GFR
Also known as: Glomerular Filtration Rate
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of Cordyceps sinensis in the Treatment of Oral Lichen Planus
2022 Aug 29 Journal of Oncology Ma H, Wang G, Guo X, Yao Y, Li C, Li X, et al.
Cordyceps sinensis contains multiple active compounds targeting key proteins such as TNF, IL-6, CD4, EGFR, and IL1B, regulating the PI3K-Akt and MAPK signaling pathways, and participating in biological processes like apoptosis, T cell activation, and oxidative stress, suggesting its potential as a crucial therapy for OLP.
Network Pharmacology Oral Lichen Planus
Study the Mechanism of Gualou Niubang Decoction in Treating Plasma Cell Mastitis Based on Network Pharmacology and Molecular Docking
2022 Jun 15 BioMed Research International Wu Z, Yang Q, Ma H
The study identified 164 ingredients and 58 intersection targets in GLNBD's treatment of PCM. Four key active compounds (quercetin, luteolin, fisetin, kaempferol) and four key proteins (ALB, EGFR, IL-6, VEGFA) were identified. Enrichment analysis revealed associations with negative regulation of apoptosis, response to hypoxia, positive regulation of transcription, and DNA-templated, with related pathways involving the pathway in cancer, phosphatidylinositol 3-kinase (PI3K) Akt signaling pathway, and AGE-RAGE signaling pathway in diabetic complications. Molecular docking validated stable binding activities between key target genes and essential active compounds, suggesting their potential role in modulating relevant pathways.
Network Pharmacology Gua Lou Niu Bang Decoction
Network Pharmacology and Molecular Docking-Based Prediction of the Molecular Targets and Signaling Pathways of Ginseng in the Treatment of Parkinson's Disease
2022 May Natural Product Communications Zhang W, Chen J, Liu H
The main active compounds of ginseng in the treatment of Parkinson's disease (PD) may be ginsenosides, and the molecular mechanism may be related to key targets such as MAPK3, MAPK14, and EGFR. The MAPK and AGE-RAGE signaling pathways may also be involved.
Network Pharmacology Parkinson's Disease GinsengPrediction the Molecular Mechanism of Shengmai Injection in Acute Treatment of COVID-19 Based on Network Pharmacology
2022 Feb Natural Product Communications Wang C, Liu A, Wu H, Yang Y
The key active compounds of Shengmai Injection (SMI) in the treatment of COVID-19 may be Schisantherin A and Moupinamide, and the molecular mechanism may be related to key targets such as EGFR and MAPK1, and may be involved in the PI3K-Akt signaling pathway and MAPK signaling pathway.
Network Pharmacology Sheng Mai San COVID-19
Exploring the Mechanism of Action of Banxia Baizhu Tianma Decoction against Preeclampsia by a Network Pharmacology Approach
2021 Mar 12 Evidence-Based Complementary and Alternative Medicine Shuqing Cheng, Xijuan Liu, Aner Chen, Haibo Li, Lulu Yan
The study indicated the improvement of pre-eclampsia with BXBZTMD by inhibiting the EGFR-JAK/STAT signaling pathway and promoting the proliferation and invasion and reduced the apoptosis of trophoblast cells. Thus lowering blood pressure in pregnant women.
Network Pharmacology Animal Study Pre-EclampsiaReview Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
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