Dyslipidemia

Presentation Slides

Chinese Medicine Research Hub

Animal Study

A. lappa (burdock root) benefits diabetic rodents by reducing blood glucose and improving lipids, but human effects are uncertain

2022 Nutraceuticals Arctium lappa Lam. and Its Related Lignans Improve Hyperglycemia and Dyslipidemia in Diabetic Rodent Models: A Systematic Review and Meta-Analysis
Watanabe S, Yamabe S, Shimada M

Chinese Medicine Research Hub

Network Pharmacology

Two varieties of chrysanthemum have similar therapeutic effects but operate through distinct mechanisms, revealing potential for precise applications in both traditional and modern medicine.

2022 International Journal of Molecular Sciences Comparison of the Chemical Components, Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum Flower against Liver-Fire Hyperactivity Syndrome of Hypertension via Integrative Analyses
Wang Y, Li Y, Guo W, Yang X, Qu J, Gao M, Chen S, Dong J, Li Q, Wang T

Chinese Medicine Research Hub

Systematic Review

Raspberry consumption can help to reduce blood glucose levels and stabilize the blood lipid profile due to its bioactive compounds.

2022 Journal of Medicinal Food Raspberry (Rubus idaeus L.), a Promising Alternative in the Treatment of Hyperglycemia and Dyslipidemias
Piña-Contreras N, Martínez-Moreno AG, Ramírez-Anaya JDP, Espinoza-Gallardo AC, Valdés EHM

Chinese Medicine Research Hub

Systematic Review

Almond intake significantly changed the concentrations of triglycerides, total cholesterol and low-density lipoproteins

2021 Food & Function The effect of almond intake on lipid profile: a systematic review and meta-analysis of randomized controlled trials
Asbaghi O, Moodi V, Hadi A, Eslampour E, Shirinbakhshmasoleh M, Ghaedi E, Miraghajani M

Chinese Medicine Research Hub

Systematic Review

Of the 7 clinical trials included, five evaluating individuals with hypertension observed a significant reduction in systolic and/or diastolic blood pressure. The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile.

2017 Critical Reviews in Food Science and Nutrition The effect of dietary intake of sesame (Sesamumindicum L.) derivatives related to the lipid profile and blood pressure: A systematic review
Carolina Alves Cardoso, Gláucia Maria Moraes de Oliveira, Luciana de Almeida Vittori Gouveia, Annie Seixas Bello Moreira & Glorimar Rosa

Chinese Medicine Research Hub

Review Article

Fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes.

2017 Nutrition Today Fenugreek: Overview of Potential Health Benefits
Singletary, Keith W.

Chinese Medicine Research Hub

Systematic Review

The studies assessed showed that sesame could have a significant effect on oxidative stress and the antioxidant defense system, being considered a food with an important antioxidant function in the different populations studied.

2016 Journal of Medicinal Food Effects of the Intake of Sesame Seeds (Sesamum indicum L.) and Derivatives on Oxidative Stress: A Systematic Review
Gouveia Lde A, Cardoso CA, de Oliveira GM, Rosa G, Moreira AS.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Dyslipidemia" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Dyslipidemia" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Dyslipidemia" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Animal Study published in 2022 in the journal Nutraceuticals found that A. lappa (burdock root) benefits diabetic rodents by reducing blood glucose and improving lipids, but human effects are uncertain This study analyzed the effects of A. lappa (burdock root) and related compounds on diabetic rodents. Results showed that these substances can lower blood glucose levels and improve triglyceride and cholesterol levels in these animals, depending on factors like the type of diabetes model used. However, it's essential to remember that these findings are based on animal studies, and we need more research to know if they apply to humans and prolonged use may have adverse effects.

A Network Pharmacology published in 2022 in the journal International Journal of Molecular Sciences found that Two varieties of chrysanthemum have similar therapeutic effects but operate through distinct mechanisms, revealing potential for precise applications in both traditional and modern medicine. The study combined network pharmacology, molecular pharmacology, and metabolomics to clarify differences between two herbs, CMF and CIF. An initial analysis was carried out via HPLC-Q-TOF-MS which revealed distinct flavonoid constituents between CMF and CIF. These findings led researchers to make predictions about the possible biological processes responsible for the therapeutic effects of these herbs on LFHSH, including their influence on inflammatory response and fatty acid production. Through a series of ELISA, molecular docking, Western blot, and metabolomics techniques, the research identified similar influences of CMF and CIF on blood pressure and resistance to tissue, organ and functional damage as well as dyslipidemia. Despite the similar outcomes, there was variation in their mechanism of action. Namely, these herbs uniquely influenced inflammatory response, various signaling pathways, lipid anabolism, the renin-angiotensin system, and metabolic abnormalities. Differing effects were believed to be due to each herb's unique regulatory capabilities which, despite the end effect similarities, offer unique pathways for effective medical application.

A Systematic Review published in 2022 in the journal Journal of Medicinal Food found that Raspberry consumption can help to reduce blood glucose levels and stabilize the blood lipid profile due to its bioactive compounds. The researchers conducted a systematic review of original articles and enzyme inhibition studies involving animal models and human clinical studies, extracting data from the PubMed, Web of Science, and Science Direct databases. The mechanisms of action investigated focused on how consumption of raspberry in different forms (like frozen, lyophilized, infusion of leaves, seed oil) and compounds extracted from it could inhibit enzymes and increase insulin production and sensitivity, thereby affecting blood glucose levels. The findings revealed that raspberry consumption, regardless of its form, consistently aided in reducing blood glucose levels. The mechanisms involved included inhibition of specific enzymes and enhancement of insulin production and sensitivity. On the other hand, the effects on the lipid profile were varied. While a decrease in cholesterol and low-density lipoprotein levels was recorded, the impact on triglyceride levels was less consistent and manifested mainly as stabilization rather than reduction. However, an increase in levels of beneficial high-density lipoproteins was reported, suggesting an overall beneficial effect on lipid profile.

A Systematic Review published in 2021 in the journal Food & Function found that Almond intake significantly changed the concentrations of triglycerides, total cholesterol and low-density lipoproteins To estimate the overall effect of almond intake, we employed the random-effect model. In total, 27 studies with 36 effect sizes were included in our analysis (1154 cases and 904 control subjects). The meta-analysis revealed that almond intake significantly changed the concentrations of triglycerides, total cholesterol, and low-density lipoproteins; however it did not have a significant effect on high-density lipoprotein levels. Meta-regression analysis indicated a linear relationship between the dose of almond and change in TG. This meta-analysis concludes that almond intake can significantly reduce lipid parameters.

A Systematic Review published in 2017 in the journal Critical Reviews in Food Science and Nutrition found that Of the 7 clinical trials included, five evaluating individuals with hypertension observed a significant reduction in systolic and/or diastolic blood pressure. The two articles that evaluated individuals with dyslipidemia showed improvement in lipid profile. The mechanisms of action are still being studied. Regarding the bias risk analysis, clinical trials included showed few descriptions of the methods applied. There are few studies about sesame ingestion, and it was observed high risk for bias in the selected studies. More standardized methods with attention to the design of studies are needed to improve the level of the evidence.

A Review Article published in 2017 in the journal Nutrition Today found that Fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. Taken together, the outcomes from human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. However, larger, adequately powered, randomized, placebo-controlled, double-blind trials examining multiple measures of carbohydrate and lipid metabolism and insulin homeostasis are needed.

A Systematic Review published in 2016 in the journal Journal of Medicinal Food found that The studies assessed showed that sesame could have a significant effect on oxidative stress and the antioxidant defense system, being considered a food with an important antioxidant function in the different populations studied. In conclusion, despite the limitations and biases of this systematic review, the studies assessed showed that sesame could have a significant effect on oxidative stress and the antioxidant defense system, being considered a food with an important antioxidant function in the different populations studied (individuals with dyslipidemia, diabetes, and hypertension), as well as in its different presentations (oil, seed flour, and capsule). However, better-controlled studies still lack to assess the positive effects on different populations. There are few clinical trials assessing the effect of sesame on oxidative stress. The studies included in this review, mainly those with sesame oil and black sesame meal capsules administered to hypertensive and prehypertensive populations, respectively, showed an increase in enzymatic (SOD, GSH, GPx, and CAT) and nonenzymatic antioxidants (vitamin C, vitamin E, and beta-carotene), as well as a reduction in oxidative stress markers (TBARS and MDA). Although several studies have reported that the exact mechanisms of oxidative stress reduction remain to be fully explained, this review showed that sesame can have a significant positive impact on the health of different popula- tions.

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