Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Uncovering the pharmacological mechanism of Shou Tai Wan on recurrent spontaneous abortion: A integrated pharmacology strategy-based research
2024 Apr Journal of Ethnopharmacology Yang K, Zeng L, Li Y, Wu L, Xiang W, Wu X, et al.
Shou Tai Wan (STW) was found to regulate PI3K/AKT, MAPK, and FoxO signaling pathways, and in animal experiments with an RSA mouse model, STW reduced embryo absorption rates, balanced Th1/Th2 cytokine expression, and demonstrated immunomodulatory effects by up-regulating the phosphorylation levels of STAT3 and STAT6 proteins and down-regulating STAT1 protein in the STAT signaling pathway. Additionally, STW up-regulated phosphorylation levels of proteins in the MAPK signaling pathway, and increased expression levels of ERK1/2 mRNA and proteins, suggesting potential therapeutic effects in treating RSA through interference with these signaling pathways.
Experimental Study Animal Study Recurrent Spontaneous Abortion Shou Tai Wan
A Potential Mechanism of Kidney-Tonifying Herbs Treating Unexplained Recurrent Spontaneous Abortion: Clinical Evidence From the Homogeneity of Embryo Implantation and Tumor Invasion
2022 Jan 26 Frontiers in Pharmacology Zhou H, Yang Y, Deng L, Yao Y, Liao X
KTH has great potential for treating URSA. Because the maintenance of pregnancy has a high similarity with tumor invasion, the research relating to tumor mechanisms should also be followed up as it may lead to new ideas and breakthroughs for research into URSA. At the same time, embryonic and decidual cells share a high degree of cellular heterogeneity and spatial structural complexity with tumor cells, and a single cell combined with spatial omics may be the best future approach for validating KTH mechanisms.
Systematic Review Unexplained Recurrent Spontaneous Abortion Kidney-Tonifying Herbs Recurrent Spontaneous AbortionReview Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
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