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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children
2023 Aug 12 European Journal of Pediatrics Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A
Polyunsaturated fatty acids are of central importance for the development and functioning of the brain and nervous system, especially during childhood development. An adequate supply of long-chain ω-3 fatty acids, such as EPA and DHA in particular, is therefore indispensable for normal brain development during foetal growth in the cerebralisation phase, as well as for visual and cognitive functions in neonates.
Review Article Polyunsaturated Fatty Acids
Effect of Combination of Dark Chocolate and Herbal Ingredients for Dysmenorrhea in Late Adolescents
2023 Jan 17 Journal of Tropical Pharmacy and Chemistry Azizah RNP, Anggreini P, Prasetya F
Randomised Controlled Trial Period Pain Dark Chocolate Honey Ginger SambilotoThe combination of dark chocolate with herbs could be one of the therapies for period pain.
Safety and Acceptance of Acupuncture and Acupressure in Children, Adolescents, and Young Adults Undergoing Hematopoietic Stem Cell Transplant
2022 Dec 01 Cancer Nursing Bettini E, Idiokitas R, Mahmood L, Jacobs S, Steinhorn D
This study demonstrates that acupuncture and acupressure are well accepted by children and their families admitted for hematopoietic stem cell transplant (HSCT) and are safe even when performed in the first 4 weeks following transplant when the patient is likely to have thrombocytopenia.
Cohort Study Children's Health
Investigating Acupoint Selection and Combinations of Acupuncture for Tic Disorders: An Association Rule Mining and Network Analysis Study
2022 Jun 10 Frontiers in Neurology Chen J, Xie Y, Lin Q, Qian Z, Feng J, Zhang J, et al.
Using data mining analysis of published studies, this study provides valuable information regarding the selection of the most effective acupoints and point combinations for clinical acupuncture practice for treating TDs.
Systematic Review Tic Disorders
Chinese Herbal Medicine for the Treatment of Children and Adolescents With Refractory Mycoplasma Pneumoniae Pneumonia: A Systematic Review and a Meta-Analysis
2021 Jun 10 Frontiers in Pharmacology Ling X, Sun X, Kong H, Peng S, Yu Z, Wen J, et al.
Despite of the apparently positive results in relieving clinical symptoms, physical signs and reducing inflammation, it is premature to confirm the efficacy of Chinese herb medicine (CHM) in treating Refractory Mycoplasma Pneumoniae Pneumonia (RMPP) because of the limitation of quality and the number of the included studies.
Systematic Review Meta-Analysis Refractory Mycoplasma Pneumoniae Children's HealthResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The combination of dark chocolate with herbs could be one of the therapies for period pain.
2023 Journal of Tropical Pharmacy and Chemistry Effect of Combination of Dark Chocolate and Herbal Ingredients for Dysmenorrhea in Late Adolescents Azizah RNP, Anggreini P, Prasetya F
Randomised Controlled Trial Dark Chocolate Ginger Honey
This test was conducted on 30 respondents who were divided into three groups, namely the positive control group (K), dark chocolate (C), and a combination of dark chocolate with herbs (C+H). Dark chocolate was combined with herbal ingredients consisting of turmeric, red ginger, moringa, sambiloto extract, and honey as a beverage 250 mL.
The study is quantitative research with quasi-experimental method. Pain measurement using the Numeric Rating Scale (NRS) sheet was given before and 2 hours after treatment. The data was analyzed using paired t-test. State the results of the values obtained the combination of dark chocolate and herbs showed a significant reduction in pain before and after treatment (p<0.05).
Acupuncture treatment has shown to be more beneficial than standard pharmacotherapy for treating attention deficit hyperactivity disorder in children and adolescents.
2021 Complementary Medicine Research The Efficacy of Acupuncture Treatment for Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis Chen YC, Wu LK, Lee MS, Kung YL
Meta-Analysis
The study employed a systematic review and meta-analysis of randomized controlled trials comparing the effects of acupuncture treatment with pharmacotherapy (specifically, methylphenidate hydrochloride) in patients diagnosed with ADHD. Ten studies, involving a total of 876 patients, were selected from 12 electronic databases that were searched from inception until February 3, 2020. Effectiveness of treatment and post-treatment hyperactivity scores formed the main outcomes, along with studying the occurrence of adverse events and post-treatment course.
In terms of the results, the meta-analysis found that acupuncture treatment demonstrated significantly higher effectiveness than pharmacotherapy and showed capabilities of reducing hyperactivity scores but to a lesser extent than pharmacotherapy. Additionally, there were no adverse events reported in the acupuncture group in two studies, and another study reported that acupuncture could even reduce adverse reactions from drugs. Lastly, three studies concluded that the positive effects of acupuncture treatment were sustained after the treatment was completed.
Omega-3 polyunsaturated fatty acids supplementation during the prenatal and perinatal period could have a protective effect on neurodevelopmental disorders including ADHD, ASD, and MDD in youth.
2020 Clinical Psychopharmacology and Neuroscience Nutritional Neuroscience as Mainstream of Psychiatry: The Evidence- Based Treatment Guidelines for Using Omega-3 Fatty Acids as a New Treatment for Psychiatric Disorders in Children and Adolescents Chang JPC, Su KP
Review Article ADHD Autism Depression
The research implemented supplementation of omega-3 polyunsaturated fatty acids also known as Omega-3 PUFAs, in different quantities and durations to youth with attention deficit hyperactivity disorder (ADHD), major depressive disorder (MDD) and autism spectrum disorder (ASD). This was carried out based on suggested dosage and duration from various randomized controlled trials and systemic literature reviews. It was observed that omega-3 PUFAs were essential nutrients not just for physical health but also for mental health, more so during the prenatal and perinatal stages of development.
The results demonstrated that clinical symptoms improved in youth with ADHD, MDD and ASD after they were supplemented with Omega-3 PUFAs, especially in cases where there was high inflammation or low baseline Omega-3 index present. The research showed very promising evidence that Omega-3 PUFAs had positive effects on lethargy and hyperactivity symptoms in ASD. There was also an inclination that Omega-3 PUFAs levels and inflammation could be potential markers for treatment response in ADHD and MDD.
Magnesium-rich mineral water effectively treats and prevents constipation in children, leading to regular, painless bowel movements.
2020 Russian Journal of Physiotherapy, Balneology and Rehabilitation The use of magnesium-containing mineral waters for functional constipation in children and adolescents Kulikov AG, Zakharova IN, Tvorogova TM, Stepurina LL, Elezova LI
Clinical Study Children's Health Constipation Magnesium
This randomized, prospective, open, comparative study involved 95 children and adolescents aged 10-16 years with functional constipation. They received sanatorium therapy for 18 days, including a sparing-exercise regimen, therapeutic nutrition, health-improving massage, and physiotherapy exercises. Participants were divided into two groups: Group 1 (55 patients) received basic treatment plus magnesium-containing mineral water, while Group 2 (40 patients) received only basic treatment. The study assessed the frequency and nature of defecation, vegetative status, and functional body reserves.
By day 5, 49% of Group 1 patients achieved daily defecation, increasing to 89.1% by the end of treatment. In contrast, only 55% of Group 2 showed positive changes by the end. The mineral water group also had softer, pain-free bowel movements, with most achieving a morning defecation reflex after consuming the water. The control group saw less significant changes in defecation nature, with only 18% reaching softer bowel movements by the end of treatment. The results indicate the effectiveness and safety of magnesium-containing mineral water in treating and preventing functional constipation in children.
Massage therapy proves more beneficial in improving ADHD symptoms in children and adolescents than traditional Ritalin treatment.
2019 Complementary Therapies in Medicine Massage therapy for the treatment of attention deficit/hyperactivity disorder (ADHD) in children and adolescents: A systematic review and meta-analysis Chen SC, Yu BYM, Suen LKP, Yu J, Ho FYY, Yang JJ, et al.
Meta-Analysis ADHD Massage
This study used a systematic review incorporating eight randomized controlled trials and three case series studies. Out of these trials, a meta-analysis of four was conducted.
The pooled analysis revealed massage therapy brought about a significant improvement in ADHD symptoms. Individual trials indicated massage was significantly different from waiting, showing great improvement specifically in conditions related to anxious-passive behaviour and antisocial behaviour.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children
2023 Aug 12 European Journal of Pediatrics Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A
Polyunsaturated fatty acids are of central importance for the development and functioning of the brain and nervous system, especially during childhood development. An adequate supply of long-chain ω-3 fatty acids, such as EPA and DHA in particular, is therefore indispensable for normal brain development during foetal growth in the cerebralisation phase, as well as for visual and cognitive functions in neonates.
Review Article Polyunsaturated Fatty AcidsInvestigating Acupoint Selection and Combinations of Acupuncture for Tic Disorders: An Association Rule Mining and Network Analysis Study
2022 Jun 10 Frontiers in Neurology Chen J, Xie Y, Lin Q, Qian Z, Feng J, Zhang J, et al.
Using data mining analysis of published studies, this study provides valuable information regarding the selection of the most effective acupoints and point combinations for clinical acupuncture practice for treating TDs.
Systematic Review Tic DisordersChinese Herbal Medicine for the Treatment of Children and Adolescents With Refractory Mycoplasma Pneumoniae Pneumonia: A Systematic Review and a Meta-Analysis
2021 Jun 10 Frontiers in Pharmacology Ling X, Sun X, Kong H, Peng S, Yu Z, Wen J, et al.
Despite of the apparently positive results in relieving clinical symptoms, physical signs and reducing inflammation, it is premature to confirm the efficacy of Chinese herb medicine (CHM) in treating Refractory Mycoplasma Pneumoniae Pneumonia (RMPP) because of the limitation of quality and the number of the included studies.
Systematic Review Meta-Analysis Refractory Mycoplasma Pneumoniae Children's HealthThe Efficacy of Acupuncture Treatment for Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis
2021 Jan Complementary Medicine Research Chen YC, Wu LK, Lee MS, Kung YL
Meta-Analysis Systematic ReviewAcupuncture treatment has shown to be more beneficial than standard pharmacotherapy for treating attention deficit hyperactivity disorder in children and adolescents.
Nutritional Neuroscience as Mainstream of Psychiatry: The Evidence- Based Treatment Guidelines for Using Omega-3 Fatty Acids as a New Treatment for Psychiatric Disorders in Children and Adolescents
2020 Nov 30 Clinical Psychopharmacology and Neuroscience Chang JPC, Su KP
Review Article Walnut Depression Autism ADHD Omega-3 Fatty Acids SardineOmega-3 polyunsaturated fatty acids supplementation during the prenatal and perinatal period could have a protective effect on neurodevelopmental disorders including ADHD, ASD, and MDD in youth.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Effect of Combination of Dark Chocolate and Herbal Ingredients for Dysmenorrhea in Late Adolescents
2023 Jan 17 Journal of Tropical Pharmacy and Chemistry Azizah RNP, Anggreini P, Prasetya F
Randomised Controlled Trial Period Pain Dark Chocolate Honey Ginger SambilotoThe combination of dark chocolate with herbs could be one of the therapies for period pain.
Dark chocolate was combined with herbal ingredients consisting of turmeric, red ginger, moringa, sambiloto extract, and honey as a beverage (250 mL). —Jinnan C 29 Oct 2023
Omega-3 fatty-acids modulate symptoms of depressive disorder, serum levels of omega-3 fatty acids and omega-6/omega-3 ratio in children. A randomized, double-blind and controlled trial
2020 May Psychiatry Research Trebatická J, Hradečná Z, Surovcová A, Katrenčíková B, Gushina I, Waczulíková I, et al.
The study concluded that an omega-3 fatty acid fish oil emulsion showed significant reductions in depressive symptoms and a decrease in omega-6/omega-3 ratio in the treatment group compared to the control group.
Clinical Study Randomised Controlled Trial Depression Children's Health Omega-6 Omega-3 Ratio
The effect of bee prepolis on primary dysmenorrhea: a randomized clinical trial
2019 Jan Obstetrics & Gynecology Science Jenabi E, Fereidooni B, Karami M, Masoumi SZ, Safari M, Khazaei S
Our study showed that the use of bee propolis for two months compared with placebo reduced primary dysmenorrhea during the first and second months after use, with no adverse effects. Therefore, it could be used as an alternative to nonsteroidal anti-inflammatory drugs for relief of primary dysmenorrhea.
Randomised Controlled Trial Propolis Period Pain
Laser Acupuncture for Relieving Nausea and Vomiting in Pediatric Patients Undergoing Chemotherapy: A Single-Blind Randomized Clinical Trial
2018 Dec 10 Journal of Pediatric Oncology Nursing Varejão CS, Santo FHE
The study concluded that laser acupuncture was effective in relieving nausea within 5 days of chemotherapy and in reducing the number of episodes of vomiting on Days 2 and 3 after chemotherapy.
Randomised Controlled Trial Children's Health
Efficacy of adding acupuncture to Methylphenidate in children and adolescents with attention deficit hyperactivity disorder: A randomized clinical trial
2018 Sep European Journal of Integrative Medicine Moharreri F, Khorsand Vakilzadeh A, Soltanifar A, Abdollahian E, Eslami S, Nahidi M
Acupuncture significantly improved the parent-reported ADHD-RS total score, hyperactivity, and impulsivity in patients with ADHD after 3 weeks, compared to the sham acupuncture group. However, it did not show a considerable improvement in attention deficit. Further investigations with larger sample sizes and longer follow-up are recommended to assess the long-term effects, and adverse effects of acupuncture on ADHD patients should be measured in future studies.
Randomised Controlled Trial ADHDStudy Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Clinical study on acupuncture acupoints around the eyes in treating myopia in children and adolescents
2020 Oct 23 Medicine Huang, Qun; Yang, Yang; Huang, Hui; Zheng, Yanlin; Wang, Wanjie; Liao, et al.
Our study will compare acupuncture Deqi with acupuncture without Deqi, and place it in a control group for the treatment of myopia. The results of this trial are expected to provide solid evidence for the effectiveness and safety of acupuncture combined with Deqi in the treatment of myopia, and hope to provide a reference for clinical practice.
Study ProtocolThe effectiveness and safety of acupuncture for patients with myopia
2020 Jun 05 Medicine Yu Z, Wang X, Zhao X, Li D, Duan J
The conclusion of this study will provide evidence for evaluating the efficacy and safety of acupuncture to delay the progression for myopia in children and adolescents.
Study ProtocolPresentation Slides
The combination of dark chocolate with herbs could be one of the therapies for period pain.
Acupuncture treatment has shown to be more beneficial than standard pharmacotherapy for treating attention deficit hyperactivity disorder in children and adolescents.
Omega-3 polyunsaturated fatty acids supplementation during the prenatal and perinatal period could have a protective effect on neurodevelopmental disorders including ADHD, ASD, and MDD in youth.
Magnesium-rich mineral water effectively treats and prevents constipation in children, leading to regular, painless bowel movements.
Massage therapy proves more beneficial in improving ADHD symptoms in children and adolescents than traditional Ritalin treatment.
Dark chocolate could reduce menstrual pain significantly in late adolescents.
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Dark chocolate was combined with herbal ingredients consisting of turmeric, red ginger, moringa, sambiloto extract, and honey as a beverage (250 mL). —Jinnan C 29 Oct 2023