Children's Health
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Related Topics
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.

Comparison of Ziziphus jujube Mill. Syrup versus polyethylene glycol in children with functional constipation: a randomized clinical trial
2025 Jan 11 Scientific Reports Keihanian F, Maleknejad S, Saeidinia A, Soltanipour S, Pirooz A
Clinical Study Randomised Controlled Trial Children's Health Constipation JujubeJujube syrup presented improved results in treating pediatric functional constipation compared to polyethylene glycol, demonstrating a potentially effective and safe alternative treatment.

Integrative traditional Chinese medicine treatment for children with obstructive sleep apnea
2023 Aug Journal of Traditional and Complementary Medicine Lai WY, Wei CC, Lin CH, Hang LW, Shih YH, Huang FW, et al.
In a retrospective cohort study, children (<12 years old) with OSA were categorized into ITCM, western medicine (WM), and surgery cohorts. The ITCM follow-up cohort showed a significant reduction in apnea-hypopnea index (AHI) and respiratory disturbance index (RDI), with an increase in body mass index (BMI). Compared to the WM cohort, ITCM resulted in a significant difference in RDI reduction. The most prescribed TCM formula in ITCM was Forsythia and Laminaria Combination, with Ephedrae Herba as the most prescribed TCM herb. Further research on the pharmacological mechanisms and clinical efficacy of ITCM for pediatric OSA is warranted.
Cohort Study Children's Health
Omega-3 supplements in the prevention and treatment of youth depression and anxiety symptoms: A scoping review
2023 Apr 20 PLOS One Reily NM, Tang S, Negrone A, Gan DZQ, Sheanoda V, Christensen H
Review Article Anxiety Children's Health
Effect of low-level laser stimulation of acupuncture points in pediatric dentistry: a systematic review
2023 Jan 24 Lasers in Medical Science Mira PCS, Vilela LD, Corona SAM, Borsatto MC
The LLLT at acupuncture points is associated with positive results on sleep bruxism, preanesthetic pain, and gag reflex in pediatric dentistry.
Systematic Review Bruxism Children's Health
Safety and Acceptance of Acupuncture and Acupressure in Children, Adolescents, and Young Adults Undergoing Hematopoietic Stem Cell Transplant
2022 Dec 01 Cancer Nursing Bettini E, Idiokitas R, Mahmood L, Jacobs S, Steinhorn D
This study demonstrates that acupuncture and acupressure are well accepted by children and their families admitted for hematopoietic stem cell transplant (HSCT) and are safe even when performed in the first 4 weeks following transplant when the patient is likely to have thrombocytopenia.
Cohort Study Children's HealthResearch insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
2025 Scientific Reports
Jujube syrup presented improved results in treating pediatric functional constipation compared to polyethylene glycol, demonstrating a potentially effective and safe alternative treatment.
Clinical Study Constipation Jujube
Comparison of Ziziphus jujube Mill. Syrup versus polyethylene glycol in children with functional constipation: a randomized clinical trial
Keihanian F, Maleknejad S, Saeidinia A, Soltanipour S, Pirooz A
2022 Phytomedicine
Parent-administered pediatric tuina is effective at reducing core symptoms of ADHD in preschool children and improves child appetite and sleep quality.
Randomised Controlled Trial ADHD Appetite Meridian Massage Sleep
Parent-administered pediatric Tuina for attention deficit/hyperactivity disorder symptoms in preschool children: A pilot randomized controlled trial embedded with a process evaluation
Chen SC, Yu J, Wang HS, Wang DD, Sun Y, Cheng HL, et al.
2022 Journal of Acupuncture and Tuina Science
The combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.
Clinical Study Meridian Massage
Clinical study on Tuina plus Shen Ling Bai Zhu San in treating children with diarrhea due to spleen deficiency
Li J
2021 African Journal of Biological Sciences
Consumption of pumpkin seeds enhances the nutritional status and improves the attention deficit of deaf female children exhibiting ADHD symptoms.
Clinical Study ADHD Iron Magnesium Pumpkin Seed
Improvement of attention deficit hyperactive disorder for deaf female children by intake pumpkin seeds
Ataya H
2021 Translational Pediatrics
Allergic rhinitis in children, according to traditional Chinese medicine, is interrelated with the functionality of lungs, spleen, and kidney and can be treated with combined Western and Chinese herbal medicines.
Review Article Hay Fever
Current status of Chinese herbal medicine to treat allergic rhinitis in children: from the perspective of Western medicine—a narrative review
Liang J, Gu Q
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.

Omega-3 supplements in the prevention and treatment of youth depression and anxiety symptoms: A scoping review
2023 Apr 20 PLOS One Reily NM, Tang S, Negrone A, Gan DZQ, Sheanoda V, Christensen H
Review Article Anxiety Children's HealthThe scientific evidence for efficacy of omega-3 supplementation in reducing symptoms of depression and anxiety in young people is inconclusive, however, it was found that most "grey literature" sources recommended the use of omega-3 supplements in young people. —Jinnan C 20 Oct 2023

Effect of low-level laser stimulation of acupuncture points in pediatric dentistry: a systematic review
2023 Jan 24 Lasers in Medical Science Mira PCS, Vilela LD, Corona SAM, Borsatto MC
The LLLT at acupuncture points is associated with positive results on sleep bruxism, preanesthetic pain, and gag reflex in pediatric dentistry.
Systematic Review Bruxism Children's Health
Traditional Chinese Medicine in Treating Children With Coronavirus Disease 2019: A Scoping Review
2022 Jul 19 Frontiers in Pediatrics Duan N, Liu B, Li X, Xiong Y, Li L, Ma Y, et al.
At present, TCM is widely used in treatment of children with COVID-19, and no obvious adverse reactions have occurred. Application of TCM is a positive option in clinical practice.
Review Article Children's Health
Therapeutic effect of scalp-based acupuncture and moxibustion as an adjunctive treatment on children with cerebral palsy comparing to conventional rehabilitation therapy: a systematic review and meta-analysis of randomized controlled trials
2022 May Translational Pediatrics Xue Y, Shi S, Zheng S, Yang Z, Xu J, Gong F
Scalp-based acupuncture therapy can effectively improve the symptoms of pediatric cerebral palsy (CP), promote the mental and psychological development of children, and improve their gross motor function, the treatment is safe.
Systematic Review Meta-Analysis Children's Health
Current status of Chinese herbal medicine to treat allergic rhinitis in children: from the perspective of Western medicine—a narrative review
2021 Dec Translational Pediatrics Liang J, Gu Q
Review Article Hay Fever Children's HealthAllergic rhinitis in children, according to traditional Chinese medicine, is interrelated with the functionality of lungs, spleen, and kidney and can be treated with combined Western and Chinese herbal medicines.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.

Comparison of Ziziphus jujube Mill. Syrup versus polyethylene glycol in children with functional constipation: a randomized clinical trial
2025 Jan 11 Scientific Reports Keihanian F, Maleknejad S, Saeidinia A, Soltanipour S, Pirooz A
Clinical Study Randomised Controlled Trial Children's Health Constipation JujubeJujube syrup presented improved results in treating pediatric functional constipation compared to polyethylene glycol, demonstrating a potentially effective and safe alternative treatment.

Parent-administered pediatric tuina for the treatment of attention deficit hyperactivity disorder symptoms: Process evaluation of a pilot randomized controlled trial
2022 Nov Complementary Therapies in Medicine Chen SC, Cheng HL, Han LF, Wu GT, Zhang RY, Suen LKP, et al.
Implementation of parent-administered pediatric tuina intervention is feasible and acceptable. The intervention can be refined by improving the TCM pattern identification procedure and adjusting outcome settings in a fully powered study in the future.
Randomised Controlled Trial Children's Health
Parent-administered pediatric Tuina for attention deficit/hyperactivity disorder symptoms in preschool children: A pilot randomized controlled trial embedded with a process evaluation
2022 Jul Phytomedicine Chen SC, Yu J, Wang HS, Wang DD, Sun Y, Cheng HL, et al.
Randomised Controlled Trial Children's Health Sleep Appetite ADHD Meridian MassageParent-administered pediatric tuina is effective at reducing core symptoms of ADHD in preschool children and improves child appetite and sleep quality.

Clinical observation of pediatric Tuina plus oral Chinese medication for pediatric anorexia due to spleen failing in transportation
2022 Apr Journal of Acupuncture and Tuina Science Xie T, Jiang H, Zhang C
Tuina manipulation of Yun Shui Ru Tu plus oral administration of Chinese medication is significantly effective in treating pediatric anorexia due to spleen failing in transportation, which can improve the appetite of children and improve the symptoms of anorexia, and the curative effect is better than that of oral administration of Chinese medication alone.
Randomised Controlled Trial Anorexia Meridian Massage Children's Health
Assessment of Allergic Rhinitis among Children after Low-Level Laser Therapy
2019 Jul 07 Open Access Macedonian Journal of Medical Sciences Moustafa Y, El Nady HG, Saber MM, Dabbous OA, Kamel TB, Abel-Wahhab KG, et al.
Laser acupuncture is a reliable, painless and non-invasive successful technique, which may be used as a complementary treatment for pediatric allergic rhinitis.
Randomised Controlled Trial Children's Health Laser AcupunctureStudy Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides

Clinical Study
Jujube syrup presented improved results in treating pediatric functional constipation compared to polyethylene glycol, demonstrating a potentially effective and safe alternative treatment.
Keihanian F, Maleknejad S, Saeidinia A, Soltanipour S, Pirooz A

Randomised Controlled Trial
Parent-administered pediatric tuina is effective at reducing core symptoms of ADHD in preschool children and improves child appetite and sleep quality.
Chen SC, Yu J, Wang HS, Wang DD, Sun Y, Cheng HL, Suen LKP, Yeung WF

Clinical Study
The combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.
Li J

Clinical Study
Consumption of pumpkin seeds enhances the nutritional status and improves the attention deficit of deaf female children exhibiting ADHD symptoms.
Ataya H

Review Article
Allergic rhinitis in children, according to traditional Chinese medicine, is interrelated with the functionality of lungs, spleen, and kidney and can be treated with combined Western and Chinese herbal medicines.
Liang J, Gu Q

Review Article
Currently, acupuncture is considered to be a safe, helpful, and available alternative option for patients who have not responded to or complied with conventional pharmacotherapy.
Doll, E., Threlkeld, B., Graff, D., Clemons, R., Mittel, O., Sowell, M. K.

Review Article
Milk and honey mixture seems to be at least as effective as dextromethorphan and levodropropizine, the most prescribed over-the-counter antitussives in Italy, in non-specific acute cough in children.
Miceli Sopo S, Greco M, Monaco S, Varrasi G, Di Lorenzo G, Simeone G

Systematic Review
We cautiously suggest that acupuncture therapy could demonstrate better clinical efficacy than pharmacological treatment or placebo treatment in treating nocturnal enuresis.
Lv ZT, Song W, Wu J, et al.
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Children's Health" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Children's Health" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Children's Health" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Clinical Study published in 2025 in the journal Scientific Reports found that Jujube syrup presented improved results in treating pediatric functional constipation compared to polyethylene glycol, demonstrating a potentially effective and safe alternative treatment. The researchers conducted a double-blind, randomized clinical trial involving children aged 2-10 years old diagnosed with functional constipation. These children were selected from patients referred to the gastroenterology clinic of 17-Shahrivar Hospital in Rasht, Iran. The eligible candidates were divided into two groups, each receiving either polyethylene glycol (PEG) or Ziziphus jujuba syrup (ZS) in a dosing range of 1-5 cc/kg/day. The patients were monitored over a three-month period, with bi-weekly check-ups in the first month, followed by monthly check-ups for the next two months. Additionally, liver and kidney function tests, as well as blood sugar levels, were verified at the start and end of the study. Out of 90 qualified children, 32 patients in the PEG group and 30 in the ZS group finished the follow-ups. The therapeutic response score in the group administered ZS showed a distinct improvement compared to those given PEG. Similarly, the average number of encopresis and pain scores, as measured by a visual analog scale, showed a significant reduction in the ZS group compared to the PEG group. Other indices, such as frequency of defecation and medication adherence, also showed a noticeable improvement in the ZS group. With only a few self-limiting side effects reported in the PEG group, it was determined that ZS provides a potential choice for functional constipation treatment without any adverse events or liver and kidney injury.
A Randomised Controlled Trial published in 2022 in the journal Phytomedicine found that Parent-administered pediatric tuina is effective at reducing core symptoms of ADHD in preschool children and improves child appetite and sleep quality. This research involved a two-arm, parallel, open-label, pilot Randomized Controlled Trial, where 64 participants were assigned to two separate groups. Parents in the first group attended an online course teaching them pediatric tuina for ADHD, which they would then apply to their children at home. The second group of parents went through online training about a progressive muscle relaxation exercise and engaged in interactive physical activities with their children at home. Both groups carried out their respective interventions every other day for two month, each session lasting at least 20 minutes. The project measured the rate of recruitment, consent, participant adherence, retention and any adverse events. Upon investigation, both groups demonstrated improvements, with moderate effect size within each group. This was reflected in improvements in core hyperactivity and impulsivity symptoms. Parents also noticed positive changes in their children’s eating habits, sleep quality, and overall parent-child relationship. No serious issues were reported in relation to implementing the parent-administered pediatric tuina or from the interactive physical activity sessions.
A Clinical Study published in 2022 in the journal Journal of Acupuncture and Tuina Science found that The combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone. Methodology: The paper reports on a clinical trial involving a total of 105 children diagnosed with diarrhea due to spleen deficiency. These children were randomly allocated into two separate groups: a control group and an observation group. The control group, consisting of 52 children, were exclusively treated with Shen Ling Bai Zhu San orally. The observation group, on the other hand, consisted of 53 children who received an additional Tuina treatment along with Shen Ling Bai Zhu San. Results: After implementing the treatments, it was found that every child in the observation group showed improvement, compared to 90% improvement rate in the control group. This correlated to a decrease in scores of primary and secondary symptoms of traditional Chinese medicine in both groups post-treatment. Furthermore, the children in the observation group who received both treatments had even lower symptom scores than the control group who only received Shen Ling Bai Zhu San. The treatments were also well-tolerated with no significant adverse reactions reported.
A Clinical Study published in 2021 in the journal African Journal of Biological Sciences found that Consumption of pumpkin seeds enhances the nutritional status and improves the attention deficit of deaf female children exhibiting ADHD symptoms. This study investigated 40 deaf female children, aged between 10 and 12 years, who exhibited symptoms of attention-deficit hyperactivity disorder (ADHD). These children were selected from El Amal school for the deaf and divided into two groups; control and experimental. Various data were gathered on personal and socio-economic factors, food habits, diet history, and clinical signs, along with performing the Attention Deficit Disorder Connected with Hyperactivity for Deaf Children test. The experimental group underwent a dietary intervention, consuming 50g of magnesium and iron-rich pumpkin seeds daily over three months. The results indicated an improvement in both iron and magnesium levels within the experimental group following the dietary intervention. Notably, compared to the control group, the levels of magnesium and iron were significantly higher in the experimental group after introducing pumpkin seeds into their diet. Furthermore, on evaluating the ADHD symptoms via the Attention Deficit Disorder Connected with Hyperactivity for Deaf Children test, the experimental group showed a more substantial improvement after dietary intervention than the control group. Over time, the findings demonstrated the potential beneficial effects of consuming pumpkin seeds on the nutritional status and ADHD symptoms in the studied population.
A Review Article published in 2021 in the journal Translational Pediatrics found that Allergic rhinitis in children, according to traditional Chinese medicine, is interrelated with the functionality of lungs, spleen, and kidney and can be treated with combined Western and Chinese herbal medicines. The methodology of this study was based on a review of both traditional Chinese and Western medical theories and practices. Chinese theory postulates that BiQiu, or allergic rhinitis in children, is primarily related to a congenital deficiency in vital qi, dysfunction of the lungs inhibiting nose orifices, and a deficiency of spleen and kidney leading to lung qi deficiency. The review looked into herbal monomers and compounds of Chinese herbal medicines as potential treatments for allergic rhinitis, while also considering the impact of external factors like the cold and inadequate diet. The review highlighted some of the effects and shortcomings of Chinese herbal medicines used alongside Western medicines for treating allergic rhinitis. Particularly, it focussed on how the unique perceptions of life science of the human body from both Eastern and Western cultures can be brought together for a comprehensive method of treatment. The study also outlined future trends of research to enhance this combined treatment approach.
A Review Article published in 2019 in the journal Neuropediatrics found that Currently, acupuncture is considered to be a safe, helpful, and available alternative option for patients who have not responded to or complied with conventional pharmacotherapy. The authors conducted an exhaustive review of existing literature exploring the use of acupuncture to address migraine headaches in children. This review encompassed understanding the neurobiological mechanisms of acupuncture, studies on adult headaches, pediatric headache studies, consideration of acupuncture's safety, and its application in other health conditions present in children. The findings of this review suggested that acupuncture emerges as a safe and effective treatment option for migraine in children. Evidence proposes that it can be effectively integrated into the primary treatment regime to reduce the child's discomfort and pain. The effectiveness of acupuncture comes with the added advantage of being safe, with negligible risks, especially important when dealing with young patients. These insights support acupuncture to be seriously considered as an auxiliary treatment strategy for migraines in children.
A Review Article published in 2015 in the journal Allergologia et Immunopathologia found that Milk and honey mixture seems to be at least as effective as dextromethorphan and levodropropizine, the most prescribed over-the-counter antitussives in Italy, in non-specific acute cough in children. Honey is recommended for non-specific acute paediatric cough by the Australian guidelines. Current available randomised clinical trials evaluated the effects of a single evening dose of honey, but multiple doses outcomes have never been studied. 134 children suffering from non-specific acute cough were randomised to receive for three subsequent evenings a mixture of milk (90 ml) and wildflower honey (10 ml) or a dose of DM or LDP adjusted for the specific age. The effectiveness was evaluated by a cough questionnaire answered by parents. Primary end-point efficacy was therapeutic success. The latter was defined as a decrease in cough questionnaire score greater than 50% after treatment compared with baseline values. Three children were excluded from the study, as their parents did not complete the questionnaire. Therapeutic success was achieved by 80% in the honey and milk group and 87% in OTC medication group (p = 0.25).
A Systematic Review published in 2015 in the journal Evidence-Based Complementary and Alternative Medicine found that We cautiously suggest that acupuncture therapy could demonstrate better clinical efficacy than pharmacological treatment or placebo treatment in treating nocturnal enuresis. In summary, the results of this study suggest that acupuncture therapy demonstrate better clinical efficacy than pharmacological treatment or placebo treatment in treating NE. Due to the low methodological qualities of included trials, the findings of current study should be interpreted with caution. Therefore, to further assess the potential beneficial effect of acupuncture therapy for NE, additional RCTs with rigorous experimental design, large-scale high quality methodological control, long follow-ups, and strict reporting specification are required.
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The scientific evidence for efficacy of omega-3 supplementation in reducing symptoms of depression and anxiety in young people is inconclusive, however, it was found that most "grey literature" sources recommended the use of omega-3 supplements in young people. —Jinnan C 20 Oct 2023