Stress

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• Signs & Symptoms
• Research Summary

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Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Stress" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Stress" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Stress" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Data Mining published in 2024 in the journal Traditional Medicine Research found that The traditional Chinese medicine prescription combination of Chrysanthemi Flos, Cassiae Semen, Lycii Fructus, Angelicae Sinensis Radix and Salviae Miltiorrhizae Radix et Rhizoma presents potential for treating retinal diseases. Methodology: The researchers employed data mining to discern a new traditional Chinese medicine (TCM) prescription against retinal diseases and explore its medication rule. This was followed by constructing a network of TCMs, core ingredients, core targets, and core pathways using network pharmacology. The binding ability between core active ingredients and core targets was then verified through molecular docking and molecular dynamics simulation techniques. Discussion: The novel TCM prescription screened in this study bears great potential in retinal diseases treatment through a unique mechanism of action. This mechanism involves TCM prescriptions that possess clearing heat and supplementing activities, associated with liver and lung meridians. The mechanism was found to act by modulating several core targets implicated in multiple core pathways such as the AGE-RAGE signaling pathway in diabetic complications, and the PI3K-Akt signaling pathway, among others. This potentially inhibits the inflammatory response, oxidative stress, and retinal neovascularization and apoptosis of retinal ganglion cells and retinal pigment epithelial cells. This improves retinal structural impairment and can have a significant impact on the treatment of retinal diseases.

A Experimental Study published in 2023 in the journal Journal of Applied Toxicology found that Virgin coconut oil shows potential therapeutic promise against Alzheimer's disease by reducing key markers and enhancing neurotransmitter parameters. In this study, the SH-SY5Y cell lines were cultured in its regular growth medium which was then differentiated by reducing its fetal bovine serum content and adding retinoic acid. Further, brain-derived neurotrophic factor was added in unison with retinoic acid, completing the differentiation process by the seventh day. The study groups comprised of a control group, groups that received virgin coconut oil, Aluminum, both or neither, an Alzheimer model group, and a group replicating the Alzheimer model exposed to Aluminum and virgin coconut oil. The measurable aspects in this study included specific indicators of Alzheimer's disease like hyperphosphorylated Tau protein, amyloid beta 1-40 peptide, and amyloid precursor protein, oxidative stress parameters, and neurotransmitter-related parameters. In the results, it was revealed that virgin coconut oil was successful in reducing levels of amyloid beta and hyperphosphorylated Tau protein in the groups. This composition also seemed to decrease oxidative stress levels associated with Alzheimer's disease, delivering improvement in neurotransmitter parameters, which supports the hypothesis that virgin coconut oil can be therapeutic against this progressive neurological disorder.

A Experimental Study published in 2023 in the journal Biomedicine & Pharmacotherapy found that Fructus Lycii and Salvia miltiorrhiza Bunge extract (FSE) shows potential as a clinical treatment for retinitis pigmentosa by inhibiting photoreceptor cell death following oxidative stress. The study utilized hydrogen peroxide to induce oxidative stress in 661 W cells, which were examined with flow cytometry and an enzyme-linked immunosorbent assay. The impact of this oxidative stress on the cells’ mitochondria was observed using an electron microscope to understand the nature of cell death. The study also analyzed the compensatory effect of the Fructus Lycii and Salvia miltiorrhiza Bunge extract on the retinal structure and function of rd10 mice using histopathological examination, fundus photographs, and electroretinography. Protein levels were evaluated using Western blot assays, specifically targeting proteins including Tumor Protein p53, Solute Carrier Family 7 Member 11, Glutathione peroxidase 4, Arachidonate-12-Lipoxygenase, and Dipeptidyl peptidase 4. The results showed that hydrogen peroxide-induced oxidative stress in 661 W cells increased oxidative stress products and certain protein expressions, while decreasing others. Notably, the activation of Glutathione peroxidase 4 did not lessen reactive oxygen species generation and had little impact on cell death. The research discovered that both Ferrostatin-1 and the extract could lessen reactive oxygen species generation and inhibit cell death of photoreceptors in retinitis pigmentosa, achieving this by inhibiting the expression of one protein and increasing the expression of two others.

A Network Pharmacology published in 2023 in the journal Annals of Translational Medicine found that The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways. The research used various databases such as Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, GeneCards, and the Online Mendelian Inheritance in Man database to gather the ingredients of RALRG and potential targets of RP and RALRG. A protein-protein interaction network was constructed to visualize these interactions. The R program was utilized to perform functional enrichment. The researchers constructed a visual RALRG-RP-pathway pharmacology network using Cytoscape 3.9.1 and applied molecular docking to compute binding affinity. The research revealed a total of 132 effective active elements in RALRG correlating to 248 target genes. Ninety-two intersection target genes were discovered from the overlap of RP- and RALRG-related genes. These intersection targets were discovered to be primarily involved in oxidative stress, responding to metal ions, and handling chemical stress. Several molecular pathways such as PI3K-AKT and MAPK were identified as closely connected to RP therapy. A potential pharmacology network was designed for the RALRG-RP-pathway with AKT1 and JUN being considered the main targets. The active ingredients luteolin, quercetin, and kaempferol were highlighted as crucial for this mechanism. RALRG overall was established as a main regulator for oxidative stress and PI3K/AKT signaling pathways in the treatment of RP.

A Experimental Study published in 2023 in the journal Nutrients found that Theabrownin from dark tea can potentially reverse insulin resistance and regulate glycolipid metabolism, with longer fermented samples showing greater effects. The study focused on TB1 and TB2, theabrownin isolated from dark tea. TB1 was fermented for 7 days whereas TB2 was fermented for 14 days. The research used HepG2 cells for the experiment. Various techniques such as Western blot and real-time PCR experiments were employed to measure the effects of TB on oxidative stress, mitochondrial function, and glycolipid regulation, which are key components of insulin resistance. The results suggest TB can significantly improve oxidative stress conditions by enhancing mitochondrial function. TB unveiled its potential in improving glycogen synthesis and glucose consumption. Furthermore, TB was found to inhibit harmful processes like gluconeogenesis and fatty acid synthesis via the regulation of various enzymes and proteins. The researchers investigated this by focusing on a signaling pathway (IRS-1/PI3K/Akt). Verification of the effects of TB on glycolipid metabolism was done using a PI3K inhibitor, highlighting a positive correlation between PI3K activation and TB's activity. Notably, the experiment showed TB2, which was fermented longer, was more effective in improving insulin resistance.

A Randomised Controlled Trial published in 2023 in the journal Journal of Medicinal Food found that Daily consumption of pecans for a month can help protect against post-meal oxidative stress in aging adults. The abstract outlines a randomized, parallel, controlled trial where 41 healthy adults aged between 50 and 75 were split into two groups. One group consumed 68 grams of pecans every day for four weeks, while the other group avoided all nuts. Blood samples were obtained from all participants before and after the intervention during fasting and at intervals of 30, 60, and 120 minutes after a meal high in saturated fats. Changes were observed in various parameters, including malondialdehyde - a marker for lipid peroxidation, total antioxidant capacity (TAC), glucose, and insulin levels. The study revealed no significant variances in fasting or post-meal TAC, glucose, or insulin for the pecan consumers compared to the control group. However, there was a noticeable tendency towards a change in fasting lipid peroxidation driven by a minor reduction for the pecan group compared to the control group. Moreover, post-meal lipid peroxidation was suppressed in the pecan group, distinctly different from the control group's results. These outcomes propose that a diet enriched in pecans for one month can provide protection against post-meal oxidative stress in older adults.

A Cohort Study published in 2023 in the journal Heliyon found that Consuming “Sneznik-1/79” mineral water significantly improves intestinal health and reduces cholesterol in type 2 diabetes patients. The study involved 60 patients with confirmed Type 2 Diabetes, who drank “Sneznik-1/79” mineral water from Serbia daily for 28 days. Researchers conducted standard biochemical tests, including glucose level, lipid profile, and stool analysis. Additionally, blood samples were taken to assess the impact of the water on oxidative stress markers. Post consumption of “Sneznik-1/79” water, a substantial decrease in total cholesterol levels was noted. Notably, all patients experienced regular daily bowel movements, indicating improved intestinal peristalsis. Half of the participants showed elimination of dysbiosis. Furthermore, there was an increase in antioxidants like superoxide dismutase and reduced glutathione, suggesting enhanced antioxidant capacity. The study highlights “Sneznik-1/79” water as a potential complementary treatment for improving gut health and reducing cholesterol in Type 2 Diabetes patients.

A Clinical Study published in 2023 in the journal Nutrients found that Consuming two medium-sized green kiwifruits an hour before bed can improve sleep quality and recovery stress balance among elite athletes. The study began with an initial assessment, after which all participants were instructed to consume two medium-sized green kiwifruits an hour before bedtime over a 4-week span. Data was collected through baseline and post-intervention questionnaires, as well as daily sleep diary entries throughout the study duration. There was a notable positive effect of kiwifruit consumption on essential aspects of sleep and recovery in professional athletes. After the intervention period, improvements were observed in sleep quality and recovery stress balances. Additionally, there was an increase in total sleep time, sleep efficiency, and a decrease in the number of times participants woke after falling asleep. The study concludes that kiwifruits positively influence sleep and recovery in high-performing athletes.

A Review Article published in 2023 in the journal Frontiers in Nutrition found that Sardines, being an affordable source of Omega-3 and other cardioprotective nutrients, can potentially reduce the need for Omega-3 supplementation and manage cardiometabolic diseases. The abstract primarily acknowledges the importance of Omega-3 polyunsaturated fatty acids with respect to managing diseases related to heart health and metabolism, for instance, type 2 diabetes, hypertension, hypertriglyceridaemia, and fatty liver disease. However, these fatty acids are not the sole beneficial component of sardines. Minerals including but not limited to calcium, potassium, and magnesium as well as substances like taurine and arginine found in sardines have a significant role in controlling mild inflammation and oxidative stress which are usually present in cardiovascular diseases and hemodynamic dysfunction. The results discussed in the abstract suggest a positive correlation between consumption of sardines and potential cardiometabolic benefits. By considering the dose-response relationship effects, a pragmatic approach towards consumption of nutrients was suggested. The intake of sardines was seen not only as a means of Omega-3 supplementation but also as a comprehensive approach to enhancing cardiovascular health. The abstract concludes with an emphasis on the many beneficial nutrients found in sardines besides Omega-3, underlining the need to shift the focus from synthetic supplementation to natural dietary improvement.

A Review Article published in 2023 in the journal Journal of Ethnopharmacology found that Traditional Chinese Medicines (TCM) could increase the survival rate of retinal ganglion cells, thereby playing an active role in treating glaucoma. Methodology: The research involved a comprehensive collection and collation of scientific articles from various databases about TCM and its application on glaucoma. The therapeutic effects of TCM, including their specific formulae, crude drugs, and active components, were analyzed based on existing experimental and clinical research. The GSE26299 database was also used for a bioinformatics analysis of glaucoma, employing the GEO database chip. Results: The traditional Chinese medicines exhibited positive effects in treating glaucoma by potentially improving the microcirculation, managing oxidative stress, and regulating the immune system, which in turn increased the survival rate of retinal ganglion cells. Furthermore, the bioinformatics analysis speculated the pathogenesis of glaucoma to be associated with multiple signaling pathways. The study concluded that TCM could alleviate and treat glaucoma through various methods, with the provision that the differentiation syndrome should be the basis for proposing suitable treatment options.

A Systematic Review published in 2023 in the journal Frontiers in Medicine found that Saffron supplementation significantly decreased oxidative stress markers and has beneficial effects in reducing oxidative stress. For this analysis, we sought to evaluate the impact of saffron supplementation on oxidative stress markers, including malondialdehyde, total antioxidant capacity, total oxidant status, glutathione peroxidase, superoxide dismutase, and prooxidant/antioxidant balance. To do this, we conducted an extensive search across databases such as PubMed/Medline, Web of Science, Cochrane CENTRAL, Scopus, and Google Scholar until December 2022. Our search criteria included randomized controlled trial studies examining the effects of oral saffron supplements on the aforementioned oxidative stress markers. The resulting data were pooled using a random effects model to analyze the results, and we assessed heterogeneity using the Cochrane values. We incorporated 16 cases into our meta-analysis, which comprised of subjects in both saffron and control groups. In our results, we found that saffron consumption resulted in significant reductions in malondialdehyde and total oxidant status levels. Furthermore, it led to a considerable increase in total antioxidant capacity and glutathione peroxidase - all of which are markers indicating oxidative stress. More specifically, within studies where the daily dosage of saffron was greater than 30 mg, and in studies lasting less than 12 weeks, we noted a significant reduction in malondialdehyde levels, especially in participants under 50 years old. Our study faced limitations, including the geographical limitation of the studies being from Iran, the varying nature of the diseases included, and potential confounding factors such as smoking, physical activity, and diet.

A Randomised Controlled Trial published in 2023 in the journal Phytotherapy Research found that Pomegranate juice supplementation has been found to effectively decrease testosterone levels in overweight and obese women diagnosed with polycystic ovary syndrome. In the methodology, the study employed a randomized controlled trial which involved 44 participants. The women, aged between 18 and 40 years, had all been diagnosed with polycystic ovary syndrome and had a body mass index exceeding 25 kg/m. They were randomly divided, with one group consuming 45 ml/day of concentrated pomegranate juice and the other group receiving no intervention. A variety of biomarkers for sex hormones, inflammation, and oxidative stress were measured before starting the trial and again after eight weeks. Further discussion of the results revealed a significant decrease in testosterone levels among the overweight and obese women with polycystic ovary syndrome who took concentrated pomegranate juice over the eight week period, in contrast to those in the control group. Apart from testosterone, no significant changes were observed for luteinizing hormone, sex hormone-binding globulin levels or for markers of inflammation and oxidative stress between the two groups.

A Review Article published in 2023 in the journal Frontiers in Aging Neuroscience found that Honey exhibits multifaceted benefits for brain health, acting as a memory booster, neuroprotective agent, anti-stress, and anti-nociceptive substance, fostering potential therapeutic applications to enhance overall cognitive well-being. This review scrutinizes 34 original articles exploring the impact of honey on brain health. Honey, traditionally known as a natural sweetener, emerges as a versatile substance with applications in nutrition, health supplementation, and brain health enhancement. The analysis identifies four key benefits: memory enhancement, neuroprotection, stress reduction, and pain alleviation. The review emphasizes the growing interest in understanding the mechanisms that underlie these effects, paving the way for potential therapeutic roles of honey in promoting cognitive well-being. The literature review underscores the significant role of honey in brain health research, shedding light on its diverse benefits, including memory improvement, neuroprotection, stress mitigation, and pain relief. The emphasis on unraveling the underlying mechanisms reflects a broader interest in establishing honey's therapeutic potential for enhancing overall brain health. This comprehensive exploration of honey's effects on cognition opens avenues for developing novel therapeutic strategies harnessing honey's natural properties.

A Network Pharmacology published in 2023 in the journal TMR Pharmacology Research found that Chrysanthemum has several active ingredients that can potentially treat dry eye by inhibiting inflammation-related factors and pathways, thus reducing inflammation of lacrimal gland tissue. The study used network pharmacology methods and various databases to further analyze the mechanism of Chrysanthemum in treating dry eye. First, the TCMSP was used to screen for candidate active ingredient molecules of chrysanthemum showcasing requisite oral bioavailability and drug similarity. The active ingredients of chrysanthemum were then identified, followed by target prediction. Cytoscape was used to construct a compound-target network for chrysanthemum. The Online Mendelian Inheritance in Man and DisGeNET databases were utilized to pinpoint pathogenic genes associated with dry eye, and the STRING database produced an interaction network and bar graph to scrutinize protein interactions. Using Venny, a final drug-active ingredient-key target-disease network was created. The study found that Chrysanthemum has eighty active ingredients corresponding to targets for treating dry eye. These key functional targets primarily regulate gene expression, oxidative stress, immune response, apoptosis, proliferation, regulation of cellular inflammation-related factors, and angiogenesis. The primary pathways associated with these key targets include interleukin signaling, metabolism, cytokine signaling in the immune system, immune system, and signal transduction, thereby improving the condition of dry eye primarily through the inhibition of inflammation-related factors.

A Review Article published in 2023 in the journal Phytomedicine found that Pomegranate and its active components can protect against natural and chemical toxic agents, impacting mechanisms such as oxidative stress, inflammation, apoptosis, and liver or cardiac function regulation. This paper is a review of various in vivo and in vitro studies focusing on pomegranate (Punica granatum) and its active components, including ellagic acid and punicalagin, and their protective effects against toxic substances. The articles were sourced from multiple databases like Web of Sciences, Google Scholar, PubMed, and Scopus spanning all available time periods until the end of September 2022. The research indicates that pomegranate and its constituents have showcased protective effects against both natural toxins, such as aflatoxins and endotoxins, and chemical toxicants like arsenic, diazinon, and carbon tetrachloride. This protection is attributed to the preventive mechanisms activated against oxidative stress, reduction of key inflammatory mediators, modulation of apoptosis, and signaling pathways associated with cellular growth. Additionally, these components appear to aid in the improvement of liver and cardiac function through the regulation of key enzymes.

A Experimental Study published in 2022 in the journal The Anatomical Record found that Pomegranate has been found to alleviate morphological and functional changes in the thyroid glands induced by Lithium Carbonate by controlling apoptosis and oxidative stress. The study divided rats into four groups: control, lithium, lithium-pomegranate, and pomegranate. For eight weeks, the rats were treated according to their respective group assignments. Following this period, they were sacrificed, and an array of assessments were conducted on the extracted thyroid glands. These evaluations included estimated levels of thyroid hormones and markers indicating oxidative stress, along with histological, immunohistochemical, and ultrastructural evaluations of the thyroid tissues. Observations in the group treated with lithium carbonate showed significant changes in thyroid hormone levels along with an increased expression of the oxidant marker and decreased expression of the antioxidant marker. Additionally, histological evaluation highlighted disorganization and follicle involution, a decline in both staining intensity and immunoreactivity of an antioxidant enzyme, an increase in collagen fiber content and Bax immunoreactivity, and marked distortions in follicular ultrastructure. However, in the group treated with both lithium carbonate and pomegranate, most of these changes were substantially mitigated, thereby indicating the potential protective role of pomegranate against lithium-induced alterations.

A Network Pharmacology published in 2022 in the journal Combinatorial Chemistry & High Throughput Screening found that The Chinese medicine formulas Zuo Gui Wan and You Gui Wan have the potential to treat premature ovarian failure through different pharmacological pathways. This study used a public database to identify the active ingredients and potential targets of the Zuo Gui Wan and You Gui Wan compounds. These were analyzed in relation to premature ovarian failure (POF) related genes obtained from OMIM and GeneCards. A protein-protein interaction network was established using STRING, and a drug-active ingredient-target gene network was constructed. The study thus identified similarities and differences in potential targets, active ingredients, and enriched pathways between the two compounds. Analyzing the drug-target-pathway network revealed that both compounds contain multiple common active ingredients, as well as unique components, and share several targets in the treatment of POF, showing similar core mechanisms of action. However, each compound also targets some unique pathways, which indicates their differential approaches to POF treatment.

A Network Pharmacology published in 2022 in the journal Antioxidants found that Kelulut honey, either alone or in combination with metformin or clomiphene, can alleviate oxidative stress and reproductive and metabolic abnormalities in rats with polycystic ovary syndrome. To examine the effects of Kelulut honey (KH), metformin, and clomiphene on polycystic ovary syndrome (PCOS), female Sprague-Dawley rats were treated with letrozole to stimulate symptoms of PCOS. The rats were then split up into six groups, each group undergoing a different kind of treatment for a period of 35 days, including KH alone, metformin alone, clomiphene alone, KH combined with metformin, and KH combined with clomiphene. The physicochemical characteristics of the honey were assessed using several tests, and its semi-volatile organic compounds were determined via gas chromatography-mass spectrometry. KH and its combinations with either metformin or clomiphene were found to improve the hormonal profile and ease oxidative stress in the rats. However, while the treatments seemed to improve the oestrus cycle, they reportedly did not affect fasting blood glucose, insulin levels, or body weight in the test subjects.

A Systematic Review published in 2022 in the journal Complementary Therapies in Medicine found that Meta-analysis revealed that lavender, particularly L. angustifolia, significantly reduces stress, making it a potentially valuable component in stress management programs. Results found that lavender significantly reduced stress levels, with a decrease in the intervention group compared to the control group. Subgroup analysis revealed that L. angustifolia species, aromatherapy as a delivery method, and student populations showed the most significant stress reduction effects.

A Systematic Review published in 2022 in the journal Advances in Nutrition found that Prunes demonstrate potential as a dietary intervention to protect against, prevent and even reverse bone loss in osteoporosis, particularly in postmenopausal women. Using sixteen preclinical trials with in vivo rodent models of osteopenia or osteoporosis, researchers investigated the effect of dietary supplementation with prunes. The research shows prunes' osteoprotective capabilities, preventing, reversing bone loss, and exerting anti-inflammatory and antioxidant effects. The prunes or their polyphenol extracts showed properties that decreased malondialdehyde and NO secretion and increased antioxidant enzyme expression. Two clinical trials further investigated prune consumption (50-100 g/d for 6-12 months) on bone health in postmenopausal women. The results of the studies revealed the promising outcome of improved bone mineral density and bone biomarker due to the consumption of dried plums. However, the effect of prunes on oxidative stress and inflammatory mediators remains less understood. The study hence emphasizes the need to investigate prunes' role in modulating the inflammatory and immune pathways related to bone health.

A Experimental Study published in 2022 in the journal BMC Complementary Medicine and Therapies found that Chrysanthemum extract has protective effects on light-damaged retinas, reducing oxidative stress and improving cellular viability. The experiment incorporated both in-vitro and in-vivo tests. In the lab, ARPE-19 cells were divided into four groups (control, light-damaged, low-dose extract, high-dose extract), treated with varying levels of chrysanthemum extract, and then exposed to light. Cellular viability and reactive oxygen species production were then observed. A similar grouping approach was used with C57BL/6J mice, where chrysanthemum extract concentration was administered before light exposure. The retinas were evaluated for function, morphology, and apoptosis post-exposure. Light-damage caused a decrease in cellular viability and an increase in reactive oxygen species production. However, treatment with chrysanthemum extract showed improvement in viability and reduction in reactive oxygen species. In mice, light damage caused dysfunction in the retinas, destruction of morphology and increased apoptosis, particularly in the retinal pigment epithelium and photoreceptor layer. Again, chrysanthemum extract treatment improved retinal function, maintained retinal structures, and reduced apoptosis. The extract achieved this by increasing concentration of anti-oxidative enzymes.

A Systematic Review published in 2022 in the journal International Journal of Environmental Research and Public Health found that Dietary strategies, such as caloric restriction and ketogenic diets, can alleviate chronic pain and enhance quality of life. This systematic review selected 16 articles from various databases including PubMed, Web of Sciences, ProQuest, and Scopus that were published within the last 6 years. These consisted of randomized clinical trials (RCTs), observational studies, and systematic reviews evaluating the effectiveness of different dietary strategies in the treatment of chronic pain. A range of assessment scales—PEDro, PVI, QUALSYT and the Quality Assessment Tool of Systematic Reviews scale— were utilized to gauge the risk of bias in these studies. The findings indicate an inconclusive consensus on the impact of an intermittent fasting (IF) diet on pain improvement. However, a caloric restriction diet emerged as a potential long-term treatment option for pain. Additionally, time-restricted food and ketogenic diets showed promising results in improving life quality in chronic conditions. Despite some studies indicating opposite results, the majority of the selected articles exhibited good methodological quality on their respective assessment scales.

A Review Article published in 2022 in the journal Molecules found that Cherries and blueberries, rich in phenolic compounds, can be effectively used in pharmaceutical products, smart foods, functional beverages, and nutraceuticals to prevent or treat diseases. The research primarily studied the health-promoting potential of cherries and blueberries, given their high nutritional density and substantial phenolic compounds. The focus was on their ability to counteract oxidative stress markers and suppress pro-inflammatory responses, which are significant factors in chronic diseases such as diabetes. The researchers analyzed these fruits for their potential incorporation into various products such as pharmaceutical preparations, smart foods, functional beverages, and nutraceuticals. In the discussion of the results, it was emphasized how cherries and blueberries exhibit significant biological potential. They were not only seen as effective in combatting oxidative stress and inflammation but also as potential immune boosters. The conclusions underscored the fruits' potential role as functional foods and their relevance to the burgeoning popularity of functional beverages, hinting at their promise for inclusion in a variety of health-related products.

A Animal Study published in 2022 in the journal Cytokine found that Walnut seed skin extract demonstrates potential hepato-renal protective effects, inhibiting inflammatory responses, oxidative stress and apoptosis, in kidney-damaged Sprague-Dawley rats. In the methodology, Sprague-Dawley rats in acute kidney injury state were divided into three groups: a healthy control, a group induced with renal ischemia/reperfusion (IR), and another group induced with renal IR and treated with walnut seed skin (WSS) extract. Blood, liver and kidney tissues were collected for serum evaluations of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, urea, and creatinine. Histopathological studies were performed on liver and kidney tissues, and gene markers related to anti-oxidant, anti-inflammatory, and apoptotic effects were measured. The results showed an improvement in deteriorated serum parameters in rats with renal ischemia pre-treated with WSS extract. Histopathological analysis revealed a protective effect of WSS on kidney and liver tissues. Though gene expression studies yielded diverse results for liver and kidney tissues, the consensus was that WSS had a pronounced protective impact on the liver. It was inferred that WSS's healing potential in renal and hepatic tissues seems to work via inhibiting inflammatory response, oxidative stress, and apoptosis.

A Randomised Controlled Trial published in 2022 in the journal Explore: The Journal of Science & Healing found that Inhalation aromatherapy using lavender and chamomile essential oils effectively reduces depression, anxiety, and stress levels in community-dwelling older adults. From a methodological perspective, the researchers adopted a three-armed, parallel, randomized, and controlled trial design. A total of 183 participants were enrolled in the study and were randomly divided into three groups: lavender, chamomile, and control group with equal numbers in each. The individuals in the experimental groups were given three drops of 1.5% lavender and chamomile essential oils to inhale for 30 consecutive nights, while the control group inhaled distilled water in the same manner. The Depression, Anxiety, and Stress-Scale (DASS) was utilized to collect data both prior to the intervention, directly following the intervention, and a month after the treatment. In terms of the results gathered, there was significant improvement in the depression, anxiety, and stress levels of individuals in the lavender and chamomile groups both immediately and one month after the treatment compared to the control group. This indicates that inhalation aromatherapy utilizing lavender and chamomile essential oils can be efficacious in reducing mental health issues among older adults residing in the community.

A Experimental Study published in 2022 in the journal Journal of Food Biochemistry found that Coconut water and coconut milk ameliorate the negative impacts of heat stress on gastrointestinal health by reducing oxidative stress and suppressing inflammatory responses. The study enlisted four different temperature exposure groups of rats, namely a control group at 30 degrees Celsius, a heat-stressed group exposed to an ambiance of 40 degrees, a heat-stressed group pre-treated with coconut water, and a heat-stressed group with coconut milk. Measurements such as skin and rectal temperatures, as well as evaluations of gastrointestinal motility factors such as intestinal transit, intestinal fluid accumulation, and colonic motility, were taken before and after a two-hour heat exposure over 14 days. Noticeable increases in gastrointestinal motility factors were observed amongst the heat-stressed rats. However, the introduction of coconut milk and water appeared to reverse these increases. Furthermore, the elevated cortisol levels and intestinal lipid peroxidation in the heat-stressed rats were significantly reduced with the introduction of both coconut products. Likewise, results showed an increase in antioxidant enzyme activities in the rats that received either coconut water or milk, in contrast to the control group. Similarly, the coconut water and milk were seen to suppress inflammatory cytokines while enhancing others. The study also noted significant improvements in intestinal morphology among heat-stressed rats treated with either coconut product.

A Review Article published in 2022 in the journal Nutrients found that Apple juice consumed in moderation has been found to positively impact markers of cardiovascular health, potentially influencing risk of cancer and neurodegenerative diseases. The methodology of this review involved examining 67 studies focused on the health implications of apple juice consumption, with special attention given to 20 interventional studies conducted on humans. The bulk of the examined studies looked at potential effects relating to oxidative stress markers, with some also looking at effects on inflammatory markers, lipid profile, and diabetes markers. The analysis of the results highlighted a noticeable association between the consumption of cloudy apple juice and markers revealing good cardiovascular health. The positive effects were especially significant in relation to oxidative stress. In addition, apple juice also exhibited beneficial influence on other health indicators like inflammation, lipid profile, and diabetes.

A Animal Study published in 2022 in the journal Plants found that The traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus. This study experimentally examined the antidepressant impacts of Gan-Mai-Da-Zao (GMDZ), a Chinese traditional medicine that contains blighted wheat, licorice, and jujube. The researchers used an unpredictable chronic mild stress model in rats, some of whom received an injection with p-chlorophenylalanine to generate a chemical model for depression. The investigators employed behavioral tests, including forced swim tests, open field tests, and sucrose preference tests, to evaluate the chronic influence of GMDZ. The oral application of GMDZ over 21 days considerably eased depressive behaviors in rats induced by either the unpredictable chronic mild stress or p-chlorophenylalanine. The treatment increased the expression of the serotonin transporter and brain-derived neurotrophic factor in the hippocampus in the rats with depression. However, rats provided with a similar herbal mixture that did not include licorice showed a significantly worse response, suggesting that licorice may play an essential role in the efficacy of GMDZ in combatting depression-like behaviors.

A Review Article published in 2022 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture can regulate both innate and adaptive immunity of IBD patients, including the balance of Th17/Treg and Th1/Th2 cells, and also modulate intestinal flora. The methodology of the research revolved around a review of existing studies related to the treatment of Inflammatory Bowel Disease (IBD) via acupuncture. The broad scope of exploration focused on the effects of acupuncture on the immunomodulatory mechanism inherent in these patients. The review pursued a detailed study of how acupuncture directly influenced both the innate and adaptive immunity systems in IBD patients as well as its regulation on their intestinal flora. The results discussion revealed that acupuncture had multiple immunomodulatory effects on IBD patients. On one hand, it influenced their innate immunity by regulating elements such as their intestinal epithelial barriers, toll-like receptors, NLRP3 inflammasomes, oxidative stress, and endoplasmic reticulum stress. On the other hand, it affected their adaptive immunity by modulating the balance of Th17/Treg and Th1/Th2 cells. Furthermore, an interesting revelation from the study was that acupuncture could also significantly regulate the intestinal flora of the patients.

A Review Article published in 2022 in the journal Critical Reviews in Food Science and Nutrition found that Goji berries, notably their polysaccharides, exhibit protective effects against inflammatory bowel disease through the preservation of healthy gut microbiota. The review encompassed an in-depth analysis of current literature specially focusing on the role of goji berry and its important functional constituents in countering Inflammatory Bowel Disease (IBD). The core attentiveness of the research is directed towards understanding the interplay between goji berries, particularly their polysaccharides, and gut microbiota. The goji berries’ protective effects were evaluated, focusing on how they curb disruption in gut microbiota, a common facet in IBD. The review concluded that goji berries, especially their polysaccharides, demonstrated appreciable benefits in averting gut microbiota disturbances seen with IBD, thus protecting against this condition. These natural substances, present in goji berries, function as prebiotics, which maintain a balanced gut microbial ecosystem. The research further revealed that proper functioning of gut microbiota and their metabolites was a crucial element in mediating these beneficial effects against IBD, thus cementing the role of dietary interventions in managing diseases linked with gut health.

A Clinical Study published in 2022 in the journal BMC Palliative Care found that Consuming chocolate with higher cocoa content can improve the nutritional status and functionality of older cancer patients in palliative care. In the conducted study, 46 older cancer patients under palliative care were divided into three groups. The control group did not have a change in their diet (CG, 15 patients). The other two groups were given intervention foods—55% cocoa chocolate (IG1, 16 patients) and white chocolate (IG2, 15 patients)—for a duration of four weeks. The primary outcome was assessed based on changes in the patients' nutritional status, as measured by the Mini Nutritional Assessment tool. Other factors examined included food consumption, body measurements, body composition, laboratory parameters, and quality of life, using the European Organization for the Research and Treatment of Cancer instrument. Discussion of the results revealed that the group consuming 55% cocoa chocolate showed an improvement in nutritional scores and functionality, as evidenced by the Mini Nutritional Assessment and the quality of life scores respectively. On the other hand, the group consuming white chocolate displayed decreased oxidative stress levels. However, body composition and anthropometric measurements remained largely unchanged across all three groups.

A Systematic Review published in 2021 in the journal Health Promotion Perspectives found that Pomegranate has been confirmed to improve clinical features and reduce inflammatory, oxidative stress, and apoptosis markers in osteoarthritis. In the methodology, a systematic review was conducted using established databases like Scopus, PubMed, Embase, WOS, ProQuest, and Google Scholar up until February 2021. Both MESH and non-MESH keyword searches were performed in the title, abstract, and keywords. The review considered full-text clinical, animal, and in vitro studies in all languages and specifically excluded review articles, book chapters, conference abstracts, and research related to pomegranate in health problems other than osteoarthritis. A manual search was performed to examine the references or citations of eligible papers as well as grey literature to discover potential researches. The results of the systematic review included twenty-three articles which all showed the beneficial impact of pomegranate across human, animal, and in vitro studies. These showed improvements in clinical presentations and reductions in inflammatory, oxidative stress, and apoptosis markers in osteoarthritis. This demonstrated the therapeutic potential of pomegranate for easing the effects of osteoarthritis.

A Review Article published in 2021 in the journal Frontiers in Pharmacology found that Chinese herbal medicines could alleviate chronic kidney disease symptoms by combating fibrosis, inflammation, oxidative stress, and encouraging repair and regeneration. The study's methodology consisted of both clinical and experimental approaches. It started with an examination of an array of traditional Chinese herbs. The criteria for considered herbs were their clinical efficacy, frequency of use in treating chronic renal disease, and a well-studied mechanism of action. Five herbs, namely, Tanshinone II A, Salvianolic acid A & B, Triptolide, Tripterygium glycosides and a monomer from Kudzu root, made the cut after having met the set criteria. The results showed that these Chinese herbs were found to possess pharmaceutical properties that were effective against fibrosis, inflammation, and oxidative stress. Furthermore, these also showed the potential to promote renal repair and regeneration, which are fundamental for treating chronic kidney disease. These findings suggest a broader scope of therapeutic treatments that could benefit the patients in a more natural and potentially less invasive way.

A Randomised Controlled Trial published in 2021 in the journal Journal of Trauma Nursing found that Auricular acupressure may be a safe and effective technique for reducing burnout and secondary traumatic stress in healthcare workers. In this prospective randomized trial with an open, parallel-group design, participants were randomized to receive one of three interventions: auricular acupuncture, auricular seed acupressure, or auricular massage. Interventions took place over a period of 3 weeks at a 334-bed Level II pediatric trauma center. Using a pre-/posttest design, the researchers analyzed self-reported scores from the State-Trait Anxiety Inventory, the Professional Quality of Life scale, and the Caring Ability Inventory. The study found that auricular seed acupressure was associated with a reduction in burnout and secondary traumatic stress. Importantly, this effect remained even after adjusting for individual pretest scores. Attempts at achieving significant effects on anxiety levels, professional quality of life, and caring ability, however, did not yield any significant improvement. Overall, the data suggest that auricular acupressure is a very effective strategy for reducing work-related stress among health care staff.

A Systematic Review published in 2021 in the journal Antioxidants found that Green tea supplementation improves total antioxidant capacity and impacts oxidative stress based on dose levels in adults. The research's methodology involved a systematic search of research materials published in English language up to 21 August 2021. Recognized online databases such as Scopus, PubMed, Embase, and ISI Web of Science were utilized with the appropriate keywords. The study focused on randomized controlled trials that evaluated green tea supplementation, and its relationship with malondialdehyde and total antioxidant capacity in adults. A random-effects model quantified the difference, and the researchers carried out meta-regression and non-linear dose-response analyses to investigate the association between the quantity of green tea consumed and the duration of the intervention. The research analysed the results obtained from sixteen randomized controlled trials, which amount to seventeen study arms comprising a total of 760 participants. The study found that green tea supplementation did have significant effects on total antioxidant capacity, and these effects were chiefly linked to gender and body mass index. However, the results showed that these effects were not significant in cases of low-dose supplementation and obese individuals. On the other hand, no relationship was found between malondialdehyde and green tea supplementation in any subgroup. Nonetheless, meta-regression analyses indicated an inverse linear connection between the change in MDA and the dosage of green tea.

A Experimental Study published in 2021 in the journal Nutrients found that Tiger nut and walnut supplementation in diets can improve testosterone levels and help control vasoconstriction, potentially benefiting hypertensive individuals. Rats were used in the experiment, placed into seven distinct groups with various diet and medicinal intake combinations including basal diet controls, supplemented processed and raw tiger nut (TN) and walnut (WN) diets, and more. Before hypertension was induced with L-NAME, the rats were given their regular diet for two weeks. After this period, they began receiving L-NAME for ten subsequent days. The scientists then measured the impacts on the rats' platelet androgen levels, ectonucleotidases, and adenosine deaminase (ADA). The L-NAME treatment resulted in a considerable decline in testosterone levels in the rats. However, the groups that were fed diets supplemented with TN and WN exhibited improved testosterone levels compared to the control group, yet their luteinizing hormone levels remained unchanged. The L-NAME-treated group also saw an increase in ATP hydrolysis and ADA activity, alongside a reduction in ADP and AMP hydrolysis. These effects were substantially reversed in the groups that were fed supplemented TN and WN diets. This suggests that TN and WN could enhance testosterone levels and modulate the purinergic system in platelets, which might be a potential mechanism through which they contribute to the control of vasoconstriction.

A Review Article published in 2021 in the journal Critical Reviews in Food Science and Nutrition found that Green tea and its component EGCG, demonstrate potential as a treatment for endometriosis by inhibiting growth, invasion, adhesion and angiogenesis. The main research methodology of this work is a narrative review. The paper comprehensively collects and reviews various preclinical studies that propose the use of green tea as a potential treatment for endometriosis. These studies explore the diverse biological properties and activities of green tea and its major bioactive component, (-)-epigallocatechin gallate, including anti-angiogenic, anti-proliferation, anti-metastasis, and apoptosis induction functions. Different potential mechanisms used by green tea to inhibit the growth of endometriosis are considered, such as its effects on inflammation, oxidative stress, invasion, adhesion, and apoptosis. The discussion of the reviewed data highlights the potential therapeutic effects of green tea acting on different molecular and cellular mechanisms in endometriosis. The researchers keenly discussed how green tea exhibited an inhibitory effect on the disease through multiple avenues, including reducing inflammation and oxidative stress, preventing tumor invasion and adhesion, promoting apoptosis (cell death), and limiting angiogenesis (the development of new blood vessels) - all these factors contribute to the growth and progression of endometriosis. The discussion elaborates on the significant roles and wider implications of these processes in understanding and potentially treating endometriosis.

A Review Article published in 2021 in the journal Critical Reviews in Food Science and Nutrition found that Coffee consumption may contribute to the prevention of several inflammatory diseases and types of cancer, with reduced mortality risk deemed safe up to 400mg of caffeine per day. The methodology used in this scholarly review was based on an extensive literature review using the PubMed/Medline database. As the primary research tool, this database facilitated the authors' collation and analysis of relevant studies concerning the impact of coffee consumption on health outcomes. The focus was to determine both the positive and negative aspects of coffee consumption, with an additional aim of providing dosage recommendations. The data collated from these studies was then summarised and analysed through a narrative approach, making the findings more digestible and interpretable. The findings suggested that coffee consumption may play a significant role in preventing inflammatory and oxidative stress-related diseases such as obesity, metabolic syndrome and type 2 diabetes. In addition, findings indicated that coffee consumption also seemed to have an association with a lower incidence of several types of cancer and a reduction in the risk of all-cause mortality. However, notable is the need for a time gap between coffee consumption and the intake of some drugs to avoid potential interactions. It was also concluded that the consumption of up to 400mg/day of caffeine was generally found to be safe for the average person.

A Experimental Study published in 2021 in the journal Journal of Neurochemistry found that Zeaxanthin dipalmitate, a wolfberry-derived carotenoid, can delay retinal degeneration in mice modelling Retinitis Pigmentosa mainly through its anti-inflammatory and oxidative stress effects. In the study's methodology, Zeaxanthin dipalmitate (ZD) was intravitreally injected into mice on postnatal day 16. Subsequent assessment of retinal function and structure were made at P25 using visual behavior tests, multi-electrode-array recordings, and immunostaining. The involved gene expressions and their regulation by ZD were delved into through transcriptome sequencing and western blotting. In the discussion of results, it was discovered that ZD treatment significantly improved the visual behavior of the mice and delayed degeneration of the retinal photoreceptors, enhancing the light responses of photoreceptors, bipolar cells, and retinal ganglion cells. The ZD treatment led to a decline of up-regulated genes connected to inflammation, apoptosis, and oxidative stress. The study found that ZD reduces the activation of signal transducer and activator of transcription 3 and chemokine ligand 2, down-regulates the expression of the inflammatory factor GFAP, and withholds extracellular signal regulated protein kinases and P38, but not JNK pathways. All these findings indicate the potential of ZD as treatment for Retinitis Pigmentosa.

A Animal Study published in 2021 in the journal Oxidative Medicine and Cellular Longevity found that Pumpkin extract exhibits potential antidepressant effects similar to fluoxetine and ameliorates biochemical and structural changes in rat brains resulting from chronic stress. The researchers used forty male albino rats, split into four different groups: a negative control group, a chronic unpredictable mild stress (CUMS) group, a fluoxetine-treated group, and a pumpkin-treated group. These rats were exposed to CUMS for 28 days, with the treatments applied during the last 14 days of this exposure period. After these 28 days, the scientists evaluated the behavioral, biochemical, and histopathological alterations in these rats. The application of pumpkin extract significantly reduced markers of stress and inflammation, while increasing antioxidant levels. Additionally, the extract helped reduce structural damage in the hippocampal region of the brain caused by exposure to CUMS. These effects were comparable to those observed by administering fluoxetine, a conventional antidepressant.

A Review Article published in 2021 in the journal Clinical Ophthalmology found that Curcumin, with its anti-inflammatory, antioxidant, antimicrobial and antimutagenic properties, is a potential therapeutic agent for retinal diseases. This review paper uses various pieces of research from the literature to detail the characteristics of curcumin, a molecule produced by plants. The paper particularly focuses on the beneficial and controversial aspects of curcumin. It talks about the retina's susceptibility to oxidative stress due to its cell composition and constant exposure to photons, highlighting that retinal ganglion cells and photoreceptors are particularly sensitive to oxidative damage. The paper also points to studies that link an imbalance in reactive oxygen species to a wide range of retinal diseases. In the discussion of results, it is stated that a number of studies suggest that curcumin can be well tolerated by humans when taken orally and does not tend to have negative effects, making it a promising candidate for retinal disease treatment. However, a primary limitation is curcumin's poor bioavailability; the body can only absorb a small fraction of the substance as an active compound. Despite that, efforts have been made to improve curcumin's accessibility to target tissues in sufficient quantities.

A Experimental Study published in 2021 in the journal Journal of Ethnopharmacology found that Fructus Lycii and Salvia miltiorrhiza Bunge extract improve retinal morphology and function by regulating the Nrf2/HO-1 pathway to curb oxidative reactions. In terms of methodology, Fructus Lycii and Salvia miltiorrhiza Bunge (FS) extracts were identified through Ultra Performance Liquid Chromatography analysis and administered intragastrically over four weeks to Rd10 mice, known to model retinitis pigmentosa. Following the animals' sacrifice, histopathological examination and Scotopic electroretinography analysis were performed. Oxidative stress markers were determined and the expression levels of Nrf2 and HO-1 mRNA were evaluated via quantitative real-time PCR. Western blot and immunohistochemistry were employed to identify the expression and distribution of Nrf2 and HO-1 protein. In the discussion of the results, substantial morphological improvements were observed regarding the thickness and number of the Outer Nuclear Layer, along with significant functional enhancements in a-amplitude and b-wave amplitude measurements, following FS extract treatment. In addition, the treatment led to a considerable escalation in superoxide dismutase and glutathione peroxidase levels and a reduction in malondialdehyde levels. Furthermore, FS extract was found to stimulate the up-regulation of Nrf2 and HO-1 mRNA and protein expression, possibly underlying the observed retinal enhancements.

A Randomised Controlled Trial published in 2021 in the journal Advances in Integrative Medicine found that Pomegranate peel extract supplementation can decrease total cholesterol and triglyceride levels while boosting antioxidant status in obese women with knee osteoarthritis. The research was a randomized, double-blind placebo-controlled trial involving 66 obese women aged 38 to 60 years old with knee osteoarthritis. These participants were split into two groups, the intervention group and control group, each containing 33 members. The intervention group received pomegranate peel extract capsules (500 mg) twice daily for 8 weeks including standard drug therapy while the control group was given a placebo during the same period. All participants' fasting blood samples, anthropometric measurements, dietary intake data, and physical activity levels were collected both before the start and at the end of the trial. Results analysis showed that pomegranate peel extract supplementation brought down levels of serum total cholesterol, triglyceride and an oxidative stress marker while enhancing levels of some antioxidant enzymes and the overall antioxidant capacity when compared to the control group. However, there were no noticeable alterations between the two groups in terms of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and body mass index by the end of the experiment.

A Randomised Controlled Trial published in 2021 in the journal Journal of Complementary and Integrative Medicine found that Avocado/soy unsaponifiables effectively treat osteoarthritis by controlling the balance between oxidant and antioxidant molecular markers. The methodology used in this study was a double-blind, randomized, placebo-controlled, cross-over trial. Forty osteoarthritis patients were classified into two groups: one received avocado/soy unsaponifiables (ASU) for three months followed by three months of placebo, and the other group received a placebo first for three months followed by three months of ASU. The patients' oxidant status was evaluated by measuring their serum malonldialdehyde (MDA). Other measures such as total antioxidant capacity, reduced glutathione, and antioxidant enzymes like superoxide dismutase and catalase were also assessed. After three months of treatment, all patients who were given avocado/soy unsaponifiables exhibited a significant decrease in their serum MDA levels, indicating lower oxidative stress. In comparison, these levels were higher at baseline and after placebo treatment. Furthermore, the treatment with avocado/soy unsaponifiables resulted in positive changes in the patients' antioxidant levels. Analysis also showed that the effect of avocado/soy unsaponifiables was consistent, regardless of the sequence in which the medication was received. These findings demonstrate that avocado/soy unsaponifiables can contribute effectively to the treatment of osteoarthritis by regulating the balance between oxidant and antioxidant molecular markers.

A Systematic Review published in 2021 in the journal Journal of Cosmetic Dermatology found that These results indicate that a certain concentration of snow fungus polysaccharides can effectively alleviate skin damage caused by UVA, and they may be used as an effective component of cosmetics. Tremella fuciformis polysaccharides (TFPS) pretreatment can reduce the oxidative stress of UVA-treated human dermal fibroblasts cells. After TFPS pretreatment, the content of ROS and MDA in the cell decreased significantly and the total antioxidant activity was increased. Among them, the active of CAT, SOD, and GSH-Px in the cells increased significantly. TFPS can also protect fibroblasts by up-regulating Nrf2 and down-regulating Keap1 expression. Finally, it was also found that TFPS pretreatment increased the content of collagen I, elastin, and hyaluronic acid (HA) in skin fibroblasts treated with UVA.

A Experimental Study published in 2021 in the journal Frontiers in Pharmacology found that The Jian-Pi-Yi-Shen (JPYS) traditional Chinese medicine formula aids in the alleviation of renal dysfunction and fibrosis in chronic kidney disease (CKD) rats by combating inflammation and cellular apoptosis. Using an established model of 5/6 nephrectomized (5/6Nx) rats, an evaluation of the effects of the JPYS formula on renal function and fibrosis was conducted. To scrutinize the formula's impacts, markers of apoptosis, inflammation, oxidative stress, and the activity of Nrf2 signaling were measured. Correlative parameters including urinary protein, SCr, BUN, glomerular sclerosis index, tubulointerstitial fibrosis score, and renal histopathology were analyzed to assess the formula's preventive effect on renal dysfunction and fibrosis. The study also evaluated the gene expression associated with fibrosis and related elements such as TGF-β and various types of collagen. The evaluation of JPYS's efficacy revealed significant protection against cell apoptosis, highlighted by altered gene expression of Bcl-2, Bax, caspase 3, caspase 9, and the number of TUNEL-positive cells. Moreover, it was observed that the JPYS formula countered the activation of the NF-κB-mediated inflammatory pathway, exhibiting a decrease in gene expression of numerous inflammatory markers in the kidney. Alongside this, the formula promoted antioxidant performance, alleviating oxidative stress as indicated by antioxidant index indicators and a reduction in reactive oxygen species biomarkers. The study also identified the upswing of essential elements like HO-1 and Nrf2 level and a decline in Keap1 expression, signaling rationale towards the formula's potential relief of renal oxidative damage.

A Review Article published in 2021 in the journal Pharmacological Research found that Baicalin, a Scutellaria baicalensis extract, has been found to have numerous therapeutic applications in liver and gut diseases by mediating apoptosis and immune response pathways. High-throughput screening and bioinformatics technology were utilized in the extraction and study of baicalin from the dried root of Scutellaria baicalensis Georgi, an herb traditionally used in Chinese medicine. The research sought to understand the biological action of baicalin, particularly how it affects diseases related to the liver and gut. The effects were associated mainly with downstream apoptosis and immune response pathways, which are induced by upstream oxidative stress and inflammation. In the discussion of the resultant findings, it was identified that baicalin engages various key factors during oxidative stress regulation. These include PI3K/Akt/NRF2, Keap-1, NF-κB, and HO-1, contributing to the healing effects of baicalin on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, ulcerative colitis, and cholestasis. Further, it was discovered that baicalin plays a therapeutic role in regulating inflammatory response and apoptosis pathways. This ability aids in the alleviation of liver diseases and suppression of hepatocellular carcinoma. Baicalin was also found to regulate the intestinal flora by promoting the production of short-chain fatty acids, shedding new light on the full range of baicalin's pharmacological effects.

A Experimental Study published in 2021 in the journal Nutrients found that Extra virgin olive oil high in minor polar compounds significantly improves kidney function, reduces oxidative stress, inflammation, and ultimately benefits the body composition. The research study tested two distinct types of extra virgin olive oils, namely Synergy with a high content and Luxolio with a medium content of minor polar compounds, on 40 patients suffering from kidney disease. The patients were administered a 40 mL dosage per day over nine weeks. Researchers assessed the impacts on renal functionality, oxidative stress, inflammation levels, and body composition, before and after a subsequent two-month wash out period. Additionally, the concentration of minor polar compounds in the oils was determined through high-performance liquid chromatography accompanied by diode-array detection and mass spectrometry (HPLC-DAD-MS). The research showed improvements in kidney function indicators such as estimated glomerular filtration rate, albuminuria, azotemia, and uric acid. Further, the patients' lipid profile also improved, as did their inflammation parameters, erythrocyte sedimentation rate, C-reactive protein, and body composition. More notably, these beneficial effects were stronger and lasted longer in those patients who had been given the Synergy oil, indicating a sustained antioxidant and anti-inflammatory impact from EVOOs with higher concentrations of minor polar compounds.

A Experimental Study published in 2021 in the journal Frontiers in Nutrition found that Supplementation with standardized saffron extract improves depressive symptoms and social relationships in healthy individuals experiencing subclinical low mood and stress. The study employed a double-blind, randomized, parallel groups design involving 56 healthy male and female participants aged between 18 and 54. They received either 30 mg standardized saffron extract or a placebo daily for 8 weeks. The saffron's chronic effects on subjective feelings of anxiety, stress, and depression were evaluated using a series of questionnaires. The acute effects of saffron following exposure to a lab-based psychosocial stressor were determined through assessing psychological and physiological parameters. As part of the process, the level of crocetin, a compound found in saffron, was quantified in the participants' urine. The results indicated that individuals who received the saffron extract reported lower depression scores and improved social relationships after the 8-week period. A significant increase in urinary crocetin levels was observed with saffron supplementation, and these changes were found to be correlated with a decrease in depression scores. Additionally, the usual decrease in heart rate variability, a reaction commonly seen during the exposure to stressors, was found to be diminished after acute intake of saffron. The findings suggest that saffron extract can help improve subclinical depressive symptoms in healthy individuals and may increase resilience against the development of stress-related psychiatric disorders.

A Systematic Review published in 2021 in the journal European Journal of Obstetrics & Gynecology and Reproductive Biology found that Compared with rehabilitation exercise or medication, acupuncture intervention can help alleviate the symptoms of urinary incontinence in middle-aged and elderly women. A total of eight studies with 607 patients were included in the evaluation. The current meta-analysis showed that compared with rehabilitation exercise or medication, acupuncture intervention significantly improved the clinical effectiveness, reduced the urine leakage in pad test and decrease the ICIQ-SF score. The results indicated that acupuncture intervention can help the patients alleviate the symptoms effectively. Based on this study, acupuncture intervention of stress urinary incontinence in middle-aged and elderly women can improve the clinical effectiveness, reduce the urine leakage in pad test and ICIQ-SF score. More high-quality studies with large sample size are required for further verification.

A Experimental Study published in 2021 in the journal Antioxidants found that Pomegranate juice extract (PPJE) appears to reduce chemotherapy-induced skin side effects by inhibiting inflammation and promoting wound repair on the skin. In this study, the impact of pomegranate (L.) juice extract (PPJE) on skin cells treated with 5-Fluorouracil (5-FU), an antineoplastic agent, was evaluated. This involved assessing the extract's ability to inhibit the release of reactive oxygen species and enhance the cellular antioxidant response of the treated skin cells. Specific attention was given to observe the overexpression of cytoprotective enzymes such as heme oxygenase-1 and NAD(P)H dehydrogenase [quinone] 1 after the introduction of PPJE. The results indicated that PPJE indeed blocked the formation of nitrotyrosine and reduced the release of cytokines, therefore indicating a dampened inflammatory response. Furthermore, it was revealed that the extract could inhibit the nuclear translocation of p65-NF-κB, a key regulator of inflammation. The study also pointed out that PPJE could curb apoptosis in cells treated with 5-FU, whilst fostering wound repair. The overall findings suggest that PPJE holds potential as a supplementary agent for managing oxidative and inflammatory issues associated with chemotherapy-induced skin side effects.

A Systematic Review published in 2021 in the journal Physical Activity and Health found that All schools of Tai Chi chuan can improve the mental health of the elderly. Tai Chi's potential mechanisms include reducing anxiety, relieving depression and stress, enhancing pulmonary and cardiovascular function, enhancing immunity and improving quality of life.

A Experimental Study published in 2021 in the journal Gaceta Sanitaria found that Ginger honey supplementation does not reduce cortisol levels, however, it significantly increases glutathione and estrogen levels in test mice. The methodology involved an in vivo pretest-posttest control group design study conducted on 2-3 month old female Balb/c mice, selected due to not having experienced conception. These mice were split into a negative control and an intervention group, the latter receiving 28mg/20g body weight of ginger honey for 14 days. Prior to the supplementation, the mice were subjected to swimming-induced stress. Cortisol, glutathione, and estrogen levels were assessed using the ELISA testing method. In the discussion of results, the findings indicated that 14 days of ginger honey supplementation did not significantly affect cortisol levels in the female mice. Contrastingly, a considerable boost was observed in both glutathione and estrogen levels. This suggests a potential role for ginger honey supplements as complementary therapies, though not for the management of cortisol-related stress.

A Experimental Study published in 2021 in the journal Brazilian Archives of Biology and Technology found that Ginger supplementation can prevent ethanol-induced reproductive dysfunction by improving hormone levels, reducing oxidative damage, inflammation, and regulating genes involved in testosterone synthesis. The methodology involved twenty-four adult male rats divided into four groups for a 28-day experiment. The researchers administered either ethanol or ginger extract to respective groups and then measured varying physiological factors related to reproductive health such as testosterone levels, antioxidant enzyme activity, concentrations of tumor necrosis factor-alpha, and gonadotropins hormones. In addition, gene expressions related to oxidative damage, inflammation, and testosterone synthesis were also examined. Animating the discussion of results, it was observed that the administration of ethanol significantly decreased levels of hormones, oxidative markers, and lowered gene expression involved in testosterone synthesis. Conversely, ethanol caused an increase in inflammatory markers and the expression of genes related to inflammation. On the other hand, rats given a ginger supplement positively reversed these effects, showing significant improvements in all factors, thus leading to the conclusion that ginger can prevent reproductive issues induced by ethanol. The results obtained from the histological study further confirmed these findings, reaffirming that ginger could effectively counter ethanol-induced reproductive dysfunction.

A Experimental Study published in 2020 in the journal Experimental Eye Research found that Gypenosides, the main functional component from the vine Gynostemma pentaphyllum, display potential as a treatment for Retinitis Pigmentosa by protecting photoreceptor cells from degeneration. In this study, researchers used zebrafish carrying a specific mutation that leads to early retinal degeneration like in Retinitis Pigmentosa, a group of genetic retinal disorders. The mutation, present in the retinitis pigmentosa GTPase regulator interacting protein 1 gene, was exposed to Gypenosides. The substance was sourced from Gynostemma pentaphyllum, a climbing vine, and previously found to combat oxidative stress and inflammation in optic neuritis cells. The results suggest significant benefits from the application of Gypenosides to retinitis pigmentosa. Treatment of the mutated zebrafish resulted in a notable decrease in the death rate of photoreceptor cells. The reaction of antioxidant genes typically associated with oxidative stress was also significantly reduced. Furthermore, there were marked reductions in reactive oxygen species and malondialdehyde production, along with diminished expression of pro-inflammatory cytokines. Overall, the outcome indicates that Gypenosides effectively counteracted the harmful effects of the mutation, protecting the photoreceptors from degeneration.

A Review Article published in 2020 in the journal The Journal of Nutritional Biochemistry found that Catechin-rich green tea extract (GTE) exercised anti-inflammatory activities can be beneficial in managing Nonalcoholic fatty liver disease (NAFLD) by reducing liver injury and gut-derived endotoxins. The research is built around the study of the anti-inflammatory properties of catechin-rich green tea extract (GTE). The primary analytical interest is its effects on inflammatory responses that contribute to Nonalcoholic fatty liver disease (NAFLD), specifically nonalcoholic steatohepatitis (NASH). The extraction focuses on inhibiting the activation of the hepatic nuclear factor kappa-B, which is known to exacerbate liver injury. The results have shown positive contributions of GTE to management of NAFLD. Itn was observed that the extract limits the activation of the hepatic nuclear factor kappa-B and in turn, reduces NASH-associated liver injury. Additionally, green tea extract was found to contain hepatic-level benefits that attenuate intracellular redox distress and pro-inflammatory signaling. It was also found to improve the gut barrier function, limit the translocation of gut-derived endotoxins, and exercise prebiotic and antimicrobial effects on the gut microbial ecosystem. These results can potentially contribute to managing NAFLD-associated morbidity.

A Experimental Study published in 2020 in the journal Frontiers in Pharmacology found that Jujube seed extract has been found to primarily reduce anxiety by regulating the GABAergic and serotonergic synapse pathways, specifically modulating GABRA1, HTR1A, and HTR2A. The research relied on a system biology method supported by Ultra Performance Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry (UPLC-Q-TOF/MS) and Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR). Initially, 35 phytochemicals were identified from the Jujube seed extract, which related to 71 anxiolytic targets. Further investigations, including protein-protein interaction, gene cluster, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analyses, were conducted to identify the anxiolytic mechanisms of the extract. The results highlighted that the main anxiolytic mechanisms of the Jujube seed extract were linked to the regulation of serotonergic and GABAergic synapse pathways. The extract's impact on the mRNA expressions of multiple gamma-aminobutyric acid type A (GABA) and serotonin (5-HT) receptors subtypes was verified in human neuroblastoma cells. Surprisingly, the extract (250 μg/mL) not only amplified the mRNA level of GABRA1 and GABRA3 alongside HTR1A, HTR2A, and HTR2B in untreated cells but also suppressed the overexpressed mRNA of GABRA1, GABRA2, HTR1A, and HTR2A in stress-induced cells.

A Systematic Review published in 2020 in the journal Complementary Therapies in Medicine found that Cinnamon supplementation significantly decreases inflammation and oxidative stress levels, serving as a potential additive for cardiometabolic health improvement. The systematic review and meta-analysis followed the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines. A comprehensive search for appropriate clinical trials was performed across multiple databases including PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, Embase, and Google Scholar until January 2020. After duplicates were removed, 1145 studies were found eligible and 12 studies were finally included in the meta-analysis, investigating the impact of cinnamon supplementation dosages ranging between 1.5 to 4 grams per day. The results of the meta-analysis revealed that cinnamon supplementation led to a significant reduction in inflammation markers, C-reactive protein and interleukin-6, alongside a decrease in malondialdehyde, an oxidative stress marker. Concurrently, an increase was observed in the total antioxidant capacity following the supplementation, implying an enhancement in the body's defensive ability against oxidative damage. Nevertheless, no significant change was identified in the levels of intercellular adhesion molecule-1 after the cinnamon supplementation.

A Review Article published in 2020 in the journal The Journal of Nutritional Biochemistry found that Honey, with its variable composition based on botanical origin, exhibits antioxidant and anti-inflammatory properties, suggesting its potential efficacy in managing obesity-related dysfunctions, including neurodegeneration, through improved glycemic control and lipid profile. The review explores honey's therapeutic potential, emphasizing its diverse bioactive compounds. The focus is on its effects in combating obesity-related dysfunctions, supported by experimental evidence from animal studies. Experimental findings indicate that honey can enhance glycemic control and lipid profile, offering protection against endothelial dysfunction and neurodegeneration in obesity. The role of honey's key constituents, particularly polyphenols, is highlighted, underscoring the need for further human studies to confirm these health benefits.

A Systematic Review published in 2020 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture at Zusanli (ST36) might be effective in reducing injuries induced by sepsis in various organs by reducing oxidative stress and inflammation. The researchers conducted a systematic review of seven databases, covering the inception of each to May 2019. They identified 54 studies that used acupuncture at ST36, a specific acupuncture point, for treating experimental sepsis, drawing from both English and Chinese literature resources. The studies reviewed suggest that acupuncture could serve as a complementary strategy in treating sepsis by reducing damage in multiple body systems: cardiac, lung, kidney, liver, gastrointestinal tract, and the immune system. It's thought to achieve these results through several mechanisms: limiting oxidative stress, managing inflammation, improving microcirculation, and upholding immune balance with the help of dopamine. Worth noting, however, is that these positive findings must be carefully considered due to the methodological quality and potential publication bias of the included studies.

A Randomised Controlled Trial published in 2020 in the journal European Journal of Integrative Medicine found that Intranasal application of essential oils such as lavender and fennel (Pinetonina™) significantly lowers cortisol levels and improves sleep quality. The study included 45 participants divided into three groups: one group received a saline nasal spray (Group 1 CTRL), the second group received a 30% concentration of Pinetonina™ in a buffered vehicle as an intranasal spray (Group 2 P30), and the third group received a 50% concentration of the same (Group 3 P50). The sprays were used once daily before bedtime for three months. The study measured salivary cortisol levels both at the beginning and end of the trial and assessed subjects' quality of sleep, anxiety levels, perceived stress, and overall quality of life using self-reported questionnaires. The study found that the groups using the 30% and 50% Pinetonina™ solutions saw significant reductions in their cortisol levels after the three-month period. The subjects in the 50% Pinetonina™ group also reported a notable improvement in their quality of sleep. However, there were no significant differences among the groups' perceived stress levels and their overall quality of life. Nevertheless, the study concluded that nightly intranasal use of Pinetonina™ could effectively lower cortisol levels and enhance sleep quality.

A Randomised Controlled Trial published in 2020 in the journal Evidence-Based Complementary and Alternative Medicine found that Group acupuncture was noninferior to individual acupuncture for treating cancer pain and was superior in many health outcomes. Group acupuncture is more cost-effective for alleviating cancer pain and should be considered for implementation trials. Biweekly acupuncture therapy offered in the group setting for 6 weeks, delivered for half the cost of individual acupuncture, was as effective as individual acupuncture for reducing cancer-related pain interference and severity and was superior to individual acupuncture in improving sleep quality, fatigue, and psychological distress. Group acupuncture may be an effective treatment option for patients who may otherwise be unable to afford it due to relatively high costs and the lack of universal coverage for acupuncture treatment. Where possible, cancer centers and practitioners should consider offering acupuncture in group-based settings, rather than individually, for routine cancer pain treatments as a more cost-effective delivery model.

A Systematic Review published in 2020 in the journal Complementary Therapies in Medicine found that Cocoa consumption significantly reduces markers of oxidative stress in the adult population, affirming its important role in the human metabolic pathway. This study systematically reviewed interventional studies to determine the impact of cocoa consumption on oxidative stress markers in adults. Numerous databases, including PubMed, Cochrane's library, Science Direct, Scopus, Google scholar and ISI web of science, were searched for all relevant literature up until March 2019. The Jadad scale was utilized to grade the quality of each study. Out of 1402 studies, 48 met the inclusion criteria for the systematic review and 16 were selected for meta-analysis. The pooled data from the random-effect model provided evidence that cocoa consumption effectively lowered malondialdehyde and 8-iso-prostaglandin F2α, but no significant changes were noted in other markers of oxidative stress. The results underscored cocoa's essential function in the human metabolic process by its potential to decrease oxidative stress.

A Systematic Review published in 2020 in the journal Integrative Cancer Therapies found that Acupuncture has therapeutic potential in management of cancer-related fatigue for cancer survivors. Given that CRF is a debilitating symptom among cancer survivors that has proven complex to manage, it is important to explore a wide range of treatment options. The findings of this systematic review and meta-analysis suggest that acupuncture has clinical applications in the management of CRF in conjunction with standard care. Investigating the physiological mechanisms underlying the effects of acupuncture on CRF with biomarkers including cytokines will provide important insights into future clinical applications. Acupuncture for cancer survivors with fatigue, particularly those receiving chemotherapy and radiation therapy that induce fatigue, can have a beneficial effect on fatigue and overall quality of life, when used as an adjunctive intervention to conventional cancer care. Therefore, it is recommended that acupuncture be incorporated into guidelines for the management of CRF in order to improve patient care.

A Systematic Review published in 2019 in the journal Food Reviews International found that Sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants. Meta-analyses revealed that sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants. However, no significant effect was observed on malondialdehyde (MDA), total antioxidant capacity and α-tocopherol levels. It was shown that MDA levels significantly decreases only when sesame seeds were used for supplementation. Sesame consumption is associated with improved oxidative status. High quality randomized controlled clinical trials from diverse regions are still needed.

A Review Article published in 2019 in the journal Applied Ecology and Environmental Research found that Chrysanthemum, rich in unique chemical compounds, offers significant health benefits such as stress relief, cardio protection, immunity boost, improved eye health, and osteoporosis risk reduction. The study primarily focuses on evaluating the most important chemical extracts of chrysanthemum. These include flavonoids, betaine, choline, and vitamin B1. Further, the researchers identified thirteen compounds unique to chrysanthemum flowers. These were extracted and analyzed to unveil their potential health benefits. In the discussion of results, the authors highlight chrysanthemum's impressive range of health benefits stemming from its chemical composition. It is revealed that chrysanthemum can potentially alleviate stress and anxiety while improving cardiovascular health. It also has properties to guard against oxidative damage and inflammation, support a healthy immune function, enhance eye health, and lessen the risk of osteoporosis. Interestingly, the herb's beneficial traits align with its traditional use in Chinese medicine, underscoring chrysanthemum's potential in promoting holistic, organic health.

A Animal Study published in 2019 in the journal Journal of Food Biochemistry found that Pomegranate rind extract has been found to decrease pain and inflammation, suggesting it could contribute to treating rheumatoid arthritis. The researchers tested the effects of various doses of pomegranate rind extract on Wistar rats within established models of pain and inflammation, such as eddy's hot plate-induced algesia, carrageenan, and Complete Freund's adjuvant-induced models. Indomethacin was also evaluated for comparison. Researchers used bioactive compounds such as phenolics and flavanoids, both of which are known for their potent antioxidant activity. The results observed showed that a dose of 200 mg/kg of pomegranate led to a clear reduction in paw swelling in the rats in both inflammation models. The data further revealed an increase in pain threshold. Through these results, it was determined that pomegranate extract acts to reduce pain and inflammation by inhibiting the activation of a number of inflammatory markers. Furthermore, this study presents the first report on the inhibitory mechanism of these markers by pomegranate rind extract, which is enriched with tannins and flavanoids.

A Systematic Review published in 2019 in the journal Nutrients found that Bioactive compounds present in different parts of radishes, such as leaves, sprouts, stem and roots, act on a variety of potential drug targets associated with ailments, such as cancer, inflammation, liver injury and diabetes. Radishes is of great pharmaceutical importance, most of which has been attributed to its antioxidant property. The administration of radish extracts under numerous pathological conditions aids in the recovery of diseases and in the prevention of harmful ailments because of their attributed bioactivities. Bioactive compounds present in different parts of radishes, such as leaves, sprouts, stem and roots, act on a variety of potential drug targets associated with ailments, such as cancer, inflammation, liver injury and diabetes. However, the in-depth molecular mechanistic studies are required to address the regulatory roles of bioactive compounds in radish extracts. In future, researches focusing on the determination and pharmacokinetic elucidation of the bioactive compounds in radishes could facilitate the designing of plant based drugs for life threatening disorders, such as cancer and diabetes. Overall, the knowledge gained from the present researches in radish should be utilized in the discovery of novel drug molecules with higher efficacy towards drug targeting with less side effects.

A Randomised Controlled Trial published in 2019 in the journal Nutrients found that Daily consumption of tart cherry juice for 12 weeks showed anti-oxidative and anti-inflammatory properties which may reduce blood pressure and lower LDL cholesterol in older adults. In the randomized-controlled clinical trial conducted, 37 participants aged between 65 and 80 were given either 480 mL of tart cherry juice or a control drink to consume daily for a span of 12 weeks. Blood biomarkers linked to inflammation and oxidative stress were analyzed both at the start and after the 12 weeks intervention. Post the intervention period, levels of several inflammation and oxidative stress blood biomarkers in the tart cherry juice group observed notable differences compared to the control group. Particularly, a perceivable elevation in DNA repair activity coupled with a reduced mean c-reactive protein level was seen. Furthermore, a significant group effect was seen in plasma levels of c-reactive protein and malondialdehyde, with a slightly less significant effect observed for oxidized low-density lipoprotein. Post- intervention plasma levels showed a decreasing trend, with c-reactive protein, malondialdehyde, and oxidized low-density lipoprotein falling by 25%, 3%, and 11% respectively compared to the baseline values.

A Randomised Controlled Trial published in 2019 in the journal Food & Function found that Daily consumption of tart cherry juice may enhance cognitive abilities in older adults, likely due to reduction of hypertension, inflammation, and oxidative stress. In this randomized controlled trial, 37 adults aged between 65 and 80 years with normal cognitive function were assigned to consume two cups of Montmorency tart cherry juice daily for a duration of 12 weeks. Participants' subjective memory and objective cognitive performance were evaluated at the starting point and after the 12-week juice supplementation using a validated memory questionnaire and a standard assortment of tests designed for cognitive assessment. Factors such as daily caloric intake and physical activity levels were also monitored during the study. After the 12-week intervention, participants who consumed tart cherry juice showed an improvement in their contentment with memory scores, demonstrated decreased scores of movement time, and performed better on a task of paired associates learning when compared to the control group. Notably, the results revealed that the tart cherry juice group demonstrated improvements on measures of visual sustained attention and spatial working memory relative to their own baseline values. These findings suggest that the potential benefits of tart cherry juice to cognitive abilities might be attributed to the juice's antioxidant and anti-inflammatory properties, and its capacity to reduce blood pressure.

A Theoretical Article published in 2019 in the journal Applied Ecology and Environmental Research found that Chrysanthemum, a plant primarily grown in China and Japan, offers significant health benefits including stress reduction, cardiovascular improvement, and lowering osteoporosis risk. The study focused on Chrysanthemum, a notable plant in the ornamental industry and traditional Chinese medicine, mainly grown in China and Japan. The researchers identified its crucial chemical extracts such as flavonoids, betaine, choline, and vitamin B1. They additionally pinpointed thirteen significant compounds of chrysanthemum flowers, including acacetin-7-0-beta- D-glucopyranoside, luteolin, acaciin, and boscialin, among others. The findings revealed that chrysanthemum tea exhibits considerable health advantages. It eases stress and anxiety, enhances cardiovascular health, protects against oxidative damage, inhibits inflammation, supports healthy immune function, ameliorates eye health, and decreases the risk for osteoporosis. In traditional Chinese medicine, chrysanthemum is considered a cold herb that dispels pathogenic heat, aids the liver, improves eyesight, and promotes detoxification. The study, therefore, endorsed the treatment with natural Chinese herbal medicine, especially chrysanthemum, over synthetic drugs for a more organic life.

A Systematic Review published in 2018 in the journal Biomolecules found that Ginger supplementation enhances the production of testosterone in males by reducing oxidative stress and increasing luteinizing hormone production, cholesterol in testes, and blood flow to the testes. The study reviewed a collection of English language articles from three databases— PubMed, Scopus, and Web of Science— from November 1991 through August 2018. Keywords for the search included "ginger" and "testosterone". The references from relevant published articles were also reviewed. The methodology encompassed both in-vivo and basic research studies that sought to discover a link between ginger and testosterone. The results revealed that ginger supplementation enhances testosterone production in males, particularly in conditions of oxidative stress. This effect is achieved primarily by increasing the production of luteinizing hormone, cholesterol levels in the testes, reducing testes oxidative stress and lipid peroxidation, enhancing antioxidant enzyme activity, normalizing blood glucose and increasing blood flow in the testes. Furthermore, the study shows a correlation between ginger supplementation and increased testicular weight, and recycling of testosterone receptors.

A Systematic Review published in 2018 in the journal Evidence-Based Complementary and Alternative Medicine found that Despite some indications of improved clinical pregnancy rates, the overall effectiveness of acupuncture as a treatment for couples with subfertility undergoing assisted reproduction therapy remains inconclusive and requires further high-quality research. This abstract summarizes the findings of systematic reviews and meta-analyses assessing the effectiveness of acupuncture in treating couples with subfertility undergoing assisted reproduction therapy (ART). The review included eleven studies published between 2009 and 2017 and examined primary outcomes of live birth and clinical pregnancy, and secondary outcomes of ongoing pregnancy, miscarriage, and adverse events. The results suggest that acupuncture may improve the clinical pregnancy rate in ART patients. However, there was insufficient evidence to support its impact on live birth rate, ongoing pregnancy rates, or miscarriage, mainly due to the low quality of the included studies. The overall effectiveness of acupuncture in treating subfertility during ART remains uncertain, emphasizing the need for further high-quality research and well-reported trials.

A Animal Study published in 2018 in the journal Scientific Reports found that Acupuncture can alleviate PTSD-related depression and anxiety by boosting protein synthesis required for synaptic plasticity via the mTOR pathway in the hippocampus. The researchers conducted their study by observing a PTSD rat model that had been induced with a single prolonged stress (SPS). They administered acupuncture at HT8, a known acupuncture point, and gathered data on the ensuing behavioral changes using the forced swimming, elevated plus maze, and open field tests. They compared these results with those achieved using fluoxetine, a common antidepressant drug. They aimed to probe the underlying mechanisms by which acupuncture might work by studying its effect on protein translation in the mTOR signaling pathway and its subsequent enhancement of the activation of synaptic proteins such as PSD95, Syn1, and GluR1 in the hippocampus. The effects of acupuncture at HT8 point resulted in a significant alleviation in both depression and anxiety-like behaviors that had earlier been induced by SPS in the rat test subjects. This alleviation of symptoms was disrupted by the administration of rapamycin. These results are comparable to those brought about by the use of fluoxetine. The results further show that acupuncture aids in regulating protein translation in the mTOR signaling pathway, boosting the activation of synaptic proteins like PSD95, Syn1, and GluR1 in the hippocampus.

A Systematic Review published in 2018 in the journal The American Journal of Clinical Nutrition found that Incorporating walnuts into the diet improved blood lipid profile without adversely affecting body weight or blood pressure. The present meta-analysis of controlled trials provides robust evidence for the benefits of walnut consumption on blood lipids without adversely affecting body weight or blood pressure and supports the results of epidemiologic studies showing inverse associations between walnut consumption and CVD risk. Despite walnuts being energy-dense, the consumption of walnuts does not promote weight gain and thus they can be incorporated into an overall healthy dietary pattern to enhance health benefits.

A Review Article published in 2018 in the journal Journal of Acupuncture and Meridian Studies found that Acupuncture effectively manages a range of post-spinal cord injury complications, including motor and sensory dysfunction, pain, neurogenic bowel and bladder, pressure ulcers, spasticity, and osteoporosis. The effect of acupuncture on post-spinal cord injury orthostatic hypotension and sexual dysfunction remains unclear. Decreased oxidative stress, inhibition of inflammation and neuronal apoptosis, regulation of the expression and activity of endogenous biological mediators, and increased regenerative stem cell production are the possible mechanisms of acupuncture therapy for spinal cord injury. Although many limitations have been reported in previous studies, given the evidence for the efficacy of acupuncture, we recommend that physicians should support the use of acupuncture therapy for SCI complications.

A Systematic Review published in 2017 in the journal Molecular Medicine Reports found that Tremella fuciformis polysaccharide alleviated hydrogen peroxide‑induced oxidative stress and apoptosis in skin fibroblasts via upregulation of SIRT1 expression, indicating that TFPS may act as a potential therapeutic agent for oxidative‑stress‑associated skin diseases and aging. We demonstrated that pretreatment with TFPS suppressed H2O2-induced oxidative stress and apoptosis in skin fibroblasts in a concentration-dependent manner and possessed excellent antioxidative properties. Therefore, our present findings may provide a theoretical basis for TFPS as an alternative herbal food supplement and potential pharmacotherapy for skin injury and aging. However, given that TFPS contains several polysaccharides and has a variety of pharmacological effects, our study, which focused on oxidative stress inhibition and anti-apoptotic effects, has limitations. Further studies are required to define the potential protective mechanisms of TFPS in H2O2-induced skin injury. In summary, we revealed that TFPS exhibits protective properties against hydrogen peroxide-induced oxidative stress and apoptosis mainly by upregulating SIRT1 and promoting downstream signaling, suggesting that TFPS is a potential therapeutic agent for oxidative stress-related skin diseases and skin aging.

A Review Article published in 2017 in the journal Evidence-Based Complementary and Alternative Medicine found that Jujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning. Jujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning. Flavonoid, cAMP, and jujuboside could be the potential bioactive ingredients to account for the aforesaid biological activities. These findings imply that jujube is a potential candidate for development of health supplements for prevention and/or treatment of neurological diseases.

A Systematic Review published in 2017 in the journal Journal of Trauma & Dissociation found that There are potential clinical benefits of acupuncture on PTSD symptoms and functional status immediately post-intervention, as well as PTSD and depressive symptoms in the months following completion of acupuncture treatment. Overall, the results of this systematic review warrant caution in promoting acupuncture as an evidence-based treatment for adult patients with PTSD despite identified positive treatment effects. We have limited confidence in estimates indicating that needle acupuncture reduces PTSD and depressive symptoms at follow-up compared to passive controls, TAU, and active interventions, and we have very limited confidence in the estimates for PTSD symptoms at post-intervention and functional status. Moreover, no significant differences were observed between acupuncture and comparators for other outcomes, including no evidence for post-intervention or longer term improves on important psychological outcomes such as anxiety symptoms and sleep quality. Evidence from RCTs does suggest that acupuncture is relatively safe. Larger trials that minimize participant attrition would improve the quality of and confidence in effect estimates.

A Clinical Study published in 2017 in the journal Food & Function found that Blueberry intake for four weeks decreased levels of a biomarker for oxidative DNA damage in postmenopausal women with pre and early stage hypertension. In the experiment, a randomized, parallel-arm, double-blind, placebo-controlled clinical trial was carried out with 40 postmenopausal women, aged 45 to 65 years, who were either pre or at stage 1 of hypertension. The participants were randomly divided into two, where one group ingested 22 g of freeze-dried highbush blueberry powder every day and the other a placebo. The biomarkers for oxidative DNA damage, oxidative stress, inflammation, and antioxidant defense were evaluated at the commencement, in the middle, and at the end of the eight week period. The levels of the biomarker for oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine (8-OHdG), were found to drop significantly in the group consuming blueberries at the end of the fourth week when compared to the placebo group. However, the levels didn't show a significant difference between the groups at the end of the eighth week. No noteworthy changes were observed in the other measured biomarkers as a result of blueberry consumption.

A Experimental Study published in 2016 in the journal Food Science and Human Wellness found that Pu-erh tea water extracts could potentially enhance liver health and reduce oxidative stress in rats on a high-fat diet. In this study, fifty SD rats were split into five distinct groups and subjected to a high-fat diet. Their body weights were noted daily. Researches measured the serum levels of malondialdehyde (MDA), glucose, catalysts such as alanine aminotransferase and aspartate aminotransferase, nitric oxide synthase, and pyruvate kinase. Besides, hepatic glycogen levels were assessed, along with the activity of liver enzymes like total superoxide dismutase, catalase, and glutathione peroxidase. These measurements were consistently undertaken for a duration of 12 weeks. The findings showcased a decrease in the body weight and fat index of rats after the administration of Pu-erh tea extract. The reduction in body weight and fat index was accompanied by a decrease in malondialdehyde and nitric oxide synthase levels. Interestingly, there was also a noticeable increase in the activities of hepatic total superoxide dismutase, catalase, and glutathione peroxidase. These findings suggest that the Pu-erh extract might reduce the oxidant stress state, inhabit lipid peroxidation, and protect liver health in rats. Simultaneously, the extracts seemed to boost the production of liver glycogen, enhance the activity of pyruvate kinase, and decrease glucose levels, thereby possibly safeguarding the liver from diseases linked to Type II Diabetes.

A Clinical Study published in 2016 in the journal Neuropediatrics found that Saffron has shown potential as an effective and tolerable treatment for major depressive disorder with anxious distress. In the study, 66 patients suffering from major depressive disorder with anxious distress were randomly chosen to be treated either with 30 mg of saffron per day or 40 mg of citalopram per day for a duration of 6 weeks. Their progress was monitored using the Hamilton Rating Scale for Depression and the Hamilton Rating Scale for Anxiety, which aided in evaluating the effects of the treatment throughout the trial. In the results observed, it was found that patients from both groups, those treated with saffron and those administered with citalopram, demonstrated significant improvement in their depression and anxiety scales. The change in the scores between the two groups was examined and it was found that there was no profound difference. Interestingly, the frequency of side effects appearing was also not significantly varied between the two groups. This study hence showcases saffron as a potential reliable and well-tolerated treatment for major depressive disorder accompanied with anxious distress.

A Systematic Review published in 2016 in the journal Journal of Medicinal Food found that The studies assessed showed that sesame could have a significant effect on oxidative stress and the antioxidant defense system, being considered a food with an important antioxidant function in the different populations studied. In conclusion, despite the limitations and biases of this systematic review, the studies assessed showed that sesame could have a significant effect on oxidative stress and the antioxidant defense system, being considered a food with an important antioxidant function in the different populations studied (individuals with dyslipidemia, diabetes, and hypertension), as well as in its different presentations (oil, seed flour, and capsule). However, better-controlled studies still lack to assess the positive effects on different populations. There are few clinical trials assessing the effect of sesame on oxidative stress. The studies included in this review, mainly those with sesame oil and black sesame meal capsules administered to hypertensive and prehypertensive populations, respectively, showed an increase in enzymatic (SOD, GSH, GPx, and CAT) and nonenzymatic antioxidants (vitamin C, vitamin E, and beta-carotene), as well as a reduction in oxidative stress markers (TBARS and MDA). Although several studies have reported that the exact mechanisms of oxidative stress reduction remain to be fully explained, this review showed that sesame can have a significant positive impact on the health of different popula- tions.

A Experimental Study published in 2016 in the journal Scientific Reports found that The component pterostilbene, found naturally in blueberries, shows potential in preventing inflammation and oxidative stress on the human cornea, suggesting protection against dry eyes. This research employed an in vitro culture model of human corneal epithelial cells, exposing these cells to a hyperosmotic medium. Gene expression was observed via RT-qPCR, while protein production or activity was found using methods including ELISA, zymography, Western blotting, and immunofluorescent staining. Reactive oxygen species' production was also monitored using a DCFDA kit. Pterostilbene was administered and its effects on the expression of pro-inflammatory mediators and reactive oxygen species production were subsequently observed. The results showed that in corneal cells exposed to hyperosmotic medium, the addition of pterostilbene resulted in a notable decrease in the expression of pro-inflammatory mediators and suppressed overproduction of reactive oxygen species. Furthermore, pterostilbene also showed a significant decrease in the levels of oxidative damage biomarkers; it was found to rebalance homeostasis between oxygenases and anti-oxidative enzymes, demonstrating that pterostilbene has potentially protective effects on the human cornea from inflammation and oxidative stress.

A Clinical Study published in 2016 in the journal Journal of the International Society of Sports Nutrition found that Powdered tart cherry supplementation surrounding endurance exercise can decrease muscle damage markers, inflammation, oxidative stress and muscle soreness, while improving performance. In this study, 27 endurance-trained runners were matched based on their race pace, age, body mass, and fat-free mass. The runners were split into two groups in a double-blind manner: a placebo group given capsules containing 480 mg of rice flour and a tart cherries group given CherryPURE® capsules. These were ingested daily for 10 days, including on the day of the half-marathon and up to 48 hours post-race. The results showed that runners given tart cherry supplementation completed their half-marathon faster (by 13%) than those given a placebo. Moreover, the tart cherry group had less muscle damage markers over time, a steady increase in antioxidant activity during recovery, 47% lower inflammatory markers, and a 34% lower pre-run soreness in the medial quadriceps compared to the placebo group. These results demonstrate the beneficial effects of tart cherry supplementation on performance and recovery in aerobically trained individuals.

A Clinical Study published in 2015 in the journal Journal of the International Society of Sports Nutrition found that Taking a powdered tart cherry supplement before and after intense resistance exercise can decrease muscle soreness, recovery strength loss, and signs of muscle damage. In the methodology of this study, 23 healthy, resistance-trained men were chosen and paired based on relative maximal back squat strength, age, body weight, and fat-free mass. They were randomly assigned to ingest capsules containing either a placebo or powdered tart cherries for 10 days, including on the day of exercise as well as 48-hours post-exercise. The subjects performed ten sets of ten repetitions at 70% of a 1-RM back squat exercise. Fasting blood samples were taken along with isokinetic MVCs and quadriceps muscle soreness ratings before the exercise and at various intervals after the exercise. In terms of the results, muscle soreness was found to be lower in the group that consumed the tart cherry supplement over the course of the exercise. Furthermore, this group showed lesser changes in serum levels of creatinine and total protein. However, no significant effects were observed for serum inflammatory or anti-inflammatory markers and no significant changes in free radical production, lipid peroxidation, or antioxidant capacity markers were seen amongst the group that took the tart cherry supplement. The group that took the supplement also showed greater changes in whole blood lymphocyte counts from before the exercise, but their lymphocyte counts returned faster to pre-exercise values compared to the placebo group.

A Randomised Controlled Trial published in 2014 in the journal Medical Care found that Improvement in post traumatic stress disorder severity was significantly greater among those receiving acupuncture than in those receiving usual PTSD care. Mean improvement in PTSD severity was significantly greater among those receiving acupuncture than in those receiving usual PTSD care (PCLΔ=19.8±13.3 vs. 9.7±12.9, P<0.001; CAPSΔ=35.0±20.26 vs. 10.9±20.8, P<0.0001). Acupuncture was also associated with significantly greater improvements in depression, pain, and physical and mental health functioning. Pre-post effect-sizes for these outcomes were large and robust. Acupuncture was effective for reducing PTSD symptoms. Limitations included small sample size and inability to parse specific treatment mechanisms. Larger multisite trials with longer follow-up, comparisons to standard PTSD treatments, and assessments of treatment acceptability are needed. Acupuncture is a novel therapeutic option that may help to improve population reach of PTSD treatment.

A Systematic Review published in 2014 in the journal The Journal of Nutrition found that Polyphenolic compounds found in walnuts not only reduce the oxidant and inflammatory load on brain cells but also improve interneuronal signaling, increase neurogenesis, and enhance sequestration of insoluble toxic protein aggregates. In conclusion, age-related increases in oxidative stress and inflammation, especially when coupled with metabolic and cardiovascular dysfunction, lead to neurodegeneration and cognitive decline. This process of brain aging occurs even in the absence of specific neurodegenerative diseases. Although most chronic neurodegenerative diseases cannot currently be cured, preventive measures earlier in life can protect cognitive function in old age and may prevent or delay the onset of debilitating neurodegenerative diseases. Dietary interventions provide a safe and palatable means of modifying the body's internal environment and, importantly, the neuronal environment within the brain. Walnut polyphenols and tocopherols can reduce oxidative stress and inflammation; furthermore, PUFAs help maintain neuronal membrane integrity and attenuate protein aggregation involved in AD. In rodent studies, the addition of dietary walnuts, equivalent to a single serving of walnuts for humans, was sufficient to improve both motor and cognitive behavior in aged animals. In humans, the inclusion of walnuts in the diet improved cardiovascular health, which is itself a risk factor for neurodegenerative diseases and age-related cognitive decline. Taken together, this evidence suggests that the integration of walnuts into a healthy diet could be an effective means of prolonging health spans, slowing the processes of brain aging, and reducing the risk of chronic neurodegenerative disease.

A Randomised Controlled Trial published in 2014 in the journal Endocrine Abstracts found that Pomegranate extract intake, rich in biophenols, lessens salivary cortisol levels, hence potentially improving health-related quality of life, particularly in stress-suffering individuals. The study was conducted using a double-blind, randomized, placebo-controlled parallel trial. Participants, ranging in age and body mass index, took either a pomegranate extract capsule or a placebo each day for a duration of 4 weeks. The extracted capsule, which contained a high concentration of biophenols, was consumed with water after a meal. In addition to tracking dietary practices and habits, health related Quality of Life was recorded before and after the study. To assess the effects, salivary cortisol and cortisone levels were measured at three distinct points in the day. In the results, there was a notable decrease in the salivary cortisol levels of participants who consumed these pomegranate extract capsules. Alongside this, the ratio of cortisol to cortisone was significantly minimized. The participants' physical and social functionality, pain levels, and overall well-being showed significant improvement during the study. Conversely, there was a slight increase in the salivary cortisol and ratio of cortisol to cortisone for participants who took the placebo.

A Experimental Study published in 2014 in the journal Evidence-Based Complementary and Alternative Medicine found that Honey, specifically its polyphenols, show promising signs of enhancing memory and counteracting neurodegenerative diseases by reducing oxidative stress and neuroinflammation. The research focuses on the analysis of the nootropic and neuropharmacological benefits of honey, with particular emphasis on its polyphenol constituents. Essentially, honey's nutritional and physiological effects on memory enhancement and various neurological activities have been examined. This study delves into the mechanistic approach in which honey, as a natural compound, can mitigate oxidative stress while enhancing the cellular antioxidant defense system - a cue to its potential role in neutralizing reactive oxygen species that have harmful effects on neurological health. The findings from the research suggest that honey and its polyphenols play a noteworthy role in neuronal health. They display a potential ability to improve memory deficits and other neurodegenerative diseases. In particular, honey polyphenols have been associated with apoptosis activities and the reduction of microglia-induced neuroinflammation. Furthermore, the direct involvement of these polyphenols in synaptic plasticity was found, which could have a substantial effect on the behavior-modulating neural circuitry. Overall, these findings indicate the possible therapeutic value of honey and its polyphenols on the health of the neurological system.

A Review Article published in 2013 in the journal Anti-Cancer Agents in Medicinal Chemistry found that Blueberries, due to their phenolic compounds, show potential as both dietary and supplemental anti-cancer agents by inhibiting cancer cell growth and promoting apoptosis. The researchers synthesized evidence from previous in vitro, in vivo, and a limited number of clinical studies to evaluate the anti-cancer efficacy of blueberries. These studies primarily focused on the fruit's phenolic compounds, which are known for their high antioxidant capacity. The mechanisms underlying the anti-cancer effects of blueberries were analyzed, such as their capacity to inhibit the production of pro-inflammatory molecules, oxidative stress, and products of oxidative stress like DNA damage. In the discussion of the results, it was found that blueberries manifest their anti-cancer properties through the inhibition of cancer cell proliferation and induction of apoptosis. This makes them promising functional foods and nutritional supplements. The evidence strongly indicates the high potential of blueberries as a preventive measure against carcinogenesis, solidifying their position as an anti-cancer fruit. The potential of blueberries in this field certainly demands further exploration.

A Review Article published in 2013 in the journal British Journal of Clinical Pharmacology found that Cocoa and chocolate, rich in antioxidant molecules like epicatechin, enhance brain health, stimulate brain perfusion, and reduce the risk of Alzheimer's disease and stroke. The study involved taking a comprehensive look at the substances contained in cocoa powder and chocolate, their absorption into the brain, and their resulting stimulatory effects on multiple areas of the brain, particularly those connected to comprehension and memory. It also delved into the beneficial effects of epicatechin, a flavonoid found abundantly in cocoa and chocolate, which showed improvements in cognition in both animals and humans. Interestingly, the research showed that the consumption of chocolate could induce mood enhancement, elaborating on its common consumption during times of emotional stress. The study further investigated flavonoids' preservation of cognitive abilities in rats during aging, noting the reduced risk of developing Alzheimer's disease and the decreased likelihood of stroke in humans, demonstrating their wider effects beyond just mood enhancement. The research then looked into flavonoids' interactions within the various signaling pathways related to proteins and lipids in the brain, shedding light on how they inhibit neuron death from neurotoxic elements like oxygen radicals, all while promoting neuron survival and synaptic plasticity. The overall intent of the research was to gather and examine the available data regarding the effects of cocoa and chocolate on brain health and cognitive capacities.

A Systematic Review published in 2013 in the journal Evidence-Based Complementary and Alternative Medicine found that Evidence of effectiveness of acupuncture for PTSD is encouraging but not cogent. Acupuncture may be a relatively safe alternative for PTSD in contrast to SSRI, if long-term therapy is needed for treatment. This is the first systematic review and meta-analysis of prospective clinical trials on the effectiveness of acupuncture for treatment of PTSD. Only 4 RCTs and 2 UCTs met the inclusion criteria for this review. Our main finding of this review is that acupuncture is effective for PTSD based on one high-quality RCT and a meta-analysis. Acupuncture has positive effects in PTSD patients, although the evidence is still lacking as to its true efficacy for this condition.

A Systematic Review published in 2011 in the journal Nutrition Journal found that These results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress. This study suggests a beneficial effect of dietary black sesame meal on a reduction in blood pressure in pre-hypertensive humans. It is likely that the antihypertensive effect is due to decreased oxidative stress. Taken together with the absence of side effects and inexpensive preparation, the regular ingestion of dietary black sesame meal may be beneficial for CVD prevention in individuals with prehypertension, or even those with hypertension. A future study that investigates this advantageous effect is suggested.

A Clinical Study published in 2010 in the journal Journal of Acupuncture and Meridian Studies found that Chinese acupuncture is safe and can be efficient in alleviating pain in patients suffering from temporomandibular disorder without clear joint pathology. The results of this study showed that Chinese acupuncture was safe as administered here and was efficient in alleviating pain in patients suffering from temporomandibular disorder not caused by an osseous source. In approximately 90% of these patients, a statistically significant pain alleviation was observed, with the pain completely gone in most patients.

A Randomised Controlled Trial published in 2009 in the journal The American Journal of Cardiology found that Pomegranate juice consumption doesn't significantly affect overall progress of carotid intima-media thickness, but may slow its progression in subjects with high oxidative stress and lipid issues. In the study, a randomized, double-blind, parallel trial was carried out to assess the impact of daily consumption of pomegranate juice on carotid intima-media thickness progression rates in subjects moderately at risk for coronary heart disease. The participants consisted of elderly men and women who already had one or more major risk factors for the disease. Half of the participants were given 240 ml of pomegranate juice daily to consume for a period of up to 18 months, while the other half were provided with a control beverage. The findings of the trial showed no significant difference in carotid intima-media thickness progression rates between the two groups who consumed pomegranate juice and the control beverage respectively. However, in-depth analyses revealed that among individuals with the highest tertiles for baseline serum lipid peroxides, triglycerides, high-density lipoprotein cholesterol and other factors, those in the pomegranate juice group had experienced notably less progression of carotid intima-media thickness.

A Clinical Study published in 2004 in the journal Clinical Nutrition found that Consumption of pomegranate juice by patients with carotid artery stenosis decreases carotid intima-media thickness and systolic blood pressure, potentially due to its strong antioxidant properties. The researchers investigated the effects of consuming pomegranate juice, enriched with potent tannins and anthocyanins, on carotid lesion progression, oxidative stress, and blood pressure in patients suffering from carotid artery stenosis. Over a period of 1-3 years, ten patients were supplemented with pomegranate juice, with blood samples collected before the treatment and during juice consumption. A control group, which did not consume pomegranate juice, was also monitored. The study revealed significant reduction in carotid intima-media thickness of up to 30% after a year of pomegranate juice consumption as compared to the control group that saw an increase of 9%. Pomegranate juice consumption was also associated with an 83% increase in the patients' serum paraoxonase 1 activity, and a significant reduction in serum LDL basal oxidative state and LDL susceptibility to copper ion-induced oxidation. Antibodies against oxidized LDL in serum levels were decreased by 19%, and total antioxidant status increased by 130%. Moreover, systolic blood pressure reduced by 12% after a year of juice consumption. Most notably, the maximal effects were observed after one year of juice consumption, with no additional significant beneficial impacts observed with further juice consumption over a span of three years.

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