Candida Albicans
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Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
New tocopherol and acylphloroglucinol derivatives from Dryopteris crassirhizoma and their antimicrobial activities
2023 Mar Fitoterapia Hai P, He Y, Wang R, Gao Y, Wu X, Chen X, et al.
When combined with fluconazole (FLC), compound 3 showed significant antifungal activity against standard Candida albicans. Furthermore, the anti-plant pathogenic fungi and bacterial activities have been evaluated in vitro, compounds 5 and 8 showed anti-Verticillium dahlia and Sclerotinia sclerotiorum with MIC value and compounds 1 and 5 exhibited moderate antibacterial activities against Micrococcus luteus.
Network Pharmacology Antimicrobial Guan Zhong
Antifungal Mechanisms of a Chinese Herbal Medicine, Cao Huang Gui Xiang, Against Candida Species
2022 Mar 09 Frontiers in Pharmacology Yue H, Xu X, He S, Cui X, Guo Y, Zhao J, et al.
The CHGX formula demonstrated potent antifungal activities against Candida species both in vitro and in vivo, with efficacy in treating C. albicans infection in mice without causing noticeable toxicity. The formula inhibited biofilm formation, filament development, and disrupted cell membrane integrity in C. albicans, leading to the accumulation of reactive oxygen species (ROS) and depletion of adenosine triphosphate (ATP), ultimately resulting in fungal cell death. The study highlights the potential of CHGX as a therapeutic option for Candida infections and elucidates its antifungal mechanisms involving multiple pathways, including the Ras1-cAMP pathway and mitochondrial protein Mcu1.
Experimental Study Antifungal
Study on the mechanism of Yupingfeng powder in the treatment of immunosuppression based on UPLC⁃QTOF⁃MS, network pharmacology and molecular biology verification
2022 Jan Life Sciences Li Y, Liu Y, Sun Y, Ma S, Ma C, Zhou H, et al.
The series of experiments demonstrate that YPF could improve Candida albicans induced immunosuppression of BALB/c mice through upregulating the activity of IL-17 pathway, suggesting that YPF might play an immunopotentiation effect and giving a clue that YPF may be used in treating Candida albicans.
Network Pharmacology ImmunosuppressionPotent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans
2010 Sep Research in Microbiology Endo EH, Garcia Cortez DA, Ueda-Nakamura T, Nakamura CV, Dias Filho BP
Experimental Study Animal Study Antifungal Candida Albicans PomegranatePunicalagin, extracted from the fruit peel of Punica granatum, displays strong antifungal activity against Candida species, especially when combined with fluconazole.
Presentation Slides
Punicalagin, extracted from the fruit peel of Punica granatum, displays strong antifungal activity against Candida species, especially when combined with fluconazole.
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