Lactobacillus
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Unpasteurised milk and dairy products intake could potentially alter gut microbiome composition which may influence psychological functioning.
Gut Microbiota Lactobacillus Raw Milk
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Estrogenic activity of fermented soymilk extracts and soy compounds
2023 Dec Applied Food Research Nishi K, Imamura I, Takemoto T, Iga K, Kiyama R
The study demonstrates the estrogenic activity of soymilk extracts and soy compounds, with greater activity observed after fermentation, highlighting complex mechanisms at the transcription level. RNA-sequencing analysis revealed up-regulation of genes related to cell division/cell cycle and DNA replication/DNA repair and down-regulation of genes associated with autophagy, suggesting enhanced cell proliferation. The estrogenic activity of soymilk extracts and soy flavonoids, especially after fermentation, offers potential pharmacological benefits, including bone protection, cancer chemoprevention, neuroprotection, and the treatment of menopausal syndromes.
Experimental Study Soy Milk MenopauseAnti-Menopausal Effect of Soybean Germ Extract and Lactobacillus gasseri in the Ovariectomized Rat Model
2023 Oct 23 Nutrients Lee SH, Lim TJ, Yun EJ, Kim KH, Lim S
Animal Study Experimental Study Soybean Bacillus MenopauseA combination of soybean germ extract and a probiotic significantly improved menopause-related conditions and mood in an ovariectomized rat model.
Sleep-Enhancing Effect of Water Extract from Jujube (Zizyphus jujuba Mill.) Seeds Fermented by Lactobacillus brevis L32
2023 Jul 27 Foods Bae GY, Ahn Y, Hong KB, Jung EJ, Suh HJ, Jo K
Experimental Study GABA Jujube Suan Zao Ren SleepThe fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.
Chronic consumption of thermally processed palm oil or canola oil modified gut microflora of rats
2021 Jan Food Science and Human Wellness Ruan M, Bu Y, Wu F, Zhang S, Chen R, Li N, et al.
Heated canola oil consumption elevated plasma total cholesterol and LDL-c levels compared with unheated canola oil, while heated palm oil did not have these effects. Additionally, consumption of heated palm oil significantly increased the relative abundance of Lactobacillus and Roseburia in the gut compared with non-heated palm oil or both canola oil groups. The heating process may enhance the effects of palm oil on the proliferation of probiotics like Lactobacillus and weaken the effects of canola oil on cholesterol transport and metabolism.
Experimental Study Gut Microbiota
Consumption of two whole kiwifruit (Actinide chinensis) per day improves lipid homeostasis, fatty acid metabolism and gut microbiota in healthy rats
2020 Aug International Journal of Biological Macromolecules Alim A, Li T, Nisar T, Ren D, Liu Y, Yang X
Analysis of gut microbiota revealed that ACF and ACFP evidently increased the microbial richness and diversity of gut microbiota. Moreover, ACF and ACFP significantly increased the abundance of beneficial bacteria (Lactobacillus and Barnesiella) and reduced harmful bacteria (Enterococcus, Escherichia, and Staphylococcus). Overall, ACFP exerts more potent health-improving effects than ACF.
Animal Study Gut Microbiota KiwifruitResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
A combination of soybean germ extract and a probiotic significantly improved menopause-related conditions and mood in an ovariectomized rat model.
2023 Nutrients Anti-Menopausal Effect of Soybean Germ Extract and Lactobacillus gasseri in the Ovariectomized Rat Model Lee SH, Lim TJ, Yun EJ, Kim KH, Lim S
Animal Study Bacillus Menopause Soybean
The study employed an ovariectomized rat model to understand the effects of a combination of soybean germ extract containing 30% isoflavone and a probiotic. The methodology included assessing the effects of this combination on several health markers including body weight, estrogen markers, uterine and bone health, vascular markers, and neurotransmitter levels in these rats.
Once implemented, the combination of soybean germ extract and the probiotic showcased significant improvement in body weight and uterine and bone health of the rats. There were also noticeable effects on the lipid profile, liver function, and vascular markers. Most interestingly, the combination had a positive impact on the levels of serotonin and norepinephrine, indicating potential mood-enhancing effects, which are crucial in managing symptoms post-menopause. This essentially shows the potential of a dietary approach towards menopausal management, especially given the observed benefits without the side effects typically associated with hormone replacement therapy.
The fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.
2023 Foods Sleep-Enhancing Effect of Water Extract from Jujube (Zizyphus jujuba Mill.) Seeds Fermented by Lactobacillus brevis L32 Bae GY, Ahn Y, Hong KB, Jung EJ, Suh HJ, Jo K
Experimental Study GABA Jujube Sleep
Methodology: An aqueous extract of jujube seeds (ZW) was fermented, following a starch-removing enzymatic degradation process, to increase its γ-aminobutyric acid (GABA) content, resulting in a fermented product (ZW-FM). The sleep-promoting effect of ZW-FM was evaluated using rodent models; specifically, sleep tests were performed on ICR mice with pentobarbital-induced sleep, while the electroencephalography analysis was undertaken in Sprague Dawley rats. Awakening relief effects of ZW-FM were assessed using a caffeine-induced insomnia model. To understand the mechanism, GABA receptor type A (GABA) antagonists were used.
Results: The groups given ZW-FM treatment displayed a longer sleep duration, particularly increased δ-wave time during non-rapid eye movement sleep, and reduced sleep latency. Particularly, the model treated with ZW-FM showed an increase in non-rapid-eye-movement sleep and a reduction in the REM sleep duration, brought about by caffeine treatment. The enhanced sleep induction caused by ZW-FM was hindered by GABA receptor antagonists, thereby validating the involvement of a GABAergic mechanism in promoting sleep.
Unpasteurised milk and dairy products intake could potentially alter gut microbiome composition which may influence psychological functioning.
2020 Nutrients Recipe for a Healthy Gut: Intake of Unpasteurised Milk Is Associated with Increased Lactobacillus Abundance in the Human Gut Microbiome Butler MI, Bastiaanssen TFS, Long-Smith C, Berding K, Morkl S, Cusack AM, et al.
Experimental Study Gut Microbiota Raw Milk
In this observational study, the impact of dietary change involving unpasteurized dairy consumption on gut microbiota and psychological state was observed among participants of a 12-week residential cookery course on an organic farm. Twenty-four participants, who primarily consumed food from the farm including unpasteurised milk and dairy products, provided faecal samples at the beginning and end of the course. Concurrently, they completed self-report questionnaires touching on mood, anxiety, and sleep aspects and nutrient intake was monitored via a food frequency questionnaire. Gut microbiota analysis was carried out using 16S rRNA gene sequencing and measurement of faecal short chain fatty acids.
Post-course, there was a significant growth in the relative abundance of a specific bacterial genus in the gut, associated with unpasteurised milk and dairy product intake. Furthermore, an increase in a particular faecal short chain fatty acid, valerate, was observed together with an elevation in the functional richness of the microbiome profile. The latter was determined by measuring the predicted neuroactive potential using a unique gut-brain module approach. Despite safety concerns, the consumption of unpasteurised milk and dairy products seemed to promote the growth of probiotic bacterial genus, known to be beneficial for various physical and mental health outcomes.
Lactic acid bacteria strains isolated from indigenous Bangladeshi raw milk demonstrate strong probiotic potential and antimicrobial activity against various pathogens.
2020 Journal of Dairy Science Characterization and evaluation of lactic acid bacteria from indigenous raw milk for potential probiotic properties Reuben RC, Roy PC, Sarkar SL, Rubayet Ul Alam ASM, Jahid IK
Experimental Study Raw Milk
The researchers isolated and evaluated lactic acid bacteria (LAB) from raw milk indigenous to Bangladesh, focusing on its probiotic potential. To do this, they conducted a series of tests examining the LAB’s antagonistic activity towards several harmful foodborne pathogens, their survivability under gastric conditions, tolerance to phenol and bile salts, adhesiveness to ileum epithelial cells, aggregation abilities, hydrophobicity and α-glucosidase inhibitory activity. They also assessed these strains’ antibiotic susceptibility, covering key antibiotics widely used in medical and veterinary practices.
The research spotlighted four LAB strains, identified as Lactobacillus casei, Lactobacillus plantarum, Lactobacillus fermentum, and Lactobacillus paracasei, as possessing strong probiotic potential. This was primarily due to their shown ability to inhibit all tested pathogens to varying degrees and competitively exclude pathogens at certain viable counts. Their antimicrobial activity was attributed to their production of bacteriocin, organic acids, and low-molecular-weight substances. Additionally of note was their resistance to several antibiotics; all four strains resisted oxacillin, and three out of four resisted vancomycin and streptomycin. The study concludes by suggesting the potential for these LAB strains to be considered probiotic candidates for application in the food industry post in-vivo evaluation.
Ganpu tea, derived from Pu-erh tea and the pericarp of Chachi, enhances antioxidant capacities and modulates gut microbiota beneficially more than Pu-erh tea alone.
2020 Nutrients Chemical Profile, Antioxidative, and Gut Microbiota Modulatory Properties of Ganpu Tea: A Derivative of Pu-erh Tea Zheng Y, Zeng X, Chen T, Peng W, Su W
Network Pharmacology Antioxidant Gan Pu Tea Gut Microbiota
A thorough chemical analysis was conducted on hot-water extracts of Ganpu tea using ultra-high performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry, which identified a total of 92 constituents. Considering the antioxidant properties of Ganpu tea, an experiment was designed and carried out where rats were fed with Ganpu tea over a long period. The same experiment was done using Pu-erh tea and the pericarp of Chachi separately, allowing for comparisons of antioxidant capacities between them and Ganpu tea.
The results showed that Ganpu tea had a substantial impact on improving the activities of superoxide dismutase and glutathione peroxidase, both essential antioxidants, more than Pu-erh tea. This indicated a superior antioxidant capacity of Ganpu tea. Further, it significantly increased the abundance of specific gut bacteria, offering a suggestion of the potential benefits of Ganpu tea in human gut microbiota modulation. The results underscore the health benefits of Ganpu tea in enhancing antioxidant activities and promoting beneficial gut microbiota.
Presentation Slides
A combination of soybean germ extract and a probiotic significantly improved menopause-related conditions and mood in an ovariectomized rat model.
The fermented jujube seeds extract significantly enhances sleep by binding to the GABA receptors, thus offers a promising natural alternative for sleep disorders treatment.
Unpasteurised milk and dairy products intake could potentially alter gut microbiome composition which may influence psychological functioning.
Lactic acid bacteria strains isolated from indigenous Bangladeshi raw milk demonstrate strong probiotic potential and antimicrobial activity against various pathogens.
Ganpu tea, derived from Pu-erh tea and the pericarp of Chachi, enhances antioxidant capacities and modulates gut microbiota beneficially more than Pu-erh tea alone.
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