Renin-Angiotensin System
Also known as: RAAS, RAS, Renin–Angiotensin–Aldosterone System
Recent Insights
Adzuki bean extracts have shown more potential than black soybean extracts in lowering blood pressure in hypertensive rats, acting on the renin-angiotensin system.
Adzuki Bean Black Soybean High Blood Pressure
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Comparison of the Chemical Components, Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum Flower against Liver-Fire Hyperactivity Syndrome of Hypertension via Integrative Analyses
2022 Nov 09 International Journal of Molecular Sciences Wang Y, Li Y, Guo W, Yang X, Qu J, Gao M, et al.
Network Pharmacology High Blood Pressure Chrysanthemum Liver Heat Syndrome Liver-Fire Hyperactivity SyndromeTwo varieties of chrysanthemum have similar therapeutic effects but operate through distinct mechanisms, revealing potential for precise applications in both traditional and modern medicine.
The Diuretic Effects of Coconut Water by Suppressing Aquaporin and Renin–Angiotensin–Aldosterone System in Saline-Loaded Rats
2022 Jun 23 Frontiers in Nutrition Wei J, Zhao M, Meng K, Xia G, Pan Y, Li C, et al.
Coconut water demonstrated significant acute diuretic effects by increasing urine excretion and promoting the excretion of sodium and chloride ions without affecting calcium concentration and pH. In prolonged diuretic experiments, coconut water increased urine output and electrolyte concentrations (Na+, K+, Cl–), while also suppressing the renin–angiotensin–aldosterone system and reducing aquaporin 1 (AQP1), AQP2, and AQP 3 expression and protein levels. These findings suggest coconut water could serve as a natural diuretic agent.
Experimental Study Animal Study Renin-Angiotensin System Aquaporin Coconut Water DiuresisBlack Soybean and Adzuki Bean Extracts Lower Blood Pressure by Modulating the Renin-Angiotensin System in Spontaneously Hypertensive Rats
2021 Jul 06 Foods Jeong EW, Park SY, Yang YS, Baek YJ, Yun DM, Kim HJ, et al.
Animal Study Black Soybean Renin-Angiotensin System High Blood Pressure Adzuki BeanAdzuki bean extracts have shown more potential than black soybean extracts in lowering blood pressure in hypertensive rats, acting on the renin-angiotensin system.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Two varieties of chrysanthemum have similar therapeutic effects but operate through distinct mechanisms, revealing potential for precise applications in both traditional and modern medicine.
2022 International Journal of Molecular Sciences Comparison of the Chemical Components, Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum Flower against Liver-Fire Hyperactivity Syndrome of Hypertension via Integrative Analyses Wang Y, Li Y, Guo W, Yang X, Qu J, Gao M, et al.
Network Pharmacology Chrysanthemum High Blood Pressure Liver Heat Syndrome
The study combined network pharmacology, molecular pharmacology, and metabolomics to clarify differences between two herbs, CMF and CIF. An initial analysis was carried out via HPLC-Q-TOF-MS which revealed distinct flavonoid constituents between CMF and CIF. These findings led researchers to make predictions about the possible biological processes responsible for the therapeutic effects of these herbs on LFHSH, including their influence on inflammatory response and fatty acid production.
Through a series of ELISA, molecular docking, Western blot, and metabolomics techniques, the research identified similar influences of CMF and CIF on blood pressure and resistance to tissue, organ and functional damage as well as dyslipidemia. Despite the similar outcomes, there was variation in their mechanism of action. Namely, these herbs uniquely influenced inflammatory response, various signaling pathways, lipid anabolism, the renin-angiotensin system, and metabolic abnormalities. Differing effects were believed to be due to each herb's unique regulatory capabilities which, despite the end effect similarities, offer unique pathways for effective medical application.
Adzuki bean extracts have shown more potential than black soybean extracts in lowering blood pressure in hypertensive rats, acting on the renin-angiotensin system.
2021 Foods Black Soybean and Adzuki Bean Extracts Lower Blood Pressure by Modulating the Renin-Angiotensin System in Spontaneously Hypertensive Rats Jeong EW, Park SY, Yang YS, Baek YJ, Yun DM, Kim HJ, et al.
Animal Study Adzuki Bean Black Soybean High Blood Pressure
The methodology used in this research involved the administration of varying volumes of black soybean and adzuki bean ethanol extracts to seven groups of rats, which included one group of normal rats and six groups of spontaneously hypertensive rats. The purpose of the extracts was to explore their antihypertensive effects on aspects such as blood pressure, the renin-angiotensin system, and aortic lesions.
The results revealed that black soybean and adzuki bean extracts significantly reduced various biomarkers such as liver weight, triglycerides, total cholesterol, and systolic blood pressure. On a comparative basis, the adzuki bean extracts (AE) demonstrated a greater antihypertensive potential than black soybean extracts (BE). Specifically, the angiotensin II level and blood pressure in the AE-treated group were lower than those in the BE-treated group, leading to the conclusion that AE exhibits higher antihypertensive potential.
Presentation Slides
Two varieties of chrysanthemum have similar therapeutic effects but operate through distinct mechanisms, revealing potential for precise applications in both traditional and modern medicine.
Adzuki bean extracts have shown more potential than black soybean extracts in lowering blood pressure in hypertensive rats, acting on the renin-angiotensin system.
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