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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Acupuncture and moxibustion treating lower urinary tract symptoms due to benign prostatic hyperplasia: a systematic review and network meta-analysis
2022 Jun Acupuncture and Herbal Medicine Chen Z, Jiang T, Peng Y, Qiang X, Yang F, Hu H, et al.
Systematic Review Meta-Analysis Acupuncture Lower Urinary Tract Symptoms Moxibustion Urinary Tract Symptoms
Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months
2022 Apr 13 Clinical Phytoscience Vahlensieck W, Heim S, Patz B, Sahin K
Meta-Analysis Randomised Controlled Trial Benign Prostatic HyperplasiaPumpkin seed extract treatment could potentially offer symptomatic relief for patients experiencing moderate lower urinary tract symptoms suggestive of benign prostate hyperplasia.
Sacral Acupuncture for Lower Urinary Tract Symptoms: A Systematic Review of Randomized Controlled Trials
2022 Feb 28 Journal of Acupuncture Research Park J, Chun SE, Park MC, Jo EH
Sacral acupuncture improved LUTS compared with the sham acupuncture group or other remedy groups, but a quantitative evaluation of the treatment effect could not be performed.
Systematic Review Lower Urinary Tract Symptoms
The effects of a Chinese herbal medicine (VGHBPH0) on patients with benign prostatic hyperplasia: A pilot study
2020 Jul 02 Journal of the Chinese Medical Association Yeh HF, Li TF, Tsai CH, Wu PW, Huang YH, Huang WJ, et al.
Clinical StudyChinese herbal medicine might improve lower urinary tract symptoms in patients with benign prostatic hyperplasia.
Effects of Pumpkin Seed in Men with Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia in the One-Year, Randomized, Placebo-Controlled GRANU Study
2014 Sep 05 Urologia Internationalis Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U
Randomised Controlled Trial Benign Prostatic Hyperplasia Pumpkin SeedPumpkin seed treatment can potentially cause a significant reduction in symptoms of benign prostatic hyperplasia in men aged 50 to 80.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Pumpkin seed extract treatment could potentially offer symptomatic relief for patients experiencing moderate lower urinary tract symptoms suggestive of benign prostate hyperplasia.
2022 Clinical Phytoscience Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months Vahlensieck W, Heim S, Patz B, Sahin K
Meta-Analysis Benign Prostatic Hyperplasia
The study methodology involved a meta-analysis of two separate studies that were randomized and placebo-controlled, focusing on the effectiveness of pumpkin seed extract in addressing urinary tract symptoms indicative of benign prostate hyperplasia. The participants included in these studies were those patients whose International Prostate Symptom Score was 13 points or higher at the baseline. The method of analysis involved assessing the response rates of patients and the improvement in prostate symptom scores at a 12-month follow-up.
The discussion of results revealed that the response rates in the group receiving pumpkin seed extract were marginally higher than that of the placebo group, giving pumpkin seed extract a slight edge. Additionally, there was a minor difference observed in the change from the baseline to 12-month Prostate Symptom Score in favour of pumpkin seed extract. The meta-analysis in general indicates that a treatment involving pumpkin seed extract may result in symptomatic relief for patients suffering from moderate urinary tract symptoms associated with benign prostate hyperplasia.
Chinese herbal medicine might improve lower urinary tract symptoms in patients with benign prostatic hyperplasia.
2020 Journal of the Chinese Medical Association The effects of a Chinese herbal medicine (VGHBPH0) on patients with benign prostatic hyperplasia: A pilot study Yeh HF, Li TF, Tsai CH, Wu PW, Huang YH, Huang WJ, et al.
Clinical Study
In the conducted single-arm pilot study, twenty patients with benign prostatic hyperplasia were instructed to take the investigated Chinese herbal medicine three times a day for 8 weeks, coupled with their ongoing Western medicine treatment. Scheduled follow-ups were completed, with patients completing questionnaires such as the international prostate symptoms scores, aging male symptoms score, and international index of erectile function, along with a questionnaire of traditional Chinese medicine body constitution. Diagnostic tools like uroflowmetry and sonography were utilized to measure changes in urine flow velocity and post-voiding residual urine volume over the study span.
The results of the study showed a significant decrease in the total prostate symptoms scores post 8 weeks of Chinese herbal medicine treatment, indicating an improvement in the patients' condition. Additionally, this study found a decrease in specific subscores measuring voiding and incomplete emptying. Further to this, a declining trend was also observed in post-voiding residual urine volume, suggesting positive impacts of Chinese herbal medicine on the patients' urinary symptoms.
Pumpkin seed treatment can potentially cause a significant reduction in symptoms of benign prostatic hyperplasia in men aged 50 to 80.
2014 Urologia Internationalis Effects of Pumpkin Seed in Men with Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia in the One-Year, Randomized, Placebo-Controlled GRANU Study Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U
Randomised Controlled Trial Benign Prostatic Hyperplasia Pumpkin Seed
In the GRANU study, 1,431 men aged 50-80 years, exhibiting symptoms of benign prostatic hyperplasia, were assigned randomly to one of three groups: those receiving pumpkin seeds, capsules filled with pumpkin seed extract, and a placebo group. The primary criterion for response was measured by a reduction in the International Prostate Symptom Score (IPSS) after 12 months. The secondary outcomes were focused around the quality of life in relation to the IPSS, individual items on the IPSS and diary-recorded nocturia.
After a year, there was no statistical difference observed between the group taking pumpkin seed extract and the placebo group. However, the group treated with pumpkin seed showed a significant descriptive difference when compared with the placebo group. The treatment was well tolerated overall and showed a clinically relevant reduction in the IPSS among the men with benign prostatic hyperplasia who were treated with pumpkin seed for 12 months.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Acupuncture and moxibustion treating lower urinary tract symptoms due to benign prostatic hyperplasia: a systematic review and network meta-analysis
2022 Jun Acupuncture and Herbal Medicine Chen Z, Jiang T, Peng Y, Qiang X, Yang F, Hu H, et al.
Systematic Review Meta-Analysis Acupuncture Lower Urinary Tract Symptoms Moxibustion Urinary Tract SymptomsElectroacupuncture shows promising results to treat Lower Urinary tract symptoms caused by BPH. However, more quality evidence needs to be yielded to further support its effectiveness. —Adrian Y 17 Feb 2023
Sacral Acupuncture for Lower Urinary Tract Symptoms: A Systematic Review of Randomized Controlled Trials
2022 Feb 28 Journal of Acupuncture Research Park J, Chun SE, Park MC, Jo EH
Sacral acupuncture improved LUTS compared with the sham acupuncture group or other remedy groups, but a quantitative evaluation of the treatment effect could not be performed.
Systematic Review Lower Urinary Tract SymptomsClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months
2022 Apr 13 Clinical Phytoscience Vahlensieck W, Heim S, Patz B, Sahin K
Meta-Analysis Randomised Controlled Trial Benign Prostatic HyperplasiaPumpkin seed extract treatment could potentially offer symptomatic relief for patients experiencing moderate lower urinary tract symptoms suggestive of benign prostate hyperplasia.
Effects of Pumpkin Seed in Men with Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia in the One-Year, Randomized, Placebo-Controlled GRANU Study
2014 Sep 05 Urologia Internationalis Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U
Randomised Controlled Trial Benign Prostatic Hyperplasia Pumpkin SeedPumpkin seed treatment can potentially cause a significant reduction in symptoms of benign prostatic hyperplasia in men aged 50 to 80.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Pumpkin seed extract treatment could potentially offer symptomatic relief for patients experiencing moderate lower urinary tract symptoms suggestive of benign prostate hyperplasia.
Chinese herbal medicine might improve lower urinary tract symptoms in patients with benign prostatic hyperplasia.
Pumpkin seed treatment can potentially cause a significant reduction in symptoms of benign prostatic hyperplasia in men aged 50 to 80.
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Electroacupuncture shows promising results to treat Lower Urinary tract symptoms caused by BPH. However, more quality evidence needs to be yielded to further support its effectiveness. —Adrian Y 17 Feb 2023