Chinese Cinnamon

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Chinese Medicine Research Hub

Meta-Analysis

Cinnamon is a safe therapeutic agent without significant adverse effects based on systematic reviews and meta-analyses.

2022 Frontiers in Pharmacology Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials
Gu DT, Tung TH, Jiesisibieke ZL, Chien CW, Liu WY

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation may help manage metabolic parameters in polycystic ovary syndrome patients by reducing fasting blood sugar, insulin, LDL-C, total cholesterol, and triacylglycerol levels.

2020 Journal of Ethnopharmacology Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis
Heydarpour F, Hemati N, Hadi A, Moradi S, Mohammadi E, Farzaei MH

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation can improve blood pressure by a modest degree.

2020 Clinical Nutrition ESPEN The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials
Hadi A, Campbell MS, Hassani B, Pourmasoumi M, Salehi-sahlabadi A, Hosseini SA

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation can significantly reduce body weight, body mass index, and waist-hip ratio.

2019 Phytotherapy Research Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta-analysis of controlled clinical trials
Zeinab Yazdanpanah,Maryam Azadi-Yazdi,Hadis Hooshmandi,Nahid Ramezani-Jolfaie,Amin Salehi-Abargouei,

Chinese Medicine Research Hub

Systematic Review

Cinnamon supplementation leads to a significant reduction in both systolic and diastolic blood pressure in adults.

2019 Critical Reviews in Food Science and Nutrition Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials
Seyed Mohammad Mousavi, Ahmad Jayedi, Yahya Jalilpiran, Maryam Hajishafiee, Azadeh Aminianfar, Ahmad Esmaillzadeh.

Chinese Medicine Research Hub

Animal Study

The herbal formula B210 can alleviate snoring in aged rats by modifying the activities and breathing time of relevant nerves.

2018 Drug Design, Development and Therapy Traditional Chinese herbal formula relieves snoring by modulating activities of upper airway related nerves in aged rats
Chung KT, Hsu CH, Lin CL, Wang SE, Wu CH

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Chinese Cinnamon" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Chinese Cinnamon" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Chinese Cinnamon" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Meta-Analysis published in 2022 in the journal Frontiers in Pharmacology found that Cinnamon is a safe therapeutic agent without significant adverse effects based on systematic reviews and meta-analyses. The researchers conducted a thorough search of PubMed, EMBASE, and the Cochrane Library, identifying relevant systematic reviews and meta-analyses on human subjects' cinnamon safety. The search consisted of articles up to September 2021, with the PRISMA 2020 guidelines followed for comprehensive reporting and transparency. The reliability of these studies' methodology was determined using methodological quality standards. The review included three meta-analyses and one systematic review, with two of the four classified as moderate quality, and the others as low quality. Generally, the academic studies found no significant harmful effects compared to a placebo, regardless of the dose or length of therapy. The findings suggest that humans well tolerate cinnamon, as no adverse reactions were observed in the study subjects. This evidence confirms the safety of cinnamon consumption, potentially providing health benefits as auxiliary treatment without significant risk of harm.

A Systematic Review published in 2020 in the journal Journal of Ethnopharmacology found that Cinnamon supplementation may help manage metabolic parameters in polycystic ovary syndrome patients by reducing fasting blood sugar, insulin, LDL-C, total cholesterol, and triacylglycerol levels. In order to evaluate the effect of cinnamon supplementation on metabolic parameters of PCOS patients, relevant clinical trials were systematically reviewed and analysed. Data was collated from multiple credible databases including PubMed, Embase, the Cochrane library, Scopus and Web of Science, up until August 2019. Studies were selected that provided information specifically about the impact of cinnamon supplementation on metabolic parameters amongst PCOS patients. Standard methods were used to assess heterogeneity, publication bias and sensitivity analysis with five clinical trials pooled together using a weighted mean-difference calculation. The findings of the meta-analysis showed that cinnamon supplementation does not significantly affect body weight and body mass index in PCOS patients. However, it was found that cinnamon supplementation led to a significant decrease in fasting blood sugar, fasting insulin, and HOMA-IR, along with reducing the serum levels of LDL-C, total cholesterol, and triacylglycerol. Additionally, there was an observed improvement in serum concentration of HDL-C with cinnamon supplementation. Ultimately illustrating that cinnamon supplementation may play a significant role in managing metabolic parameters in polycystic ovary syndrome patients.

A Systematic Review published in 2020 in the journal Clinical Nutrition ESPEN found that Cinnamon supplementation can improve blood pressure by a modest degree. Meta-analysis of 9 RCTs with 641 participants showed significant reductions in both systolic (WMD: −5.17 mmHg, 95% CI: −9.35 to −0.99, P = 0.01) and diastolic blood pressure (WMD: −3.36 mmHg, 95% CI: −5.67 to −1.04, P ≤ 0.001) after cinnamon supplementation. Subgroup analyses indicated that these results were significant only when cinnamon was administered at the dosages of ≤2 g/day, for a period longer than 8 weeks, and in participants with a baseline BMI of ≥30 kg/m2.

A Systematic Review published in 2019 in the journal Phytotherapy Research found that Cinnamon supplementation can significantly reduce body weight, body mass index, and waist-hip ratio. In the meta-analysis, various databases (including Medline, ISI Web of Science, Scopus, Google Scholar, and Cochrane Library) were searched without limitations until August 2019 for relevant randomized controlled clinical trials. The risk of bias of the randomized controlled clinical trials was appraised with the Cochrane collaboration's tool. The random-effects model was employed for the meta-analysis. The conclusive results indicate that cinnamon supplementation has a notable effect in reducing body mass index, body weight, and waist-hip ratio. Meanwhile, cinnamon supplementation didn't yield significant effects on waist circumference and body fat mass. These results were deduced from twenty-one randomized controlled trials involving a total of 1,480 participants.

A Systematic Review published in 2019 in the journal Critical Reviews in Food Science and Nutrition found that Cinnamon supplementation leads to a significant reduction in both systolic and diastolic blood pressure in adults. This systematic review and meta-analysis included studies up to July 2019, sourced from databases like PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar. The research focused on randomized clinical trials that primarily explored the effect of oral cinnamon supplementation on blood pressure parameters, including systolic or diastolic blood pressure. From the 469 citations, nine trials involving 641 subjects were included. The results inferred that cinnamon supplementation leads to a noticeable decrease in both systolic and diastolic blood pressure. A more remarkable effect on systolic blood pressure was observed in trials using less or equal to 2g cinnamon, lasting for 12 weeks or more, and included participants under the age of 50. Diastolic blood pressure was also reduced using lower doses of cinnamon. No significant non-linear associations were detected between cinnamon supplementation dosage, study duration, and both systolic and diastolic blood pressure.

A Animal Study published in 2018 in the journal Drug Design, Development and Therapy found that The herbal formula B210 can alleviate snoring in aged rats by modifying the activities and breathing time of relevant nerves. In this study, aged rats were treated intraperitoneally with the herbal formula B210, a compound of specific herbal components, or a placebo (sham treatment). The effects of the treatment on snoring quality were analysed by comparing pressure and frequency of snoring, activities of the phrenic nerve, the recurrent laryngeal nerve, and the hypoglossal nerve, as well as inspiratory time and expiratory time of the phrenic nerve, and pre-inspiratory time of the hypoglossal nerve. The results of the study showed that the rats that received the B210 treatment exhibited a marked decrease in snoring pressure and frequency, compared to those that received the sham treatment. Furthermore, there was a notable increase in the activities of the upper airway related nerves - the phrenic nerve, the recurrent laryngeal nerve, and the hypoglossal nerve - observable in the aged rats that received the B210 treatment, demonstrating an extension in the inspiratory and expiratory times of the phrenic nerve, and a prolongation of the pre-inspiratory time of the hypoglossal nerve. These findings point to the possibility of B210's role in alleviating snoring through modulating the activities and breathing times of the nerves related to the upper airway in aged rats.

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