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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis
2023 Oct Annals of Translational Medicine Wu J, Sun Z, Zhang D, Liu H, Wu J, Zhang S
Network Pharmacology Goji Berry Dang Gui Ginkgo Folium Retinitis Pigmentosa Shu Di HuangThe research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.
Identification of Taohong Siwu Decoction in Treating Chronic Glomerulonephritis Using Network Pharmacology and Molecular Docking
2022 Nov Natural Product Communications Du G, Qu X, Hu J, Zhang Y, Cai Y
The molecular mechanism of Taohong Siwu Decoction (THSWD) in the treatment of chronic glomerulonephritis (CGN) from the perspective of network pharmacology are components such as beta-sitosterol, kaempferol, and quercetin and key action targets such as TNF, IL-6, AKT1 protein kinase, and MAPK14 protein kinase play a synergistic role in autoimmune, infection, and inflammatory response-related pathways.
Network Pharmacology Chronic Glomerulonephritis
Potential Molecular Mechanisms of Ephedra Herb in the Treatment of Nephrotic Syndrome Based on Network Pharmacology and Molecular Docking
2022 Jul 05 BioMed Research International Yao T, Wang Q, Han S, Lu Y, Xu Y, Wang Y
The study identified 22 main active ingredients in EH, such as quercetin, kaempferol, luteolin, and naringenin, targeting 105 NS-related genes. The PPI network revealed 53 core targets, including AKT1, TNF, IL6, VEGFA, and IL1B, crucial in NS treatment. Enrichment analysis highlighted pathways like PI3K-Akt signaling, TNF signaling, and AGE-RAGE signaling. Molecular docking confirmed good binding between active ingredients (kaempferol, luteolin, quercetin, naringenin) and target proteins (AKT1, TNF), suggesting potential mechanisms for EH in NS treatment.
Network PharmacologyStudy the Mechanism of Gualou Niubang Decoction in Treating Plasma Cell Mastitis Based on Network Pharmacology and Molecular Docking
2022 Jun 15 BioMed Research International Wu Z, Yang Q, Ma H
The study identified 164 ingredients and 58 intersection targets in GLNBD's treatment of PCM. Four key active compounds (quercetin, luteolin, fisetin, kaempferol) and four key proteins (ALB, EGFR, IL-6, VEGFA) were identified. Enrichment analysis revealed associations with negative regulation of apoptosis, response to hypoxia, positive regulation of transcription, and DNA-templated, with related pathways involving the pathway in cancer, phosphatidylinositol 3-kinase (PI3K) Akt signaling pathway, and AGE-RAGE signaling pathway in diabetic complications. Molecular docking validated stable binding activities between key target genes and essential active compounds, suggesting their potential role in modulating relevant pathways.
Network Pharmacology Gua Lou Niu Bang Decoction
Multiple Mechanisms of Shenqi Pill in Treating Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking
2022 Jun 26 Evidence-Based Complementary and Alternative Medicine Tong X, Xu S, Zhai D
The study identified 15 anti-NAFLD bioactive ingredients in SQP, including quercetin, kaempferol, stigmasterol, diosgenin, and tetrahydroalstonine. Key target proteins against NAFLD were AKT1, TNF, MAPK8, IL-6, and VEGFA. The main pathways involved PI3K/Akt signaling, HIF-1 signaling, MAPK signaling, and TNF signaling. Molecular docking predicted binding of quercetin, kaempferol, stigmasterol, diosgenin, and tetrahydroalstonine with AKT1, TNF, and MAPK8, suggesting their potential role in SQP's anti-NAFLD effects.
Network Pharmacology Shen Qi Wan Non-Alcoholic Fatty Liver DiseaseResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.
2023 Annals of Translational Medicine Mechanism and ingredients prediction of Radix Salviae-Angelicae Sinensis Radix-Lycii Fructus-Rehmanniae Radix Praeparata-Ginkgo Folium for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis Wu J, Sun Z, Zhang D, Liu H, Wu J, Zhang S
Network Pharmacology Dang Gui Ginkgo Folium Goji Berry
The research used various databases such as Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, GeneCards, and the Online Mendelian Inheritance in Man database to gather the ingredients of RALRG and potential targets of RP and RALRG. A protein-protein interaction network was constructed to visualize these interactions. The R program was utilized to perform functional enrichment. The researchers constructed a visual RALRG-RP-pathway pharmacology network using Cytoscape 3.9.1 and applied molecular docking to compute binding affinity.
The research revealed a total of 132 effective active elements in RALRG correlating to 248 target genes. Ninety-two intersection target genes were discovered from the overlap of RP- and RALRG-related genes. These intersection targets were discovered to be primarily involved in oxidative stress, responding to metal ions, and handling chemical stress. Several molecular pathways such as PI3K-AKT and MAPK were identified as closely connected to RP therapy. A potential pharmacology network was designed for the RALRG-RP-pathway with AKT1 and JUN being considered the main targets. The active ingredients luteolin, quercetin, and kaempferol were highlighted as crucial for this mechanism. RALRG overall was established as a main regulator for oxidative stress and PI3K/AKT signaling pathways in the treatment of RP.
Review Articles
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The research unveils luteolin, quercetin, and kaempferol in RALRG as promising complementary components for RP treatment, with a key role in managing oxidative stress and PI3K/AKT signaling pathways.
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