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Honey exhibits multifaceted benefits for brain health, acting as a memory booster, neuroprotective agent, anti-stress, and anti-nociceptive substance, fostering potential therapeutic applications to enhance overall cognitive well-being.
2023 Frontiers in Aging Neuroscience Honey on brain health: A promising brain booster Zamri NA, Ghani N, Ismail CAN, Zakaria R, Shafin N
Review Article Brain Health Cognitive Function Honey
This review scrutinizes 34 original articles exploring the impact of honey on brain health. Honey, traditionally known as a natural sweetener, emerges as a versatile substance with applications in nutrition, health supplementation, and brain health enhancement. The analysis identifies four key benefits: memory enhancement, neuroprotection, stress reduction, and pain alleviation. The review emphasizes the growing interest in understanding the mechanisms that underlie these effects, paving the way for potential therapeutic roles of honey in promoting cognitive well-being.
The literature review underscores the significant role of honey in brain health research, shedding light on its diverse benefits, including memory improvement, neuroprotection, stress mitigation, and pain relief. The emphasis on unraveling the underlying mechanisms reflects a broader interest in establishing honey's therapeutic potential for enhancing overall brain health. This comprehensive exploration of honey's effects on cognition opens avenues for developing novel therapeutic strategies harnessing honey's natural properties.
Green tea's catechins demonstrate therapeutic effects against neurodegenerative diseases via anti-inflammatory, antioxidant actions, and activating diverse brain cellular pathways.
2022 Molecules Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits Afzal O, Dalhat MH, Altamimi ASA, Rasool R, Alzarea SI, Almalki WH, et al.
Review Article Alzheimer's Disease Cognitive Function Green Tea
The research primarily evaluates the effect of polyphenolic compounds found in green tea, known as catechins, on neurodegenerative diseases. By conducting several interventional and observational studies on humans, the research explores the anti-cancer, anti-obesity, antidiabetic, anti-inflammatory, and neuroprotective properties of these compounds. The biological, pharmacological, antioxidant, and metal chelating abilities of catechins, particularly their influence on different cellular pathways within the brain, are intensively studied.
The results elucidate that catechins exhibit multiple neuroprotective effects. Their anti-inflammatory and antioxidant properties help to inhibit excessive production of cytokines, and inflammatory pathways, while also controlling metal ions and free radicals. Researchers have further established that catechins may curb the phosphorylation of the tau protein and aggregation of amyloid beta, both key markers in neurodegenerative diseases. Additionally, these compounds show potential in reducing alpha-synuclein levels and augmenting dopamine levels. Hence, they significantly contribute to the prevention and treatment of neurodegenerative diseases, including Alzheimer's, Parkinson's, multiple sclerosis, and cognitive deficits.
Bioactive components in green tea have demonstrated potential neuroprotective effects and might play a role in preventing Alzheimer’s disease.
2022 Food Science and Human Wellness Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: Clinical evidence Lange KW, Lange KM, Nakamura Y
Systematic Review EGCG Neuroprotective
In this study, the researchers focused on the potential preventative effects of bioactive compounds, specifically (-)-epigallocatechin-3-gallate, present in tea, on Alzheimer's disease (AD). This interest was based on recognition of the importance of lifestyle-related factors, including diet, in the primary prevention of AD. They compiled and analyzed the findings from various preclinical studies which pointed towards the neuroprotective qualities of these compounds.
The results reveal an association between the consumption of green tea and a reduction in the risk of age-related cognitive decline and AD. However, these results do not establish a causal relationship. That is, while people who drink green tea appear to have lower rates of AD, the study cannot confirm that green tea consumption is the reason for this reduced prevalence. The researchers also emphasized that while the preventative effects of green tea were deduced from preclinical (animal) studies, human-based clinical trials yielded unsatisfactory evidence regarding tea's preventive or therapeutic effect on AD.
The jujube tree bears fruit endowed with substantial nutritional value and contains numerous phytochemical components with reported antioxidant, anti-cancer and neuroprotective properties.
2022 Traditional Medicine Research Jujube (Ziziphus jujuba Mill. (Rhamnaceae)): a review on its pharmacological properties and phytochemistry Aafi E, Reza M, Mirabzadeh M
Theoretical Article Anticancer Antioxidant Jujube
The research implemented an analysis of the jujube tree, its fruit, and its long history of usage in traditional medicine, focusing primarily on its use in traditional Persian and Chinese medicines. The varied geographical distribution of the tree was studied, especially its presence in tropical and subtropical regions across Europe and Asia. Researchers took into account the tree’s resilience to soil salinity and alkalinity as part of its general characteristics.
The core of the study involved an in-depth investigation into the nutritional composition and pharmacological properties of the jujube fruit. The fruit's contents were categorized into proteins, minerals, vitamins, organic acids, and carbohydrates. Furthermore, a range of phytochemical components such as polyphenols, flavonoids, terpenoids, anthocyanins, alkaloids, and carotenoids were identified.
Research noted both the fruit's nutraceutical and cosmeceutical potential. It also explored the medicinal properties of all elements of the plant, not just the fruit.
The physiological impacts of the jujube were also evaluated across various medical contexts, seeking to understand its impact on different organs and tissues, as well as its influence on various health conditions and concerns. Culminating in the identification of antioxidant, anti-cancer, antimicrobial, neuroprotective, cardioprotective, hepatoprotective properties. Noteworthy, are also its health-promoting effects, with strong references to anti-aging properties.
The combined use of chamomile and saffron with usual medication enhances the efficacy against depression and ensures long term improvement.
2022 Heliyon A randomized clinical trial to test efficacy of chamomile and saffron for neuroprotective and anti-inflammatory responses in depressive patients Ahmad S, Azhar A, Tikmani P, Rafique H, Khan A, Mesiya H, et al.
Randomised Controlled Trial Anti-Inflammatory Chamomile Neuroprotective
This research was a randomized, open, blinded trial with 120 participants split evenly into a test and control group. After consent was obtained, a patient health questionnaire was filled out to determine depression scores. Participants in the test group received herbal tea sachets, containing 20 mg of chamomile and 1 mg of saffron, twice per day for a month in addition to their regular medications. Control group participants only received their standard allopathic medicine. Blood samples were taken both before and after the treatment period.
The test showed significant improvement in depressive symptoms for both groups. However, in the test group, the addition of the herbal teas amplified the effect of the medications. The herbal adjuvant therapy reduced inflammatory markers and tryptophan levels in plasma, which increased the availability of tryptophan in the brain, a key aspect in managing depression. Consequently, the research concluded that inclusion of these herbs enhances the effectiveness of the conventional treatment against depression and provides long term benefits.
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