Lemon

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• Definition
• Introduction
• Signs & Symptoms
• Research Summary

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Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Lemon" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Lemon" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Lemon" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2024 in the journal Pharmaceuticals found that Lemongrass essential oil can effectively treat periodontitis, gingivitis, oral malodour, skin aging, and dandruff, and it is comparable to certain established treatments. The methodology used in the research followed a scoping review design, which was aimed at identifying, summarizing, and synthesizing existing literature related to the clinical applications of lemongrass essential oil. Three databases, namely PubMed, Web of Science, and Scopus, were utilized, following the PRISMA-ScR guidelines, to find articles published within approximately a 10-year timeframe. The results of the review suggest that patients have received noticeable therapeutic benefits from treatments that were primarily administered oromucosally and topically. It can be deduced that the efficacy of lemongrass essential oil in treating periodontitis, gingivitis, and oral malodour is similar to that of chlorhexidine and doxycycline. Moreover, the oil has demonstrated potential in treating skin conditions such as pityriasis versicolor, preventing skin aging, and having anti-dandruff effects. The diverse range of applications of the oil and its efficacy when compared to established treatments highlight its potential for clinical applications.

A Clinical Study published in 2022 in the journal Jurnal Kebidanan found that Lavender aromatherapy is more effective in reducing pain intensity during active Phase I labor than lemon aromatherapy. The methodology employed for this study was a quasi-experimental format utilizing a non-equivalent control group pretest and posttest design. The research was conducted in the City of Mataram with a total of 30 mothers, 15 of whom were given lavender aromatherapy and the remaining 15 given lemon aromatherapy. All participants were selected using a total sampling technique. The results showed a marked decrease in pain intensity for those mothers who were given lavender aromatherapy compared to those who received lemon aromatherapy, during the active phase I of labor. Despite both groups displaying a significant decline in discomfort according to the posttest data, the average decrease was more pronounced for the group that used lavender aromatherapy. This evidence advocates for the further exploration of lavender's potential uses in childbirth pain relief management.

A Meta-Analysis published in 2022 in the journal Frontiers in Pharmacology found that Certain species of citrus extracts effectively control dyslipidemia, reducing total cholesterol, LDL, and triglycerides while increasing HDL, primarily due to their rich antioxidant composition. The methodology involved systematic surveys of research databases including PubMed, Scopus, LILACS, and SciELO. The team utilised several descriptors like dyslipidemias, hypercholesterolemia, hyperlipidemias, lipoproteins, and cholesterol. From the initial findings, 958 articles were identified and after critical assessment, 26 studies were selected that showed the efficacy of certain species extracts in controlling dyslipidemia. Of these, 25 studies were incorporated into a meta-analysis conducted using R software. Assessment of potential bias was carried out as per Cochrane methodology and ARRIVE guidelines for preclinical and clinical studies respectively. From the total number of collected studies, the results consistently showed the effectiveness of these species extracts on dyslipidemia, reducing total cholesterol, LDL, and triglycerides while elevating HDL levels. The active composition of these extracts, particularly rich in flavonoids which are powerful antioxidants, was identified as the crucial factor. The bias risk across all studies was found to be critically low to moderate. Nevertheless, the high heterogeneity values noticed across the studies suggest some inconsistency in the evidence provided.

A Randomised Controlled Trial published in 2022 in the journal European Journal of Nutrition found that Lemon juice boosts gastric secretions and emptying rate, and reduces blood sugar response to starchy food, potentially due to acid-inhibition of digestion enzyme in saliva. Methodology: In this randomized, crossover study, 10 subjects consumed either water, lemon juice diluted in water, or black tea with bread at breakfast. Using magnetic resonance imaging, the finger-prick method, and visual analogue scales, researchers measured gastric volumes, the concentrations of glucose in the blood, and the perception of appetite over a period of three hours. Discussion of Results: Lemon juice consumption resulted in a significant increase in gastric content volume, as well as a faster rate of gastric emptying, compared to water. It also elicited a lower glycemic response compared to water. However, no significant effect was observed with tea consumption. Correspondingly, changes in appetite perception and gastric volumes showed a strong correlation, though there were no significant differences among the different drinks. The findings suggest that the observed reduction in glycemic response could primarily be attributed to the interruption of starch digestion due to the acid-inhibition of the salivary enzyme responsible for starch hydrolysis.

A Systematic Review published in 2021 in the journal BMC Cancer found that D-Limonene, a bioactive compound found in citrus peels, shows potential anticancer activity and is better tolerated in breast cancer patients compared to its derivative perillyl alcohol. For the methodology, the researchers conducted a comprehensive scoping review. They included peer-reviewed journal articles that reported on the effects of d-limonene and its derivatives on breast cancer in human subjects. They retrieved articles from academic databases including PubMed, EMBASE, CINAHL, Web of Science, and Cochrane reviews, and also through iterative review of bibliographies of relevant manuscripts. Titles and abstracts underwent a first round of screening against the inclusion criteria, followed by consensus meetings and full article review which resulted in the selection of a final set of studies. The results were reported in accordance with the PRISMA extension for scoping reviews. In the discussion of the results, out of 367 records, five articles reporting on both phase 1 and phase 2 trials were included in the final review. Studies assessing the effect of d-limonene indicated it was well tolerated in participants and demonstrated that d-limonene concentrated in breast tissue could cause a reduction in tumor cyclin D1 expression, associated with halting tumor proliferation. Trials with perillyl alcohol, however, showed low tolerance and no effect on breast cancer. The analysis did not reveal a meaningful change in serum biomarkers linked with breast cancer, with the exception of an increase in insulin-like growth factor-1 levels, which is typically associated with higher cancer risk.

A Randomised Controlled Trial published in 2020 in the journal European Journal of Nutrition found that Lemon juice, but not black tea, can lower and delay the blood glucose concentration peak after consuming bread. The methodology used in this research consisted of a randomized crossover study involving three test groups consuming equal portions of bread partnered with three different beverages: water, black tea, and lemon juice. Each participant's capillary blood glucose concentrations were monitored over a 180-minute period using the finger-prick method. Additionally, the participants' free-choice energy intake was assessed three hours after the bread and beverage consumption to gauge the effects of the different beverages. The results of the research showed a distinct difference between the effects of lemon juice and black tea on the glycemic response to bread. It was found that black tea didn't affect the blood glucose responses. However, lemon juice significantly reduced and delayed the peak of blood glucose concentration. It's noteworthy that the pH-lowering effect of the lemon juice performed similarly to other acidic foods, indicating that incorporating acidic drinks or foods in starch-rich meals is an effective strategy to minimize their glycemic impact. Interestingly, none of the beverages tested had an impact on the participants' ad libitum energy intake.

A Review Article published in 2019 in the journal Neuropediatrics found that Currently, acupuncture is considered to be a safe, helpful, and available alternative option for patients who have not responded to or complied with conventional pharmacotherapy. The authors conducted an exhaustive review of existing literature exploring the use of acupuncture to address migraine headaches in children. This review encompassed understanding the neurobiological mechanisms of acupuncture, studies on adult headaches, pediatric headache studies, consideration of acupuncture's safety, and its application in other health conditions present in children. The findings of this review suggested that acupuncture emerges as a safe and effective treatment option for migraine in children. Evidence proposes that it can be effectively integrated into the primary treatment regime to reduce the child's discomfort and pain. The effectiveness of acupuncture comes with the added advantage of being safe, with negligible risks, especially important when dealing with young patients. These insights support acupuncture to be seriously considered as an auxiliary treatment strategy for migraines in children.

A Experimental Study published in 2019 in the journal Integrative Cancer Therapies found that Lemongrass extract has potential as a supplement to chemotherapy, reducing colon cancer growth, enhancing treatment effectiveness, and mitigating side effects like weight loss. The study utilized both human colorectal cancer models and APC transgenic mice to assess the effectiveness and potential preventive properties of lemongrass extract. The researchers initially tested the impact of the extract in vitro, observing its influence on cancer cells over time and in relation to does. Moreover, they analyzed the extract's effects when orally administered to mice with colon cancer xenografts. This was done to understand its effectiveness in handling colon cancer and potential negative impacts on healthy cells. The latter part of the study focused on the interaction of lemongrass extract with two common chemotherapy treatments used for colon cancer, FOLFOX and Taxol. This was done not only to understand how the extract might influence the chemotherapy's results but also to assess if it could ameliorate any side effects of these potent treatments. It was found that ethanolic lemongrass extract demonstrated a potent anticancer effect by inducing apoptosis (cell death) in colon cancer cells without negatively impacting the healthy cells. This effect was noticed to be both time and dose-dependent. Moreover, when fed to mice with colon cancer xenografts, the extract not only inhibited cancer growth but was well tolerated by the animals. Significant implications were evidenced when the extract was given alongside FOLFOX. Not only did it enhance the effectiveness of this chemotherapy treatment, but it also actively countered weight loss, one of the common side effects. Finally, the lemongrass extract effectively reduced intestinal tumors in APC transgenic mice, suggesting its potential role for preventative measures against colon cancer. Based on these results, the researchers concluded that lemongrass extract may be a promising supplemental treatment for colorectal cancer in the future.

A published in 2018 in the journal BioMed Research International found that Citrus limon extracts could be a promising antioxidant source for the prevention and/or treatment of oxidative stress-related diseases. Extracts from Citrus limon exhibit powerful antioxidant properties, expressed by its capacity to scavenge DPPH radicals and to reduce power, and the extracts reduce H2O2-induced DNA via its antioxidant activities. These antioxidant activities and inhibitory effects of the extracts on DNA and cell damage may further prove that Citrus limon is useful as a medicinal plant for cancer chemoprevention. The results obtained show that Citrus limon extracts contain high enough levels of phenolic and flavonoid compounds. This is correlated with a remarkable antioxidant activity towards the reduction of iron, and a relatively high power against scavenging free radicals.

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