Hyaluronic Acid
Recent Insights
A combination of epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid may effectively clear HPV infections and cervical lesions in women.
Cervical Dysplasia EGCG Folic Acid
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report
2023 Mar 22 Journal of Personalized Medicine Grandi G, Botticelli L, Fraia PD, Babalini C, Masini M, Unfer V
Case Report Vitamin B12 Cervical Cancer Cervical Lesions HA Folic Acid Cervical Dysplasia Green Tea EGCG HPVThe combination of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid could effectively counter precancerous lesions of the uterine cervix caused by HPV infections.
Evaluating the Efficacy of Pervistop®, a New Combination Based on EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on Patients with Human Papilloma Virus (HPV) Persistent Infections and Cervical Lesions: A Pilot Study
2023 Mar 10 Journal of Clinical Medicine Aragona C, Bezerra Espinola MS, Bilotta G, Porcaro G, Calcagno M
Randomised Controlled Trial Cervical Dysplasia Vitamin B12 Folic Acid Hyaluronic Acid Green Tea HPV EGCGA combination of epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid may effectively clear HPV infections and cervical lesions in women.
Iminosugar idoBR1 Isolated from Cucumber Cucumis sativus Reduces Inflammatory Activity
2020 Jun 23 ACS Omega Nash RJ, Bartholomew B, Penkova YB, Rotondo D, Yamasaka F, Stafford GP, et al.
IdoBR1 demonstrated anti-inflammatory activity by reducing lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α) in THP-1 cells and ex vivo human blood. It selectively inhibited human α-l-iduronidase and sialidases from both bacteria (Tannerella forsythia) and human THP-1 cells. IdoBR1, along with cucumber extract, reduced the binding of hyaluronic acid (HA) to CD44 in LPS-stimulated THP-1 cells, suggesting its potential role as an anti-inflammatory agent by inhibiting induced sialidase involved in the production of functionally active HA adhesive CD44. Additionally, idoBR1 is excreted unchanged in urine following consumption, warranting further evaluation of its importance in the diet.
Experimental Study Inflammation CucumberResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The combination of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid could effectively counter precancerous lesions of the uterine cervix caused by HPV infections.
2023 Journal of Personalized Medicine The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report Grandi G, Botticelli L, Fraia PD, Babalini C, Masini M, Unfer V
Case Report Cervical Cancer Cervical Dysplasia Cervical Lesions
The methodology used in this research centred around treating a 39-year-old patient who had a history of HPV, cervix lesions, and multiple failed surgical attempts to treat the condition. The treatment plan applied was unique, utilizing a blend of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid, administered over an eight week period.
The results showed promising effects, with the patient's histological and cytological analyses revealing only a chronic cervicitis instead of any malignant lesions or cellular dysplasia. Therefore, the necessity for invasive total hysterectomy was minimized, demonstrating the potential for the selected treatment plan to manage precancerous lesions of the uterine cervix.
A combination of epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid may effectively clear HPV infections and cervical lesions in women.
2023 Journal of Clinical Medicine Evaluating the Efficacy of Pervistop®, a New Combination Based on EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on Patients with Human Papilloma Virus (HPV) Persistent Infections and Cervical Lesions: A Pilot Study Aragona C, Bezerra Espinola MS, Bilotta G, Porcaro G, Calcagno M
Randomised Controlled Trial Cervical Dysplasia EGCG Folic Acid
Forty women with persistent HPV infections and cervical lesions were enrolled in this study and were then divided into two groups. Women in the treatment group were given a 12-week treatment comprising of 200mg epigallocatechin gallate, 400µg folic acid, 1mg vitamin B12, and 50mg hyaluronic acid. In contrast, the control group received no treatment.
A significant difference was noted between the two groups post-treatment. In the control group, the majority of women still had a Low-Grade Squamous Intraepithelial Lesion (LSIL) at the close of the study, with varying changes in viral DNA content. However, in the case of the treated group, most women had achieved full viral clearance, showing no signs of lesions post-treatment, thus highlighting the potential effectiveness of the treatment combination.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
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The combination of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid could effectively counter precancerous lesions of the uterine cervix caused by HPV infections.
A combination of epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid may effectively clear HPV infections and cervical lesions in women.
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