Gan Cao
Also known as: Chinese Liquorice, Glycyrrhiza uralensis
Recent Insights
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Ai Ye Anti-Inflammatory Antioxidant
The traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus.
Depression Gan Cao Gan Mai Da Zao Tang
The Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
Gan Cao Gan Cao Da Zao Tang Gan Mai Da Zao Tang
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
A mechanistic review of pharmacological activities of homeopathic medicine licorice against neural diseases
2023 Mar 06 Frontiers in Neuroscience Zulfugarova P, Zivari-Ghader T, Maharramova S, Ahmadian E, Eftekhari A, Khalilov R, et al.
Licorice extract and/or its active components can be used safely in therapeutic doses for optimizing the management of a multiple neurodegenerative disorders, and hampering the extent of neural tissue injury and neurologic deficits subsequent to cerebrovascular accidents.
Review Article Gan Cao Licorice Neurological Disorders Neurodegenerative Diseases
Clinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID‐19 by dual binding to IL-6/STAT3
2022 Jun Computers in Biology and Medicine Luo W, Ding R, Guo X, Zhan T, Tang T, Fan R, et al.
This work provided some potential candidate Chinese medicine formulas for moderate COVID-19. Among them, Gancao-Banxia was considered the most potential herbal pair with strong bioinformatics suggesting resistance against COVID. SARS-CoV-2 models will be needed to validate this possibility in the future.
Meta-Analysis COVID-19 Gan CaoJing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
2022 Mar Pharmacological Research - Modern Chinese Medicine Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Randomised Controlled Trial Gan Cao Ai Ye Antiviral COVID-19 Jing Si Herbal Drink Immunity Antioxidant Yu Jen Cao Yu Xing Cao Anti-Inflammatory Mai Dong Chrysanthemum Jie GengThe Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models
2022 Jan 19 Plants Li YX, Cheng KC, Hsu CT, Cheng JT, Yang TT
Animal Study Depression Serotonin Gan Cao Gan Mai Da Zao TangThe traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus.
Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
2021 Dec 14 Plants Wahab S, Annadurai S, Abullais SS, Das G, Ahmad W, Ahmad MF, et al.
Licorice could be a natural alternative for current therapy to exterminate new emerging disorders with mild side effects. This review will provide systematic insights into this ancient drug for further development and clinical use.
Review Article Gan CaoResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
2022 Pharmacological Research - Modern Chinese Medicine Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Ai Ye Anti-Inflammatory Antioxidant
The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19.
Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.
The traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus.
2022 Plants Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models Li YX, Cheng KC, Hsu CT, Cheng JT, Yang TT
Animal Study Depression Gan Mai Da Zao Tang Serotonin
This study experimentally examined the antidepressant impacts of Gan-Mai-Da-Zao (GMDZ), a Chinese traditional medicine that contains blighted wheat, licorice, and jujube. The researchers used an unpredictable chronic mild stress model in rats, some of whom received an injection with p-chlorophenylalanine to generate a chemical model for depression. The investigators employed behavioral tests, including forced swim tests, open field tests, and sucrose preference tests, to evaluate the chronic influence of GMDZ.
The oral application of GMDZ over 21 days considerably eased depressive behaviors in rats induced by either the unpredictable chronic mild stress or p-chlorophenylalanine. The treatment increased the expression of the serotonin transporter and brain-derived neurotrophic factor in the hippocampus in the rats with depression. However, rats provided with a similar herbal mixture that did not include licorice showed a significantly worse response, suggesting that licorice may play an essential role in the efficacy of GMDZ in combatting depression-like behaviors.
The Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
2021 Complementary Therapies in Medicine Licorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data Coyle ME, Liu J, Yang H, Wang K, Zhang AL, Guo X, et al.
Experimental Study Gan Cao Da Zao Tang Gan Mai Da Zao Tang Jujube
The methodology of this study involved exploring classical Chinese medicine textbooks to find the most frequent herbal mix used for symptoms similar to menopause. The approach taken was to sort and identify the formulas from the Encyclopedia of Traditional Chinese Medicine, a comprehensive resource in this field. Following this, a thorough review of randomized controlled trials was performed in order to determine the efficacy of the most common formula.
In terms of results, it was discovered that the Licorice and Jujube formula (LJF) was the most commonly found, mentioned in 36% of the analyzed references. The review of controlled trials revealed that the LJF might be effectively utilized for the improvement of sleep-related symptoms. Additionally, experimental studies hinted at potential benefits of the LJF, including sedative, antidepressant-like, estrogenic, and antiprogestogenic effects.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
A mechanistic review of pharmacological activities of homeopathic medicine licorice against neural diseases
2023 Mar 06 Frontiers in Neuroscience Zulfugarova P, Zivari-Ghader T, Maharramova S, Ahmadian E, Eftekhari A, Khalilov R, et al.
Licorice extract and/or its active components can be used safely in therapeutic doses for optimizing the management of a multiple neurodegenerative disorders, and hampering the extent of neural tissue injury and neurologic deficits subsequent to cerebrovascular accidents.
Review Article Gan Cao Licorice Neurological Disorders Neurodegenerative DiseasesJing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
2022 Mar Pharmacological Research - Modern Chinese Medicine Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Randomised Controlled Trial Gan Cao Ai Ye Antiviral COVID-19 Jing Si Herbal Drink Immunity Antioxidant Yu Jen Cao Yu Xing Cao Anti-Inflammatory Mai Dong Chrysanthemum Jie GengThe Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology
2021 Dec 14 Plants Wahab S, Annadurai S, Abullais SS, Das G, Ahmad W, Ahmad MF, et al.
Licorice could be a natural alternative for current therapy to exterminate new emerging disorders with mild side effects. This review will provide systematic insights into this ancient drug for further development and clinical use.
Review Article Gan CaoLicorice (Glycyrrhiza spp.) and jujube (Ziziphus jujuba Mill.) formula for menopausal symptoms: Classical records, clinical evidence and experimental data
2021 Aug Complementary Therapies in Medicine Coyle ME, Liu J, Yang H, Wang K, Zhang AL, Guo X, et al.
Experimental Study Systematic Review Licorice Jujube Gan Mai Da Zao Tang Gan Cao Gan Cao Da Zao Tang MenopauseThe Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
An “essential herbal medicine”—licorice: A review of phytochemicals and its effects in combination preparations
2020 Mar Journal of Ethnopharmacology Jiang M, Zhao S, Yang S, Lin X, He X, Wei X, et al.
This work comprehensively reviews the state on ethnobotany, ethnopharmacological uses, phytochemicals, combined applications, quality control and toxicology of licorice. It will provide systematic insights into this ancient drug for further development and clinical use.
Review Article Gan CaoClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Presentation Slides
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
The traditional Chinese medicine Gan Mai Da Zao Tang may lessen depressive behaviors in rats, likely through licorice increasing serotonin transporter and brain-derived neurotrophic factor signals in the hippocampus.
The Licorice and Jujube formula is seen as commonly used and potentially effective for treating menopausal symptoms as per classical Chinese medicine.
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