Bone Density

Presentation Slides

Chinese Medicine Research Hub

Systematic Review

Kidney tonic herbs may enhance bone density and reduce fracture risk in patients with primary osteoporosis.

2023 Medicine Effects of kidney tonic herbs for primary osteoporosis: A systematic review and meta-analysis
Li W, Ye B, Huang Z, Zhou H, Feng J, Chen Q, Huang H, Meng S, Qie F, Shi X.

Chinese Medicine Research Hub

Clinical Study

Alkaline drinking water significantly improves spine bone density in postmenopausal women with osteoporosis, more than standard treatment alone.

2021 Journal of Menopausal Medicine Effect of Alkaline Drinking Water on Bone Density of Postmenopausal Women with Osteoporosis
Fasihi S, Fazelian S, Farahbod F, Moradi F, Dehghan M

Chinese Medicine Research Hub

Experimental Study

Extract of pumpkin seeds displays estrogenic properties, potentially offering a solution to alleviate symptoms of menopausal syndromes resulting from estrogen deficiency.

2019 Phytotherapy Research Supplementation with extract of pumpkin seeds exerts estrogenic effects upon the uterine, serum lipids, mammary glands, and bone density in ovariectomized rats
Lestari B, Walidah Z, Utomo RY, Murwanti R, Meiyanto E

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Bone Density" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Bone Density" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Bone Density" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Systematic Review published in 2023 in the journal Medicine found that Kidney tonic herbs may enhance bone density and reduce fracture risk in patients with primary osteoporosis. This research gathered and analyzed data from 43 randomized controlled trials involving 4349 participants, selected through extensive scrutiny conducted by two researchers. The aim was to evaluate the effectiveness and safety of Kidney tonic herbs in the treatment of primary osteoporosis. A comprehensive search of literature across eight electronic databases was performed up to September 30, 2022. The main focus of these trials was changes in bone mineral density of the lumbar area. The results, obtained through meta-analyses using RevMan 5.3 and Stata 16, indicated that kidney tonic herbs significantly increased bone mineral density in various anatomic sites. Examples of these are the lumbar area, femoral neck, and femoral trochanter. Moreover, the research found a decrease in fracture incidence, with no serious side effects reported. The herbs also showed superior pain relief potential. However, the impact of these herbs on fall incidence needs further exploration.

A Clinical Study published in 2021 in the journal Journal of Menopausal Medicine found that Alkaline drinking water significantly improves spine bone density in postmenopausal women with osteoporosis, more than standard treatment alone. The study involved 100 postmenopausal women with osteoporosis, equally divided into an intervention group and a control group, each consisting of 50 women. The intervention group received calcium D daily, 1.5 liters of alkaline water daily with a pH of 8.6 ± 0.3, and a weekly Osteofos tablet (70 mg). The control group received only calcium D and the Osteofos tablet. The study duration was three months, and bone mineral density was measured using bone densitometry for the femur and spine, both before and after the intervention. After the three-month intervention, both groups showed significant increases in the mean T-scores of the femur and spine bones. Notably, the increase in the spine T-scores was significantly greater in the intervention group compared to the control group. However, there were no significant differences in the changes in the femur T-scores between the two groups.

A Experimental Study published in 2019 in the journal Phytotherapy Research found that Extract of pumpkin seeds displays estrogenic properties, potentially offering a solution to alleviate symptoms of menopausal syndromes resulting from estrogen deficiency. In the study, scientists conduct in vitro analysis using a colorimetric-based assay on kidney cells derived from Chinese hamsters. Furthermore, they perform in vivo experiments involving 7-week old female rats that were specially prepared to model menopausal conditions. These rats are split into differing groups, each receiving a different dosage of pumpkin seed extract. Other observable parameters include uterine weight, condition of mammary glands, serum lipid levels, and bone density measured after a period of 30 days. The researchers also utilize a computer-based technique called molecular docking to investigate how certain active compounds in the pumpkin seed extract respond to estrogen receptors. Separately, this study indicates the pumpkin seed extract's positive impact on uterine weight and mammary gland health in rats, demonstrating properties similar to the hormone 17β-estradiol. Additionally, consumption of the extract led to improved lipid profile - with increased levels of good cholesterol and decreased bad cholesterol- and improved bone density. The study suggests that these beneficial results align with the growth of bone-building cells and decrease in bone-resorbing cells. The digital validation confirms the strength of interactions between active compounds found in the extract and the estrogen receptors.

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