Intestinal Barrier
Recent Insights
A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.
Gut Microbiota Intestinal Barrier Snow Fungus
Tremella fuciformis polysaccharides effectively reduce inflammation in ulcerative colitis, promoting healing by restoring intestinal and mucus barrier functions.
Intestinal Barrier Polysaccharides Snow Fungus
Related Topics
Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis
2024 Nov International Journal of Biological Macromolecules Peng G, Wang S, Zhang H, Xie F, Jiao L, Yuan Y, et al.
Animal Study Gut Microbiota Ulcerative Colitis Intestinal Barrier Snow FungusThis article was submitted by Jinnan C. and is awaiting moderation..
A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.
Therapeutic potential of seaweed extracts: In vitro and in vivo studies on alleviating inflammation and enhancing intestinal barrier function.
2024 Jun Food Bioscience Kim YR, Park S, Kim JY
Seaweed Inflammation Intestinal BarrierThis article was submitted by Jinnan C. and is awaiting moderation..
Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors
2023 Jan Food & Function Zhao S, Hu S, Sun K, Luo L, Zeng L
Experimental Study Animal Study Pu-Erh Tea Depression katanaPu-erh tea can potentially prevent depression-like behaviors induced by nighttime blue light from electronic devices by reshaping gut microbiota and increasing short-chain fatty acids generation.
Acupuncture improves the symptoms, intestinal microbiota, and inflammation of patients with mild to moderate Crohn's disease: A randomized controlled trial
2022 Mar EClinicalMedicine Bao C, Wu L, Wang D, Chen L, Jin X, Shi Y, et al.
Randomised Controlled Trial Acupuncture Crohn's DiseaseAcupuncture effectively induced and sustained remission in active Crohn's disease patients, linked to an increase in anti-inflammatory gut bacteria and improved intestinal barrier.
Effect and molecular mechanism research of Astragalus membranaceus on inhibiting intestinal absorption of six alkaloids of Aconitum carmichaelii in spleen deficiency rats
2022 Jan Chinese Herbal Medicines Chen X, Liang X, Kong X, Ji M, Naeem A, Li C, et al.
HQ as an intestinal barrier modulator improves the physiological changes of the intestinal environment of spleen deficiency to reduce the absorption of toxic components, leading to a decrease in the absorption of drug-like molecules.
Network Pharmacology Animal Study Fu ZiResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.
2024 International Journal of Biological Macromolecules Tremella aurantialba polysaccharides alleviate ulcerative colitis in mice by improving intestinal barrier via modulating gut microbiota and inhibiting ferroptosis Peng G, Wang S, Zhang H, Xie F, Jiao L, Yuan Y, et al.
Animal Study Gut Microbiota Snow Fungus Ulcerative Colitis
The methodology used in this research involved isolating TA 2-1, a specific polysaccharide from Tremella Aurantialba, and studying its effects on ulcerative colitis. This was done by introducing it to Caco-2 cells that were undergoing ferroptosis and assessing its impact on cell viability. The influence of TA 2-1 was also examined in mice with artificially induced ulcerative colitis, verifying its ameliorating effects in an in-vivo context. The structure of TA 2-1 and its components were analysed and the polysaccharide's interaction with gut microbiota was explored to understand how it might modulate symptoms or prevent cell death.
The results of this study showed that TA 2-1 does not only decrease the rate of cell death in epithelial cells undergoing ferroptosis, but it also repairs the intestinal barrier by upregulating specific proteins such as claudin-1 and zonula occludens-1. TA 2-1 was also found to suppress lipid peroxidation, thus inhibiting ferroptosis. Further investigation revealed that TA 2-1 may alleviate ulcerative colitis by influencing the composition or metabolites of gut microbiota. This research offers promising insight into the potential of TA 2-1 in treating ulcerative colitis.
Pu-erh tea can potentially prevent depression-like behaviors induced by nighttime blue light from electronic devices by reshaping gut microbiota and increasing short-chain fatty acids generation.
2023 Food & Function Long-term Pu-erh tea consumption improves blue light-induced depression-like behaviors Zhao S, Hu S, Sun K, Luo L, Zeng L
Experimental Study Depression katana Pu-Erh Tea
The methodology used involved administering water or Pu-erh tea to two groups of mice for 120 days, followed by a 45-day exposure to a blue light simulating electronic equipment during the night. The effect of the tea and blue light on the mice's behavior and gut microbiota was then studied. Results indicated that the blue light induced depression-like behaviors and upset the gut microbiota in mice that were previously healthy.
In the discussion of results, it was noted that the intake of Pu-erh tea significantly reshaped the mice's gut microbiota, especially the metabolism of short-chain fatty acids, which helped protect the integrity of the intestinal barrier. This improvement not only lessened damage to the blood-brain barrier, but also reduced neuroinflammation by inhibiting certain cellular pathways. This ultimately regulated neurotransmitters like brain-derived neurotrophic factor and serotonin, demonstrating the potential of Pu-erh tea to prevent blue light induced depression-like behaviors by impacting the gut-brain axis.
Acupuncture effectively induced and sustained remission in active Crohn's disease patients, linked to an increase in anti-inflammatory gut bacteria and improved intestinal barrier.
2022 EClinicalMedicine Acupuncture improves the symptoms, intestinal microbiota, and inflammation of patients with mild to moderate Crohn's disease: A randomized controlled trial Bao C, Wu L, Wang D, Chen L, Jin X, Shi Y, et al.
Randomised Controlled Trial Acupuncture Crohn's Disease
In a 48-week randomized, sham controlled, parallel-group clinical trial conducted at a Chinese tertiary outpatient clinic, 66 drug-resistant, mild to moderately active Crohn's disease patients were randomly assigned equally to a control or acupuncture plus moxibustion treatment group. Three treatment sessions were provided weekly for 12 weeks, followed by 36 weeks of follow-up.
The acupuncture treatment was significantly more effective than the sham treatment in terms of clinical remission and response rates by week 12, results which were maintained at week 48. The acupuncture group also displayed lower Crohn's disease activity indices and C-reactive protein levels and a decreased recurrence rate. Post-treatment, this group demonstrated an increase in the diversity and relative abundance of intestinal microbiota, particularly anti-inflammatory bacteria, as well as reduced plasma levels of diamine oxidase, lipopolysaccharide, and Th1/Th17 related cytokines.
Chinese medicine's unique immune regulation, intestinal flora regulation, and improved intestinal barrier function offer new approaches to managing chronic Inflammatory Bowel Disease.
2021 Phytomedicine A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease Yang L, Luo H, Tan D, Zhang S, Zhong Z, Wang S, et al.
Systematic Review Inflammatory Bowel Disease
The study involved a comprehensive review of literature from peer-reviewed and clinical databases such as PubMed, Web of Science, ClinicalTrials.gov, MEDLINE, EMBASE, Springer LINK, Wan-fang database, the Chinese Biomedicine Database, and the China National Knowledge Infrastructure. Keywords such as inflammatory bowel disease (including Ulcerative colitis or Crohn's disease) and Chinese medicine were used, focusing on studies conducted between 1997 and 2021, while excluding those that did not meet specific criteria.
The review primarily focused on the pathogenesis of IBD and how Chinese medicine plays a role in its treatment, particularly in immune regulation, intestinal flora regulation, and improvement of intestinal barrier function. The collective findings present exciting progress in understanding how multi-herbal Chinese medicine can potentially contribute to the treatment of IBD.
Chinese medicine presents unique advantages in managing Inflammatory Bowel Disease (IBD) through immune regulation, intestinal flora regulation, and improvement of intestinal barrier function.
2021 Phytomedicine A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease Yang L, Luo H, Tan D, Zhang S, Zhong Z, Wang S, et al.
Systematic Review Inflammatory Bowel Disease
In their research, the researchers conducted a systematic review of studies that assessed the effects and mechanics of Chinese medicine in treating IBD. They performed a literature search on various peer-reviewed and clinical databases, including reputable international and Chinese sources. The keywords used for this comprehensive search included "inflammatory bowel disease", "Ulcerative colitis", "Crohn's disease", and "Chinese medicine". Only articles from the period of 1997-2021 that met their exclusion criteria were chosen for the review.
The compiled research illuminates recent progression in using Chinese medicine to treat IBD. Certain studies specifically look at how Chinese medicine impacts immune regulation, intestinal flora regulation, and the enhancement of intestinal barrier function in IBD patients. This information could serve as a key reference for further exploration regarding the potential of classical multi-herbal Chinese medicine in treating IBD.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Presentation Slides
A polysaccharide from Tremella aurantialba improves ulcerative colitis symptoms by targeting epithelial cell ferroptosis and modulating the gut microbiota.
Pu-erh tea can potentially prevent depression-like behaviors induced by nighttime blue light from electronic devices by reshaping gut microbiota and increasing short-chain fatty acids generation.
Acupuncture effectively induced and sustained remission in active Crohn's disease patients, linked to an increase in anti-inflammatory gut bacteria and improved intestinal barrier.
Chinese medicine's unique immune regulation, intestinal flora regulation, and improved intestinal barrier function offer new approaches to managing chronic Inflammatory Bowel Disease.
Chinese medicine presents unique advantages in managing Inflammatory Bowel Disease (IBD) through immune regulation, intestinal flora regulation, and improvement of intestinal barrier function.
Tremella fuciformis polysaccharides effectively reduce inflammation in ulcerative colitis, promoting healing by restoring intestinal and mucus barrier functions.
Sign In
Users not signed in are limited to viewing the 5 most recent items of content.