Endothelial Dysfunction
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Effect of pomegranate juice on vascular adhesion factors: A systematic review and meta-analysis
2021 Jan Phytomedicine Asgary S, Karimi R, Joshi T, Kilpatrick KL, Moradi S, Samimi Z, et al.
Meta-Analysis Systematic Review IL-6 PomegranateThe study reveals that pomegranate juice does not significantly affect vascular adhesion factors, but can effectively reduce the inflammatory marker, interleukin-6.
Honey and obesity-related dysfunctions: a summary on health benefits
2020 Aug The Journal of Nutritional Biochemistry Terzo S, Mulè F, Amato A
Review ArticleHoney, with its variable composition based on botanical origin, exhibits antioxidant and anti-inflammatory properties, suggesting its potential efficacy in managing obesity-related dysfunctions, including neurodegeneration, through improved glycemic control and lipid profile.
The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review
2020 Mar Complementary Therapies in Medicine Wang P, Zhang Q, Hou H, Liu Z, Wang L, Rasekhmagham R, et al.
Meta-Analysis Systematic Review PomegranatePomegranate juice supplementation notably diminishes inflammation and vascular dysfunction markers in adults, offering potential cardiovascular health benefits.
Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial
2019 Dec 13 Phytotherapy Research Shin YK, Hsieh YS, Han AY, Lee KW, Seol GH
In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.
Randomised Controlled Trial Dang Shen
Microencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome
2019 Jul 25 Nutrients Estrada-Luna D, Carreón-Torres E, Bautista-Pérez R, Betanzos-Cabrera G, Dorantes-Morales A, Luna-Luna M, et al.
MiPo supplementation in women with ACS improved the lipid profile, increased paraoxonase–1 (PON1) activity, and reverted the negative effects of HDL on endothelial function observed during the postprandial period, suggesting potential benefits for cardiovascular health.
Randomised Controlled Trial Clinical StudyResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The study reveals that pomegranate juice does not significantly affect vascular adhesion factors, but can effectively reduce the inflammatory marker, interleukin-6.
2021 Phytomedicine Effect of pomegranate juice on vascular adhesion factors: A systematic review and meta-analysis Asgary S, Karimi R, Joshi T, Kilpatrick KL, Moradi S, Samimi Z, et al.
Meta-Analysis IL-6 Pomegranate
In order to evaluate the role of pomegranate in endothelial dysfunction, databases including PubMed, Scopus, Web of Science, Cochrane, and Google Scholar were utilized up until July 2020. Relevant studies were chosen that examined pomegranate's impacts on vascular adhesion factors, namely intercellular adhesion molecule 1, vascular cell adhesion molecule 1, E-selectin, and interleukin-6. Computational tools were used to analyse this large data set.
The results demonstrated that human studies showed no significant effects of pomegranate juice on intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin compared to the control group. However, results revealed that pomegranate juice could significantly lower interleukin-6. Despite the absence of significant impacts on vascular adhesion factors, the notable reduction of interleukin-6 suggests the potential of pomegranate juice in treating endothelial dysfunction-related conditions such as cardiovascular diseases.
Honey, with its variable composition based on botanical origin, exhibits antioxidant and anti-inflammatory properties, suggesting its potential efficacy in managing obesity-related dysfunctions, including neurodegeneration, through improved glycemic control and lipid profile.
2020 The Journal of Nutritional Biochemistry Honey and obesity-related dysfunctions: a summary on health benefits Terzo S, Mulè F, Amato A
Review Article
The review explores honey's therapeutic potential, emphasizing its diverse bioactive compounds. The focus is on its effects in combating obesity-related dysfunctions, supported by experimental evidence from animal studies.
Experimental findings indicate that honey can enhance glycemic control and lipid profile, offering protection against endothelial dysfunction and neurodegeneration in obesity. The role of honey's key constituents, particularly polyphenols, is highlighted, underscoring the need for further human studies to confirm these health benefits.
Pomegranate juice supplementation notably diminishes inflammation and vascular dysfunction markers in adults, offering potential cardiovascular health benefits.
2020 Complementary Therapies in Medicine The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review Wang P, Zhang Q, Hou H, Liu Z, Wang L, Rasekhmagham R, et al.
Meta-Analysis Pomegranate
The research used a broad approach, systematically reviewing and performing a meta-analysis of 16 randomised controlled trials including 572 participants, as per the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses guidelines. Relevant articles and references were found via the PubMed/Medline and SCOPUS databases, with screening carried out up until May 2019. The studies explored the impact of pomegranate juice supplements.
The discussion reveals that pomegranate supplementation conspicuously reduced the levels of certain pro-inflammatory and vascular dysfunction markers. However, the research found no significant reduction in some other markers when compared to a placebo. Despite not all markers recording significant reduction, the overall findings strongly suggest pomegranate supplements as a viable tactic for reducing inflammation in adults, potentially offering cardiovascular health advantages.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Effect of pomegranate juice on vascular adhesion factors: A systematic review and meta-analysis
2021 Jan Phytomedicine Asgary S, Karimi R, Joshi T, Kilpatrick KL, Moradi S, Samimi Z, et al.
Meta-Analysis Systematic Review IL-6 PomegranateThe study reveals that pomegranate juice does not significantly affect vascular adhesion factors, but can effectively reduce the inflammatory marker, interleukin-6.
Honey and obesity-related dysfunctions: a summary on health benefits
2020 Aug The Journal of Nutritional Biochemistry Terzo S, Mulè F, Amato A
Review ArticleHoney, with its variable composition based on botanical origin, exhibits antioxidant and anti-inflammatory properties, suggesting its potential efficacy in managing obesity-related dysfunctions, including neurodegeneration, through improved glycemic control and lipid profile.
The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review
2020 Mar Complementary Therapies in Medicine Wang P, Zhang Q, Hou H, Liu Z, Wang L, Rasekhmagham R, et al.
Meta-Analysis Systematic Review PomegranatePomegranate juice supplementation notably diminishes inflammation and vascular dysfunction markers in adults, offering potential cardiovascular health benefits.
Importance of maintaining a low omega–6/omega–3 ratio for reducing inflammation
2018 Nov Open Heart DiNicolantonio JJ, O’Keefe JH
The study concludes that omega-3 PUFAs, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), exhibit anti-inflammatory effects by reducing markers of inflammation, adhesion molecules, and atherosclerosis-related factors, contrasting with the proinflammatory effects associated with omega-6 PUFAs, particularly LA.
Experimental Study Systematic Review Omega-6 Omega-3 RatioClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial
2019 Dec 13 Phytotherapy Research Shin YK, Hsieh YS, Han AY, Lee KW, Seol GH
In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.
Randomised Controlled Trial Dang ShenMicroencapsulated Pomegranate Reverts High-Density Lipoprotein (HDL)-Induced Endothelial Dysfunction and Reduces Postprandial Triglyceridemia in Women with Acute Coronary Syndrome
2019 Jul 25 Nutrients Estrada-Luna D, Carreón-Torres E, Bautista-Pérez R, Betanzos-Cabrera G, Dorantes-Morales A, Luna-Luna M, et al.
MiPo supplementation in women with ACS improved the lipid profile, increased paraoxonase–1 (PON1) activity, and reverted the negative effects of HDL on endothelial function observed during the postprandial period, suggesting potential benefits for cardiovascular health.
Randomised Controlled Trial Clinical StudyPresentation Slides
The study reveals that pomegranate juice does not significantly affect vascular adhesion factors, but can effectively reduce the inflammatory marker, interleukin-6.
Honey, with its variable composition based on botanical origin, exhibits antioxidant and anti-inflammatory properties, suggesting its potential efficacy in managing obesity-related dysfunctions, including neurodegeneration, through improved glycemic control and lipid profile.
Pomegranate juice supplementation notably diminishes inflammation and vascular dysfunction markers in adults, offering potential cardiovascular health benefits.
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