Anaemia
Also known as: Anemia
Recent Insights
The herbal decoction Jian-Pi-Yi-Shen reduces symptoms of chronic kidney disease and anaemia by improving iron metabolism and inhibiting the JAK2-STAT3 signaling pathway.
Anaemia Chronic Kidney Disease Jian Pi Yi Shen Formula
Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
Anaemia Haemoglobin Honey
Black pepper and its major component, piperine, can effectively regulate anemia of inflammation by reducing the overexpression of hepcidin, a hormone that controls iron levels.
Anaemia Black Pepper Hepcidin
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
Anaemia Erythropoietin Iron
Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
Anaemia Erythropoietin Iron
Jian-Pi-Yi-Shen, a traditional Chinese medicine, helps treat anemia in chronic kidney disease by stimulating erythropoietin production and regulating iron recycling.
Anaemia Chronic Kidney Disease Erythropoietin
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Jian-Pi-Yi-Shen formula restores iron metabolism from dysregulation in anemic rats with adenine-induced nephropathy
2023 Aug Journal of Ethnopharmacology Li C, Huang H, Wang R, Zhang C, Huang S, Wu J, et al.
Experimental Study Animal Study Jian Pi Yi Shen Formula Chronic Kidney Disease AnaemiaThe herbal decoction Jian-Pi-Yi-Shen reduces symptoms of chronic kidney disease and anaemia by improving iron metabolism and inhibiting the JAK2-STAT3 signaling pathway.
Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia
2022 Aug 04 Journal of Asian Multicultural Research for Medical and Health Science Study A A, Astuti A, Leli L, Saad R
Randomised Controlled Trial Honey Anaemia Pregnancy HaemoglobinHoney, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway
2021 May Free Radical Biology and Medicine Banerjee S, Katiyar P, Kumar L, Kumar V, Saini SS, Krishnan V, et al.
Experimental Study Anaemia Black Pepper HepcidinBlack pepper and its major component, piperine, can effectively regulate anemia of inflammation by reducing the overexpression of hepcidin, a hormone that controls iron levels.
Iron deficiency without anaemia: a diagnosis that matters
2021 Mar Clinical Medicine Al-Naseem A, Sallam A, Choudhury S, Thachil J
The review concludes that IDWA is poorly recognized by clinicians despite its high prevalence, emphasizes the importance of iron sufficiency during pregnancy, highlights the need for preoperative correction of IDWA to reduce transfusion and postoperative anaemia risk, and recommends oral iron as the first-line treatment, with intravenous supplementation in specific situations.
Review ArticleA Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
2020 Nov 26 Frontiers in Pharmacology Chen J, Tsim KWK
Review Article Jujube Anaemia Iron ErythropoietinFlavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The herbal decoction Jian-Pi-Yi-Shen reduces symptoms of chronic kidney disease and anaemia by improving iron metabolism and inhibiting the JAK2-STAT3 signaling pathway.
2023 Journal of Ethnopharmacology Jian-Pi-Yi-Shen formula restores iron metabolism from dysregulation in anemic rats with adenine-induced nephropathy Li C, Huang H, Wang R, Zhang C, Huang S, Wu J, et al.
Experimental Study Chronic Kidney Disease Jian Pi Yi Shen Formula
Methodology used included an analysis of network pharmacology, chemical profiling, and in vivo experiments on the effect of Jian-Pi-Yi-Shen (JPYS) on renal anemia and chronic kidney disease (CKD). The active compounds in JPYS were detected in in vivo experiment, and their potential targets were predicted by network pharmacology. An animal model of CKD-related anemia was developed using adenine-feeding for further analysis. The estimation of renal injury was conducted using blood tests, histopathological examinations, and fibrosis degree assessment while the levels of JAK2, STAT3 and iron metabolism-related factors were measured through various techniques.
Discussion of the results reveals that 164 active ingredients, including prototypes and metabolites in JPYS, were discovered and 21 core targets were identified. Many of these core targets were associated with the JAK2-STAT3 signaling pathways. Experimental results demonstrated that JPYS treatment significantly improved hematological parameters and iron metabolism in CKD rats, decreased certain indicators of renal damage, and suppressed the expression of JAK2 and STAT3.
Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
2022 Journal of Asian Multicultural Research for Medical and Health Science Study Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia A A, Astuti A, Leli L, Saad R
Randomised Controlled Trial Haemoglobin Honey Pregnancy
This quasi-experimental study with a pretest-posttest design involved 30 pregnant women divided into two groups: one receiving Fe (Control Group) and the other Honey + Fe (Intervention Group) for 60 days. Blood and urine analyses revealed a remarkable increase in hemoglobin levels in the Honey + Fe group (2.80 ± 0.26 g/dl), surpassing the Fe control group (0.80 ± 0.13 g/dl). Moreover, the Intervention Group demonstrated a notable decrease in 8-Ohdg levels (-4.23 ± 1.32 nmol/ml, p = 0.031), indicating reduced oxidative stress, while the Fe control group exhibited less significant changes (2.98 ± 1.30 nmol/ml, p = 0.322). Independent T Test confirmed the Honey + Fe group's superior effectiveness in increasing hemoglobin levels and decreasing 8-Ohdg levels in anemic pregnant women (p = 0.001 and p = 0.002, respectively).
The study underscores the synergistic benefits of honey and iron supplementation in enhancing hemoglobin levels and mitigating oxidative stress among anemic pregnant women. The robust findings, supported by statistical significance, emphasize the potential clinical relevance of incorporating honey into anemia management strategies, offering a more effective approach compared to iron supplementation alone.
Black pepper and its major component, piperine, can effectively regulate anemia of inflammation by reducing the overexpression of hepcidin, a hormone that controls iron levels.
2021 Free Radical Biology and Medicine Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway Banerjee S, Katiyar P, Kumar L, Kumar V, Saini SS, Krishnan V, et al.
Experimental Study Black Pepper Hepcidin
The study involves a two-tier investigation, first in vitro, and then in vivo. In the laboratory, different black pepper extracts were interacted with a human liver cell line known as HepG2, and the one derived from methanol (BPME) showed the most promising result because it reduced the transcription of the hepcidin gene significantly. In addition to BPME, piperine was proven to almost entirely suppress hepcidin protein expression at specific concentrations.
In the subsequent in vivo experimentation, live mice were artificially induced with an elevated level of hepcidin through oil of turpentine injections. Then they were administered with BPME and piperine, the effects of which significantly reduced the enhanced hepcidin expression. The molecular interaction studies further suggest that piperine directly binds with SMAD1 and STAT3 proteins, the critical factors behind the overexpression of hepcidin.
The study found a demonstrable downregulation in hepcidin expression with the use of both the methanol extract of black pepper and the bioactive alkaloid piperine. These substances also interacted with some proteins to lower the overexpression of hepcidin initiated by inflammation. Additionally, there was a noticeable increase in iron bioavailability in the liver of treated test animals, pointing to the potential of these compounds to rectify anemia of inflammation. The findings posited black pepper as a possible therapeutic option for managing this anemic condition.
Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
2020 Frontiers in Pharmacology A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence Chen J, Tsim KWK
Review Article Erythropoietin Iron Jujube
Jujube promotes erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, possesses potential capacity in recycling heme iron during erythrophagocytosis, exhibits bidirectional role in regulating immune response under different conditions, contains numerous minerals including iron.
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
2020 Frontiers in Pharmacology A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence Chen J, Tsim KWK
Review Article Erythropoietin Iron Jujube
Traditionally in China, jujube is considered as a medicinal fruit that is being used in treating blood deficiency. In this review, the beneficial effects of jujubes on the hematopoietic functions are summarized and discussed. As illustrated in cell and animal models, the application of jujube extract possessed beneficial effects, including regulation of erythropoiesis via activation of hypoxia inducible factor-induced erythropoietin, potential capacity in recycling heme iron during erythrophagocytosis and bi-directional regulation of immune response. Thus, the blood-nourishing function of jujube is being proposed here. Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Taken together, these findings provide several lines of evidence for further development of jujube as supplementary products for prevention and/or treatment of anemia.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Iron deficiency without anaemia: a diagnosis that matters
2021 Mar Clinical Medicine Al-Naseem A, Sallam A, Choudhury S, Thachil J
The review concludes that IDWA is poorly recognized by clinicians despite its high prevalence, emphasizes the importance of iron sufficiency during pregnancy, highlights the need for preoperative correction of IDWA to reduce transfusion and postoperative anaemia risk, and recommends oral iron as the first-line treatment, with intravenous supplementation in specific situations.
Review ArticleA Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
2020 Nov 26 Frontiers in Pharmacology Chen J, Tsim KWK
Review Article Jujube Anaemia Iron ErythropoietinFlavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence
2020 Nov 26 Frontiers in Pharmacology Jianping Chen and Karl W. K. Tsim
Flavonoid, polysaccharide and triterpenoid within jujube could serve as the potential active ingredients accounting for the aforementioned health benefits. Taken together, these findings provide several lines of evidence for further development of jujube as supplementary products for prevention and/or treatment of anemia.
Review Article Anemia Jujube Anaemia
Efficacy and safety of Danggui Buxue Decoction in combination with western medicine treatment of anemia for renal anemia: a systematic review and meta-analysis
2017 Mar Annals of Translational Medicine Zhao MM, Zhang Y, Li LS, Yu ZK, Li B
Danggui Buxue Decoction in combination with conventional western medicine (CWM) for renal anemia might be superior to CWM alone and there was no adverse event in the experimental group, it might be more effective when the ratio of Radix Astragali to Radix Angelicae Sinensis was 5:1. However, the quality of included studies was not high, and less attention was paid to the safety, high quality randomized controlled trials are needed to further confirm the findings.
Systematic Review Meta-Analysis Anaemia Renal AnemiaClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Effect of Honey to Levels Hemoglobin and Levels of 8-Hydroxy-2-Deoxyguanosin (8-Ohdg) in Pregnant Women with Anemia
2022 Aug 04 Journal of Asian Multicultural Research for Medical and Health Science Study A A, Astuti A, Leli L, Saad R
Randomised Controlled Trial Honey Anaemia Pregnancy HaemoglobinHoney, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
The Efficacy and Safety of Vitamin C for Iron Supplementation in Adult Patients With Iron Deficiency Anemia
2020 Nov 02 JAMA Oncology Li N, Zhao G, Wu W, Zhang M, Liu W, Chen Q, et al.
Among patients with IDA, oral iron supplements alone were equivalent to oral iron supplements plus vitamin C in improving hemoglobin recovery and iron absorption. These findings suggest that on-demand vitamin C supplements are not essential to take along with oral iron supplements for patients with IDA.
Randomised Controlled Trial Iron Deficiency Anaemia Anaemia Vitamin CPresentation Slides
The herbal decoction Jian-Pi-Yi-Shen reduces symptoms of chronic kidney disease and anaemia by improving iron metabolism and inhibiting the JAK2-STAT3 signaling pathway.
Honey, combined with Iron (Fe), effectively enhances hemoglobin levels and reduces oxidative stress markers in anemic expectant mothers.
Black pepper and its major component, piperine, can effectively regulate anemia of inflammation by reducing the overexpression of hepcidin, a hormone that controls iron levels.
Flavonoids from jujube have been found to stimulate the expression of erythropoietin (EPO), a hormone stimulating blood production.
Recent studies have indicated that jujube possesses a wide range of pharmacological activities in nervous system, cardiovascular system, as well as anti-oxidation and anti-cancer properties.
Jian-Pi-Yi-Shen, a traditional Chinese medicine, helps treat anemia in chronic kidney disease by stimulating erythropoietin production and regulating iron recycling.
Angelica Sinensis polysaccharide treatment has been found to effectively alleviate anaemia of chronic disease in rats by inhibiting inflammatory pathways and mobilizing iron.
Black soyabean seed coat extract significantly decreases hepcidin expression, leading to improved iron metabolism and potential treatment for iron-deficiency anaemia.
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