to improve exercise performance in young healthy adults.

A Meta-Analysis published in 2017 in the journal Pharmacological Research found that Consuming pomegranate juice consistently can lead to significant reductions in both systolic and diastolic blood pressure, suggesting its potential cardioprotective benefits. A systematic review and meta-analysis were conducted to investigate the correlation between pomegranate juice consumption and its effects on blood pressure. A comprehensive search was performed in Medline and Scopus databases to identify relevant randomized placebo-controlled trials (RCTs). The collected data from eligible studies were subsequently analyzed using a random-effects model. Additionally, quality assessment, sensitivity analysis, and evaluation of potential publication bias were carried out using standard methods. The findings showed that pomegranate juice was effective in significantly reducing both systolic and diastolic blood pressure, regardless of the duration of consumption and the dose consumed each day. These results remained stable even after sensitivity analyses. Furthermore, even doses greater than 240 cc recorded a nearly significant effect in reducing diastolic blood pressure. Thus, the study suggests the consistent effects of pomegranate juice consumption on lowering blood pressure.

A Review Article published in 2017 in the journal Oxidative Medicine and Cellular Longevity found that Honeybee products like honey, propolis, and royal jelly have demonstrated potential benefits in treating metabolic diseases, cancers, and other illness types. The research reviewed the effects and mechanisms of honey, propolis, and royal jelly on various health conditions. Their uses in correlation to metabolic diseases and different types of cancers were meticulously explored. Honey was examined for its microbial inhibiting and wound healing properties and its role in treating other diseases. The study found that honey demonstrated potential benefits such as microbial inhibition, wound healing, and effects on other diseases. Propolis was reported to have various health benefits related to gastrointestinal disorders, allergies, and issues related to gynecology, oral health, and dermatology. Royal jelly displayed protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. While these were potential benefits and effects elucidated, the specific mechanisms of action remain undetermined.

A Review Article published in 2016 in the journal Polish Journal of Food and Nutrition Sciences found that Goji berries, classified as superfruits, possess potential beneficial implications in the dietary prevention of diseases like diabetes, cardiovascular diseases, and cancer. The paper begins with a brief introduction of goji berries, their rich nutrient content, and the ideal conditions for their cultivation. It proceeds to delve into the berry's chemical composition and an extensive enumeration of health benefits that these chemicals can offer. The discussion of results further exemplifies how the myriad bioactive compounds found in these superfruits could potentially combat prevalent diseases of affluence such as diabetes, cardiovascular diseases, and cancer. Nonetheless, the paper also addresses safety concerns of goji consumption by discussing potentially harmful components for human health, possible allergic reactions, and interactions with other substances.

A Randomised Controlled Trial published in 2016 in the journal The American Journal of Clinical Nutrition found that Montmorency tart cherry juice intake can significantly lower systolic blood pressure in men with early hypertension, with improvements linked to phenolic acids. In a carefully controlled, blinded, crossover study employing a randomized Latin square design, fifteen male participants showing early signs of hypertension were given either a 60-mL dose of Montmorency tart cherry (MC) concentrate or a placebo. A recovery period of at least 14 days was allowed between tests to eliminate lingering effects from the previous test. Observations centred on microvascular reactivity, arterial stiffness, blood pressure, and phenolic acid absorption, and these were collected at designated intervals before and up to eight hours after consuming the MC concentrate or placebo. The analysis of the data revealed that consumption of the MC concentrate resulted in a significant reduction in systolic blood pressure in comparison to the placebo, reaching maximum impact two hours after intake. Crucially, this positive effect was found to coincide with an increase in circulating protocatechuic and vanillic acid 1-2 hours post consumption. Thus, it is suggested that the benefits of MC for cardiovascular health, particularly for blood pressure control, can be directly attributed to the influence of these circulating phenolic acids.

A Review Article published in 2016 in the journal International Urogynecology Journal found that Some comparative trials showed the benefit of acupuncture to be comparable with antimuscarinic treatment for overactive bladder. Initial animal studies suggest several biochemical mechanisms of action underlying the effect of acupuncture on overactive bladder (OAB) suppression. The experience in humans includes two case series and six comparative trials. All studies demonstrated subjective improvement in OAB symptoms, and some reported objective improvement in urodynamic studies. Notably, some comparative trials showed the benefit of acupuncture to be comparable with antimuscarinic treatment. Despite their limitations, existing studies serve as a promising foundation for suggesting a role for acupuncture as an alternative therapy for OAB. Further well-designed studies are required to investigate optimal technique and their outcomes.

A Experimental Study published in 2016 in the journal Scientific Reports found that The component pterostilbene, found naturally in blueberries, shows potential in preventing inflammation and oxidative stress on the human cornea, suggesting protection against dry eyes. This research employed an in vitro culture model of human corneal epithelial cells, exposing these cells to a hyperosmotic medium. Gene expression was observed via RT-qPCR, while protein production or activity was found using methods including ELISA, zymography, Western blotting, and immunofluorescent staining. Reactive oxygen species' production was also monitored using a DCFDA kit. Pterostilbene was administered and its effects on the expression of pro-inflammatory mediators and reactive oxygen species production were subsequently observed. The results showed that in corneal cells exposed to hyperosmotic medium, the addition of pterostilbene resulted in a notable decrease in the expression of pro-inflammatory mediators and suppressed overproduction of reactive oxygen species. Furthermore, pterostilbene also showed a significant decrease in the levels of oxidative damage biomarkers; it was found to rebalance homeostasis between oxygenases and anti-oxidative enzymes, demonstrating that pterostilbene has potentially protective effects on the human cornea from inflammation and oxidative stress.

A Systematic Review published in 2016 in the journal Complementary Medicine Research found that Acupuncture therapy is more effective than NSAID in improving clinical efficacy rates and pain scores for treatment of chrondomalacia patellae. To our knowledge, this is the first meta-analysis of acupuncture therapy in the treatment of CMP. Seven RCT involving 707 patients with CMP were selected for this meta-analysis. Based on the findings of the present systematic review, acupuncture therapy can further improve the clinical effect and pain scores when compared with NSAID controls. However, the potential beneficial effect of acupuncture is possibly overstated owing to the low general methodological quality of the included RCT. Conclusions regarding the safety of acupuncture therapy cannot be drawn since the eligible trials provide no evidence on this aspect.

A Review Article published in 2015 in the journal Journal of Traditional Chinese Medicine found that Acupuncture, as an adjuvant therapy or monotherapy, can protect and restore dopaminergic neurons, bearing positive implications for the Parkinson's disease treatment. Methodologically, animal studies were used to investigate the effects of acupuncture treatment on Parkinson's disease. An examination was conducted to see if the treatment was neuroprotective, if it could protect dopaminergic neurons from degeneration, and restorative, if it could restore tyrosine hydroxylase positive dopaminergic terminals in the striatum. These pathways were monitored at both molecular and cellular levels. The research also looked into whether the protection was mediated through the same mechanisms as other neuroprotective agents such as anti-oxidative stress, anti-inflammatory, and anti-apoptotic pathways. The results indicated that acupuncture was not only neuroprotective and restorative, but also seen to improve motor performance in animal models of Parkinsonism. The protective effect appeared to be mediated through common mechanisms of other neuroprotective agents, while restoration of function involved activation of certain compensatory brain regions to correct the imbalances stemming from the loss of dopaminergic neurons. Furthermore, clinical studies in China and Korea depicted a positive impact of acupuncture in treating Parkinson's disease, specifically by reducing the dosage of dopaminergic medications and the associated side effects.

A Systematic Review published in 2015 in the journal Oncotarget found that Traditional Chinese medicine psycho-behavioral interventions represent beneficial adjunctive therapies for cancer patients. The six TCM PBIs analyzed were acupuncture, Chinese massage, Traditional Chinese Medicine five elements musical intervention (TCM FEMI), Traditional Chinese Medicine dietary supplement (TCM DS), Qigong and Tai Chi. Although both TCM PBIs and non-TCM PBIs reduced functional impairments in cancer patients and led to pain relief, depression remission, reduced time to flatulence following surgery and sleep improvement, TCM PBIs showed more beneficial effects as assessed by reducing both fatigue and gastrointestinal distress. In particular, acupuncture relieved fatigue, reduced diarrhea and decreased time to flatulence after surgery in cancer patients, while therapeutic Chinese massage reduced time to flatulence and time to peristaltic sound.

A Systematic Review published in 2015 in the journal Alternative Therapies in Health and Medicine found that Compound formulas of traditional Chinese medicine, compared with placebo, can provide benefits to patients with the common cold, with no serious side effects having been identified in the included trials. A total of 6 randomized, double-blind, placebo-controlled trials involving 1502 participants were included. Most trials had a low risk of bias. Five were conducted in mainland China and 1 in Hong Kong; 5 were multicenter clinical trials and 1 was a single-center trial; 4 were published in Chinese and 2 were published in English. Compound formulas of TCM were superior to placebos in reducing disease symptoms, inducing recovery from a TCM syndrome, and increasing quality of life. In addition, the formulas were superior in shortening the duration of the main symptoms, the amount of time for a decline in temperature of at least 0.5°C to occur, and the duration of any fever. The team did not perform a summary meta-analysis due to clinical heterogeneity. No serious adverse event (AE) occurred in either the treatment or the control groups. This systematic review indicated that compound formulas of TCM, compared with placebo, can provide benefits to patients with the common cold, with no serious side effects having been identified in the included trials. However, due to the small number of included studies and of participants and the unclear risk of some biases in the included studies, more high-quality, large-scale RCTs are still warranted to clarify fully the effectiveness and safety of compound formulas of TCM in treating the common cold.

A Systematic Review published in 2015 in the journal Cochrane Database of Systematic Reviews found that There is moderate‐quality evidence from individual studies suggesting that acupuncture improved pelvic pain more than usual prenatal care. The evidence is current to 19 January 2015. We included 34 randomised studies in this updated review, with 5121 pregnant women, aged 16 to 45 years. Women were from 12 to 38 weeks’ pregnant. Studies looked at different treatments for pregnant women with low‐back pain, pelvic pain or both types of pain. All treatments were added to usual prenatal care, and were compared with usual prenatal care alone in 23 studies. Studies measured women's symptoms in different ways, ranging from self‐reported pain and sick leave to the results of specific tests.

A Systematic Review published in 2015 in the journal Journal of Functional Foods found that Goji berry was identified as a rich source of antioxidant compounds, with health-promoting properties comparable with other common fruit species. A number of things lead to the confusion between the different species and genotypes of cultivated Lycium. In this study, wolfberry was identified as a rich source of antioxidant compounds; the observed analytical fingerprint demonstrated that the species represents a rich source of organic acids and polyphenolic compounds, especially cinnamic acids and catechins; this research suggested that identified nutraceuticals might contribute to the total phytocomplex of these fruits. This study developed an important tool to assess goji chemical composition and bioactivity, using different chromatographic methods for comprehensive authentication and quality control of its fruits: well-designed clinical trials with phytochemically well-characterized extracts are required before the potential of goji as a medicinal plant or food can be definitively assessed. Goji berry fruit is devoid of toxicity but caution is advised with regard to possible drug interactions as well as with products of unknown or dubious origin; for this reason, the development of rigorous quality control protocols for goji products is urgently needed: this research showed that analytical fingerprinting could be an important tool to assess quality, chemical composition, and bioactivity of wolfberry fruits, helping to find new sources of natural health-promoting compounds.

A Systematic Review published in 2015 in the journal Journal of Functional Foods found that The antioxidants present in goji berries have comparable health-promoting properties to those found in other common fruits. The researchers studied the quality traits of goji berries and the levels of potentially fruitful compounds. They employed high-performance liquid chromatography (HPLC) - a technique widely-used to identify and separate components in a mixture - to examine the health-promoting compounds in goji berries, comparing these to what's found in other common fruits. The researchers found that goji berries are a rich source of antioxidant compounds. It was determined that their health-promoting properties are akin to those of other common fruits. The characteristic "fingerprint" obtained through this study could help improve our understanding of this fruit, which is increasingly being recognized as a functional food due to its antioxidant properties.

A Systematic Review published in 2015 in the journal Nutrition Today found that The alleged benefits of raw milk, including improved nutrition, prevention of lactose intolerance, or provision of "good" bacteria, lack scientific basis and are considered myths. The review aims to bring clarity to the ongoing public debate on the benefits and risks of raw milk consumption. It delves into the historical context of pasteurization and how it significantly reduced the incidence of illnesses associated with raw milk. Furthermore, it critically analyzes the prevalence of pathogens in raw milk, revealing that up to a third of all samples could be contaminated with human pathogens, regardless of being sourced from healthy animals or milk appearing to be of good quality. The study also critically investigates the widely claimed benefits of raw milk. It notes that claims about raw milk's ability to impart improved nutrition, aid in the prevention of lactose intolerance, or provide 'good' bacteria are not grounded in scientific fact but are rather myths. Regarding the hypothesis that consuming raw milk might protect against allergies and asthma for children growing up in farming environments, the study acknowledges some epidemiological data suggesting a lowered risk. However, it cautions against attributing this protective effect directly to raw milk consumption since numerous environmental factors are likely involved.

A Systematic Review published in 2015 in the journal Cochrane Database of Systematic Reviews found that Chinese herbal medicine may provide an effective treatment during the acute phase of UTI and when given prophylactically to prevent recurrence in the six months following treatment. We found limited evidence from seven RCTs about the possible role of Chinese herbal medicine as a treatment for recurrent UTI, either as the sole intervention or as an adjunct to antibiotic treatment for post‐menopausal women. CHM may provide an effective treatment during the acute phase of UTI and when given prophylactically to prevent recurrence in the six months following treatment. However, the small number and poor quality of the included studies meant that it was not possible to formulate robust conclusions on the use of CHM for recurrent UTI in women, when administered alone or as an adjunct to antibiotics.

A Systematic Review published in 2015 in the journal Open Heart found that Clinically, ingestion of capsaicin-or its less stable non-pungent analogue capsiate-has been shown to boost metabolic rate modestly. This brief overview should make it clear that dietary capsaicin—and, likely to a more limited degree, non-pungent capsiate—has intriguing potential for health promotion. Rodent studies suggest that capsaicin may merit clinical evaluation with respect to endothelial function, progression of atherosclerosis (most notably in diabetics), angina, non-alcoholic fatty liver disease, cardiac hypertrophy, metabolic syndrome, hypertension, obesity and gastric ulceration.

A Practice Guideline published in 2015 in the journal Otolaryngology-Head and Neck Surgery found that Clinicians may offer acupuncture, or refer to a clinician who can offer acupuncture, for patients with allergic rhinitis who are interested in nonpharmacologic therapy. The primary purpose of this guideline is to address quality improvement opportunities for all clinicians, in any setting, who are likely to manage patients with allergic rhinitis, as well as to optimize patient care, promote effective diagnosis and therapy, and reduce harmful or unnecessary variations in care. The guideline is intended to be applicable for both pediatric and adult patients with allergic rhinitis. Children under the age of 2 years were excluded in this clinical practice guideline because rhinitis in this population may be different than in older patients and is not informed by the same evidence base.

A Systematic Review published in 2015 in the journal Complementary Medicine Research found that Acupuncture therapies demonstrate some potential benefits in treating psoriasis vulgaris, despite conflictions in individual study results. The research conducted a comprehensive review of numerous databases including Embase, CENTRAL, PubMed, AMED, CINAHL and others, seeking prospective randomized controlled trials that evaluate the performance of acupuncture therapies for treating psoriasis vulgaris. This was carried out with no language restrictions. With the utilisation of the Cochrane risk of bias tool, the studies were carefully assessed. The primary measuring tool was the Psoriasis Area Severity Index (PASI) score. Results from the six individual studies, involving 522 participants, presented conflicting outcomes in regard to PASI reduction, lesion reduction (non-PASI), PASI score, and relapse rate. Quantitative analysis was carried out on five of the studies. However, the diversity in interventions, comparators, and reported outcomes rendered meta-analysis implausible. Despite the conflictions in individual study results, the outcome indicated some potential benefit of acupuncture therapies in treating psoriasis vulgaris.

A Systematic Review published in 2014 in the journal The Journal of Alternative and Complementary Medicine found that This meta-analysis suggests that acupuncture had positive effects on cognitive function after stroke. Twenty-one trials with a total of 1421 patients met inclusion criteria. Pooled random-effects estimates of the change in the Mini-Mental State Examination were calculated for the comparison of acupuncture with no acupuncture in addition to medicine or rehabilitation. Following 4 weeks and 8 weeks of intervention with acupuncture, the merged mean difference was 3.14 (95% confidence interval [CI], 2.06–4.21; p<.00001) and 2.03 (95% CI, 0.26–3.80; p=0.02), respectively. For the comparison of 3–4 weeks of acupuncture with no acupuncture in addition to medicine or rehabilitation groups, the merged MD in Neurobehavioral Cognitive State Examination total scores was 5.63 (95% CI, 3.95–7.31; p<.00001). For the comparison of 8–12 weeks of acupuncture with no acupuncture in addition to medicine or rehabilitation groups, the P300 latency merged MD was −12.80 (95% CI, −21.08 to −4.51; p<.00001), while the P300 amplitude merged MD was 1.38 (95% CI, 0.93–1.82; p<.00001). Overall, the study quality was rated as moderate on the basis of the Cochrane Handbook for Systematic Reviews of Interventions (part 2: 8.5).

A Experimental Study published in 2014 in the journal Phytotherapy Research found that Jujube fruit promotes the growth of nerve cells and boosts anti-oxidant enzyme production in brain cells. The methodology focused on the application of a water extract from the jujube fruit to cultured astrocytes (star-shaped glial cells in the brain and spinal cord) and observing any resulting changes over a 24-hour period. Researchers utilized a protein kinase A inhibitor, H89, to ascertain if it lessened the apparent jujube-induced expression of neurotrophic factors, assessed in a concentration-dependent manner. In the discussion of results, it was established that the jujube extract effectively stimulated the expression of several key neurotrophic factors including nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. These are pivotal in neural survival, growth, and differentiation. Concurrently, the extract also enhanced the transcriptional expressions of various significant enzymes responsible for anti-oxidation in a comparable concentration-dependent manner, indicating that jujube not only contributes to neural growth but also fosters the astrocytes' resistance to oxidative stress.

A Randomised Controlled Trial published in 2014 in the journal Endocrine Abstracts found that Pomegranate extract intake, rich in biophenols, lessens salivary cortisol levels, hence potentially improving health-related quality of life, particularly in stress-suffering individuals. The study was conducted using a double-blind, randomized, placebo-controlled parallel trial. Participants, ranging in age and body mass index, took either a pomegranate extract capsule or a placebo each day for a duration of 4 weeks. The extracted capsule, which contained a high concentration of biophenols, was consumed with water after a meal. In addition to tracking dietary practices and habits, health related Quality of Life was recorded before and after the study. To assess the effects, salivary cortisol and cortisone levels were measured at three distinct points in the day. In the results, there was a notable decrease in the salivary cortisol levels of participants who consumed these pomegranate extract capsules. Alongside this, the ratio of cortisol to cortisone was significantly minimized. The participants' physical and social functionality, pain levels, and overall well-being showed significant improvement during the study. Conversely, there was a slight increase in the salivary cortisol and ratio of cortisol to cortisone for participants who took the placebo.

A Systematic Review published in 2014 in the journal BMC Chemistry found that Germination is thought to improve the nutritional and medicinal qualities of mung beans. In recent years, studies have shown that the sprouts of mung beans after germination have more obvious biological activities and more plentiful secondary metabolites since relevant biosynthetic enzymes are activated during the initial stages of germination. During the germination process of the mung bean, its chemical constituents undergo a series of biochemical reactions. One such reaction is the synthesis of small active compounds from macromolecular substances, promoting absorption and utilization. Another change observed during germination is the formation and accumulation of many types of active substances, such as polyphenols, saponins, vitamin C, etc. Therefore, we believes that these changes in the chemical composition of mung beans during germination will lead to substantial and important changes in the pharmacological activities of mung beans as well.

A Systematic Review published in 2014 in the journal BMC Chemistry found that A study demonstrated that all pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-12β, tumor necrosis factor (TNF)-α, and inducible NO synthase (iNOS), were dramatically down regulated in cells treated with 3.7 mg/mL polyphenols. In Asia, mung beans have been used in various cuisines and in folk remedies to treat toxic poisoning, heat stroke associated with thirst, irritability, and fever; these beneficial effects of mung beans are thought to be related to the inflammatory response. Researchers have analyzed the anti-inflammatory effects of mung bean ethanol extracts on lipopolysaccharide (LPS)-stimulated macrophages. The extract mainly included polyphenols, gallic acid, vitexin, and isovitexin and markedly reduced the activity of murine macrophages through the prevention of pro-inflammatory gene expression without cytotoxicity. Moreover, a study demonstrated that all pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-12β, tumor necrosis factor (TNF)-α, and inducible NO synthase (iNOS), were dramatically down regulated in cells treated with 3.7 mg/mL polyphenols. These results suggested that the ethanol extract had great potential to improve the clinical symptoms of inflammation-associated diseases, such as allergies and diabetes. The immune modulatory activities of mung bean water extracts and monomers on human peripheral blood mononuclear cells (PBMCs) have also been evaluated by BrdU immunoassay, secretion of interferon-gamma (IFN-γ) and IL-10, and elucidation of the responding cells by flow cytometry. The results demonstrated that 20 μg/mL genistein, phytic acid, and syringic acid induce a Th1-predominant immune response through significant suppression of IL-10 secretion and promotion of IFN-γ secretion. The study concluded that several non-nutritional ingredients of mung beans, such as flavonoids, acids, and plant hormones, are most likely to be important in the modulation of human immunity.

A Systematic Review published in 2014 in the journal BMC Chemistry found that Mung bean protein, tannin, and other polyphenols are thought to combine with organophosphorus pesticides, mercury, arsenic, and other heavy metals, promoting the excretion of sediments from the body. In ancient books, mung beans were well known for their detoxification activities. Mung bean protein, tannin, and other polyphenols are thought to combine with organophosphorus pesticides, mercury, arsenic, and other heavy metals, promoting the excretion of sediments from the body. Mung beans have been shown to possess antioxidant, antimicrobial, and anti-inflammatory activities. Moreover, mung beans have antidiabetic, antihypertensive, lipid metabolism accommodation, antihypertensive, and antitumor effects, among others.

A Systematic Review published in 2014 in the journal BMC Complementary Medicine and Therapies found that Guizhi Fuling formula shows potential in treating uterine fibroids. This comprehensive review analyzed 21 trials (including three meta-analyses and eight individual trials) regarding the effectiveness of Guizhi Fuling Formula combined with mifepristone in treating uterine fibroids. The results indicated potential benefits in reducing fibroid volume and uterine size compared to mifepristone alone. However, the overall methodological quality of the included trials was deemed poor, with issues such as unclear randomization procedures and lack of blinding. Further high-quality clinical trials with larger sample sizes are recommended to provide more conclusive evidence on the efficacy of this treatment approach for uterine fibroids.

A Systematic Review published in 2013 in the journal BMC Complementary Medicine and Therapies found that Cinnamomum Zeylanicum shows potential medicinal effects such as reducing blood glucose levels and possessing anti-microbial properties. The researchers conducted a thorough systematic review using databases such as PubMed, Web of Science, and SciVerse Scopus. The documents considered were those published before December 31, 2012. Keywords like "Cinnamomum zeylanicum", "Ceylon cinnamon", "True cinnamon", and "Sri Lankan cinnamon" were used to filter the studies. Furthermore, a manual search was performed in the reference lists to add more relevant studies. The review discovered numerous benefits of CZ. After excluding duplicate articles, a total of 70 studies were analysed. These studies pointed to medicinal benefits such as anti-microbial and anti-parasitic activity, lowering blood glucose levels, reducing blood pressure and serum cholesterol, antioxidant properties, and an ability to inhibit symptoms of Alzheimer's. Other listed benefits included reducing the effects of osteoporosis and gastric ulcers, anti-inflammatory and pain relieving properties, aiding wound healing, and having liver-protecting effects, all with minimal toxic and adverse effects reported.

A Systematic Review published in 2013 in the journal Cochrane Database of Systematic Reviews found that Despite its widespread use during assisted reproductive technology (ART) cycles, acupuncture does not appear to improve live birth or pregnancy rates in couples dealing with subfertility. This passage discusses a meta-analysis that aimed to determine the effectiveness and safety of acupuncture as an adjunct to assisted reproductive technology (ART) cycles for couples dealing with subfertility. The review included 20 randomized controlled trials, analyzing the impact of acupuncture on live birth rate, ongoing pregnancy rate, miscarriage rate, and side effects. The findings indicate that acupuncture did not show any overall benefit in improving live birth or pregnancy rates during ART cycles, regardless of whether it was performed around oocyte retrieval or embryo transfer. Additionally, acupuncture did not have significant side effects. The authors conclude that there is no evidence supporting the use of acupuncture to enhance live birth or pregnancy rates in assisted conception.

A Systematic Review published in 2013 in the journal Cochrane Database of Systematic Reviews found that When acupuncture was compared with no treatment, there appeared to be a benefit from acupuncture, but acupuncture appeared to be less effective than hormone therapy. We found insufficient evidence to determine whether acupuncture is an effective treatment for controlling vasomotor menopausal symptoms. When we compared acupuncture with sham acupuncture, there was no evidence of any significant difference in their effect on menopausal vasomotor symptoms. When we compared acupuncture with no treatment there appeared to be a benefit from acupuncture, but acupuncture appeared to be less effective than hormone therapy (HT). These findings should be treated with great caution as the evidence was of low or very low quality and the studies comparing acupuncture versus no treatment or HT were not controlled with sham acupuncture or placebo HT. Data on adverse effects were lacking.

A Systematic Review published in 2013 in the journal Human Reproduction Update found that The meta-analysis indicates that while adjuvant acupuncture does not show a pooled benefit for in vitro fertilization (IVF) across all trials, it appears to have a more significant effect in trials with lower baseline pregnancy rates, warranting further investigation and confirmation in additional studies. This passage presents a meta-analysis that aimed to assess the overall pooled effects of adjuvant acupuncture on in vitro fertilization (IVF) clinical pregnancy success rates, as well as identify factors that might explain the heterogeneity of results across trials. The analysis included 16 trials with 4021 participants and found no statistically significant difference between acupuncture and control groups when combining all trials or analyzing sham-controlled and no adjuvant treatment-controlled trials separately. However, the study identified baseline pregnancy rate as a significant effect modifier, with trials having lower control group pregnancy rates showing larger effects of adjuvant acupuncture. Overall, the meta-analysis did not find a pooled benefit of adjuvant acupuncture for IVF, but the potential benefit in trials with lower baseline pregnancy rates requires further exploration and confirmation in additional studies due to potential confounders and publication bias.

A Systematic Review published in 2013 in the journal Cochrane Database of Systematic Reviews found that Compared with no treatment and standard therapy, acupuncture improves pain and stiffness in people with fibromyalgia. There is low to moderate-level evidence that compared with no treatment and standard therapy, acupuncture improves pain and stiffness in people with fibromyalgia. There is moderate-level evidence that the effect of acupuncture does not differ from sham acupuncture in reducing pain or fatigue, or improving sleep or global well-being. EA is probably better than MA for pain and stiffness reduction and improvement of global well-being, sleep and fatigue. The effect lasts up to one month, but is not maintained at six months follow-up. MA probably does not improve pain or physical functioning. Acupuncture appears safe. People with fibromyalgia may consider using EA alone or with exercise and medication. The small sample size, scarcity of studies for each comparison, lack of an ideal sham acupuncture weaken the level of evidence and its clinical implications. Larger studies are warranted.

A Review Article published in 2013 in the journal Journal of Agricultural and Food Chemistry found that Recent phytochemical studies of jujube fruits have shed some light on their biological effects, such as the anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, and gastrointestinal protective activities and inhibition of foam cell formation in macrophages. The nutritional jujube (Ziziphus jujube Mill.) fruit belonging to the Rhamnaceous family grows mostly in Europe, southern and eastern Asia, and Australia, especially the inland region of northern China. Jujube has a long history of usage as a fruit and remedy. The main biologically active components are vitamin C, phenolics, flavonoids, triterpenic acids, and polysaccharides. Recent phytochemical studies of jujube fruits have shed some light on their biological effects, such as the anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, and gastrointestinal protective activities and inhibition of foam cell formation in macrophages. A stronger focus on clinical studies and phytochemical definition of jujube fruits will be essential for future research efforts. This review may be useful for predicting other medicinal uses and potential drug or food interactions and may be beneficial for people living where the jujube fruits are prevalent and health care resources are scarce.

A Review Article published in 2012 in the journal Journal of Psychopharmacology found that Curcumin, a component of Indian spice turmeric, presents a potential natural treatment for depression, influencing neurotransmitters and protecting against several biological systems compromised in depression. The research methodology involved an extensive review of the varying influences and effects of curcumin on systems implicated in depression. These included neurotransmitter systems like serotonin and dopamine which are critical to mood regulation. The study also explored the effects of curcumin on hypothalamus-pituitary-adrenal disturbances, famously associated with stress response and mood disorders. In terms of results, curcumin demonstrated promising potential as an antidepressant in animal models of depression. Additionally, it was found to help moderate damage to neurological systems and intestinal permeability, both of which are often compromised in major depressive disorders. It also exhibited properties that could help lower inflammation and protect against oxidative stress and mitochondrial damage. Together, these findings position curcumin as a promising natural treatment for depression.

A Systematic Review published in 2012 in the journal Molecular Biology Reports found that Traditional Chinese medicines had a better effect on the normalization of alanine aminotransferase and disappearance of radiological steatosis in the treatment of non-alcoholic fatty liver disease. RCTs comparing either TCM formulations alone or in combination with placebo, ursodeoxycholic acid, insulin sensitizers, lipid-lowering drugs, or antioxidants were included. The category of most usually used herbs in the treatment of NAFLD was also calculated. Five thousand nine hundred and four patients from 62 RCTs were included for meta-analysis and 25,661 patients from 419 clinical studies were for TCM formulation analysis. Comparing with western medicines mentioned above, TCM had a better effect on the normalization of alanine aminotransferase and disappearance of radiological steatosis in the treatment of NAFLD. Furthermore, 246 kinds of Chinese herbs were included in our present study, with an average of 10 herbs (range 1–31) in each formulation. Hawthorn Fruit (321 times in 17,670 patients) was the most often used herb in the treatment of NAFLD. In conclusion, TCM is of modest benefit to the treatment of NAFLD.

A Systematic Review published in 2012 in the journal The Journal of Alternative and Complementary Medicine found that The meta-analysis suggests that acupuncture does not provide significant benefits in improving the outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments. The article conducted a systematic review with a meta-analysis of trials on acupuncture during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment. The pooled analysis of 17 trials showed that acupuncture did not significantly impact clinical pregnancy, biochemical pregnancy, ongoing pregnancy, implantation rate, live birth, or miscarriage outcomes. Therefore, the study concludes that there are no significant benefits of acupuncture in improving IVF or ICSI outcomes.

A published in 2012 in the journal BMC Complementary Medicine and Therapies found that Complementary and alternative medicine (CAM) therapies have the potential to provide supportive care for women presenting with threatened miscarriage. Within fertility research, acupuncture demonstrates beneficial hormonal responses with decreased miscarriage rates, raising the possibility acupuncture may promote specific beneficial effects in early pregnancy. With the lack of current medical options for women presenting with threatened miscarriage it is timely to examine the possible treatment benefits of providing CAM therapies such as acupuncture.

A Systematic Review published in 2012 in the journal The American Journal of Clinical Nutrition found that Regular chocolate or cocoa consumption, rich in flavan-3-ols, has been associated with improved insulin resistance and blood vessel function, suggesting potential cardiovascular benefits. The study systematically reviewed 42 randomized controlled trials involving 1297 participants to investigate the impact of chocolate, cocoa, and flavan-3-ols on major cardiovascular disease risk factors. Utilizing a comprehensive search across multiple databases, the researchers conducted meta-analyses, assessing acute and short-term chronic interventions. Results revealed consistent improvements, including reduced insulin resistance (HOMA-IR), enhanced flow-mediated dilatation (FMD), and favorable effects on blood pressure and cholesterol levels. The findings indicate promising cardiovascular benefits associated with chocolate or cocoa consumption. Notably, the study highlights improvements in insulin sensitivity, blood vessel function, and blood pressure, emphasizing the potential positive impact of flavan-3-ols found in these products.

A Randomised Controlled Trial published in 2011 in the journal European Journal of Nutrition found that Consumption of tart cherry juice can increase exogenous melatonin that is beneficial in improving sleep duration and quality and might be of benefit in managing disturbed sleep. Total melatonin content was significantly elevated (P < 0.05) in the cherry juice group, whilst no differences were shown between baseline and placebo trials. There were significant increases in time in bed, total sleep time and sleep efficiency total (P < 0.05) with cherry juice supplementation. Although there was no difference in timing of the melatonin circardian rhythm, there was a trend to a higher mesor and amplitude.

A Systematic Review published in 2011 in the journal Nutrition Journal found that These results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress. This study suggests a beneficial effect of dietary black sesame meal on a reduction in blood pressure in pre-hypertensive humans. It is likely that the antihypertensive effect is due to decreased oxidative stress. Taken together with the absence of side effects and inexpensive preparation, the regular ingestion of dietary black sesame meal may be beneficial for CVD prevention in individuals with prehypertension, or even those with hypertension. A future study that investigates this advantageous effect is suggested.

A Randomised Controlled Trial published in 2011 in the journal Climacteric found that Pumpkin seed oil supplementation may increase good cholesterol levels, lower diastolic blood pressure, and alleviate menopausal symptoms in postmenopausal women. In this pilot study employing a randomized, double-blinded and placebo-controlled design, 35 women that were either naturally menopausal or had prematurely entered menopause due to benign surgical intervention partook. Over the span of 12 weeks, participants received either pumpkin seed oil or wheat germ oil (serving as the placebo) at a dosage of 2 grams daily. Measurements of serum lipids, fasting plasma glucose, blood pressure and completion of a questionnaire regarding menopausal symptoms were taken before and after the supplementation period, and changes across these factors were evaluated. Following supplementation, women who received pumpkin seed oil displayed increased concentrations of high density lipoprotein cholesterol (commonly known as good cholesterol) and a reduction in diastolic blood pressure. Additionally, there was a notable decline in the severity of menopausal symptoms, including hot flushes, headaches, and joint pain, thanks to this supplementation. Contrarily, symptoms of depression and feelings of being unloved heightened among women in the group that received wheat germ oil.

A Clinical Study published in 2004 in the journal Clinical Nutrition found that Consumption of pomegranate juice by patients with carotid artery stenosis decreases carotid intima-media thickness and systolic blood pressure, potentially due to its strong antioxidant properties. The researchers investigated the effects of consuming pomegranate juice, enriched with potent tannins and anthocyanins, on carotid lesion progression, oxidative stress, and blood pressure in patients suffering from carotid artery stenosis. Over a period of 1-3 years, ten patients were supplemented with pomegranate juice, with blood samples collected before the treatment and during juice consumption. A control group, which did not consume pomegranate juice, was also monitored. The study revealed significant reduction in carotid intima-media thickness of up to 30% after a year of pomegranate juice consumption as compared to the control group that saw an increase of 9%. Pomegranate juice consumption was also associated with an 83% increase in the patients' serum paraoxonase 1 activity, and a significant reduction in serum LDL basal oxidative state and LDL susceptibility to copper ion-induced oxidation. Antibodies against oxidized LDL in serum levels were decreased by 19%, and total antioxidant status increased by 130%. Moreover, systolic blood pressure reduced by 12% after a year of juice consumption. Most notably, the maximal effects were observed after one year of juice consumption, with no additional significant beneficial impacts observed with further juice consumption over a span of three years.

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