Diarrhoea
Recent Insights
Traditional Chinese medicine therapies, like acupuncture and moxibustion, effectively alleviate irritable bowel syndrome with diarrhea symptoms, and reduce recurrence rates.
Chinese Medicine Diarrhoea Irritable Bowel Syndrome
Acupuncture combined with moxibustion showed the best outcomes in terms of efficacy and quality of life improvement for adults with irritable bowel syndrome complicated with diarrhea.
Acupuncture Diarrhoea Irritable Bowel Syndrome
The combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.
Diarrhoea Meridian Massage Spleen Deficiency
Acupuncture treatment can improve the clinical effectiveness of diarrhea-predominant irritable bowel syndrome or functional diarrhea.
Diarrhoea
Dark chocolate with high cocoa content can affect colonic functionality and stimulate certain brain regions in healthy adults.
Brain Activity Cocoa Dark Chocolate
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
External therapy of traditional Chinese medicine for treating irritable bowel syndrome with diarrhea: A systematic review and meta-analysis
2022 Aug 09 Frontiers in Medicine Wei X, Wen Y, Wei Y, Liang X, Ma X, Zhang B, et al.
Systematic Review Meta-Analysis Diarrhoea Chinese Medicine Irritable Bowel SyndromeTraditional Chinese medicine therapies, like acupuncture and moxibustion, effectively alleviate irritable bowel syndrome with diarrhea symptoms, and reduce recurrence rates.
Acupuncture and Moxibustion in the Treatment of Adult Diarrhea Irritable Bowel Syndrome: A Network Meta-analysis
2022 Jun 28 Computational and Mathematical Methods in Medicine Jiang X, Guo X, Zhou J, Ye S
Meta-Analysis Acupuncture Moxibustion Irritable Bowel Syndrome DiarrhoeaAcupuncture combined with moxibustion showed the best outcomes in terms of efficacy and quality of life improvement for adults with irritable bowel syndrome complicated with diarrhea.
Therapeutic Potential of Nelumbo nucifera (Sacred Lotus) in CNS Disorders
2022 Jun 09 Dhaka University Journal of Pharmaceutical Sciences Mitra K, Raihan MA, Rahman MA, Rouf R, Reza HM, Uddin SJ, et al.
Nelumbo nucifera stem has shown a wide range of pharmacological activities, including anti-ischaemic, antioxidant, hepatoprotective, anti-inflammatory, anti-fertility, anti-arrhythmic, antifibrotic, antiviral, anti-proliferative, anti-diarrhoeal, psychopharmacological, immune-modulatory, hypoglycaemic, aldose reductase inhibitory, antibacterial, aphrodisiac, anti-platelet, cardiovascular, anti-obesity, lipolytic, hypocholesterolaemic, hepato-protective, anticancer, and diuretic activities.
Review Article Lotus Lotus SeedClinical study on Tuina plus Shen Ling Bai Zhu San in treating children with diarrhea due to spleen deficiency
2022 Feb Journal of Acupuncture and Tuina Science Li J
Clinical Study Diarrhoea Spleen Deficiency Meridian MassageThe combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.
Acupuncture for Adults with Diarrhea-Predominant Irritable Bowel Syndrome or Functional Diarrhea: A Systematic Review and Meta-Analysis
2020 Nov 23 Neural Plasticity Jianbo Guo, Xiaoxiao Xing, Jiani Wu, Hui Zhang, Yongen Yun, Zongshi Qin, et al.
Systematic Review Meta-Analysis DiarrhoeaAcupuncture treatment can improve the clinical effectiveness of diarrhea-predominant irritable bowel syndrome or functional diarrhea.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Traditional Chinese medicine therapies, like acupuncture and moxibustion, effectively alleviate irritable bowel syndrome with diarrhea symptoms, and reduce recurrence rates.
2022 Frontiers in Medicine External therapy of traditional Chinese medicine for treating irritable bowel syndrome with diarrhea: A systematic review and meta-analysis Wei X, Wen Y, Wei Y, Liang X, Ma X, Zhang B, et al.
Systematic Review Chinese Medicine Irritable Bowel Syndrome
Adhering to the guidelines for systematic reviews, multiple databases including PubMed and Cochrane Library, and several Chinese databases were thoroughly searched. The focus was randomized controlled trials that compared traditional Chinese external therapies with western medicine for irritable bowel syndrome with diarrhea up until the end of 2021. Two authors were independently responsible for screening, data extraction and study assessment. Study quality assessment involved both the Jadad scale and Cochrane Collaborative's risk of bias tool. Meta-analysis was performed on the data collated using Review Manager software.
The gathered data revealed that of the twenty-one studies examined, including a total of 1,862 subjects, acupuncture and moxibustion were the most prevalent external therapies. The results of the meta-analysis indicated that in comparison to the control group, the experimental group demonstrated marked improvement. Notably, the experimental group had superior clinical effectiveness rates, better clinical cure rates, and reduced recurrence. Additionally, there was significant improvement in irritable bowel syndrome related quality of life within the experimental group. Despite these promising results, the publication bias of the included studies was noted as a potential limitation.
Acupuncture combined with moxibustion showed the best outcomes in terms of efficacy and quality of life improvement for adults with irritable bowel syndrome complicated with diarrhea.
2022 Computational and Mathematical Methods in Medicine Acupuncture and Moxibustion in the Treatment of Adult Diarrhea Irritable Bowel Syndrome: A Network Meta-analysis Jiang X, Guo X, Zhou J, Ye S
Meta-Analysis Acupuncture Irritable Bowel Syndrome Moxibustion
The study was conducted by searching major databases, including PubMed, The Cochrane Library, Embase, and database from China, for randomized controlled trials. These trials explored the effects of acupuncture and moxibustion on individuals suffering from irritable bowel syndrome complicated with diarrhea. The selected studies underwent a rigorous bias assessment and their data were analyzed using Stata 16.0 statistical software.
The analysis encompassed 21 studies overall, considering 1626 patients undergoing 8 different therapeutic measures. The study found that treatments such as acupuncture, warming needle moxibustion, and a combination of acupuncture with sandwiched or heat-sensitive moxibustion revealed significantly improved outcomes when compared to the drug pinaverium bromide. On the other hand, pinaverium bromide demonstrated the lowest efficacy and effect on quality of life. The most frequently used acupuncture points were GV20, GV29, ST 25, ST37, ST36, SP6, LR3, and CV12.
The combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.
2022 Journal of Acupuncture and Tuina Science Clinical study on Tuina plus Shen Ling Bai Zhu San in treating children with diarrhea due to spleen deficiency Li J
Clinical Study Meridian Massage Spleen Deficiency
Methodology: The paper reports on a clinical trial involving a total of 105 children diagnosed with diarrhea due to spleen deficiency. These children were randomly allocated into two separate groups: a control group and an observation group. The control group, consisting of 52 children, were exclusively treated with Shen Ling Bai Zhu San orally. The observation group, on the other hand, consisted of 53 children who received an additional Tuina treatment along with Shen Ling Bai Zhu San.
Results: After implementing the treatments, it was found that every child in the observation group showed improvement, compared to 90% improvement rate in the control group. This correlated to a decrease in scores of primary and secondary symptoms of traditional Chinese medicine in both groups post-treatment. Furthermore, the children in the observation group who received both treatments had even lower symptom scores than the control group who only received Shen Ling Bai Zhu San. The treatments were also well-tolerated with no significant adverse reactions reported.
Acupuncture treatment can improve the clinical effectiveness of diarrhea-predominant irritable bowel syndrome or functional diarrhea.
2020 Neural Plasticity Acupuncture for Adults with Diarrhea-Predominant Irritable Bowel Syndrome or Functional Diarrhea: A Systematic Review and Meta-Analysis Jianbo Guo, Xiaoxiao Xing, Jiani Wu, Hui Zhang, Yongen Yun, Zongshi Qin, et al.
Systematic Review
In this systematic review and meta-analysis, the effectiveness and safety of 31 acupuncture concerned studies for patients with IBS-D or FD were evaluated. We found that acupuncture can significantly reduce the number of stools per week in IBS-D or FD patients, improve patients’ overall symptoms, improve the total effective rate, decrease the recurrence rate, and reduce the pain level of patients. Based on the results, we believe that acupuncture can improve the quality of life of patients with IBS-D or FD. Although the number of adverse events in the acupuncture group was similar to that in the control group, the majority of adverse events in the acupuncture group were subcutaneous hemorrhage. With such slight adverse events, we have observed that acceptance among patients has not been reduced. Moreover, the withdrawal rate of patients in the acupuncture group was still slightly lower than that in the control group.
Dark chocolate with high cocoa content can affect colonic functionality and stimulate certain brain regions in healthy adults.
2019 British Journal of Nutrition Effect of cocoa on the brain and gut in healthy subjects: a randomised controlled trial Fox M, Meyer-Gerspach AC, Wendebourg MJ, Gruber M, Heinrich H, Sauter M, et al.
Randomised Controlled Trial Brain Activity Cocoa Dark Chocolate
The study involved a controlled, randomised experiment including healthy volunteers who were given 100g of either dark chocolate (with 72% cocoa content) or white chocolate (with no cocoa content) for five consecutive days. The volunteers then recorded any abdominal symptoms and stool consistency using the Bristol Stool Score. Gastric emptying as well as intestinal and colonic transit time were examined using scintigraphy and marker studies, while the activity in different brain regions was assessed using combined positron emission tomography-computed tomography imaging techniques.
The study found that dark chocolate did not alter the functionality of the upper gastrointestinal tract. Nevertheless, it was observed that the consumption of dark chocolate led to harder stool consistency. As for the brain, an increased uptake of fluorodeoxyglucose was noticed within the visual cortex, with other regions like the somatosensory, motor and pre-frontal cortices also showing heightened activity. This suggests that dark chocolate may potentially influence certain brain functions.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
External therapy of traditional Chinese medicine for treating irritable bowel syndrome with diarrhea: A systematic review and meta-analysis
2022 Aug 09 Frontiers in Medicine Wei X, Wen Y, Wei Y, Liang X, Ma X, Zhang B, et al.
Systematic Review Meta-Analysis Diarrhoea Chinese Medicine Irritable Bowel SyndromeTraditional Chinese medicine therapies, like acupuncture and moxibustion, effectively alleviate irritable bowel syndrome with diarrhea symptoms, and reduce recurrence rates.
Therapeutic Potential of Nelumbo nucifera (Sacred Lotus) in CNS Disorders
2022 Jun 09 Dhaka University Journal of Pharmaceutical Sciences Mitra K, Raihan MA, Rahman MA, Rouf R, Reza HM, Uddin SJ, et al.
Nelumbo nucifera stem has shown a wide range of pharmacological activities, including anti-ischaemic, antioxidant, hepatoprotective, anti-inflammatory, anti-fertility, anti-arrhythmic, antifibrotic, antiviral, anti-proliferative, anti-diarrhoeal, psychopharmacological, immune-modulatory, hypoglycaemic, aldose reductase inhibitory, antibacterial, aphrodisiac, anti-platelet, cardiovascular, anti-obesity, lipolytic, hypocholesterolaemic, hepato-protective, anticancer, and diuretic activities.
Review Article Lotus Lotus SeedAcupuncture for Adults with Diarrhea-Predominant Irritable Bowel Syndrome or Functional Diarrhea: A Systematic Review and Meta-Analysis
2020 Nov 23 Neural Plasticity Jianbo Guo, Xiaoxiao Xing, Jiani Wu, Hui Zhang, Yongen Yun, Zongshi Qin, et al.
Systematic Review Meta-Analysis DiarrhoeaAcupuncture treatment can improve the clinical effectiveness of diarrhea-predominant irritable bowel syndrome or functional diarrhea.
This systematic review and meta-analysis show that acupuncture treatment can decrease the recurrence rate, and reduce the pain level of patients. Despite conventional drugs that can temporarily alleviate symptoms, many patients still suffer from the IBS-D or FD, and the recurrence rate was as high as 40% after 3 months. It has been reported that approximately 60.1% of the drug treatment patients stop taking drugs on their own due to the lack of obvious symptom improvement — 22 Apr 2021
Acupuncture for Diarrhoea-Predominant Irritable Bowel Syndrome: A Network Meta-Analysis
2018 May 27 Evidence-Based Complementary and Alternative Medicine Zhu L, Ma Y, Ye S, Shu Z
Systematic Review Meta-AnalysisAcupuncture may improve diarrhoea-predominant irritable bowel syndrome better than drugs and has the fewest side effects.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Traditional Chinese medicine therapies, like acupuncture and moxibustion, effectively alleviate irritable bowel syndrome with diarrhea symptoms, and reduce recurrence rates.
Acupuncture combined with moxibustion showed the best outcomes in terms of efficacy and quality of life improvement for adults with irritable bowel syndrome complicated with diarrhea.
The combination of Tuina (Chinese therapeutic massage) and Shen Ling Bai Zhu San is more effective in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.
Acupuncture treatment can improve the clinical effectiveness of diarrhea-predominant irritable bowel syndrome or functional diarrhea.
Dark chocolate with high cocoa content can affect colonic functionality and stimulate certain brain regions in healthy adults.
Acupuncture may improve diarrhoea-predominant irritable bowel syndrome better than drugs and has the fewest side effects.
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This systematic review and meta-analysis show that acupuncture treatment can decrease the recurrence rate, and reduce the pain level of patients. Despite conventional drugs that can temporarily alleviate symptoms, many patients still suffer from the IBS-D or FD, and the recurrence rate was as high as 40% after 3 months. It has been reported that approximately 60.1% of the drug treatment patients stop taking drugs on their own due to the lack of obvious symptom improvement — 22 Apr 2021