Nootropic

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Chinese Medicine Research Hub

Review Article

Morinda citrifolia (Noni) exhibits potential therapeutic activities for treating central nervous system disorders by targeting mainly receptors, enzyme transporters, and has neuroprotective activity.

2022 Journal of Pharmaceutical Negative Results A comprehensive review on potential pharmacological activities of Morinda citrifolia Linn. for the treatment of central nervous system disorders
Asiya Begum, Vijayapandi Pandy, Jithendra Chimakurthy, Rama Rao Nadendla

Chinese Medicine Research Hub

Experimental Study

Honey, specifically its polyphenols, show promising signs of enhancing memory and counteracting neurodegenerative diseases by reducing oxidative stress and neuroinflammation.

2014 Evidence-Based Complementary and Alternative Medicine Neurological Effects of Honey: Current and Future Prospects
Mijanur Rahman M, Gan SH, Khalil MI

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Nootropic" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Nootropic" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Nootropic" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2022 in the journal Journal of Pharmaceutical Negative Results found that Morinda citrifolia (Noni) exhibits potential therapeutic activities for treating central nervous system disorders by targeting mainly receptors, enzyme transporters, and has neuroprotective activity. The research involved gathering existing scholarly literature across databases such as ResearchGate, Medline, and Wikipedia. It focused on the impact of the Noni plant on receptors, enzyme transporters, and the various methods for evaluating CNS disorders. The antidepressant effects of the Morinda citrifolia fruit were assessed in vitro using Monoamine Oxidase (MAO) A and B bioassays. The antipsychotic activity was determined by measuring the degree of inhibition of dopaminergic receptors by the Methanolic extract of Noni. In the discussion of the results, the findings suggested that Morinda citrifolia fruit has potential therapeutic benefits. The Noni fruit appears to work synergistically due to its constituent active compounds that inhibit MAOA and MAOB enzymes, displaying antidepressant activity. Moreover, it showed an antipsychotic activity attributed to the Methanolic extract of Noni inhibiting dopaminergic receptors. Other notable activities include anti-craving for alcohol dependence, judged by CPP test, anxiolytic activity exhibited by the administration of benzodiazepine and MMC in mouse models, and also neuroprotective ability by reducing brain impairment caused by reperfusion injury.

A Experimental Study published in 2014 in the journal Evidence-Based Complementary and Alternative Medicine found that Honey, specifically its polyphenols, show promising signs of enhancing memory and counteracting neurodegenerative diseases by reducing oxidative stress and neuroinflammation. The research focuses on the analysis of the nootropic and neuropharmacological benefits of honey, with particular emphasis on its polyphenol constituents. Essentially, honey's nutritional and physiological effects on memory enhancement and various neurological activities have been examined. This study delves into the mechanistic approach in which honey, as a natural compound, can mitigate oxidative stress while enhancing the cellular antioxidant defense system - a cue to its potential role in neutralizing reactive oxygen species that have harmful effects on neurological health. The findings from the research suggest that honey and its polyphenols play a noteworthy role in neuronal health. They display a potential ability to improve memory deficits and other neurodegenerative diseases. In particular, honey polyphenols have been associated with apoptosis activities and the reduction of microglia-induced neuroinflammation. Furthermore, the direct involvement of these polyphenols in synaptic plasticity was found, which could have a substantial effect on the behavior-modulating neural circuitry. Overall, these findings indicate the possible therapeutic value of honey and its polyphenols on the health of the neurological system.

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