Post-Stroke Depression
Recent Insights
Acupuncture could help manage different types of depression by increasing neuroplasticity, decreasing brain inflammation, and reducing side effects of conventional antidepressant treatment.
Brain Inflammation Chronic Pain-Related Depression Depression
Chai Hu Shu Gan San (a traditional Chinese Medicine) is a promising in treating depression, especially in post-stroke and postpartum cases.
Chai Hu Shu Gan San Post-Stroke Depression Postpartum Depression
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Research Articles
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Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression
2022 Apr Current Neuropharmacology Yang NN, Lin LL, Li YJ, Li HP, Cao Y, Tan CX, et al.
Review Article Depression Brain Inflammation Postpartum Depression Chronic Pain-Related Depression Post-Stroke DepressionAcupuncture could help manage different types of depression by increasing neuroplasticity, decreasing brain inflammation, and reducing side effects of conventional antidepressant treatment.
Does acupuncture combined with antidepressants have a better therapeutic effect on post-stroke depression? A systematic review and meta-analysis
2020 Dec 17 Acupuncture in Medicine Kun Zhang, Guangwei Cui, Yuan Gao, Weidong Shen
Systematic Review Meta-Analysis Stroke RehabilitationAcupuncture combined with antidepressants showed a more favourable effect on the treatment of post-stroke depression than antidepressants alone.
The effectiveness of acupuncture therapy in patients with post-stroke depression
2019 May Medicine Zhang, X.-Y., Li, Y.-X., Liu, D.-L., et al.
This meta-analysis provides evidence supporting the viewpoint that acupuncture is an effective and safe treatment for post-stroke depression (PSD). Subgroup analyses further revealed that acupuncture alone resulted in better outcomes than drug therapy in improving depressive symptoms. Further high-quality trials are needed to systematically evaluate the effectiveness of acupuncture for PSD and develop standardized acupuncture protocols.
Meta-Analysis Stroke Rehabilitation Post-Stroke Depression DepressionEvaluation of the curative effect of acupuncture manipulation of regulating governor vessel and unblocking brain on the patients with post stroke depression associated with anxiety
2018 Mar World Journal of Acupuncture-Moxibustion WANG Y, HAN Y, HU Y, ZHANG L
Acupuncture manipulation of regulating the governor vessel and unblocking brain demonstrated superior effects on anxiety state and motor function in post-stroke depression patients compared to escitalopram, with rapid onset for depression improvement and equivalent long-term efficacy, while both methods were equally effective in improving activities of daily living.
Randomised Controlled Trial Post-Stroke Depression Acupuncture AnxietyTreatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials
2018 Feb 17 BMC Complementary Medicine and Therapies Sun Y, Xu X, Zhang J, Chen Y
Systematic Review Meta-Analysis Chai Hu Shu Gan San Post-Stroke Depression Postpartum DepressionChai Hu Shu Gan San (a traditional Chinese Medicine) is a promising in treating depression, especially in post-stroke and postpartum cases.
Research Insights
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Acupuncture could help manage different types of depression by increasing neuroplasticity, decreasing brain inflammation, and reducing side effects of conventional antidepressant treatment.
2022 Current Neuropharmacology Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression Yang NN, Lin LL, Li YJ, Li HP, Cao Y, Tan CX, et al.
Review Article Brain Inflammation Chronic Pain-Related Depression Depression
The study under review examines the possible mechanisms and clinical effectiveness of acupuncture in the treatment of different forms of depression. To do this, the researchers examined existing studies and evidence involving both human patients and animal models. A significant aspect of the investigation involved assessing how acupuncture influences neuroplasticity within the hippocampus and neural networks, along with probing the role of this non-pharmaceutical therapy in modulating brain inflammation, which had potential implications for alleviating depressive disorders.
The discussions of the results indicated that acupuncture showed considerable promise in the relief of primary depression, especially in milder cases. It was also found useful in the management of post-stroke depression, pain-related depression, and post-partum depression. The study noted positive outcomes both when acupuncture was offered as a stand-alone treatment, and when combined with conventional pharmacological treatments. It was observed that the combination of acupuncture and anti-depressant drugs not only improved primary and secondary depressive symptoms but also managed to reduce the side-effects often associated with medication regimens, which are frequent contributors to high dropout rates in pharmacological treatments.
Acupuncture combined with antidepressants showed a more favourable effect on the treatment of post-stroke depression than antidepressants alone.
2020 Acupuncture in Medicine Does acupuncture combined with antidepressants have a better therapeutic effect on post-stroke depression? A systematic review and meta-analysis Kun Zhang, Guangwei Cui, Yuan Gao, Weidong Shen
Systematic Review Stroke Rehabilitation
Thirteen randomized controlled trials (RCTs) involving 904 participants were included in the study. The results of this meta-analysis showed that, compared with antidepressants alone, acupuncture combined with antidepressants led to a significant decrease in the HAMD score, had a better effective rate and lower National Institutes of Health Stroke Scale (NIHSS) scores, and led to a significant increase in the Barthel index scores.
Chai Hu Shu Gan San (a traditional Chinese Medicine) is a promising in treating depression, especially in post-stroke and postpartum cases.
2018 BMC Complementary Medicine and Therapies Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials Sun Y, Xu X, Zhang J, Chen Y
Systematic Review Chai Hu Shu Gan San Postpartum Depression
The review assessed the efficacy of Chai Hu Shu Gan San, a traditional Chinese medicine, in treating depression. Out of 560 initial studies, 42 trials met inclusion criteria. These studies were conducted in China from 2006 to 2016, involving 3234 patients with depression. Chai Hu Shu Gan San demonstrated better efficacy compared to controls, especially in post-stroke and postpartum depression. However, the methodological quality of the included studies was assessed as low, with high risks of bias. While Chai Hu Shu Gan San showed promise, further rigorously designed randomized controlled trials are needed for a conclusive evaluation of its safety and efficacy in treating depression.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression
2022 Apr Current Neuropharmacology Yang NN, Lin LL, Li YJ, Li HP, Cao Y, Tan CX, et al.
Review Article Depression Brain Inflammation Postpartum Depression Chronic Pain-Related Depression Post-Stroke DepressionAcupuncture could help manage different types of depression by increasing neuroplasticity, decreasing brain inflammation, and reducing side effects of conventional antidepressant treatment.
Does acupuncture combined with antidepressants have a better therapeutic effect on post-stroke depression? A systematic review and meta-analysis
2020 Dec 17 Acupuncture in Medicine Kun Zhang, Guangwei Cui, Yuan Gao, Weidong Shen
Systematic Review Meta-Analysis Stroke RehabilitationAcupuncture combined with antidepressants showed a more favourable effect on the treatment of post-stroke depression than antidepressants alone.
Treatment of depression with Chai Hu Shu Gan San: a systematic review and meta-analysis of 42 randomized controlled trials
2018 Feb 17 BMC Complementary Medicine and Therapies Sun Y, Xu X, Zhang J, Chen Y
Systematic Review Meta-Analysis Chai Hu Shu Gan San Post-Stroke Depression Postpartum DepressionChai Hu Shu Gan San (a traditional Chinese Medicine) is a promising in treating depression, especially in post-stroke and postpartum cases.
Herbal medicine (Gan Mai Da Zao decoction) for depression: A systematic review and meta-analysis of randomized controlled trials
2014 Dec Maturitas Jun JH, Choi TY, Lee JA, Yun KJ, Lee MS
In summary, our systematic review and meta-analysis failed to provide evidence of the superiority of GMDZ decoction over anti-depressant therapies for major depression, post-surgical depression, or depression in the elderly, although there was evidence of an effect in post-stroke depression.
Systematic Review Meta-Analysis Gan Mai Da Zao TangSystem review on treating post-stroke depression with acupuncture
2014 Jun World Journal of Acupuncture-Moxibustion ZHANG W, SUN J, GAO Y, PEI L, WU X, CHEN L, et al.
The meta-analysis of 13 included randomized controlled trials (845 patients) indicated a statistically significant difference in HAMD scale scores at the end of treatment between acupuncture and western medicine groups. However, susceptibility analysis (excluding low-quality studies) showed non-significant differences, and the reliability of the results was deemed low. Adverse events were significantly lower in the acupuncture group, with a 68% reduction in the risk of adverse events. The overall evidence quality, assessed by the GRADE system, was deemed fairly low for both HAMD scores and adverse events. The study concludes that while acupuncture appeared more effective than western medicine, the results are less reliable, and further high-quality randomized controlled trials are needed for confirmation.
Review Article AcupunctureClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
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Presentation Slides
Review Article
Acupuncture could help manage different types of depression by increasing neuroplasticity, decreasing brain inflammation, and reducing side effects of conventional antidepressant treatment.
Yang NN, Lin LL, Li YJ, Li HP, Cao Y, Tan CX, Hao XW, Ma SM, Wang L, Liu CZ
Systematic Review
Acupuncture combined with antidepressants showed a more favourable effect on the treatment of post-stroke depression than antidepressants alone.
Kun Zhang, Guangwei Cui, Yuan Gao, Weidong Shen
Systematic Review
Chai Hu Shu Gan San (a traditional Chinese Medicine) is a promising in treating depression, especially in post-stroke and postpartum cases.
Sun Y, Xu X, Zhang J, Chen Y
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Post-Stroke Depression" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Post-Stroke Depression" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Post-Stroke Depression" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Review Article published in 2022 in the journal Current Neuropharmacology found that Acupuncture could help manage different types of depression by increasing neuroplasticity, decreasing brain inflammation, and reducing side effects of conventional antidepressant treatment. The study under review examines the possible mechanisms and clinical effectiveness of acupuncture in the treatment of different forms of depression. To do this, the researchers examined existing studies and evidence involving both human patients and animal models. A significant aspect of the investigation involved assessing how acupuncture influences neuroplasticity within the hippocampus and neural networks, along with probing the role of this non-pharmaceutical therapy in modulating brain inflammation, which had potential implications for alleviating depressive disorders. The discussions of the results indicated that acupuncture showed considerable promise in the relief of primary depression, especially in milder cases. It was also found useful in the management of post-stroke depression, pain-related depression, and post-partum depression. The study noted positive outcomes both when acupuncture was offered as a stand-alone treatment, and when combined with conventional pharmacological treatments. It was observed that the combination of acupuncture and anti-depressant drugs not only improved primary and secondary depressive symptoms but also managed to reduce the side-effects often associated with medication regimens, which are frequent contributors to high dropout rates in pharmacological treatments.
A Systematic Review published in 2020 in the journal Acupuncture in Medicine found that Acupuncture combined with antidepressants showed a more favourable effect on the treatment of post-stroke depression than antidepressants alone. Thirteen randomized controlled trials (RCTs) involving 904 participants were included in the study. The results of this meta-analysis showed that, compared with antidepressants alone, acupuncture combined with antidepressants led to a significant decrease in the HAMD score, had a better effective rate and lower National Institutes of Health Stroke Scale (NIHSS) scores, and led to a significant increase in the Barthel index scores.
A Systematic Review published in 2018 in the journal BMC Complementary Medicine and Therapies found that Chai Hu Shu Gan San (a traditional Chinese Medicine) is a promising in treating depression, especially in post-stroke and postpartum cases. The review assessed the efficacy of Chai Hu Shu Gan San, a traditional Chinese medicine, in treating depression. Out of 560 initial studies, 42 trials met inclusion criteria. These studies were conducted in China from 2006 to 2016, involving 3234 patients with depression. Chai Hu Shu Gan San demonstrated better efficacy compared to controls, especially in post-stroke and postpartum depression. However, the methodological quality of the included studies was assessed as low, with high risks of bias. While Chai Hu Shu Gan San showed promise, further rigorously designed randomized controlled trials are needed for a conclusive evaluation of its safety and efficacy in treating depression.
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