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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
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Therapeutic Effect and Mechanism of Acupuncture in Autoimmune Diseases
2022 Mar 10 The American Journal of Chinese Medicine Jing Wang, Fangyi Zhu, Wei Huang, Zhengyi Chen, Ping Zhao, Yanting Lei, et al.
Review Article Rheumatoid Arthritis Inflammatory Bowel Disease Multiple SclerosisAcupuncture shows promising results in managing autoimmune diseases by potentially regulating immune responses.
Role of traditional Chinese medicine in incomplete immune reconstitution of HIV/AIDS: a review
2022 Jan Traditional Medicine Research Ji SX, Zhang HY, Wan TJ, Wen L, Feng QS
In conclusion, highly active antiretroviral therapy (HAART) is still the most effective treatment for HIV/AIDS, but it cannot completely achieve immunological reconstruction. Because of the outstanding advantages of TCM in regulating immunity, it is usually chosen as a supplementary treatment for incomplete immune reconstitution (IIR) in China.
Review Article Immunity AIDSThe efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis
2021 Dec Complementary Therapies in Medicine An-Fang Hsiao, Yi-Chieh Lien, I-Shiang Tzeng, Chien-Ting Liu, Sheng-Hsun Chou, Yi-Shiung Horng
Systematic Review Meta-Analysis Knee Osteoarthritis Arthritis TurmericTurmeric curcuminoids are associated with better pain relief than NSAIDs in knee osteoarthritis.
Chinese herbal medicine for incomplete immune reconstruction in patients with AIDS undergoing antiretroviral treatment: A systematic review of randomized trials
2021 Oct Journal of Traditional Chinese Medical Sciences Shen C, Li J, Lian Y, Lan H, Pu F, Zhang W, et al.
Jianpi Yiqi medicinal paste, Wenshen Jianpi granules, Shenling Fuzheng capsules, Aikeqing granules, Guipi decoction, and TGTs may be effective in increasing CD4+ within 12 months, and Mianyi No.2 granules (JT) and Chinese medicine granules may show long-term effects.
Systematic Review Chinese Herbal Medicine AIDS ImmunityEffect of fennel on primary dysmenorrhea: a systematic review and meta-analysis
2021 Jan 11 Journal of Complementary and Integrative Medicine Hadis Shahrahmani, Masumeh Ghazanfarpour, Nasim Shahrahmani, Fatemeh Abdi, Robert D. E. Sewell and Mahmoud Rafieian-Kopaei
Systematic Review Meta-AnalysisFennel intake decreased significantly the intensity of dysmenorrhea compared to placebo and was similar to non-steroidal anti-inflammatory drugs such as mefenamic acid.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Acupuncture shows promising results in managing autoimmune diseases by potentially regulating immune responses.
2022 The American Journal of Chinese Medicine Therapeutic Effect and Mechanism of Acupuncture in Autoimmune Diseases Jing Wang, Fangyi Zhu, Wei Huang, Zhengyi Chen, Ping Zhao, Yanting Lei, et al.
Review Article Inflammatory Bowel Disease Multiple Sclerosis Rheumatoid Arthritis
The methodology of the study involved a comprehensive review of how acupuncture, a form of traditional Chinese medicine, may be employed as a treatment method for autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. The research was based on existing knowledge and accumulating data, investigating the role of acupuncture in regulating immune responses during these conditions.
The discussion of the results revealed that acupuncture showed promise in managing these diseases. It was noted that the positive outcomes observed might be linked to the potential of acupuncture to regulate abnormal immune responses which are characteristic of autoimmune diseases. Despite the fact that the precise mechanism through which this achieved is not fully understood, the findings indicate a promising alternative method of managing autoimmune conditions.
Turmeric curcuminoids are associated with better pain relief than NSAIDs in knee osteoarthritis.
2021 Complementary Therapies in Medicine The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis An-Fang Hsiao, Yi-Chieh Lien, I-Shiang Tzeng, Chien-Ting Liu, Sheng-Hsun Chou, Yi-Shiung Horng
Systematic Review Arthritis Knee Osteoarthritis Turmeric
The meta-analysis results showed that curcuminoids were significantly more effective than comparators regarding visual analogue scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain scores.
However, no significant difference in pain relief or AEs between the high-dose (daily dose ≥1000 mg or total dose ≥42 gm) and low-dose (daily dose <1000 mg or total dose <42 gm) curcuminoid treatments was observed.
When comparing curcumininoids versus NSAIDs, a significant difference in VAS pain was found. For AE analysis, three of our included studies used NSAIDs as comparators, with all reporting higher AE rates in the NSAID group, though significance was reached in only one study.
Fennel intake decreased significantly the intensity of dysmenorrhea compared to placebo and was similar to non-steroidal anti-inflammatory drugs such as mefenamic acid.
2021 Journal of Complementary and Integrative Medicine Effect of fennel on primary dysmenorrhea: a systematic review and meta-analysis Hadis Shahrahmani, Masumeh Ghazanfarpour, Nasim Shahrahmani, Fatemeh Abdi, Robert D. E. Sewell and Mahmoud Rafieian-Kopaei
Systematic Review
Meta-analysis of these trials showed that F. vulgare intake decreased significantly the intensity of dysmenorrhea compared to the placebo. However, the effect of Mefenamic acid with F. vulgare was not different from each other.
The F. vulgare alleviates dysmenorrhea. Regarding the same effect of F. vulgare with NSAIDs, it is highly recommend to the women suffered from dysmenorrhea specifically the ones who have high tendency toward herbal medicine.
Modified Tao-Hong Siwu Tang (MTST) appears more effective than non-steroidal anti-inflammatory drugs (NSAIDs), and a combination of Tao-Hong Siwu Tang with oral contraceptives (OCs) offers benefits over OCs alone for treating primary dysmenorrhea.
2020 Explore: The Journal of Science & Healing Herbal medicine (Taohong Siwu Tang) for the treatment of primary dysmenorrhea: A systematic review and meta-analysis Ji HR, Park KS, Woo HL, Lee MJ, Yoon JG, Lee HJ, et al.
Systematic Review Period Pain Tao Hong Si Wu Tang
This systematic review aimed to assess the efficacy and safety of Tao-Hong Siwu Tang (TST) in treating primary dysmenorrhea. Conducted across various databases, the review identified five randomized controlled trials (RCTs) meeting inclusion criteria. The meta-analysis revealed suggestive evidence that modified TST (MTST) might have a favorable effect compared to non-steroidal anti-inflammatory drugs (NSAIDs) in managing primary dysmenorrhea (RR = 1.53, 95% CI = 1.37–1.72), with one RCT indicating MTST's superiority in reducing recurrence rates (RR = 0.31, 95% CI = 0.15–0.63, P = 0.001). Furthermore, combining TST with oral contraceptives (OCs) appeared beneficial compared to OCs alone (RR = 1.35, 95% CI = 1.02–1.79, P = 0.04). However, moderate evidence quality due to bias uncertainties and limited RCTs highlighted the need for cautious interpretation. The study emphasized the demand for alternative treatments, given NSAID and OC limitations, while stressing the need for rigorous large-scale trials to clarify TST's role in primary dysmenorrhea management.
Chrysanthemum, rich in unique chemical compounds, offers significant health benefits such as stress relief, cardio protection, immunity boost, improved eye health, and osteoporosis risk reduction.
2019 Applied Ecology and Environmental Research A review of chrysanthemum, the eastern queen in traditional Chinese medicine with healing power in modern pharmaceutical sciences SHAHRAJABIAN, M. H., SUN, W., ZANDI, P., et al.
Review Article Anti-Inflammatory Antioxidant Cardioprotective Effects
The study primarily focuses on evaluating the most important chemical extracts of chrysanthemum. These include flavonoids, betaine, choline, and vitamin B1. Further, the researchers identified thirteen compounds unique to chrysanthemum flowers. These were extracted and analyzed to unveil their potential health benefits.
In the discussion of results, the authors highlight chrysanthemum's impressive range of health benefits stemming from its chemical composition. It is revealed that chrysanthemum can potentially alleviate stress and anxiety while improving cardiovascular health. It also has properties to guard against oxidative damage and inflammation, support a healthy immune function, enhance eye health, and lessen the risk of osteoporosis. Interestingly, the herb's beneficial traits align with its traditional use in Chinese medicine, underscoring chrysanthemum's potential in promoting holistic, organic health.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Therapeutic Effect and Mechanism of Acupuncture in Autoimmune Diseases
2022 Mar 10 The American Journal of Chinese Medicine Jing Wang, Fangyi Zhu, Wei Huang, Zhengyi Chen, Ping Zhao, Yanting Lei, et al.
Review Article Rheumatoid Arthritis Inflammatory Bowel Disease Multiple SclerosisAcupuncture shows promising results in managing autoimmune diseases by potentially regulating immune responses.
No access to full-text —Rachael L 7 Apr 2022
Role of traditional Chinese medicine in incomplete immune reconstitution of HIV/AIDS: a review
2022 Jan Traditional Medicine Research Ji SX, Zhang HY, Wan TJ, Wen L, Feng QS
In conclusion, highly active antiretroviral therapy (HAART) is still the most effective treatment for HIV/AIDS, but it cannot completely achieve immunological reconstruction. Because of the outstanding advantages of TCM in regulating immunity, it is usually chosen as a supplementary treatment for incomplete immune reconstitution (IIR) in China.
Review Article Immunity AIDSThe efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis
2021 Dec Complementary Therapies in Medicine An-Fang Hsiao, Yi-Chieh Lien, I-Shiang Tzeng, Chien-Ting Liu, Sheng-Hsun Chou, Yi-Shiung Horng
Systematic Review Meta-Analysis Knee Osteoarthritis Arthritis TurmericTurmeric curcuminoids are associated with better pain relief than NSAIDs in knee osteoarthritis.
Chinese herbal medicine for incomplete immune reconstruction in patients with AIDS undergoing antiretroviral treatment: A systematic review of randomized trials
2021 Oct Journal of Traditional Chinese Medical Sciences Shen C, Li J, Lian Y, Lan H, Pu F, Zhang W, et al.
Jianpi Yiqi medicinal paste, Wenshen Jianpi granules, Shenling Fuzheng capsules, Aikeqing granules, Guipi decoction, and TGTs may be effective in increasing CD4+ within 12 months, and Mianyi No.2 granules (JT) and Chinese medicine granules may show long-term effects.
Systematic Review Chinese Herbal Medicine AIDS ImmunityEffect of fennel on primary dysmenorrhea: a systematic review and meta-analysis
2021 Jan 11 Journal of Complementary and Integrative Medicine Hadis Shahrahmani, Masumeh Ghazanfarpour, Nasim Shahrahmani, Fatemeh Abdi, Robert D. E. Sewell and Mahmoud Rafieian-Kopaei
Systematic Review Meta-AnalysisFennel intake decreased significantly the intensity of dysmenorrhea compared to placebo and was similar to non-steroidal anti-inflammatory drugs such as mefenamic acid.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Review Article
Acupuncture shows promising results in managing autoimmune diseases by potentially regulating immune responses.
Jing Wang, Fangyi Zhu, Wei Huang, Zhengyi Chen, Ping Zhao, Yanting Lei, Yumei Liu, Xijun Liu, Bo Sun, Hulun Li
Systematic Review
Turmeric curcuminoids are associated with better pain relief than NSAIDs in knee osteoarthritis.
An-Fang Hsiao, Yi-Chieh Lien, I-Shiang Tzeng, Chien-Ting Liu, Sheng-Hsun Chou, Yi-Shiung Horng
Systematic Review
Fennel intake decreased significantly the intensity of dysmenorrhea compared to placebo and was similar to non-steroidal anti-inflammatory drugs such as mefenamic acid.
Hadis Shahrahmani, Masumeh Ghazanfarpour, Nasim Shahrahmani, Fatemeh Abdi, Robert D. E. Sewell and Mahmoud Rafieian-Kopaei
Systematic Review
Modified Tao-Hong Siwu Tang (MTST) appears more effective than non-steroidal anti-inflammatory drugs (NSAIDs), and a combination of Tao-Hong Siwu Tang with oral contraceptives (OCs) offers benefits over OCs alone for treating primary dysmenorrhea.
Ji HR, Park KS, Woo HL, Lee MJ, Yoon JG, Lee HJ, Hwang DS, Lee CH, Jang JB, Lee JM
Review Article
Chrysanthemum, rich in unique chemical compounds, offers significant health benefits such as stress relief, cardio protection, immunity boost, improved eye health, and osteoporosis risk reduction.
SHAHRAJABIAN, M. H., SUN, W., ZANDI, P., CHENG, Q.
Randomised Controlled Trial
Avocado oil supplement combined with exercise improves joint function in osteoarthritis over traditional treatments like NSAIDS and multivitamins with exercise.
Chandra A, Kumar A, Kumar M, Kumar M, Dikshit H
Systematic Review
Acupuncture might reduce menstrual pain and associated symptoms more effectively compared to no treatment or NSAIDs.
Woo HL, Ji HR, Pak YK, Lee H, Heo SJ, Lee JM, Park KS
Systematic Review
Acupoint-stimulation can relieve pain effectively in the treatment of primary dysmenorrhea and offers advantages compared with treatment by NSAIDs.
Xu, Y., Zhao, W., Li, T. et al.
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for AIDS" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for AIDS" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for AIDS" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Review Article published in 2022 in the journal The American Journal of Chinese Medicine found that Acupuncture shows promising results in managing autoimmune diseases by potentially regulating immune responses. The methodology of the study involved a comprehensive review of how acupuncture, a form of traditional Chinese medicine, may be employed as a treatment method for autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. The research was based on existing knowledge and accumulating data, investigating the role of acupuncture in regulating immune responses during these conditions. The discussion of the results revealed that acupuncture showed promise in managing these diseases. It was noted that the positive outcomes observed might be linked to the potential of acupuncture to regulate abnormal immune responses which are characteristic of autoimmune diseases. Despite the fact that the precise mechanism through which this achieved is not fully understood, the findings indicate a promising alternative method of managing autoimmune conditions.
A Systematic Review published in 2021 in the journal Complementary Therapies in Medicine found that Turmeric curcuminoids are associated with better pain relief than NSAIDs in knee osteoarthritis. The meta-analysis results showed that curcuminoids were significantly more effective than comparators regarding visual analogue scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain scores. However, no significant difference in pain relief or AEs between the high-dose (daily dose ≥1000 mg or total dose ≥42 gm) and low-dose (daily dose <1000 mg or total dose <42 gm) curcuminoid treatments was observed. When comparing curcumininoids versus NSAIDs, a significant difference in VAS pain was found. For AE analysis, three of our included studies used NSAIDs as comparators, with all reporting higher AE rates in the NSAID group, though significance was reached in only one study.
A Systematic Review published in 2021 in the journal Journal of Complementary and Integrative Medicine found that Fennel intake decreased significantly the intensity of dysmenorrhea compared to placebo and was similar to non-steroidal anti-inflammatory drugs such as mefenamic acid. Meta-analysis of these trials showed that F. vulgare intake decreased significantly the intensity of dysmenorrhea compared to the placebo. However, the effect of Mefenamic acid with F. vulgare was not different from each other. The F. vulgare alleviates dysmenorrhea. Regarding the same effect of F. vulgare with NSAIDs, it is highly recommend to the women suffered from dysmenorrhea specifically the ones who have high tendency toward herbal medicine.
A Systematic Review published in 2020 in the journal Explore: The Journal of Science & Healing found that Modified Tao-Hong Siwu Tang (MTST) appears more effective than non-steroidal anti-inflammatory drugs (NSAIDs), and a combination of Tao-Hong Siwu Tang with oral contraceptives (OCs) offers benefits over OCs alone for treating primary dysmenorrhea. This systematic review aimed to assess the efficacy and safety of Tao-Hong Siwu Tang (TST) in treating primary dysmenorrhea. Conducted across various databases, the review identified five randomized controlled trials (RCTs) meeting inclusion criteria. The meta-analysis revealed suggestive evidence that modified TST (MTST) might have a favorable effect compared to non-steroidal anti-inflammatory drugs (NSAIDs) in managing primary dysmenorrhea (RR = 1.53, 95% CI = 1.37–1.72), with one RCT indicating MTST's superiority in reducing recurrence rates (RR = 0.31, 95% CI = 0.15–0.63, P = 0.001). Furthermore, combining TST with oral contraceptives (OCs) appeared beneficial compared to OCs alone (RR = 1.35, 95% CI = 1.02–1.79, P = 0.04). However, moderate evidence quality due to bias uncertainties and limited RCTs highlighted the need for cautious interpretation. The study emphasized the demand for alternative treatments, given NSAID and OC limitations, while stressing the need for rigorous large-scale trials to clarify TST's role in primary dysmenorrhea management.
A Review Article published in 2019 in the journal Applied Ecology and Environmental Research found that Chrysanthemum, rich in unique chemical compounds, offers significant health benefits such as stress relief, cardio protection, immunity boost, improved eye health, and osteoporosis risk reduction. The study primarily focuses on evaluating the most important chemical extracts of chrysanthemum. These include flavonoids, betaine, choline, and vitamin B1. Further, the researchers identified thirteen compounds unique to chrysanthemum flowers. These were extracted and analyzed to unveil their potential health benefits. In the discussion of results, the authors highlight chrysanthemum's impressive range of health benefits stemming from its chemical composition. It is revealed that chrysanthemum can potentially alleviate stress and anxiety while improving cardiovascular health. It also has properties to guard against oxidative damage and inflammation, support a healthy immune function, enhance eye health, and lessen the risk of osteoporosis. Interestingly, the herb's beneficial traits align with its traditional use in Chinese medicine, underscoring chrysanthemum's potential in promoting holistic, organic health.
A Randomised Controlled Trial published in 2019 in the journal International Journal of Basic & Clinical Pharmacology found that Avocado oil supplement combined with exercise improves joint function in osteoarthritis over traditional treatments like NSAIDS and multivitamins with exercise. In this study, 90 osteoarthritis patients were randomly sorted into three groups for different treatments: one group took multivitamins associated with exercise, the second group took NSAIDS, and the third, avocado oil combined with strengthening exercises. The pain and knee functionality of each participant were measured using the Visual Analogue Scale and Oxford Knee score respectively. Throughout the three-month treatment course, the group that used avocado oil alongside exercises outperformed the others. They had the highest Oxford Knee scores, indicating better knee functionality, and also had higher average Pain Threshold scores from the Visual Analogue Scale. Hence, this study postulates that avocado oil, coupled with muscle exercises, offers a more effective solution for managing osteoarthritis over NSAIDS and multivitamins.
A Systematic Review published in 2018 in the journal Medicine found that Acupuncture might reduce menstrual pain and associated symptoms more effectively compared to no treatment or NSAIDs. The results of this study suggest that acupuncture might reduce menstrual pain and associated symptoms more effectively compared to no treatment or NSAIDs, and the efficacy could be maintained during a short-term follow-up period. Despite limitations due to the low quality and methodological restrictions of the included studies, acupuncture might be used as an effective and safe treatment for females with primary dysmenorrhea.
A Systematic Review published in 2017 in the journal BMC Complementary Medicine and Therapies found that Acupoint-stimulation can relieve pain effectively in the treatment of primary dysmenorrhea and offers advantages compared with treatment by NSAIDs. The current evidence reveals that acupoint-stimulation in the treatment of primary dysmenorrhea has some obvious advantages compared with treatment by NSAIDs. The advantages are that acupoint-stimulation can alleviate the symptoms of dysmenorrhoea, reduce the level of peripheral blood PGF2α and has fewer side effect, so it can be used to treat primary dysmenorrhea patients, especially individuals with NSAIDs contraindication.
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No access to full-text —Rachael L 7 Apr 2022