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Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for HIE" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for HIE" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for HIE" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Systematic Review published in 2023 in the journal Nutrients found that Vitamin D supplementation significantly reduces pain levels in people suffering from primary dysmenorrhea. In the methodology of this study, a systematic database search was conducted for randomized controlled trials assessing the effects of oral vitamin D supplementation on relieving the symptoms of primary dysmenorrhea. The trials included comparisons of vitamin D treatment with placebo or standard care. Pain levels due to dysmenorrhea were gauged using a visual analogue or numerical rating scale. Analyses were conducted using a standardized mean difference in a meta-analysis. The results indicated that pain levels were considerably lower in participants who took vitamin D compared to the placebo, showcasing vitamin D's effectiveness in managing dysmenorhea-related pain. Notably, these relief effects were recorded regardless of the vitamin D administration duration (more or less than 70 days) and frequency, provided that the average weekly dosage was above 50,000 IU. This suggests that the significant pain relief provided by vitamin D supplementation could make it a potent alternative treatment for primary dysmenorrhea.

A Cohort Study published in 2022 in the journal Metabolites found that Frequent consumption of sugar-sweetened coffee can adversely affect blood sugar control in patients with diabetes mellitus in Korea. This study focused on adult coffee consumption patterns in Korea using data collected from the Korea National Health and Nutrition Examination Survey between 2008 to 2020. The consuming habits of 5671 diabetic patients were analyzed considering how often they consumed a mixture of coffee with sugar and creamer, referred commonly as 3-in-1 coffee. The methods used involved assessing these patterns through a 24-hour recall. Blood sugar control was evaluated using fasting blood glucose levels and hemoglobin A1c levels, in line with the targets set by the Korean Diabetes Association. The results revealed that nearly half of the diabetic patients in this study consumed sugar-sweetened coffee. These patients demonstrated significantly higher fasting blood glucose and hemoglobin A1c levels compared to those who did not partake in such consumption. The findings also indicated an increased likelihood of patients failing to achieve their blood sugar control targets, corresponding to the frequency of their consumption of sugar-sweetened coffee.

A Systematic Review published in 2022 in the journal Dermatologic Therapy found that Long Dan Xie Gan formula used as an adjuvant therapy may hasten skin healing, relieve pain symptoms, and prevent persistent pain in acute herpes zoster patients. For the methodology, multiple databases such as PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journal Database, and Wanfang were searched by two independent authors for relevant randomized controlled trials (RCT) until July 31, 2021. The chosen studies analysed the additive effects of LDXG formula, in different forms such as decoction, capsule, or pill, for acute herpes zoster management. Nine RCTs fitting the criteria were selected, totaling 821 patients for the meta-analysis. Concerning the results, statistical analysis using a random effect model revealed that adding LDXG formula to conventional therapy noticeably shortened the time of blister resolution, crust formation, and pain resolution. It also reduced the pain intensity and incidence of lingering pain for those with acute herpes zoster in comparison to conventional treatment alone. Yet, this evidence was assessed as being of very low to moderate certainty, indicating interpretation of these results should be cautious due to statistical heterogeneity and/or an unclear risk of bias existing.

A Review Article published in 2022 in the journal Trends in Cardiovascular Medicine found that Consuming 2-3 cups of coffee daily can help prevent cardiovascular disease and drinking at least 3 cups of green tea has similar benefits. In this review, researchers examined the effects of habitual coffee and tea consumption on cardiovascular disease (CVD) prevention. Specifically, they studied the association between 2-3 cups of coffee or tea consumed daily and their beneficial effects on metabolic syndrome, including hypertension and diabetes mellitus, focusing on how these popularly consumed beverages might affect lipid levels. The analysis of findings drew a correlation between moderate coffee intake and a reduced risk of several cardiovascular conditions, such as coronary heart disease, heart failure, arrhythmia, stroke, and CVD, in addition to lowering mortality from all causes. It was also noted that the benefits extended to higher tea consumption as well, particularly in the case of green tea, where it led to improved survival rates in population-based studies.

A Systematic Review published in 2022 in the journal Journal of Ethnopharmacology found that Chinese herbal medicine has shown effectiveness in treating amenorrhea caused by antipsychotic drugs, with an overall treatment effectiveness rate of 0.91, but the duration of treatment is relatively long, and further research is required to explore its application in this context. The passage presents a meta-analysis of traditional Chinese herbal medicine for treating amenorrhea caused by antipsychotic drugs. Chinese herbal medicine was found to be effective, with an overall success rate of 0.91, but the treatment duration was often lengthy, exceeding three months. Commonly used herbal remedies included Danggui, Chuanxiong, Taoren, Honghua, Gancao, Fuling, Baizhu, Xiangfu, Chaihu, Shudihuang, and Baishao. The study suggests that Chinese herbal medicine can be a viable option for managing this condition, but further research is needed to understand its mechanisms and optimize treatment approaches.

A Meta-Analysis published in 2022 in the journal Frontiers in Pharmacology found that Cinnamon is a safe therapeutic agent without significant adverse effects based on systematic reviews and meta-analyses. The researchers conducted a thorough search of PubMed, EMBASE, and the Cochrane Library, identifying relevant systematic reviews and meta-analyses on human subjects' cinnamon safety. The search consisted of articles up to September 2021, with the PRISMA 2020 guidelines followed for comprehensive reporting and transparency. The reliability of these studies' methodology was determined using methodological quality standards. The review included three meta-analyses and one systematic review, with two of the four classified as moderate quality, and the others as low quality. Generally, the academic studies found no significant harmful effects compared to a placebo, regardless of the dose or length of therapy. The findings suggest that humans well tolerate cinnamon, as no adverse reactions were observed in the study subjects. This evidence confirms the safety of cinnamon consumption, potentially providing health benefits as auxiliary treatment without significant risk of harm.

A Cohort Study published in 2022 in the journal Frontiers in Pharmacology found that The majority of reproductive age women with endometriosis in Taiwan use traditional Chinese medicine, specifically Gui Zhi Fu Ling Wan, to relieve related symptoms. The methodology of this study involved analyzing the use of TCM among women with endometriosis in Taiwan. Researchers evaluated the usage, frequency of service, and the specific Chinese herbal products prescribed for endometriosis using a randomly sampled cohort of 1,000,000 beneficiaries from the National Health Insurance Research Database. In terms of results, it was found that most women with endometriosis used TCM in dealing with their symptoms. These women were more likely to seek out TCM treatment than those without symptoms. Gui-Zhi-Fu-Ling-Wan, a Cinnamon Twig and Poria Pill known for its sedative and anti-inflammatory properties, was the most commonly prescribed Chinese herbal formula. This specific TCM plays a significant role in treating the discomfort associated with endometriosis, showing a preference towards natural remedies over conventional ones.

A Systematic Review published in 2022 in the journal The American Journal of Chinese Medicine found that Fresh and dried ginger displays key botanical, phytochemical and ethnopharmacological differences, which are fundamental for their specific clinical uses in treating gastrointestinal issues. The methodology used in the research involved a retrospective comparison between Sheng Jiang (SJ, meaning fresh ginger) and Gan Jiang (GJ, meaning dried ginger), two traditional Chinese herbs. The comparison was undertaken specifically considering aspects of botany, phytochemistry, and ethnopharmacology. The research also delved into exploring the traditionally attributed use of ginger, in both its fresh and dried forms, for the treatment of gastrointestinal disorders, and its relationship with human gut microbiota - an aspect that hasn't been considered extensively previously. The results displayed notable differences between fresh and dried ginger in terms of botany, phytochemical, and ethnopharmacological properties. Fresh and dried ginger are cultivated differently and display distinct physical appearances. This research proposed that these differences lay the foundation for how these two forms of ginger are applied clinically. Furthermore, discussing the pharmacology of gut microbiota-related gastrointestinal benefits, it is suggested that fresh and dried ginger could present innovative and potent avenues for preventing and treating gastrointestinal disorders.

A Systematic Review published in 2021 in the journal Complementary Therapies in Medicine found that Turmeric curcuminoids are associated with better pain relief than NSAIDs in knee osteoarthritis. The meta-analysis results showed that curcuminoids were significantly more effective than comparators regarding visual analogue scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain scores. However, no significant difference in pain relief or AEs between the high-dose (daily dose ≥1000 mg or total dose ≥42 gm) and low-dose (daily dose <1000 mg or total dose <42 gm) curcuminoid treatments was observed. When comparing curcumininoids versus NSAIDs, a significant difference in VAS pain was found. For AE analysis, three of our included studies used NSAIDs as comparators, with all reporting higher AE rates in the NSAID group, though significance was reached in only one study.

A Review Article published in 2021 in the journal Disease and Diagnosis found that Lavender aromatherapy, whether administered through massage or inhalation, appears effective in reducing active phase labor pain. The researchers conducted their study by performing a detailed search using a number of specific keywords such as lavender, childbirth, labor, pregnancy, labor pain, aromatherapy, and delivery across multiple databases. These databases included MEDLINE/PubMed, Scopus, and Google Scholar. Using these keywords they extracted relevant data from the seven most reliable studies they found, two of which originated in Egypt and Indonesia, and remaining five in Iran. The chosen studies depicted a range of qualities, with some using massage aromatherapy, and others applying inhalation as their method of practice. In analyzing these studies, it was found that all of them indicated that lavender aromatherapy, regardless of whether it was applied via massage or inhalation, had the potential to lessen the pain felt during the active phase of labor. The studies provided basis for insightful consideration of the application of lavender aromatherapy as a viable method for managing labor pain.

A published in 2021 in the journal Frontiers in Medicine found that Adding acupuncture to conventional therapy may decrease the subsequent endometriosis risk in female rheumatoid arthritis patients. Between 1998 and 2010, female subjects with RA were recruited from a nationwide database (5,736 patients; age ≥20 years). Enrolled patients included 2,407 acupuncture users and 2,407 nonusers randomly selected using propensity scores. The occurrence of endometriosis was recorded through the end of 2012. Cox proportional hazards regression was used to estimate the adjusted hazard ratio (HR) associated with acupuncture use. Results: During the follow-up period, 35 acupuncture users and 94 non-users developed endometriosis, with incidence rates of 2.36 and 4.91 per 1,000 person-years, respectively. Acupuncture use was associated with a 55% lower endometriosis risk. Those who received high intensity acupuncture (≥15 packages) had the greatest benefit. The results of multivariable analysis demonstrated that the use of acupuncture was related to a significantly reduced risk of endometriosis. In the subgroup analysis, the medium- to high-level intensity acupuncture use was found to possibly lessen the risk of having endometriosis for more than 70%. We discovered that the post-rheumatoid arthritis acupuncture use would significantly reduce the risk of endometriosis in a dose-dependent manner.

A Experimental Study published in 2021 in the journal Frontiers in Nutrition found that Supplementation with standardized saffron extract improves depressive symptoms and social relationships in healthy individuals experiencing subclinical low mood and stress. The study employed a double-blind, randomized, parallel groups design involving 56 healthy male and female participants aged between 18 and 54. They received either 30 mg standardized saffron extract or a placebo daily for 8 weeks. The saffron's chronic effects on subjective feelings of anxiety, stress, and depression were evaluated using a series of questionnaires. The acute effects of saffron following exposure to a lab-based psychosocial stressor were determined through assessing psychological and physiological parameters. As part of the process, the level of crocetin, a compound found in saffron, was quantified in the participants' urine. The results indicated that individuals who received the saffron extract reported lower depression scores and improved social relationships after the 8-week period. A significant increase in urinary crocetin levels was observed with saffron supplementation, and these changes were found to be correlated with a decrease in depression scores. Additionally, the usual decrease in heart rate variability, a reaction commonly seen during the exposure to stressors, was found to be diminished after acute intake of saffron. The findings suggest that saffron extract can help improve subclinical depressive symptoms in healthy individuals and may increase resilience against the development of stress-related psychiatric disorders.

A Systematic Review published in 2021 in the journal Chinese Medicine found that Traditional Chinese medicines might have various beneficial effects for non-alcoholic fatty liver disease such as improving TCM syndrome score, liver function, and body lipid profile. A total of 53 RCTs involving 5997 participants with NAFLD were included in this review. Each included RCT tested a different TCMs giving a total of 53 TCMs identified in this study. Based on the evaluation of the RCT results, TCMs might have various beneficial effects such as improving TCM syndrome score, liver function, and body lipid profile. A range of non-serious, reversible adverse effects associated with the use of TCMs were also reported. However, no conclusion about the efficacy and safety of TCMs in NAFLD can be made. The quality of reporting was generally poor and the risks of bias was mostly uncertain in all trials. There is some evidence from RCTs that supported the effectiveness and safety of TCMs for NAFLD. However, no conclusive recommendations can be made due to the questionable quality of the RCTs. Improvement in the RCT protocol, the use of a larger sample size, a setting of multicenter, and a more focused approach in selecting TCMs are recommended for developing high quality evidence about the use of TCMs in managing NAFLD.

A Clinical Study published in 2021 in the journal Food & Function found that Consumption of blueberries can alter levels of certain beneficial compounds in the blood, potentially contributing to improved cognitive function in older adults. The research method involved a study on 38 healthy older adults between 60 to 75 years of age, over a 90-day period. Participants were randomly assigned to two groups – a blueberry group and a control group. The blueberry group received 24 grams of freeze-dried blueberries, equivalent to a cup of fresh berries, every day, while the control group received no treatment. Blood samples were taken from the subjects before breakfast and two hours post-breakfast, on the start day, the 45th day and the 90th day. Additionally, the study subjects also took cognitive tests on these days. Results showed that after 90 days, there were significant changes in the levels of circulating phenolic compounds, including such compounds as hippuric acid, phloroglucinaldehyde and syringic acid, among others, in the blood of those who had consumed blueberries. Moreover, improvements in cognitive functions were observed and these changes were linked to alterations in the concentrations of specific phenolic compounds like ferulic acid-glucuronide, syringic acid, and malvidin-3-galactoside. These results suggest a correlation between daily blueberry consumption, changes in phenolic compounds in the blood, and improvements in brain performance.

A Systematic Review published in 2021 in the journal Food & Function found that Almond intake significantly changed the concentrations of triglycerides, total cholesterol and low-density lipoproteins To estimate the overall effect of almond intake, we employed the random-effect model. In total, 27 studies with 36 effect sizes were included in our analysis (1154 cases and 904 control subjects). The meta-analysis revealed that almond intake significantly changed the concentrations of triglycerides, total cholesterol, and low-density lipoproteins; however it did not have a significant effect on high-density lipoprotein levels. Meta-regression analysis indicated a linear relationship between the dose of almond and change in TG. This meta-analysis concludes that almond intake can significantly reduce lipid parameters.

A Review Article published in 2020 in the journal Journal of Functional Foods found that Jujube fruits contain a high amount of various bioactive compounds exerting antioxidant, anti-inflammatory, antiobesity, anti-cardiovascular disease, hepatoprotective, antidiabetic, anti-microbial, anticancer, and gastrointestinal-protective effects. The scientific evidence has shown that jujube fruits contain a high amount of various bioactive compounds, including ascorbic acid, triterpenic acids, phenolic acids, amino acids, saponins, cerebrosides, flavonoids, polysaccharides, and mineral constituents. These phytoconstituents play important roles to suppress different diseases, exerting the antioxidant, anti-inflammatory, antiobesity, anti-cardiovascular disease, hepatoprotective, antidiabetic, anti-microbial, anticancer, and gastrointestinal-protective effects.

A Review Article published in 2020 in the journal Horticulture Research found that In jujube fruit, the contents of sugar, vitamin C, and cyclic adenosine monophosphate (cAMP) are around 2, 100, and 1000 times those of apple, respectively. The fruit is particularly rich in nutrients, and its contents of sugar, vitamin C and B, cyclic nucleotide, proline, triterpenic acid, potassium, iron, and zinc are the highest among many fruits. The contents of sugar, vitamin C, and cyclic adenosine monophosphate (cAMP) are around 2, 100, and 1000 times those of apple, respectively. The fruit is also a rich source of polysaccharides, triterpenic acids, flavonoids, alkaloids, polyphenols, and pigments.

A Systematic Review published in 2020 in the journal BJOG: An International Journal of Obstetrics & Gynaecology found that Acupuncture appeared to be beneficial for treatment and prophylaxis of recurrent urinary tract infections. Five RCTs involving 341 participants were included. Methodological quality of studies and strength of the evidence were low to moderate. The chance of achieving a composite cure with acupuncture therapies was greater than that with antibiotics. The risk of UTI recurrence was lower with acupuncture than with no treatment and sham acupuncture. Acupuncture appeared to be beneficial for treatment and prophylaxis of recurrent urinary tract infections, noting the limitations of the current evidence. Given the growing challenge of antibiotic resistance, there is a need for high-quality RCTs of non-pharmacological interventions such as acupuncture.

A published in 2020 in the journal Deutsches Arzteblatt International found that Acupuncture may be considered in patients with persistent, idiopathic vulvar pruritus. Vulvar pruritus is a complex symptom of multifactorial origin, frequently affecting the patient’s quality of life. The treatment of patients with chronic pruritus (>6 weeks) is particularly challenging and often requires a multimodal strategy with an interdisciplinary approach. Besides the elimination of potential triggers and continuous lipid-replenishing basic care, antifungal agents and glucocorticoids are paramount. Medical professionals not specialized in the field should refer patients with refractory and/or suspicious lesions to an experienced gynecologist. A specimen should be obtained by punch biopsy for histological evaluation to rule out (pre-) malignant lesions. It is central to the management of vulvar pruritus to offer a detailed discussion of the condition and treat patients with empathy. Their complaints should be taken seriously and patients should be informed about what could cause their symptoms and which treatment options are available for them.

A Systematic Review published in 2019 in the journal The American Journal of Chinese Medicine found that Chinese medicine treatments involving the Bladder and Conception Vessel meridians may be more effective to relieve asthma symptoms than non-meridian interventions. In 204 RCTs that were identified and used in a meta-synthesis, meridians were used 521 times, with the bladder meridian being the most frequently used. Furthermore, 23 RCTs were included in the meta-analysis. Surface under the cumulative ranking (SUCRA) revealed that the bladder–conception vessel–governor vessel–stomach multiplex meridian intervention was more effective than non-meridian interventions in relieving asthma symptoms. Additionally, either bladder–conception vessel–stomach or bladder–conception vessel–governor vessel–kidney multiplex meridians may be selected in interventions. This study suggests that practitioners target multiplex meridians, especially the meridians of the bladder and conception vessel, to effectively relieve asthma symptoms.

A Systematic Review published in 2019 in the journal Evidence-Based Complementary and Alternative Medicine found that Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products. The six studies included in this systematic review reported decreases in the incidence and severity of gout following the ingestion of cherries. Gout patients regularly ingesting cherry extract/juice reported fewer gout flare ups than those patients who did not supplement their diets with cherry products. Overall, we observed a positive correlation between the consumption of tart cherry juice and a decrease in serum uric acid concentration.

A Systematic Review published in 2019 in the journal Climacteric found that Acupuncture significantly alleviated breast cancer treatment-related menopause symptoms for at least 3 months, but not hot flushes. In total, 943 patients from 13 RCTs were analyzed. The meta-analysis showed that acupuncture had no significant long-term maintenance effect on the frequency or severity of hot flushes, but had a significant 3-month maintenance effect of ameliorating menopause symptoms at 3 months after treatment ended. No adverse events were reported.

A Meta-Analysis published in 2019 in the journal Phytotherapy Research found that Chamomile has demonstrative positive effects on generalized anxiety disorders and sleep quality, but exhibits minimal impact on state anxiety and insomnia. The methodology of this study involved rigorous systematic review and meta-analysis across multiple databases, including PubMed, Science Direct, Cochrane Central, and Scopus. The aim was to determine the efficacy and safety of chamomile for managing state anxiety, generalized anxiety disorders, sleep quality and insomnia in humans. Relevant randomized control trials were retrieved, yielding a total of 12 trials used for this study. Statistical analyses were performed with the meta package of R statistical software version 3.4.3 and RevMan version 5.3. The results indicated that chamomile had a significant positive effect on generalized anxiety disorders (GAD) and improved sleep quality. Improvements in GAD were observed after 2 and 4 weeks of chamomile treatment. However, no significant effects were noted in the treatment of state anxiety or insomnia. Mild adverse events were reported in three trials. In conclusion, chamomile was determined to be effective and safe for treating GAD and improving sleep quality, but showed less impact on state anxiety and insomnia.

A Systematic Review published in 2018 in the journal JBRA Assisted Reproduction found that Acupuncture performed on the day of embryo transfer has a significant effect on embryo implantation, however, a negative one. According to our findings, physicians should encourage their patients to avoid undergoing acupuncture on the day of ET, since it diminishes the chances of getting pregnant. It still has to be elucidated the mechanisms by which acupuncture negatively affects embryo implantation. In conclusion, acupuncture performed on the day of ET has a significant effect on embryo implantation, however, a negative one. Therefore, clinicians should encourage their patients to avoid this technique the day of ET.

A Systematic Review published in 2018 in the journal Evidence-Based Complementary and Alternative Medicine found that Compared with other therapies, acupuncture at ST38 appeared to reach a better therapeutic effectiveness in improving the recovery of shoulder joint mobility. The results of our meta-analysis revealed significant differences in acupuncture at Tiaokou (as sole treatment or in combination with shoulder acupoints) versus other therapies (acupuncture at shoulder acupoints, tuina, exercise of the affected shoulder, and oral NSAIDs) for the relief of shoulder pain. What is more, compared with other therapies, acupuncture at Tiaokou appeared to reach a better therapeutic effectiveness in improving the recovery of shoulder joint mobility.

A Theoretical Article published in 2018 in the journal Nutrients found that Traditional Chinese medicines have shown promising benefits for prostate cancer treatment due to unique formulas, extracts, and compounds that exhibit anti-cancer effects. In their study, the researchers analyzed numerous reports detailing the use of Chinese medicines in treating prostate cancer, specifically focusing on diverse traditional formulas, medicinal extracts and isolated compounds. Clinical trials of these diverse therapies were scrutinized to gain insights into their effects and potential advantages in the fight against prostate cancer. In discussing the results, it was evident that several Traditional Chinese Medicine (TCM) treatments exhibited distinct advantages in combating prostate cancer, offering protective effects. Compounds from these traditional medicines demonstrated significant anti-prostate cancer effects. However, the researchers noted difficulties in ascertaining the applications of Chinese medicines due to their multicomponent nature, complex action mechanisms, and high therapeutic doses. The researchers concluded by challenging the perspective of current research, questioning emphasis between formulas, extracts, and compounds in the context of clinical prostate cancer treatment.

A Systematic Review published in 2018 in the journal Sleep Medicine Reviews found that The results showed that even fragile populations such as the elderly and dialysis patients can benefit from acupressure to improve sleep quality. Thirty-two eligible randomized controlled trials of moderate to high quality which employed polysomnography, actigraphy, or self-assessment sleep quality tools were included. We conducted a meta-analysis using a random effects model with the Pittsburgh sleep quality index (PSQI) as the primary outcome measure (968 adult patients, 13 trials) for trials investigating the effects of traditional Chinese medicine acupressure compared with standard and sham treatments. We performed subgroup analyses to detect sources of heterogeneity, identify the use of acupoints in different populations and explore the contributions of PSQI domains to the total score change. Comparison with the sham group (7 trials with 385 patients) yielded low heterogeneity and an overall effect of 13%–19% improvement in the PSQI score. Based on data from four trials (n = 250), sleep latency and sleep duration were most affected. No adverse effects were reported in any of the reviewed trials.

A Experimental Study published in 2017 in the journal Tissue and Cell found that Coconut water and milk demonstrate protective effects against ulceration, reducing inflammation, promoting cell proliferation and supporting mucosal homeostasis. The study was conducted in two phases using 45 male wistar rats divided into 9 groups. The first phase involved treatment of five groups with different substances: normal saline, 95% ethanol, coconut water, coconut milk, and Omeprazole. Ulceration was induced with 95% ethanol except in the saline-control group. The second phase involved four groups: a control group, an ulcer control group receiving acetic acid, a group receiving coconut milk and another receiving Omeprazole. Drug treatments were administered twice daily for 3-6 days post-ulcer induction. Afterwards, blood was collected for haemocytometry and gastric tissues were harvested for histological examinations. In this study, both coconut water and milk, as well as Omeprazole, led to reduced ulcer scores and gastric lesion indices compared to the ulcer control groups. They also resulted in significantly lower white blood cell, neutrophil, and lymphocyte counts compared to the ulcer and overall control groups. Coconut milk, in particular, was associated with a significant reduction in C-reactive protein. The experimental treatments also led to reduced neutrophil infiltration and an increase in mucus cell density. Notably, the coconut milk group showed significantly higher expressions of EGFR and CD31, indicating catalysis of mucosa homeostasis through angiogenesis and mucosal cell proliferation.

A Systematic Review published in 2017 in the journal PLOS One found that Acupuncture is non-inferior to hormone therapy or other applied relaxation therapies in alleviating the symptoms of menopause for its safety, non-invasive and especially considering the side effect of hormone therapy. This meta-analysis of women with breast cancer confirms that acupuncture had no significant effect on the severity of hot flush, but did significantly alleviate the symptoms of menopause. We conclude that acupuncture is non-inferior to hormone therapy or other applied relaxation therapies in alleviating the symptoms of menopause for its safety, non-invasive and especially considering the side effect of hormone therapy. Recent studies show that use of acupuncture does not correlate with increased levels of plasma estradiol. Considering the safety and lack of serious adverse effects associated with acupuncture, in contrast to hormone therapy, acupuncture should be considered for treating hot flush and menopause syndrome in women with breast cancer.

A Systematic Review published in 2017 in the journal The Journal of Alternative and Complementary Medicine found that The majority of randomised controlled trials showed benefit for acupuncture over control in the treatment of diabetic neuropathy, Bell's palsy, and carpal tunnel syndrome. Fifteen studies were included: 13 original RCTs, a long-term follow-up, and a re-analysis of a prior RCT. The selected RCTs studied acupuncture for neuropathy caused by diabetes, Bell's palsy, carpal tunnel syndrome, human immunodeficiency virus (HIV), and idiopathic conditions. Acupuncture is probably effective in the treatment of HIV-related neuropathy, and there is insufficient evidence for its benefits in idiopathic neuropathy. Acupuncture appears to improve nerve conduction study parameters in both sensory and motor nerves. Acupuncture is beneficial in some peripheral neuropathies, but more rigorously designed studies using sham-acupuncture control are needed to characterize its effect and optimal use better.

A Systematic Review published in 2016 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture was superior to either sham acupuncture or medication (including Itopride, Mosapride, and Domperidone) in relieving the major symptoms of functional dyspepsia. Acupuncture therapy (including manual and electroacupuncture) achieved statistically significant effect in improving the overall symptoms and quality of life of functional dyspepsia patients comparing to sham acupuncture and is superior to medication (prokinetic agents) in ameliorating the major symptoms of functional dyspepsia (postprandial fullness and early satiation).

A Systematic Review published in 2016 in the journal Archives of Gynecology and Obstetrics found that Acupuncture improves the clinical pregnancy rate among women undergoing IVF and the IVF outcome results were significantly superior in the acupuncture group when acupuncture was conducted during controlled ovarian hyperstimulation. When the studies were restricted to Asian or non-Asian area patients, compared with traditional acupuncture and other methods, electrical acupuncture yielded better IVF outcomes. Optimal positive effects could be expected using acupuncture in IVF during controlled ovarian hyperstimulation, especially in Asian area. However, as a limitation of this review, most of the included studies did not mention the number of embryos transferred.

A Systematic Review published in 2016 in the journal Scientific Reports found that Clinicians may consider Tai Chi as a viable complementary and alternative medicine for chronic pain conditions. The aggregated results have indicated that Tai Chi showed positive evidence on immediate relief of chronic pain from osteoarthritis. The valid duration of Tai Chi practice for osteoarthritis may be more than 5 weeks. And there were some beneficial evidences regarding the effects of Tai Chi on immediate relief of chronic pain from low back pain and osteoporosis. Therefore, clinicians may consider Tai Chi as a viable complementary and alternative medicine for chronic pain conditions.

A Randomised Controlled Trial published in 2016 in the journal The Journal of Nutrition found that Dietary omega-3 intake shows promise in lowering systolic blood pressure. A study involving 312 participants investigated the effects of achievable dietary intake of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on blood pressure and vascular function. Participants were divided into groups receiving different doses of EPA+DHA for 8 weeks. Overall, there were no significant effects observed. However, in individuals with isolated systolic hypertension (SHT), a clinically meaningful reduction in systolic blood pressure (5 mm Hg) was noted with a low dose of EPA+DHA (0.7 g). The study suggests that even modest omega-3 intake may have potential benefits in reducing cardiovascular risk for individuals with SHT. Further research is recommended for conclusive results.

A Randomised Controlled Trial published in 2015 in the journal Annals of Allergy, Asthma & Immunology found that Four weeks of acupuncture treatment is a safe and effective option for clinical management of seasonal allergic rhinitis in the Melbourne area for patients' symptom relief and quality of life improvement. A total of 175 participants were included in this trial. RA was significantly better than SA for decreasing SAR symptom severity (sneezing, mean difference −0.28, 95% confidence interval −0.51 to −0.05; itchiness of ears and palate, mean difference −0.40, 95% confidence interval −0.69 to −0.11) at the end of treatment and improving participants' QoL at the end of the treatment and follow-up phases. Furthermore, the acupuncture treatment was safe and well tolerated.

A Systematic Review published in 2015 in the journal Italian Journal of Pediatrics found that Acupuncture may have a beneficial effect with respect to peak expiratory flow in children with asthma. The results indicate that acupuncture, in the form of traditional needle acupuncture or laser acupuncture, may provide benefit with respect to PEF and perhaps FEV1, along with asthma-specific anxiety level. However, these findings are based on the results of three studies and should be interpreted with caution. In addition, the results of Karlson and Bennicke indicate a significant effect of acupuncture on medication use and symptoms in younger children. The quality assessment shows that the study quality was not high, with four of the studies being blinded. In addition, the acupuncture points used varied among studies. Methodologic variability remains an issue. However, the results suggest that acupuncture may have a beneficial effect with respect to PEF or PEF variability in children with asthma. The efficacy of acupuncture on other outcome measures is unclear.

A Systematic Review published in 2013 in the journal Evidence-Based Complementary and Alternative Medicine found that Our findings suggest that acupressure at the SP6 acupoint may provide more effective pain relief than that of control treatment. This is the first systematic review to evaluate the effectiveness of acupuncture or acupressure at the SP6 acupoint for relieving pain associated with primary dysmenorrhea. Our findings suggest that acupuncture at the SP6 acupoint may not be more effective than acupuncture at an unrelated (GB39) acupoint for the relief of dysmenorrhea-associated pain (assessed using a VAS). In contrast, our findings suggest that acupressure at the SP6 acupoint may provide more effective relief from dysmenorrhea-associated pain than control interventions. Clearly, there is a need for high-quality, randomized controlled trials to clarify the effectiveness of acupuncture/acupressure at the SP6 acupoint for the treatment of pain resulting from primary dysmenorrhea.

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