Di Huang
Also known as: Rehmanniae Radix
Recent Insights
Shu Di Huang, traditionally used in Chinese medicine, may effectively treat attention deficit hyperactivity disorder by rectifying neurodevelopmental abnormalities, neuronal apoptosis, and energy metabolism failures.
ADHD Di Huang Neurodevelopmental Disorders
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation
2022 Jan Frontiers in Pharmacology Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang
Experimental Study Women's Health Shao Yao Si Wu Tang Oestradiol Shu Di HuangSi Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
Ethnopharmacological Survey of Traditional Chinese Medicine Pharmacy Prescriptions for Dysmenorrhea
2021 Dec 21 Frontiers in Pharmacology Su KH, Su SY, Ko CY, Cheng YC, Huang SS, Chao J
The study concludes that Angelica sinensis (Dang Gui), Ligusticum chuanxiong Hort (Chuan Qiong), Rehmannia glutinosa Libosch (Di Huang), Paeonia lactiflora Pall (Bai Shao), Hedysarum polybotrys Hand.-Mazz (Hong Qi), Lycium chinense Mill (Gou Qi Zi), and Cinnamomum cassia (Gui Zhi) are the seven core medicinal materials frequently used in TCM prescriptions for dysmenorrhea, forming 58 combinations with 107 association rules. The study emphasizes the valuable knowledge on TCM pharmacy prescriptions for dysmenorrhea and suggests potential avenues for future pharmacological research and the development of naturally derived medications.
Network Pharmacology Period PainElucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation
2019 Mar 05 Evidence-Based Complementary and Alternative Medicine Huang GC, Tsai YZ, Lee CJ, Chang HY, Wang CC
In this study, we recommend that if the ratio of Shu Di Huang and Shao Yao should be increased, the function of SWT will be more forceful against menstrual disorder patterns through activating aromatase and antioxidative properties.
Network Pharmacology Si Wu TangThe Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex
2018 Oct 14 Evidence-Based Complementary and Alternative Medicine Yuan H, Yang M, Han X, Ni X
Review Article Neurodevelopmental Disorders ADHD Di HuangShu Di Huang, traditionally used in Chinese medicine, may effectively treat attention deficit hyperactivity disorder by rectifying neurodevelopmental abnormalities, neuronal apoptosis, and energy metabolism failures.
Rehmanniae Radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology
2017 Feb Journal of Ethnopharmacology Liu C, Ma R, Wang L, Zhu R, Liu H, Guo Y, et al.
The successful inclusion of Rehmanniae Radix in clinical trials and preclinical studies for the management of osteoporosis has attracted rising attentions for identifying potential anti-osteoporotic candidates from this plant and clinical existing TCM formulas, which will further speed up anti-osteoporosis drug discovery processes. Properly designed and well controlled prospective studies are still needed to further demonstrate bone protective actions and safe use of this herb and its ingredients
Review Article Osteoporosis Di HuangResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
2022 Frontiers in Pharmacology Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang
Experimental Study Oestradiol Shao Yao Shu Di Huang
In the methodology of the study, a testosterone-treated MCF-7 cell model was employed to determine the effects of each herb in the SWT formula. Key metrics that were considered included the regulation of estradiol, antioxidative effects, and the total polyphenol and polysaccharide contents as quality markers. The study also explored the potential ability of certain elements within the formula to act as an aromatase promoter, notably catalpol and other elements.
In terms of results, certain herbs in SWT such as catalpol showed an ability to significantly increase estradiol content and boost upregulation in cell culture, indicating their role as potential aromatase promoters within the formula. Antioxidant activity was also strong in other compounds like pentagalloylglucose, gallic acid, and ferulic acid. These antioxidative effects were attributed to the presence of polyphenols in the herbs. Furthermore, the herb with the strongest antioxidant effects could possibly help ameliorate menstrual disorder patterns due to its ability to prevent ROS damage to the ovaries.
Shu Di Huang, traditionally used in Chinese medicine, may effectively treat attention deficit hyperactivity disorder by rectifying neurodevelopmental abnormalities, neuronal apoptosis, and energy metabolism failures.
2018 Evidence-Based Complementary and Alternative Medicine The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex Yuan H, Yang M, Han X, Ni X
Review Article ADHD Neurodevelopmental Disorders
Rehmanniae radix preparata, a scrophulariaceae plant that has been used for millennia for nourishing kidney-yin, essence and filling marrow in traditional Chinese medicine, has been discovered to have antioxidant, antisenescence, anti-inflammatory, and neuroprotective properties. Particularly telling is the active component, Catalpol, evidently helps elevate brain-derived neurotrophic factor and curbs neuronal apoptosis and energy metabolism failure.
The results visualized with this study rest on an analysis of Rehmanniae radix preparata's effects on both mice and rats, wherein it inhibited spontaneous activity, improved learning and memory subsequent to thalamic arcuate nucleus injury, and revealed antidepressant effects. This leads us to the conclusion that the properties of Rehmanniae radix preparata align with the areas of dysfunction seen in ADHD, which exhibits hyperactivity-impulsivity and impairments in learning and memory, issues tied fundamentally to anomalies in the cortex mediated by dysfunction in neuronal development, apoptosis, and energy metabolism.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
The Therapeutic Effect of the Chinese Herbal Medicine, Rehmanniae Radix Preparata, in Attention Deficit Hyperactivity Disorder via Reversal of Structural Abnormalities in the Cortex
2018 Oct 14 Evidence-Based Complementary and Alternative Medicine Yuan H, Yang M, Han X, Ni X
Review Article Neurodevelopmental Disorders ADHD Di HuangShu Di Huang, traditionally used in Chinese medicine, may effectively treat attention deficit hyperactivity disorder by rectifying neurodevelopmental abnormalities, neuronal apoptosis, and energy metabolism failures.
Rehmanniae Radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology
2017 Feb Journal of Ethnopharmacology Liu C, Ma R, Wang L, Zhu R, Liu H, Guo Y, et al.
The successful inclusion of Rehmanniae Radix in clinical trials and preclinical studies for the management of osteoporosis has attracted rising attentions for identifying potential anti-osteoporotic candidates from this plant and clinical existing TCM formulas, which will further speed up anti-osteoporosis drug discovery processes. Properly designed and well controlled prospective studies are still needed to further demonstrate bone protective actions and safe use of this herb and its ingredients
Review Article Osteoporosis Di HuangPresentation Slides
Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
Shu Di Huang, traditionally used in Chinese medicine, may effectively treat attention deficit hyperactivity disorder by rectifying neurodevelopmental abnormalities, neuronal apoptosis, and energy metabolism failures.
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