Eicosapentaenoic Acid

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Chinese Medicine Research Hub

Meta-Analysis

Omega-3 fatty acid supplements can effectively alleviate symptoms of dry eye disease, especially when consumed in high doses for a long term and with high eicosapentaenoic acid levels.

2023 Journal of Clinical Medicine Efficacy of Omega-3 Intake in Managing Dry Eye Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Wang WX, Ko ML

Chinese Medicine Research Hub

Randomised Controlled Trial

Dietary omega-3 intake shows promise in lowering systolic blood pressure.

2016 The Journal of Nutrition Consumption of Fish Oil Providing Amounts of Eicosapentaenoic Acid and Docosahexaenoic Acid That Can Be Obtained from the Diet Reduces Blood Pressure in Adults with Systolic Hypertension: A Retrospective Analysis
Minihane AM, Armah CK, Miles EA, Madden JM, Clark AB, Caslake MJ, Packard CJ, Kofler BM, Lietz G, Curtis PJ, Mathers JC, Williams CM, Calder PC

Chinese Medicine Research Hub

Review Article

Serotonin function, influenced by vitamin D and omega-3 fatty acids, plays a critical role in neuropsychiatric disorders and certain behavioral functions.

2015 The FASEB Journal Vitamin D and the omega‐3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior
Patrick RP, Ames BN

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Eicosapentaenoic Acid" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Eicosapentaenoic Acid" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Eicosapentaenoic Acid" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Meta-Analysis published in 2023 in the journal Journal of Clinical Medicine found that Omega-3 fatty acid supplements can effectively alleviate symptoms of dry eye disease, especially when consumed in high doses for a long term and with high eicosapentaenoic acid levels. The methodology of this study involved an intensive review of data from multiple reliable sources like PubMed, Embase, and others covering the timespan from 2013 to 2023. The focus was on randomized clinical trials that studied the impact of omega-3 fatty acids on patients with dry eye disease and provided accessible pre- and post-intervention data. Studies with overlapping participants were excluded, as were studies without omega-3 supplementation or not featuring a placebo control or quantitative assessments. Independent reviewers extracted data pertaining to dry eye symptom scores and other related metrics. The results showed that patients who were administered omega-3 treatment demonstrated considerable improvement in symptoms of dry eye disease compared to those on a placebo treatment. The meta-regression analysis deduced positive correlations between the daily dose of omega-3, duration of omega-3 intake, and percentage of eicosapentaenoic acid, with a reduction in dry eye symptom scores. Similar trends were observed with other dry eye related metrics. These findings provide substantial evidence on the beneficial effect of omega-3 fatty acid supplements in managing dry eye disease. However, due to the diversity in patient characteristics and the heterogeneity in study results, care should be taken in widely applying these findings.

A Randomised Controlled Trial published in 2016 in the journal The Journal of Nutrition found that Dietary omega-3 intake shows promise in lowering systolic blood pressure. A study involving 312 participants investigated the effects of achievable dietary intake of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on blood pressure and vascular function. Participants were divided into groups receiving different doses of EPA+DHA for 8 weeks. Overall, there were no significant effects observed. However, in individuals with isolated systolic hypertension (SHT), a clinically meaningful reduction in systolic blood pressure (5 mm Hg) was noted with a low dose of EPA+DHA (0.7 g). The study suggests that even modest omega-3 intake may have potential benefits in reducing cardiovascular risk for individuals with SHT. Further research is recommended for conclusive results.

A Review Article published in 2015 in the journal The FASEB Journal found that Serotonin function, influenced by vitamin D and omega-3 fatty acids, plays a critical role in neuropsychiatric disorders and certain behavioral functions. The paper synthesizes prior research into serotonin's role in managing various brain functions and behaviours, and how its dysfunction is commonly seen in conditions like attention deficit hyperactivity disorder, bipolar disorder, schizophrenia, and impulsive behavior. The researchers then put forward potential mechanisms showing the influence of vitamin D and the marine omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, on serotonin synthesis, release, and function in the brain. Serotonin in the brain is synthesized from tryptophan by tryptophan hydroxylase 2, a process that is activated by a vitamin D hormone. Possible mechanisms proposed include eicosapentaenoic acid increasing serotonin release from presynaptic neurons by lowering E2 series prostaglandins, and docosahexaenoic acid affecting serotonin receptor action by increasing cell membrane fluidity in postsynaptic neurons. The study posits that suboptimal levels of vitamin D and omega-3 fatty acids, in combination with genetic factors at key developmental stages, could lead to dysfunctional serotonin activation and function – a possible underlying mechanism behind neuropsychiatric disorders and depression. The paper suggests that optimizing vitamin D and marine omega-3 fatty acid intake could potentially curtail and modulate the severity of brain dysfunction.

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