Intestinal Flora
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Traditional Chinese medicine exhibits fewer side effects while effectively controlling inflammation and serum uric acid in gout patients.
Gout Intestinal Flora
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Extraction, structural-activity relationships, bioactivities, and application prospects of Pueraria lobata polysaccharides as ingredients for functional products: A review
2023 Jul International Journal of Biological Macromolecules Wang J, Dai G, Shang M, Wang Y, Xia C, Duan B, et al.
It was found that PLPs possess various bioactivities, including antioxidation, antidiabetic, immunomodulatory, hypolipidemic, antibacterial activities, regulation of intestinal flora, etc. The linkage patterns of glycosidic bonds might influence the bioactivities of PLPs. Meanwhile, PLPs have great development prospects in the health food and medical industries due to their non-toxicity. These discoveries establish a solid foundation for expanding the application and investigations of PLPs.
Review Article Ge Gen
Plant flavonoids bioavailability in vivo and mechanisms of benefits on chronic kidney disease: a comprehensive review
2022 Sep 22 Phytochemistry Reviews Lin Y, Fang J, Zhang Z, Farag MA, Li Z, Shao P
Plant flavonoids exhibit an alleviating effect on CKD through various mechanisms, including the reduction of oxidative stress, immune modulation, anti-inflammation, inhibition of renal fibrosis, anti-apoptosis, and regulation of gut flora. The study explores how plant flavonoids contribute to the improvement of renal health in CKD patients by regulating the intestinal flora through the gut-kidney axis. Additionally, the review introduces the products and development prospects of plant flavonoids in the context of CKD.
Review Article Cucumber Chronic Kidney DiseasePhytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity
2022 May 30 Journal of Pharmacy and Pharmacology Liu ZQ, Sun X, Liu ZB, Zhang T, Zhang LL, Wu CJ
Intestinal Flora GoutTraditional Chinese medicine exhibits fewer side effects while effectively controlling inflammation and serum uric acid in gout patients.
A Review on the Immunomodulatory Mechanism of Acupuncture in the Treatment of Inflammatory Bowel Disease
2022 Jan 15 Evidence-Based Complementary and Alternative Medicine Liu Z, Jiao Y, Yu T, Wang H, Zhang Y, Liu D, et al.
Review Article Acupuncture Inflammatory Bowel DiseaseAcupuncture can regulate both innate and adaptive immunity of IBD patients, including the balance of Th17/Treg and Th1/Th2 cells, and also modulate intestinal flora.
A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease
2021 Nov Phytomedicine Yang L, Luo H, Tan D, Zhang S, Zhong Z, Wang S, et al.
Systematic Review Inflammatory Bowel DiseaseChinese medicine presents unique advantages in managing Inflammatory Bowel Disease (IBD) through immune regulation, intestinal flora regulation, and improvement of intestinal barrier function.
Chinese medicine's unique immune regulation, intestinal flora regulation, and improved intestinal barrier function offer new approaches to managing chronic Inflammatory Bowel Disease.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Traditional Chinese medicine exhibits fewer side effects while effectively controlling inflammation and serum uric acid in gout patients.
2022 Journal of Pharmacy and Pharmacology Phytochemicals in traditional Chinese medicine can treat gout by regulating intestinal flora through inactivating NLRP3 and inhibiting XOD activity Liu ZQ, Sun X, Liu ZB, Zhang T, Zhang LL, Wu CJ
Gout
In the methodology, the research used herbs as a primary resource, focusing on their phytochemicals. The study examined how these phytochemicals exert anti-inflammatory effects by inactivating the NF-κB and NLRP3 inflammasome, as well as lowering uric acid through the inhibition of xanthine oxidase activity and the up-regulation of URAT1 and GLUT9 expressions. Further, the study explored the relation of changes in intestinal flora and gout, with Chinese herbs acting like prebiotics to modify this flora.
In terms of results, the study found an increase in the abundance of certain beneficial bacteria, such as Bifidobacterium, Lactobacillus, Bacteroidetes, and Prevotella, and a decrease in Proteus and the Firmicutes/Bacteroidetes ratio post traditional Chinese medicine treatment. The alterations in the intestinal flora led to changes in its metabolites, which eventually impacted inflammatory signaling pathways, regulating gene expressions and suppressing xanthine oxidase activity. The study also observed the relation between the disruption of the intestinal barrier and the onset of gout.
Acupuncture can regulate both innate and adaptive immunity of IBD patients, including the balance of Th17/Treg and Th1/Th2 cells, and also modulate intestinal flora.
2022 Evidence-Based Complementary and Alternative Medicine A Review on the Immunomodulatory Mechanism of Acupuncture in the Treatment of Inflammatory Bowel Disease Liu Z, Jiao Y, Yu T, Wang H, Zhang Y, Liu D, et al.
Review Article Acupuncture Inflammatory Bowel Disease
The methodology of the research revolved around a review of existing studies related to the treatment of Inflammatory Bowel Disease (IBD) via acupuncture. The broad scope of exploration focused on the effects of acupuncture on the immunomodulatory mechanism inherent in these patients. The review pursued a detailed study of how acupuncture directly influenced both the innate and adaptive immunity systems in IBD patients as well as its regulation on their intestinal flora.
The results discussion revealed that acupuncture had multiple immunomodulatory effects on IBD patients. On one hand, it influenced their innate immunity by regulating elements such as their intestinal epithelial barriers, toll-like receptors, NLRP3 inflammasomes, oxidative stress, and endoplasmic reticulum stress. On the other hand, it affected their adaptive immunity by modulating the balance of Th17/Treg and Th1/Th2 cells. Furthermore, an interesting revelation from the study was that acupuncture could also significantly regulate the intestinal flora of the patients.
Chinese medicine's unique immune regulation, intestinal flora regulation, and improved intestinal barrier function offer new approaches to managing chronic Inflammatory Bowel Disease.
2021 Phytomedicine A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease Yang L, Luo H, Tan D, Zhang S, Zhong Z, Wang S, et al.
Systematic Review Inflammatory Bowel Disease
The study involved a comprehensive review of literature from peer-reviewed and clinical databases such as PubMed, Web of Science, ClinicalTrials.gov, MEDLINE, EMBASE, Springer LINK, Wan-fang database, the Chinese Biomedicine Database, and the China National Knowledge Infrastructure. Keywords such as inflammatory bowel disease (including Ulcerative colitis or Crohn's disease) and Chinese medicine were used, focusing on studies conducted between 1997 and 2021, while excluding those that did not meet specific criteria.
The review primarily focused on the pathogenesis of IBD and how Chinese medicine plays a role in its treatment, particularly in immune regulation, intestinal flora regulation, and improvement of intestinal barrier function. The collective findings present exciting progress in understanding how multi-herbal Chinese medicine can potentially contribute to the treatment of IBD.
Chinese medicine presents unique advantages in managing Inflammatory Bowel Disease (IBD) through immune regulation, intestinal flora regulation, and improvement of intestinal barrier function.
2021 Phytomedicine A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease Yang L, Luo H, Tan D, Zhang S, Zhong Z, Wang S, et al.
Systematic Review Inflammatory Bowel Disease
In their research, the researchers conducted a systematic review of studies that assessed the effects and mechanics of Chinese medicine in treating IBD. They performed a literature search on various peer-reviewed and clinical databases, including reputable international and Chinese sources. The keywords used for this comprehensive search included "inflammatory bowel disease", "Ulcerative colitis", "Crohn's disease", and "Chinese medicine". Only articles from the period of 1997-2021 that met their exclusion criteria were chosen for the review.
The compiled research illuminates recent progression in using Chinese medicine to treat IBD. Certain studies specifically look at how Chinese medicine impacts immune regulation, intestinal flora regulation, and the enhancement of intestinal barrier function in IBD patients. This information could serve as a key reference for further exploration regarding the potential of classical multi-herbal Chinese medicine in treating IBD.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Extraction, structural-activity relationships, bioactivities, and application prospects of Pueraria lobata polysaccharides as ingredients for functional products: A review
2023 Jul International Journal of Biological Macromolecules Wang J, Dai G, Shang M, Wang Y, Xia C, Duan B, et al.
It was found that PLPs possess various bioactivities, including antioxidation, antidiabetic, immunomodulatory, hypolipidemic, antibacterial activities, regulation of intestinal flora, etc. The linkage patterns of glycosidic bonds might influence the bioactivities of PLPs. Meanwhile, PLPs have great development prospects in the health food and medical industries due to their non-toxicity. These discoveries establish a solid foundation for expanding the application and investigations of PLPs.
Review Article Ge GenPlant flavonoids bioavailability in vivo and mechanisms of benefits on chronic kidney disease: a comprehensive review
2022 Sep 22 Phytochemistry Reviews Lin Y, Fang J, Zhang Z, Farag MA, Li Z, Shao P
Plant flavonoids exhibit an alleviating effect on CKD through various mechanisms, including the reduction of oxidative stress, immune modulation, anti-inflammation, inhibition of renal fibrosis, anti-apoptosis, and regulation of gut flora. The study explores how plant flavonoids contribute to the improvement of renal health in CKD patients by regulating the intestinal flora through the gut-kidney axis. Additionally, the review introduces the products and development prospects of plant flavonoids in the context of CKD.
Review Article Cucumber Chronic Kidney DiseaseA Review on the Immunomodulatory Mechanism of Acupuncture in the Treatment of Inflammatory Bowel Disease
2022 Jan 15 Evidence-Based Complementary and Alternative Medicine Liu Z, Jiao Y, Yu T, Wang H, Zhang Y, Liu D, et al.
Review Article Acupuncture Inflammatory Bowel DiseaseAcupuncture can regulate both innate and adaptive immunity of IBD patients, including the balance of Th17/Treg and Th1/Th2 cells, and also modulate intestinal flora.
A recent update on the use of Chinese medicine in the treatment of inflammatory bowel disease
2021 Nov Phytomedicine Yang L, Luo H, Tan D, Zhang S, Zhong Z, Wang S, et al.
Systematic Review Inflammatory Bowel DiseaseChinese medicine presents unique advantages in managing Inflammatory Bowel Disease (IBD) through immune regulation, intestinal flora regulation, and improvement of intestinal barrier function.
Chinese medicine's unique immune regulation, intestinal flora regulation, and improved intestinal barrier function offer new approaches to managing chronic Inflammatory Bowel Disease.
Presentation Slides
Traditional Chinese medicine exhibits fewer side effects while effectively controlling inflammation and serum uric acid in gout patients.
Acupuncture can regulate both innate and adaptive immunity of IBD patients, including the balance of Th17/Treg and Th1/Th2 cells, and also modulate intestinal flora.
Chinese medicine's unique immune regulation, intestinal flora regulation, and improved intestinal barrier function offer new approaches to managing chronic Inflammatory Bowel Disease.
Chinese medicine presents unique advantages in managing Inflammatory Bowel Disease (IBD) through immune regulation, intestinal flora regulation, and improvement of intestinal barrier function.
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