Thyroid Disease
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Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.

Emerging therapeutic role of Prunella vulgaris in thyroid disease
2022 Jul Chinese Herbal Medicines Zhang W, Wuhan Q, Na M, Hu R, Mu Q, Bao X
Herbs such as P. vulgaris have great potential for treating thyroid disorders owing to their anti-oxidation and immunological effects and are frequently used as ingredients in herbal recipes. P. vulgaris is thought to combat drug toxicity within the body, therefore its own active ingredients have attracted much attention. The use of P. vulgaris with other drugs resulted in significant elimination of swollen nodules, reduced inflammatory response, and improved thyroid function. These effects of P. vulgaris benefit the clinical treatment of thyroid disease while having reduced drug-induced side effects and improved therapeutic effects. However, with only a few studies presenting treatment with Prunella vulgaris alone, further investigation is needed to to explore the physiological mechanisms.
Review Article Xia Ku Cao
Summary of Experience in Treating Hyperthyroidism with TCM Syndrome Differentiation
2022 Jan Journal of Biosciences and Medicines Chen X, Wang L, Liu Z, Ren K, Qi G
In accordance with the principle of TCM syndrome differentiation, hyperthyroidism is classified according to different syndrome types and different treatment methods are adopted, and the effect is remarkable.
Hyperthyroidism
Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules
2021 Oct 15 Medicine Han Q, Xu N, Chen B, Wu W, Sheng L
PV combined with levothyroxine sodium tablets or thyroxin tablets has more benefits for thyroid nodules, further improving the clinical efficiency, reducing the diameter of nodules and reducing the occurrence of adverse reactions. However, the quality of these studies is uncertain, and higher quality and more RCTs are needed to provide comprehensive evidence-based medical evidence in the future.
Systematic Review Meta-Analysis Xia Ku Cao
Successful intervention with Chinese herbal medicine for hyperthyroidism: Two case reports and a literature review
2021 Jul Explore: The Journal of Science & Healing Chia-Hui Lin, Chun-Pang Lin, Sheng-Teng Huang
As for the hyperthyroidism almost was controlled by Western medicine instead of CHM, we report that JWXYS as well as Prunella vulgaris, Fritillaria thunbergii, and Crassostrea gigas was a safe and effective formula and we propose that CHM may be considered as either a first choice or combination therapy to control hyperthyroidism.
Xia Ku Cao Mu Li Zhe Bei Mu Jia Wei Xiao Yao San Hyperthyroidism
Meta-analysis-based systematic review of effect of traditional Chinese medicine intervention in treatment of diabetic nephropathy on thyroid function
2021 Jun 16 Annals of Palliative Medicine Zhang X, Wu M, Zhou J, Zhou R, Luo Q, Yue R, et al.
Systematic Review Meta-Analysis Thyroid DiseaseChinese medicine could effectively improve thyroid function and the clinical symptoms of patients with diabetic nephropathy.
Research insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.

2021 Annals of Palliative Medicine
Chinese medicine could effectively improve thyroid function and the clinical symptoms of patients with diabetic nephropathy.
Systematic Review
Meta-analysis-based systematic review of effect of traditional Chinese medicine intervention in treatment of diabetic nephropathy on thyroid function
Zhang X, Wu M, Zhou J, Zhou R, Luo Q, Yue R, et al.

2018 Journal of Integrative Medicine
Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy against thyroid-relevant illnesses.
Systematic Review
An overview of the contribution of acupuncture to thyroid disorders
Cheng FK

2016 Annals of Translational Medicine
Chinese medicine warming and invigorating drugs combined with levothyroxine may improve treatment of hypothyroidism caused by Hashimoto disease more than levothyroxine alone.
Systematic Review
A systematic review of combinatorial treatment with warming and invigorating drugs and levothyroxine for hypothyroidism caused by Hashimoto disease
Xiangwen Cheng, Zixiao Wei, Guangde Zhang, Xin Shao, Bo Li, Rui Gao
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.

Emerging therapeutic role of Prunella vulgaris in thyroid disease
2022 Jul Chinese Herbal Medicines Zhang W, Wuhan Q, Na M, Hu R, Mu Q, Bao X
Herbs such as P. vulgaris have great potential for treating thyroid disorders owing to their anti-oxidation and immunological effects and are frequently used as ingredients in herbal recipes. P. vulgaris is thought to combat drug toxicity within the body, therefore its own active ingredients have attracted much attention. The use of P. vulgaris with other drugs resulted in significant elimination of swollen nodules, reduced inflammatory response, and improved thyroid function. These effects of P. vulgaris benefit the clinical treatment of thyroid disease while having reduced drug-induced side effects and improved therapeutic effects. However, with only a few studies presenting treatment with Prunella vulgaris alone, further investigation is needed to to explore the physiological mechanisms.
Review Article Xia Ku Cao
Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules
2021 Oct 15 Medicine Han Q, Xu N, Chen B, Wu W, Sheng L
PV combined with levothyroxine sodium tablets or thyroxin tablets has more benefits for thyroid nodules, further improving the clinical efficiency, reducing the diameter of nodules and reducing the occurrence of adverse reactions. However, the quality of these studies is uncertain, and higher quality and more RCTs are needed to provide comprehensive evidence-based medical evidence in the future.
Systematic Review Meta-Analysis Xia Ku Cao
Meta-analysis-based systematic review of effect of traditional Chinese medicine intervention in treatment of diabetic nephropathy on thyroid function
2021 Jun 16 Annals of Palliative Medicine Zhang X, Wu M, Zhou J, Zhou R, Luo Q, Yue R, et al.
Systematic Review Meta-Analysis Thyroid DiseaseChinese medicine could effectively improve thyroid function and the clinical symptoms of patients with diabetic nephropathy.

An overview of the contribution of acupuncture to thyroid disorders
2018 Nov Journal of Integrative Medicine Cheng FK
Systematic Review Randomised Controlled Trial Thyroid DiseaseFindings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy against thyroid-relevant illnesses.

A systematic review of combinatorial treatment with warming and invigorating drugs and levothyroxine for hypothyroidism caused by Hashimoto disease
2016 Nov 23 Annals of Translational Medicine Xiangwen Cheng, Zixiao Wei, Guangde Zhang, Xin Shao, Bo Li, Rui Gao
Systematic Review Meta-Analysis Thyroid DiseaseChinese medicine warming and invigorating drugs combined with levothyroxine may improve treatment of hypothyroidism caused by Hashimoto disease more than levothyroxine alone.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.

An overview of the contribution of acupuncture to thyroid disorders
2018 Nov Journal of Integrative Medicine Cheng FK
Systematic Review Randomised Controlled Trial Thyroid DiseaseFindings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy against thyroid-relevant illnesses.

The effects of acupuncture after thyroid surgery: A randomized, controlled trial
2014 Dec 1 Surgery Iacobone M, Citton M, Zanella S, Scarpa M, Pagura G, Tropea S, et al.
This academic research showed high efficacy of acupuncture for pain relief after thyroid surgery. Patients with regular acupuncture treatments required less pain killers and experienced less side effects.
Randomised Controlled Trial Thyroid DiseaseStudy Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.

Acupuncture for Hashimoto thyroiditis: study protocol for a randomized controlled trial
2021 Jan 21 Trials Wang S, Zhao J, Zeng W, Du W, Zhong T, Gao H, et al.
The study aims to assess whether penetration needling of Hand-Yangming meridian (PNHM) acupuncture therapy can effectively reduce concentrations of anti-thyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), and improve thyroid hormone levels, subsequently enhancing the quality of life for HT patients.
Study Protocol Hashimoto Disease Acupuncture
The efficacy of acupuncture for the treatment and the fertility improvement in child-bearing period female with Hashimoto Disease A randomized controlled study
2020 Jul 02 Medicine Li, Fangyuan; Qi, Zhang; Hua, Lu; Wang, Xinxin; Ling, Mi; Juan, et al.
This will be the first large-scale trial specifically evaluating acupuncture therapy in child-bearing period female with Hashimoto thyroiditis.
Study Protocol Acupuncture Hashimoto Disease
The efficacy of acupuncture for the treatment and the fertility improvement in child-bearing period female with Hashimoto Disease
2020 Jul 02 Medicine Li F, Qi Z, Hua L, Wang X, Ling M, Juan D
This will be the first large-scale trial specifically evaluating acupuncture therapy in child-bearing period females with Hashimoto thyroiditis. If the study confirms the effectiveness of acupuncture treatment, more consistent acupuncture therapy can be set up for clinical practice.
Study Protocol Hashimoto Disease Female FertilityPresentation Slides

Systematic Review
Chinese medicine could effectively improve thyroid function and the clinical symptoms of patients with diabetic nephropathy.
Zhang X, Wu M, Zhou J, Zhou R, Luo Q, Yue R, Jin S.

Systematic Review
Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy against thyroid-relevant illnesses.
Cheng FK

Systematic Review
Chinese medicine warming and invigorating drugs combined with levothyroxine may improve treatment of hypothyroidism caused by Hashimoto disease more than levothyroxine alone.
Xiangwen Cheng, Zixiao Wei, Guangde Zhang, Xin Shao, Bo Li, Rui Gao
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Thyroid Disease" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Thyroid Disease" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Thyroid Disease" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Systematic Review published in 2021 in the journal Annals of Palliative Medicine found that Chinese medicine could effectively improve thyroid function and the clinical symptoms of patients with diabetic nephropathy. A meta-analysis conducted to evaluate the thyroid function of patients with DN found that it was impaired to varying degrees. Analysis of the clinical efficacy of TCM intervention in the treatment of DN showed that TCM could effectively improve the clinical symptoms of patients and improve the treatment effect. However, due to the small sample size, only the curative effect after the treatment was analyzed, and the long-term efficacy of TCM intervention in the treatment of DN remains unknown. Follow-up research of a higher quality involving larger samples, and multi-center RCT trials should be carried out to supplement the deficiencies of this research, and more accurately evaluate the clinical efficacy of TCM intervention in the treatment of DN.
A Systematic Review published in 2018 in the journal Journal of Integrative Medicine found that Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy against thyroid-relevant illnesses. Analysing 29 clinical projects that were retrieved from 29 major digital databases and include 1757 patients aged 7–79 years from China, Italy, Korea, Macedonia and Russia, this narrative review offers an overview of the efficacy, and evaluated the safe and cost-effective use of acupuncture against hyperthyroidism, hypothyroidism and thyroid-relevant illnesses. Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy. In addition to showing the role of acupuncture as an alternative and complementary medicine or as an adjunctive therapy for curative and rehabilitative purposes, more well-designed researches are needed to achieve reliable data.
A Systematic Review published in 2016 in the journal Annals of Translational Medicine found that Chinese medicine warming and invigorating drugs combined with levothyroxine may improve treatment of hypothyroidism caused by Hashimoto disease more than levothyroxine alone. This systematic review pooled several indices of hypothyroidism caused by HT according to “China’s Guidelines for the Diagnosis and Treatment of Thyroid Disease” and correlation studies. The results showed that the combination of warming and invigorating drugs and levothyroxine increased FT3 and FT4 levels, and reduced TSH, TPOAb, and TGAb levels in patients with hypothyroidism cause by HT more than levothyroxine alone after treatments of 8 weeks or longer. With the exception of FT4, the results were stable. In conclusion, we cautiously recommend prescribing warming and invigorating drugs along with levothyroxine for the treatment of hypothyroidism caused by Hashimoto disease. However, high-quality evidence is needed to confirm these results. To guarantee evidence quality, a strict study design, which includes a large sample, an unbiased randomization method, full concealment, proper blinding, and appropriate statistical analyses, is vital. In addition, clinical curative effects of TCM, such as TCM syndromes, should be standardized and unified to reduce clinical heterogeneity and methodology heterogeneity. Finally, a strict registration system for clinical trials is required to remove reporting biases.
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