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Green tea treatment has shown potential in improving oral hygiene and gingival health, and reducing periodontitis and caries.
The methodology of this research consisted of systematic literature review focusing on clinical trials that evaluated the impact of green tea on managing periodontitis and caries. Various databases including MedLine (PubMed), Scopus, and the Cochrane Library were utilized for gathering relevant studies. Eighteen suitable studies were selected, encompassing 870 subjects.
The results reveal a noticeable positive effect from green tea treatment. This effect was realized in the reduction of gingival index, plaque index, gingival bleeding index and bleeding on probing when compared to a control group. It was also noted that when considered among chlorhexidine control groups, green tea showed a slight negative effect. There was additionally a significant positive effect seen in the reduction of clinical attachment level and probing pocket depth with green tea treatment.
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Our dose-response analysis indicated that moderate green tea consumption (500–1000 mL/d) was associated with a 21% to 24% lower risk of stroke.
2023 Nutrition Green tea consumption and the risk of stroke: A systematic review and meta-analysis of cohort studies Wang ZM, Chen B, Zhou B, Zhao D, Wang LS
Systematic Review Green Tea Stroke Stroke Risk
The meta-analysis aimed to clarify the inconsistent findings in epidemiologic studies regarding the link between green tea consumption and stroke risk. Five prospective cohort studies, involving 645,393 participants and 11,421 stroke cases, were analyzed. The summary relative risk (RR) revealed a substantial association, indicating a 26% reduction in stroke risk with the highest green tea consumption. The dose-response analysis indicated a nonlinear relationship, and compared with non-consumers, various levels of green tea intake showed progressively reduced RRs for stroke, emphasizing a potential protective effect.
The findings from the meta-analysis strongly suggest an inverse association between green tea consumption and stroke risk. Notably, the highest green tea consumption demonstrated a significant 26% risk reduction. The dose-response analysis further highlighted a nonlinear relationship, with moderate consumption levels (500–1000 mL/d) showing the most substantial risk reduction. These results provide support for recommending green tea consumption as a measure for the primary prevention of stroke.
Green tea helps alleviate symptoms in multiple benign gynecological disorders, primarily due to a compound called Epigallocatechin-3-gallate.
2023 Nutrients Green Tea and Benign Gynecologic Disorders: A New Trick for An Old Beverage? Hazimeh D, Massoud G, Parish M, Singh B, Segars J, Islam MS
Review Article EGCG Green Tea Period Pain
The paper reviews the role of the compound Epigallocatechin-3-gallate found in green tea, and its effects on various benign gynecological conditions. The compound is noted for its antioxidant and prooxidant qualities, allowing it to interact with multiple cellular pathways that are crucial for disease pathogenesis. The studied conditions include uterine fibroids, endometriosis, dysmenorrhea, adenomyosis, menopause, and polycystic ovary syndrome. The research accounts for the specific mechanisms through which the compound might affect each condition, such as anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms.
The results suggest that green tea consumption can lead to improved symptom management in these disorders. It was found to lessen the intensity of symptoms associated with uterine fibroids and endometriosis, by invoking anti-fibrotic, anti-angiogenic, and pro-apoptotic mechanisms. It also helped manage pain linked with dysmenorrhea and adenomyosis through reducing uterine contractility and widely felt pain. Additionally, it showed efficacy in weight and osteoporosis control during menopause, and showed potential benefits in managing polycystic ovary syndrome. However, claims regarding its influence on fertility were deemed controversial.
Epigallocatechin gallate (EGCG), a green tea component, showed potential in treating uterine fibroids and associated infertility without causing liver toxicity or folate deficiency.
2023 Nutrients Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women Siblini H, Al-Hendy A, Segars J, González F, Taylor HS, Singh B, et al.
Cohort Study EGCG Green Tea Uterine Fibroids
The study involved the pre-testing of a green tea substance known as Epigallocatechin gallate (EGCG) on a cohort of premenopausal women, aged 18 to 40, with and without uterine fibroids, in order to evaluate its safety. The subjects were randomized into three groups, each receiving different treatments. One group took just a daily dose of 800 mg of EGCG, one group combined this EGCG dose with 100 mg of Clomiphene citrate for five days, and the third group combined it with 5 mg of Letrozole for the same period.
The results showed that none of the subjects displayed signs of drug-induced liver injury, and all had normal serum folate levels. Hence, the findings suggest that the daily intake of 800mg of EGCG, whether consumed alone or in combination with Clomiphene citrate or Letrozole for five days, is well-tolerated and not related to any liver toxicity or folate deficiency in women of reproductive age.
Heavy coffee consumption increases the risk of cardiovascular disease mortality in individuals with severe hypertension, while green tea consumption does not.
2023 Journal of the American Heart Association Coffee and Green Tea Consumption and Cardiovascular Disease Mortality Among People With and Without Hypertension Teramoto M, Yamagishi K, Muraki I, Tamakoshi A, Iso H
Cohort Study Coffee Green Tea High Blood Pressure
With the use of the Japan Collaborative Cohort Study, researchers assessed 18,609 participants, both male and female, aged between 40 to 79 years. These participants had varying blood pressure levels, categorized into optimal and normal BP, high-normal BP, and two stages of hypertension. They completed a questionnaire about their lifestyle, diet, and medical history, and underwent health examinations, which were followed up until 2009. The association of coffee and green tea consumption on cardiovascular disease mortality was then calculated using a Cox proportional hazard model.
It was found over an 18.9 year follow-up period that heavy coffee consumption was linked to increased risk of cardiovascular disease mortality among those suffering from the second to third grade of hypertension. In stark contrast, people with optimal and normal, high-normal blood pressure and first grade hypertension did not show such associations between coffee consumption and cardiovascular disease mortality. Interestingly, the risk of cardiovascular disease mortality was not found to be increased across any blood pressure categories in relation to green tea consumption.
The combination of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid could effectively counter precancerous lesions of the uterine cervix caused by HPV infections.
2023 Journal of Personalized Medicine The Association of Four Natural Molecules—EGCG, Folic Acid, Vitamin B12, and HA—To Counteract HPV Cervical Lesions: A Case Report Grandi G, Botticelli L, Fraia PD, Babalini C, Masini M, Unfer V
Case Report Cervical Cancer Cervical Dysplasia Cervical Lesions
The methodology used in this research centred around treating a 39-year-old patient who had a history of HPV, cervix lesions, and multiple failed surgical attempts to treat the condition. The treatment plan applied was unique, utilizing a blend of epigallocatechin gallate, vitamin B12, folic acid, and hyaluronic acid, administered over an eight week period.
The results showed promising effects, with the patient's histological and cytological analyses revealing only a chronic cervicitis instead of any malignant lesions or cellular dysplasia. Therefore, the necessity for invasive total hysterectomy was minimized, demonstrating the potential for the selected treatment plan to manage precancerous lesions of the uterine cervix.
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