Insights & Discussion
Two varieties of chrysanthemum have similar therapeutic effects but operate through distinct mechanisms, revealing potential for precise applications in both traditional and modern medicine.
The study combined network pharmacology, molecular pharmacology, and metabolomics to clarify differences between two herbs, CMF and CIF. An initial analysis was carried out via HPLC-Q-TOF-MS which revealed distinct flavonoid constituents between CMF and CIF. These findings led researchers to make predictions about the possible biological processes responsible for the therapeutic effects of these herbs on LFHSH, including their influence on inflammatory response and fatty acid production.
Through a series of ELISA, molecular docking, Western blot, and metabolomics techniques, the research identified similar influences of CMF and CIF on blood pressure and resistance to tissue, organ and functional damage as well as dyslipidemia. Despite the similar outcomes, there was variation in their mechanism of action. Namely, these herbs uniquely influenced inflammatory response, various signaling pathways, lipid anabolism, the renin-angiotensin system, and metabolic abnormalities. Differing effects were believed to be due to each herb's unique regulatory capabilities which, despite the end effect similarities, offer unique pathways for effective medical application.
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The traditional Chinese medicine prescription combination of Chrysanthemi Flos, Cassiae Semen, Lycii Fructus, Angelicae Sinensis Radix and Salviae Miltiorrhizae Radix et Rhizoma presents potential for treating retinal diseases.
2024 Traditional Medicine Research Exploring a novel traditional Chinese medicine prescription containing Chrysanthemi Flos for retinal diseases: an integrated strategy of data mining and network pharmacology Zhang JX, Zhang KL, Chang XW, Gu JF, Wei SB, Zhu BY, et al.
Data Mining Chrysanthemum Retinitis Pigmentosa
Methodology: The researchers employed data mining to discern a new traditional Chinese medicine (TCM) prescription against retinal diseases and explore its medication rule. This was followed by constructing a network of TCMs, core ingredients, core targets, and core pathways using network pharmacology. The binding ability between core active ingredients and core targets was then verified through molecular docking and molecular dynamics simulation techniques.
Discussion: The novel TCM prescription screened in this study bears great potential in retinal diseases treatment through a unique mechanism of action. This mechanism involves TCM prescriptions that possess clearing heat and supplementing activities, associated with liver and lung meridians. The mechanism was found to act by modulating several core targets implicated in multiple core pathways such as the AGE-RAGE signaling pathway in diabetic complications, and the PI3K-Akt signaling pathway, among others. This potentially inhibits the inflammatory response, oxidative stress, and retinal neovascularization and apoptosis of retinal ganglion cells and retinal pigment epithelial cells. This improves retinal structural impairment and can have a significant impact on the treatment of retinal diseases.
Natural calcium-rich mineral waters offer a bioavailable calcium source, beneficial for bone health, cardiovascular function, weight management, and overall well-being.
2023 Nutrients Exploring the Potential Benefits of Natural Calcium-Rich Mineral Waters for Health and Wellness: A Systematic Review Pop MS, Cheregi DC, Onose G, Munteanu C, Popescu C, Rotariu M, et al.
Systematic Review Bone Health Calcium Cardiovascular Disease
This systematic review analyzed peer-reviewed articles, clinical trials, and experimental studies from the past decade. It focused on the health benefits of calcium-rich mineral waters, especially for individuals with lactose intolerance or on plant-based diets. The review process assessed the contribution of these waters to daily calcium intake and their bioavailability compared to other calcium sources.
The review found that natural mineral waters high in calcium can significantly enhance calcium intake, with improved absorption rates. These waters show promise in promoting bone health and cardiovascular function, including potential reductions in blood pressure and cardiovascular disease risk. Some evidence suggests benefits in weight management. However, the review highlighted the need for further research on interactions with other dietary components, effects on specific health conditions, and long-term consumption impacts. Despite these gaps, calcium-rich mineral waters are recognized as a valuable dietary calcium source for a diverse population.
Consuming a honey-based gel, such as 'Bear Strength honey gel,' led to a notable reduction in diastolic and mean arterial blood pressure, with gender-specific improvements in redox status among healthy adults.
2023 Biomedical Reports Evaluation of the effects of a honey‑based gel on blood redox biomarkers and the physiological profile of healthy adults: A pilot study Patouna A, Sevdalis P, Papanikolaou K, Kourti M, Skaperda Z, Jamurtas A, et al.
Clinical Study High Blood Pressure Honey
The study included 20 healthy participants (10 men, 10 women) who incorporated 70g of 'Bear Strength honey gel' into their daily diet for 14 days. Physiological parameters (weight, height, BMI, body fat, waist-to-hip ratio, resting heart rate, and blood pressure) and hematological data were evaluated before and after consumption. Redox biomarkers, including Glutathione (GSH), catalase (CAT), total antioxidant capacity (TAC), protein carbonyls (PCARBS), and thiobarbituric reactive substances (TBARS), were measured.
Post-consumption, the honey-based gel showed a significant decrease in diastolic and mean arterial blood pressure, particularly in women. However, no significant changes were observed in other physiological or hematological variables. Notably, GSH levels increased in both genders, TAC increased universally, and TBARS levels decreased in the total group and women. PCARBS levels decreased exclusively in the women's group. These findings highlight the honey-based gel's potential positive impact on blood pressure and redox status, emphasizing gender-specific effects in healthy adults.
Sardines, being an affordable source of Omega-3 and other cardioprotective nutrients, can potentially reduce the need for Omega-3 supplementation and manage cardiometabolic diseases.
2023 Frontiers in Nutrition Eating more sardines instead of fish oil supplementation: Beyond omega-3 polyunsaturated fatty acids, a matrix of nutrients with cardiovascular benefits Santos HO, May TL, Bueno AA
Review Article Cardiovascular Disease Cholesterol High Blood Pressure
The abstract primarily acknowledges the importance of Omega-3 polyunsaturated fatty acids with respect to managing diseases related to heart health and metabolism, for instance, type 2 diabetes, hypertension, hypertriglyceridaemia, and fatty liver disease. However, these fatty acids are not the sole beneficial component of sardines. Minerals including but not limited to calcium, potassium, and magnesium as well as substances like taurine and arginine found in sardines have a significant role in controlling mild inflammation and oxidative stress which are usually present in cardiovascular diseases and hemodynamic dysfunction.
The results discussed in the abstract suggest a positive correlation between consumption of sardines and potential cardiometabolic benefits. By considering the dose-response relationship effects, a pragmatic approach towards consumption of nutrients was suggested. The intake of sardines was seen not only as a means of Omega-3 supplementation but also as a comprehensive approach to enhancing cardiovascular health. The abstract concludes with an emphasis on the many beneficial nutrients found in sardines besides Omega-3, underlining the need to shift the focus from synthetic supplementation to natural dietary improvement.
Jin Si Huang Ju tea, a traditional Chinese beverage, contains compounds that potentially reduce lipids, mitigate insulin resistance and reduce liver inflammation in vitro.
2023 European Journal of Medicinal Chemistry Effects and mechanism of action of Chrysanthemum morifolium (Jinsi Huangju) on hyperlipidemia and non-alcoholic fatty liver disease Li X, Li R, Wang X, Zhang X, Xiao Z, Wang H, et al.
Animal Study Cholesterol Chrysanthemum NAFLD
The researchers identified 14 compounds in the Jinsi Huangju tea using different spectroscopic techniques, 11 of which had not been previously identified in this plant. Two of these compounds, apigenin-7-O-6″-malonylglucoside and luteolin-7-O-6″-malonylglucoside, were synthesized for the first time with a yield of 1.2% over 5 steps.
In the findings, the natural compound apigenin-7-O-6″-malonylglucoside was found to inhibit the function of pancreatic lipase, reduce cellular lipid contents, and attenuate insulin resistance when tested in vitro. It was also observed to restore lipid and inflammatory profiles in plasma and the liver, as well as reduce hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) mouse models. Thus, Jinsi Huangju and its active components are strong candidates for the development of drugs or functional foods that could provide a therapeutic strategy for hyperlipidaemia and NAFLD.
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