Endometrial Cancer

Presentation Slides

Chinese Medicine Research Hub

Review Article

Isoflavones, mainly found in soy-derived products, show beneficial effects on bone health, potential cancer risk reduction, and alleviation of menopausal symptoms, but not on cardiovascular risk.

2020 Nutrients Scientific Evidence Supporting the Beneficial Effects of Isoflavones on Human Health
Gómez-Zorita S, González-Arceo M, Fernández-Quintela A, Eseberri I, Trepiana J, Portillo MP

Chinese Medicine Research Hub

Systematic Review

The literature overall supports an inverse association between green tea and cardiovascular disease-related health outcomes, while the included meta-analyses generally suggested an inverse association between green tea and BMI-related and blood pressure outcomes.

2020 European Journal of Clinical Nutrition Green tea and cancer and cardiometabolic diseases: a review of the current epidemiological evidence
Abe SK, Inoue M

Chinese Medicine Research Hub

Meta-Analysis

Coffee consumption shows a strong association with decreased risk of liver and endometrial cancer.

2020 BMC Cancer Coffee drinking and cancer risk: an umbrella review of meta-analyses of observational studies
Zhao LG, Li ZY, Feng GS, Ji XW, Tan YT, Li HL, Gunter MJ, Xiang YB

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Endometrial Cancer" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Endometrial Cancer" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Endometrial Cancer" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2020 in the journal Nutrients found that Isoflavones, mainly found in soy-derived products, show beneficial effects on bone health, potential cancer risk reduction, and alleviation of menopausal symptoms, but not on cardiovascular risk. The study examined the potential uses of isoflavones, phenolic compounds mostly found in soy-derived foods and several vegetables. Isoflavones are seen as potential alternative therapies for hormone-dependent disorders due to their near-identical chemical structure to estradiol. These disorders include certain cancers, cardiovascular diseases, and menopausal symptoms. The investigation involved reviewing existing scientific evidence to evaluate the potential effects of isoflavones on these diseases and health concerns. In assessing the results, the review found evidence suggesting that isoflavones could have a beneficial effect on postmenopausal women's bone health, contributing to osteoporosis prevention and treatment. However, observed study results were not entirely conclusive due to discrepancies among study designs. Contrarily, there appeared to be no significant protective effect against cardiovascular risk with soy isoflavones. In terms of cancer, preliminary observations suggested that isoflavones may reduce some types of cancer risks, such as breast and endometrial cancer. Lastly, isoflavones showed a potential role in reducing hot flushes associated with menopause. Concerning safety, most common adverse effects were mild and observed at the gastrointestinal level.

A Systematic Review published in 2020 in the journal European Journal of Clinical Nutrition found that The literature overall supports an inverse association between green tea and cardiovascular disease-related health outcomes, while the included meta-analyses generally suggested an inverse association between green tea and BMI-related and blood pressure outcomes. The evidence on green tea consumption and health outcomes presented in this review suggests green tea may be favorable for cardiovascular disease, particularly stroke, and certain cancers such as endometrial, esophageal, lung, non-Hodgkins lymphoma, oral, and ovarian cancer. More evidence is needed to assess the impact of green tea on breast, gastric, and liver cancer risk. Additional studies could also help clarify the suggested null association with certain cancer sites: colorectal, pancreatic, and prostate cancer. Possible minor adverse events on health from green tea consumption were reported in one study, however these must be interpreted cautiously within the study context and possible finer dose-response implications. The findings for green tea and diabetes risk were inconclusive. For BMI the current evidence suggests a possible weak association, while the evidence is stronger supporting a decrease in blood pressure from green tea. More studies investigating a possible association between green tea consumption and other health outcomes such as cognition, injuries, respiratory disease would be informative to more completely assess the impact of green tea on human health. In conclusion, our review suggests green tea may have health benefits especially for cardiovascular disease and certain cancer sites.

A Meta-Analysis published in 2020 in the journal BMC Cancer found that Coffee consumption shows a strong association with decreased risk of liver and endometrial cancer. The randomized umbrella review included a total of 28 individual meta-analyses and 36 summary associations for 26 different types of cancer. In order to collect this data, a variety of databases like PubMed, Embase, Web of Science and the Cochrane database were searched to find systematic reviews and meta-analyses of relationships between coffee consumption and cancer incidence. The summary effect size was estimated for each association using both the fixed and random effects model. A detailed evaluation of heterogeneity, small-study effects, and excess significance bias was also carried out. The results showed 17 out of 28 meta-analyses to be significant. For the highest versus the lowest categories, 4 out of 26 associations showed a more stringent value. There were notable dose-response associations for five types of cancer. Majority of the studies (69%) displayed low heterogeneity. There was evidence of excessive significance bias and publication bias in three and six associations respectively. Data exhibited that coffee intake was inversely proportional to the risk of contracting liver and endometrial cancer. All this remained constant even when the analysis was restricted only to the meta-analysis of cohort studies.

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