Shao Yao
Also known as: Bai Shao, Paeonia lactiflora, Paeoniae Alba
Recent Insights
The Gui Zhi-Shao Yao herb pair in traditional Chinese medicine potentially treats chronic pain, anxiety, and depression through interactions with nine key targets.
Anxiety Chronic Pain Depression
Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
Oestradiol Shao Yao Shu Di Huang
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Identification of the Anti-Inflammatory Compound, Paeoniflorigenone, in Radix Paeoniae Alba for the Treatment of Polycystic Ovary Syndrome Through Network Pharmacology and Molecular Docking
2022 Oct Natural Product Communications Li J, Wang G, Chu S, Liu D, Zhao H, Li H
This study manifested that the most effective anti-inflammation compound of RPA was paeoniflorigenone and provided a potential therapeutic strategy for PCOS treatment.
Network Pharmacology Shao YaoElucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation
2022 Jan Frontiers in Pharmacology Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang
Experimental Study Shao Yao Si Wu Tang Oestradiol Shu Di HuangSi Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
A network pharmacology approach to predict potential targets and mechanisms of “Ramulus Cinnamomi (cassiae) – Paeonia lactiflora” herb pair in the treatment of chronic pain with comorbid anxiety and depression
2022 Jan 31 Annals of Medicine Pan HT, Xi ZQ, Wei XQ, Wang K
Network Pharmacology Shao Yao Chronic Pain Anxiety DepressionThe Gui Zhi-Shao Yao herb pair in traditional Chinese medicine potentially treats chronic pain, anxiety, and depression through interactions with nine key targets.
Evaluating the Therapeutic Mechanisms of Selected Active Compounds in Cornus Officinalis and Paeonia Lactiflora in Rheumatoid Arthritis via Network Pharmacology Analysis
2021 Apr 21 Frontiers in Pharmacology Li Q, Hu S, Huang L, Zhang J, Cao G
We systematically revealed the pharmacological and molecular roles of Cornus officinalis and Paeonia lactiflora, further establishing them as important candidate drugs in the treatment and management of rheumatoid arthritis (RA).
Network Pharmacology Shao Yao Shan Zhu Yu
Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation
2019 Mar 05 Evidence-Based Complementary and Alternative Medicine Huang GC, Tsai YZ, Lee CJ, Chang HY, Wang CC
In this study, we recommend that if the ratio of Shu Di Huang and Shao Yao should be increased, the function of SWT will be more forceful against menstrual disorder patterns through activating aromatase and antioxidative properties.
Network Pharmacology Si Wu TangResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The Gui Zhi-Shao Yao herb pair in traditional Chinese medicine potentially treats chronic pain, anxiety, and depression through interactions with nine key targets.
2022 Annals of Medicine A network pharmacology approach to predict potential targets and mechanisms of “Ramulus Cinnamomi (cassiae) – Paeonia lactiflora” herb pair in the treatment of chronic pain with comorbid anxiety and depression Pan HT, Xi ZQ, Wei XQ, Wang K
Network Pharmacology Anxiety Chronic Pain Depression
The methodology in this research utilised network pharmacology to explore the active components of the "Gui Zhi-Shao Yao" herb pair and their possible targets. Initially, 15 active compounds were identified through a series of analysis which revealed about 130 potential targets. By considering the intersections between the targets of the "Gui Zhi-Shao Yao" herb pair and chronic pain, anxiety disorder, and mental depression, nine vital targets were identified and listed in order of importance.
The results discussion revealed that the "Gui Zhi-Shao Yao" herb pairing acted on the nine identified key targets to alleviate chronic pain, anxiety, and depression. Gene ontology and pathway analysis demonstrated that there were 11 primary pathways, including AGE-RAGE signalling pathway, IL-17 signalling pathway, and TNF signalling pathway. These pathways appear to be actively involved in the pathological processes, providing a holistic understanding of how the "Gui Zhi-Shao Yao" herb pair functions therapeutically.
Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
2022 Frontiers in Pharmacology Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang
Experimental Study Oestradiol Shu Di Huang Si Wu Tang
In the methodology of the study, a testosterone-treated MCF-7 cell model was employed to determine the effects of each herb in the SWT formula. Key metrics that were considered included the regulation of estradiol, antioxidative effects, and the total polyphenol and polysaccharide contents as quality markers. The study also explored the potential ability of certain elements within the formula to act as an aromatase promoter, notably catalpol and other elements.
In terms of results, certain herbs in SWT such as catalpol showed an ability to significantly increase estradiol content and boost upregulation in cell culture, indicating their role as potential aromatase promoters within the formula. Antioxidant activity was also strong in other compounds like pentagalloylglucose, gallic acid, and ferulic acid. These antioxidative effects were attributed to the presence of polyphenols in the herbs. Furthermore, the herb with the strongest antioxidant effects could possibly help ameliorate menstrual disorder patterns due to its ability to prevent ROS damage to the ovaries.
Presentation Slides
The Gui Zhi-Shao Yao herb pair in traditional Chinese medicine potentially treats chronic pain, anxiety, and depression through interactions with nine key targets.
Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
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