In the pilot study, 15 older adults who were suffering from chronic insomnia but were otherwise healthy participated in a randomized, double-blind, crossover design. The study lasted for 6 weeks, with each participant receiving both the proprietary tart cherry juice blend and a placebo for 2 weeks with a 2-week washout period between the two treatments. Sleep continuity and insomnia severity were evaluated by analyzing 2-week mean values derived from daily sleep diaries and the Insomnia Severity Index respectively.

The tart cherry juice blend was found to bring significant improvements in all assessed sleep variables before and after treatment. These improvements were particularly noticed in reducing insomnia severity, specifically the minutes awake after sleep onset, compared to placebo. Sleep latency, total sleep time, or sleep efficiency didn't show any notable improvements compared to placebo. The benefits of the tart cherry juice on sleep for older adults with insomnia were in the range of effect sizes seen in studies using valerian or melatonin, which are the most commonly studied natural products for insomnia. But these effects were considerably less than evidence-based insomnia treatments such as hypnotic agents and cognitive-behavioral therapies.