Si Wu Tang
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Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
Oestradiol Shao Yao Shu Di Huang
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation
2022 Jan Frontiers in Pharmacology Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang
Experimental Study Women's Health Shao Yao Si Wu Tang Oestradiol Shu Di HuangSi Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure
2021 Nov Journal of Ethnopharmacology Zhou F, Song Y, Liu X, Zhang C, Li F, Hu R, et al.
Our findings indicated that Si-Wu-Tang (SWT) protected ovarian function of Cy-induced premature ovarian failure (POF) mice by improving the antioxidant ability and promoting ovarian angiogenesis, thereby providing scientific evidence for the treatment of POF using SWT.
Network Pharmacology Si Wu Tang
Si-Wu-Tang ameliorates fibrotic liver injury via modulating intestinal microbiota and bile acid homeostasis
2021 Nov 04 Chinese Medicine Xue X, Wu J, Ding M, Gao F, Zhou F, Xu B, et al.
Si-Wu-Tang (SWT) decreased inflammatory response, reconstructed gut microbiota-mediated bile acid (BA) homeostasis as well as activated farnesoid X receptor (FXR) pathways, which eventually protected against CCl4-induced fibrotic liver injury.
Animal Study Si Wu Tang
Si-Wu-Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4-JNK and Caspase-8-GSDMD Signaling Pathways
2020 Aug 11 Evidence-Based Complementary and Alternative Medicine Zhang Y, Zhou G, Chen Z, Guan W, Zhang J, Bi M, et al.
Our present study indicated that Si-Wu-Tang alleviates MCD diet-induced NAFLD in mice in part via inhibiting TLR4-JNK signaling and Caspase-8-GSDMD signaling. In conclusion, Si-Wu-Tang may have potential for clinical application in treating NAFLD.
Network Pharmacology Animal Study Si Wu Tang NAFLD
Systematic Pharmacological Methodology to Explore the Pharmacological Mechanism of Siwu Decoction for Osteoporosis
2019 Oct 31 Medical Science Monitor Bao T, Yang K, Long Z, Zeng L, Li Y
The therapeutic effect of Siwu decoction (SWD) on osteoporosis may be achieved by interfering with the biological processes and signaling pathways related to the development of osteoporosis that found in this research.
Systematic Review Si Wu TangResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
2022 Frontiers in Pharmacology Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang
Experimental Study Oestradiol Shao Yao Shu Di Huang
In the methodology of the study, a testosterone-treated MCF-7 cell model was employed to determine the effects of each herb in the SWT formula. Key metrics that were considered included the regulation of estradiol, antioxidative effects, and the total polyphenol and polysaccharide contents as quality markers. The study also explored the potential ability of certain elements within the formula to act as an aromatase promoter, notably catalpol and other elements.
In terms of results, certain herbs in SWT such as catalpol showed an ability to significantly increase estradiol content and boost upregulation in cell culture, indicating their role as potential aromatase promoters within the formula. Antioxidant activity was also strong in other compounds like pentagalloylglucose, gallic acid, and ferulic acid. These antioxidative effects were attributed to the presence of polyphenols in the herbs. Furthermore, the herb with the strongest antioxidant effects could possibly help ameliorate menstrual disorder patterns due to its ability to prevent ROS damage to the ovaries.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
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Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
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