Acne Vulgaris
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
The Effectiveness of Manual Acupuncture Therapy for Acne Vulgaris: A Case Report
2022 Oct 31 Journal of Agromedicine and Medical Sciences Fredy DM, Nareswari I
The acupuncture mechanism works directly on acne lesions by improving microcirculation, reducing proinflammatory reactions, and increasing anti-inflammatory, as well as regulating the HPA axis which can reduce stress and improve hormones. Manual acupuncture can be considered a non-pharmacological therapeutic modality to treat AV with minimal side effects.
Case Report Acne
Network Pharmacology-Based Investigation on the Mechanism of the JinGuanLan Formula in Treating Acne Vulgaris
2022 Jul 13 Evidence-Based Complementary and Alternative Medicine Gholais NS, Shi C, Zhang J, Liao B, Albarmaqi RA, Tang X, et al.
JinGuanLan (JGL) formula might reverse the pathological changes associated with acne vulgaris through its antiinflammatory effect and regulate the excessive lipogenesis in sebaceous glands via different signalling pathways.
Network Pharmacology Jin Guan Lan Acne
Efficacy of acupuncture in improving symptoms and quality of life of patients with acne vulgaris: a randomized sham acupuncture-controlled trial
2022 Apr 18 Acupuncture in Medicine Jiao R, Zhai X, Zhang X, Xiong Z, Liu Z
Acupuncture may not effectively relieve the symptoms of patients with moderate or severe acne vulgaris (AV), or improve quality of life (QoL).
Randomised Controlled Trial Acupuncture Acne
Progress of different treatment modalities to limit the use of antibiotics in the treatment of acne
2022 Jan 03 Our Dermatology Online Sanjel K, Zhang XM
Although multiple guidelines recommend limiting the use and decreasing antibiotic resistance, antibiotics are frequently used agents for moderate to severe acne. Topical alternatives, spironolactone, isotretinoin, combined oral contraceptives, and fire needles are all effective therapeutic alternatives.
Acne
The effects of green tea on acne vulgaris: A systematic review and meta‐analysis of randomized clinical trials
2020 Aug 19 Phytotherapy Research Kim S, Park TH, Kim WI, Park S, Kim JH, Cho MK
Green tea extract (GTE) significantly reduced the number of inflammatory lesions in acne. Subgroup analysis revealed that topical GTE application was more effective in reducing both inflammatory and non-inflammatory lesions compared to oral intake. The study suggests that topical GTE application is beneficial for acne treatment without significant adverse events, while oral GTE intake has limited effects. However, the authors recommend further high-quality clinical trials for confirmation.
Systematic Review AcneResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Acupuncture has similar efficacy compared to pharmacotherapies for acne vulgaris, however acupuncture interventions reported less adverse effects and may be a treatment option.
2018 Evidence-Based Complementary and Alternative Medicine Acupuncture for Acne Vulgaris: A Systematic Review and Meta-Analysis Mansu SSY, Liang H, Parker S, Coyle ME, Wang K, Zhang AL, et al.
Systematic Review Acne Skin Conditions
There was no statistical difference in the efficacy of acupuncture compared to pharmacotherapies for acne vulgaris; however acupuncture interventions reported less adverse effects. Poor methodological quality of trial design and lack of consistent reporting of outcome measures from some trials were found in this review; therefore results should be interpreted with caution. Future trials should include rigorous methodological design and reporting should follow standard reporting conventions such as CONSORT and STRICTA. Quality of life measures and further understanding of the mechanisms of acupuncture on acne should also be considered for future studies.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
The effects of green tea on acne vulgaris: A systematic review and meta‐analysis of randomized clinical trials
2020 Aug 19 Phytotherapy Research Kim S, Park TH, Kim WI, Park S, Kim JH, Cho MK
Green tea extract (GTE) significantly reduced the number of inflammatory lesions in acne. Subgroup analysis revealed that topical GTE application was more effective in reducing both inflammatory and non-inflammatory lesions compared to oral intake. The study suggests that topical GTE application is beneficial for acne treatment without significant adverse events, while oral GTE intake has limited effects. However, the authors recommend further high-quality clinical trials for confirmation.
Systematic Review Acne
Efficacy of photodynamic therapy for the treatment of inflammatory acne vulgaris: A systematic review and meta‐analysis
2019 Oct 25 Journal of Cosmetic Dermatology Tang X, Li C, Ge S, Chen Z, Lu L
Photodynamic therapy (PDT) is beneficial for improving the clinical efficacy of inflammatory acne vulgaris, which can be widely used to treat inflammatory acne vulgaris in clinic.
Systematic Review
Promising plant-derived secondary metabolites for treatment of acne vulgaris: a mechanistic review
2019 Aug 26 Archives of Dermatological Research Soleymani S, Farzaei MH, Zargaran A, Niknam S, Rahimi R
Various molecular mechanisms were involved in effects of phytochemicals including antioxidant, anti-inflammatory, immunomodulatory, antibacterial, antiandrogenic, reducing sebum production, and lipogenesis inhibitory activities. Therefore, phytochemicals seem to be a precious source for identifying new medicines for treatment of acne vulgaris
Review Article
The Gut Microbiome as a Major Regulator of the Gut-Skin Axis
2018 Jul 10 Frontiers in Microbiology Salem Iman, Ramser Amy, Isham Nancy, Ghannoum Mahmoud A.
Basic science research and clinical studies have demonstrated the gut microbiome’s contribution to host homeostasis, allostasis, and the pathogenesis of disease. Through complex immune mechanisms, the influence of the gut microbiome extends to involve distant organ systems including the skin. With intentional modulation of the microbiome, probiotics, prebiotics, and synbiotics have proven beneficial in the prevention and/or treatment of inflammatory skin diseases including acne vulgaris, AD, and psoriasis.
Review Article MicrobiomeAcupuncture for Acne Vulgaris: A Systematic Review and Meta-Analysis
2018 Mar 12 Evidence-Based Complementary and Alternative Medicine Mansu SSY, Liang H, Parker S, Coyle ME, Wang K, Zhang AL, et al.
Systematic Review Meta-Analysis Skin Conditions AcneAcupuncture has similar efficacy compared to pharmacotherapies for acne vulgaris, however acupuncture interventions reported less adverse effects and may be a treatment option.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Efficacy of acupuncture in improving symptoms and quality of life of patients with acne vulgaris: a randomized sham acupuncture-controlled trial
2022 Apr 18 Acupuncture in Medicine Jiao R, Zhai X, Zhang X, Xiong Z, Liu Z
Acupuncture may not effectively relieve the symptoms of patients with moderate or severe acne vulgaris (AV), or improve quality of life (QoL).
Randomised Controlled Trial Acupuncture AcneEfficacy of ah shi Point Acupuncture on Acne Vulgaris
2010 Sep Acupuncture in Medicine Son BK, Yun Y, Choi IH
Acupuncture treatment of moderate acne vulgaris was associated with reduction of inflammatory lesions and improvement of the quality of life.
Randomised Controlled Trial Acupuncture Ah Shi Points AcneStudy Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Efficacy of acupuncture in improving the symptoms and the quality of life of patients with moderate or severe acne vulgaris: study protocol for a randomized controlled trial
2020 Jun 23 BMC Complementary Medicine and Therapies Jiao R, Huang M, Zhang W, Liu Z
We expect to evaluate the effectiveness of acupuncture in ameliorating the symptoms and improving the quality of life (QoL) of patients with moderate or severe acne vulgaris (AV) compared with sham acupuncture with more robust evidence.
Study Protocol Acne
Observation for clinical effect of acupuncture combined with conventional therapy in the treatment of acne vulgaris
2020 May Medicine Kou L, Yu N, Ren J, Yang B, Tao Y
This trial may provide evidence regarding the clinical effectiveness, safety, and cost-effectiveness of acupuncture for patients with acne vulgaris.
Study Protocol Acne Acupuncture Acne Vulgaris
Efficacy of acupuncture in improving the symptoms and the quality of life of patients with moderate or severe acne vulgaris: a protocol for a randomized controlled trial
2020 Mar 23 Trials Ruimin Jiao, Man Huang, Weina Zhang, Zhishun Liu
We expect to evaluate the effectiveness of acupuncture in ameliorating the symptoms and improving the quality of life (QoL) of patients with moderate or severe acne vulgaris (AV) compared with sham acupuncture with more robust evidence.
Study Protocol AcupuncturePresentation Slides
Acupuncture has similar efficacy compared to pharmacotherapies for acne vulgaris, however acupuncture interventions reported less adverse effects and may be a treatment option.
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