Air Pollution

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Chinese Medicine Research Hub

Korean pear extracts appear to alleviate air pollution-related respiratory hypersensitivity by modulating beneficial gut microflora and suppressing pro-inflammatory cytokines.

2023 Journal of Medicinal Food Effects of Pear Extracts on Microbiome and Immunocytokines to Alleviate Air Pollution-Related Respiratory Hypersensitivity
Yang M, Lee U, Cho HR, Lee KB, Shin YJ, Bae MJ, Park KY

Chinese Medicine Research Hub

Network Pharmacology

The primary ingredient of Shenling Baizhu powder, Rutin, can improve polycystic ovary syndrome and postmenopausal osteoporosis by binding to the aromatic hydrocarbon receptor, thus inhibiting cell apoptosis.

2022 PeerJ Prevention of polycystic ovary syndrome and postmenopausal osteoporosis by inhibiting apoptosis with Shenling Baizhu powder compound
Liang J, Bao A, Ma H, Dong W, Li W, Wu X, Li H, Hou H, Chen Y, Fu J, Shao C

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Air Pollution" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Air Pollution" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Air Pollution" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A published in 2023 in the journal Journal of Medicinal Food found that Korean pear extracts appear to alleviate air pollution-related respiratory hypersensitivity by modulating beneficial gut microflora and suppressing pro-inflammatory cytokines. In the preclinical and randomized double-blind clinical studies, mild-asthma subjects living in Seoul, Korea were divided into two groups: one receiving a daily treatment of pear extracts for four weeks, and a placebo group. The pear extract was tested for its ability to mitigate respiratory hypersensitivity connected to air pollution. The treatment's effects were evaluated based on the toxicokinetic study of exposure biomarkers for airborne polyaromatic hydrocarbons and levels of pro-inflammatory cytokines in human subjects. In terms of results, it was found that those individuals receiving daily pear extract exhibited decreased levels of exposure biomarkers related to airborne polyaromatic hydrocarbons. Furthermore, the pear extract treatment was associated with a significant increase in populations of fiber-degrading bacteria that boost beneficial gut microflora crucial for immune defense. Additionally, the extracts significantly suppressed the production of various pro-inflammatory cytokines, as per the preclinical tests conducted on asthma-induced mice. Overall, these outcomes suggest a beneficial role of Korean pear extracts in mitigating air pollution-related respiratory hypersensitivity.

A Network Pharmacology published in 2022 in the journal PeerJ found that The primary ingredient of Shenling Baizhu powder, Rutin, can improve polycystic ovary syndrome and postmenopausal osteoporosis by binding to the aromatic hydrocarbon receptor, thus inhibiting cell apoptosis. In this study, the active ingredients of Shenling Baizhu powder were identified using a Chinese medicine database, and Rutin emerged as having the highest binding affinity to the aromatic hydrocarbon receptor. This was determined through molecular dynamics simulation, eliminating any ambiguity. Then, to assess the efficacy of Rutin, it was used therapeutically on ovarian granulosa and osteoblast cell lines, with varying concentrations to determine the optimum dosage. Analyzing the results showed that the introduction of Rutin to both ovarian granulosa and osteoblast cell lines resulted in modified protein expressions, indicative of cellular adjustments. Specifically, expressions of the apoptosis-associated protein and the aromatic hydrocarbon receptor, among others, were decreased while the expression of protein Bcl-2 was increased. Moreover, cell proliferation was seen to significantly accelerate in both cell lines after treatment with Rutin.

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