Endometrium
Recent Insights
Pomegranate juice extract may reduce the damage to the endometrium in Polycystic ovary syndrome through its antioxidant, anti-inflammatory, anti-fibrotic, and anti-proliferative effects.
Endometrium PCOS Pomegranate
Acupuncture shows promise in improving endometrial receptivity and fertility outcomes in infertile women, but further high-quality research is needed to establish its effectiveness definitively.
Endometrium Female Fertility
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
New concepts on the etiology of endometriosis
2023 Feb 06 Journal of Obstetrics and Gynaecology Research Cousins FL, McKinnon BD, Mortlock S, Fitzgerald HC, Zhang C, Montgomery GW, et al.
Recent developments include the identification of over 40 genetic risk factors, the role of retrograde menstruation in the transfer of endometrial stem/progenitor cells, insights into the glandular structure through lineage tracing and tissue clearing microscopy, identification of somatic mutations, including cancer driver genes, in normal and eutopic endometrium, exploration of methylome sequencing for gene regulation, single-cell RNA sequencing for transcriptome analysis, and the use of endometrial epithelial organoid cultures for studying endometriosis, offering potential for personalized medicine.
Experimental Study Review Article Endometriosis
The Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors
2022 Sep 07 Evidence-Based Complementary and Alternative Medicine Lin J, Ma H, Li H, Han J, Guo T, Qin Z, et al.
In conclusion, CAM therapy has certain advantages in the treatment of infertility caused by endometrial factors. Although it is not the main intervention and treatment measure for infertility caused by endometrial factors, it is still being more widely used because it can restore the physiological function of endometrium, improve the pregnancy rate, adjust the psychological state of women, and improve the quality of life.
Review Article Complementary Medicine Female FertilityRole of pomegranate extract in restoring endometrial androgen receptor expression, proliferation, and pinopodes in a rat model of polycystic ovary syndrome
2022 Sep Morphologie Ibrahim MAA, Sadek MT, Sharaf Eldin HEM
Experimental Study Animal Study PCOS Pomegranate EndometriumPomegranate juice extract may reduce the damage to the endometrium in Polycystic ovary syndrome through its antioxidant, anti-inflammatory, anti-fibrotic, and anti-proliferative effects.
Effects of Acupuncture on Endometrium and Pregnancy Outcomes in Patients with Polycystic Ovarian Syndrome Undergoing in vitro Fertilization-Embryo Transfer: A Randomized Clinical Trial
2022 Apr 13 Chinese Journal of Integrative Medicine Wu J, Ning Y, Ye Y, Liu Y, Tang M, Hu S, et al.
Acupuncture can improve the proportion of type A endometrium, regulate the levels of serum E 2 and P on the day of hCG injection, and improve the pregnancy rate in patients with PCOS infertility undergoing IVF-ET.
Randomised Controlled Trial Endometrium IVF Acupuncture
Effect of Bushen Yutai Recipe on IVF Patients Subjected to Mild Ovarian Stimulation
2020 Nov 12 Frontiers in Medicine Jiang X, Yan H, Zhong X, Tong G, Zhang W
In conclusion, the TCM could increase the E2 during the IVF stage, with a higher number of oocytes and higher-quality embryos. It also improved the endometrium and increased the level of VEGF gene expression. By enhancing the fresh embryo transfer rate in a minimal ovarian stimulation protocol and by improving the clinical pregnancy and ongoing pregnancy rates, the Bushen Yutai recipe could be able to increase fresh embryo transfer and higher-quality embryos.
Randomised Controlled Trial Bu Shen Yu Tai Ovarian Function IVFResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Pomegranate juice extract may reduce the damage to the endometrium in Polycystic ovary syndrome through its antioxidant, anti-inflammatory, anti-fibrotic, and anti-proliferative effects.
2022 Morphologie Role of pomegranate extract in restoring endometrial androgen receptor expression, proliferation, and pinopodes in a rat model of polycystic ovary syndrome Ibrahim MAA, Sadek MT, Sharaf Eldin HEM
Experimental Study PCOS Pomegranate
To test the possible benefits of pomegranate juice extract (PJE) on endometrial injury in Polycystic ovary syndrome (PCOS), forty adult albino rats were divided into four groups, control, PJE-treated, letrozole-treated (PCOS), and PJE & PCOS groups. The respective treatments were administered for a duration of three weeks. Serum and tissue samples were assayed for Follicle-stimulating hormone, Luteinizing hormone, testosterone, estradiol, and malondialdehyde. Uterine samples were also tested using a range of histological staining techniques and a scanning electron microscope.
In the rat model of PCOS, significant increases in certain biochemical indicators in serum samples were observed while uterine sections showed numerous alterations to the endometrium, signs of inflammation and an increase in the endometrial collagen fiber content. Additionally, there was increased expression of certain immunohistochemical staining markers and a decrease in the mean number of pinopodes observed through scanning electron microscopy. However, these various potentially harmful biochemical, histological and immunohistochemical alterations were efficiently reduced with the administration of PJE. This points towards the potential benefits of PJE in addressing and potentially reducing endometrial injury associated with PCOS.
Acupuncture shows promise in improving endometrial receptivity and fertility outcomes in infertile women, but further high-quality research is needed to establish its effectiveness definitively.
2019 BMC Complementary Medicine and Therapies Acupuncture in improving endometrial receptivity: a systematic review and meta-analysis Zhong, Y., Zeng, F., Liu, W. et al.
Systematic Review Female Fertility
This systematic review aimed to assess the effectiveness of acupuncture in improving endometrial receptivity (ER) based on randomized controlled trials (RCTs). The review included RCTs of infertile women with low ER and excluded other causes of infertility or non-RCTs. The researchers conducted an extensive search through various databases up to August 2018 without language restrictions. After analyzing the collected data, they found evidence indicating that acupuncture may enhance pregnancy rate, embryo transfer rate, trilinear endometrium, endometrial thickness, and decrease resistive index, pulse index, and peak systolic velocity/end-diastolic blood velocity when compared with medication, sham acupuncture, or physiotherapy. However, the overall level of evidence was mostly very low or low. Despite the statistically significant results, the authors emphasize the need for more large-scale, long-term RCTs with robust methodologies to further validate the efficacy and safety of acupuncture for women with low ER
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
New concepts on the etiology of endometriosis
2023 Feb 06 Journal of Obstetrics and Gynaecology Research Cousins FL, McKinnon BD, Mortlock S, Fitzgerald HC, Zhang C, Montgomery GW, et al.
Recent developments include the identification of over 40 genetic risk factors, the role of retrograde menstruation in the transfer of endometrial stem/progenitor cells, insights into the glandular structure through lineage tracing and tissue clearing microscopy, identification of somatic mutations, including cancer driver genes, in normal and eutopic endometrium, exploration of methylome sequencing for gene regulation, single-cell RNA sequencing for transcriptome analysis, and the use of endometrial epithelial organoid cultures for studying endometriosis, offering potential for personalized medicine.
Experimental Study Review Article EndometriosisThe Treatment of Complementary and Alternative Medicine on Female Infertility Caused by Endometrial Factors
2022 Sep 07 Evidence-Based Complementary and Alternative Medicine Lin J, Ma H, Li H, Han J, Guo T, Qin Z, et al.
In conclusion, CAM therapy has certain advantages in the treatment of infertility caused by endometrial factors. Although it is not the main intervention and treatment measure for infertility caused by endometrial factors, it is still being more widely used because it can restore the physiological function of endometrium, improve the pregnancy rate, adjust the psychological state of women, and improve the quality of life.
Review Article Complementary Medicine Female FertilityAcupuncture in improving endometrial receptivity: a systematic review and meta-analysis
2019 Mar 13 BMC Complementary Medicine and Therapies Zhong, Y., Zeng, F., Liu, W. et al.
Systematic Review Meta-Analysis Endometrium Female FertilityAcupuncture shows promise in improving endometrial receptivity and fertility outcomes in infertile women, but further high-quality research is needed to establish its effectiveness definitively.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Effects of Acupuncture on Endometrium and Pregnancy Outcomes in Patients with Polycystic Ovarian Syndrome Undergoing in vitro Fertilization-Embryo Transfer: A Randomized Clinical Trial
2022 Apr 13 Chinese Journal of Integrative Medicine Wu J, Ning Y, Ye Y, Liu Y, Tang M, Hu S, et al.
Acupuncture can improve the proportion of type A endometrium, regulate the levels of serum E 2 and P on the day of hCG injection, and improve the pregnancy rate in patients with PCOS infertility undergoing IVF-ET.
Randomised Controlled Trial Endometrium IVF AcupunctureEffect of Bushen Yutai Recipe on IVF Patients Subjected to Mild Ovarian Stimulation
2020 Nov 12 Frontiers in Medicine Jiang X, Yan H, Zhong X, Tong G, Zhang W
In conclusion, the TCM could increase the E2 during the IVF stage, with a higher number of oocytes and higher-quality embryos. It also improved the endometrium and increased the level of VEGF gene expression. By enhancing the fresh embryo transfer rate in a minimal ovarian stimulation protocol and by improving the clinical pregnancy and ongoing pregnancy rates, the Bushen Yutai recipe could be able to increase fresh embryo transfer and higher-quality embryos.
Randomised Controlled Trial Bu Shen Yu Tai Ovarian Function IVFPresentation Slides
Pomegranate juice extract may reduce the damage to the endometrium in Polycystic ovary syndrome through its antioxidant, anti-inflammatory, anti-fibrotic, and anti-proliferative effects.
Acupuncture shows promise in improving endometrial receptivity and fertility outcomes in infertile women, but further high-quality research is needed to establish its effectiveness definitively.
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