GFR

Exploring the mechanism of Danggui Sini Decoction in the treatment of myocardial infarction: A systematic review, network pharmacology, and molecular docking

2024 Oct 18   Medicine   Li Z, Liu S, Zhang R, Li B

Network Pharmacology and Molecular Docking Analysis Explores the Mechanisms of Cordyceps sinensis in the Treatment of Oral Lichen Planus

2022 Aug 29   Journal of Oncology   Ma H, Wang G, Guo X, Yao Y, Li C, Li X, et al.

Cordyceps sinensis contains multiple active compounds targeting key proteins such as TNF, IL-6, CD4, EGFR, and IL1B, regulating the PI3K-Akt and MAPK signaling pathways, and participating in biological processes like apoptosis, T cell activation, and oxidative stress, suggesting its potential as a crucial therapy for OLP.

Study the Mechanism of Gualou Niubang Decoction in Treating Plasma Cell Mastitis Based on Network Pharmacology and Molecular Docking

2022 Jun 15   BioMed Research International   Wu Z, Yang Q, Ma H

The study identified 164 ingredients and 58 intersection targets in GLNBD's treatment of PCM. Four key active compounds (quercetin, luteolin, fisetin, kaempferol) and four key proteins (ALB, EGFR, IL-6, VEGFA) were identified. Enrichment analysis revealed associations with negative regulation of apoptosis, response to hypoxia, positive regulation of transcription, and DNA-templated, with related pathways involving the pathway in cancer, phosphatidylinositol 3-kinase (PI3K) Akt signaling pathway, and AGE-RAGE signaling pathway in diabetic complications. Molecular docking validated stable binding activities between key target genes and essential active compounds, suggesting their potential role in modulating relevant pathways.

Network Pharmacology and Molecular Docking-Based Prediction of the Molecular Targets and Signaling Pathways of Ginseng in the Treatment of Parkinson's Disease

2022 May   Natural Product Communications   Zhang W, Chen J, Liu H

The main active compounds of ginseng in the treatment of Parkinson's disease (PD) may be ginsenosides, and the molecular mechanism may be related to key targets such as MAPK3, MAPK14, and EGFR. The MAPK and AGE-RAGE signaling pathways may also be involved.

Prediction the Molecular Mechanism of Shengmai Injection in Acute Treatment of COVID-19 Based on Network Pharmacology

2022 Feb   Natural Product Communications   Wang C, Liu A, Wu H, Yang Y

The key active compounds of Shengmai Injection (SMI) in the treatment of COVID-19 may be Schisantherin A and Moupinamide, and the molecular mechanism may be related to key targets such as EGFR and MAPK1, and may be involved in the PI3K-Akt signaling pathway and MAPK signaling pathway.

Chinese herbal medicine for diabetic kidney disease: a systematic review and meta-analysis of randomised placebo-controlled trials

2019 Apr   BMJ Open   Zhang L, Yang L, Shergis J, Zhang L, Zhang AL, Guo X, et al.

The study concludes that CHM, when used as an adjunct to conventional treatments, shows greater reduction in albuminuria and improved glomerular filtration rate in DKD patients.