Bile Acid

Presentation Slides

Chinese Medicine Research Hub

Animal Study

Kiwifruit polysaccharides may alleviate the toxic effects of acrylamide by improving gut health and enhancing bile acid metabolism.

2023 Frontiers in Nutrition Effects of kiwi fruit (Actinidia chinensis) polysaccharides on metabolites and gut microbiota of acrylamide-induced mice
Chen M, Chen X, Wang K, Cai L, Liu N, Zhou D, Jia W, Gong P, Liu N, Sun Y

Chinese Medicine Research Hub

Animal Study

The botanical drug formula Chaihu-Shugan-San potentially alleviates depression symptoms by modulating bile acid metabolism and altering gut microbiota and hippocampal gene expression.

2022 Frontiers in Pharmacology Chaihu-shugan-san alleviates depression-like behavior in mice exposed to chronic unpredictable stress by altering the gut microbiota and levels of the bile acids hyocholic acid and 7-ketoDCA
Ma C, Yuan D, Renaud SJ, Zhou T, Yang F, Liou Y, Qiu X, Zhou L, Guo Y

Chinese Medicine Research Hub

Theoretical Article

Consumption of oat β-glucan may lower cholesterol and risk of cardiovascular disease by altering gut bacteria and their effects on bile acid and cholesterol metabolism.

2019 Frontiers in Nutrition The Cholesterol-Lowering Effect of Oats and Oat Beta Glucan: Modes of Action and Potential Role of Bile Acids and the Microbiome
Joyce SA, Kamil A, Fleige L, Gahan CGM

Chinese Medicine Research Hub

Experimental Study

Pu-erh tea was found to lower triglyceride and total cholesterol levels more significantly than green, oolong, or black teas.

2019 Nature Communications Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Huang, F., Zheng, X., Ma, X. et al.

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Bile Acid" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Bile Acid" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Bile Acid" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Animal Study published in 2023 in the journal Frontiers in Nutrition found that Kiwifruit polysaccharides may alleviate the toxic effects of acrylamide by improving gut health and enhancing bile acid metabolism. In this study, the team explored the potential protective effects of kiwifruit polysaccharides on disorders induced by acrylamide (a toxic ingredient found in high-temperature, carbohydrate-rich food) on gut microbiota and systemic metabolism. They measured changes in gut microbiota and serum metabolites in mice subjected to acrylamide-induced toxicity, focusing primarily on the effects on mice's bodily features, liver health, and liver enzyme activity. The results revealed that treatment with kiwifruit polysaccharides not only improved the mice's overall health and liver function but also restored the balance in their gut microbiota by increasing microbial diversity and the abundance of beneficial bacteria. Furthermore, it was found that the polysaccharides had a significant impact on amino and bile acid-related metabolic pathways, proving their potential in protecting against toxicity. A strong correlation was also found between certain bacteria and the critical metabolites of bile acid metabolism, providing a deeper understanding of the protective mechanisms of kiwifruit polysaccharides.

A Animal Study published in 2022 in the journal Frontiers in Pharmacology found that The botanical drug formula Chaihu-Shugan-San potentially alleviates depression symptoms by modulating bile acid metabolism and altering gut microbiota and hippocampal gene expression. The study employed a well-known mouse model of depression, chronic unpredictable mild stress (CUMS) mice, to investigate the impact of Chaihu-Shugan-San (CSS), a traditional botanical drug formula. The researchers focused on whether CSS modulates the levels of bile acids and the composition of gut microflora, and consequently, depression-like symptoms. Additionally, they examined the effects of bile acid manipulation and fecal microbiota transplantation on the antidepressant effects of CSS. A key part of this investigation involved looking into how CSS could influence the abundance of specific microbial strains in the colon, serum levels of various bile acids, and the expression of genes connected to bile acid transport and neurotrophic signaling in the hippocampus. In their findings, the researchers observed that administering CSS increased the amounts of certain microbes in the mice's colon and elevated the serum levels of specific bile acids. CSS administration also resulted in alterations in the expression of genes within the hippocampus that are implicated in bile acid transport and neurotrophic signaling. It was also noted that fecal microbiota transplantation from CSS-treated mice to untreated or cholestyramine-treated CUMS mice restored serum levels of select bile acids and helped to alleviate depression-like symptoms.

A Theoretical Article published in 2019 in the journal Frontiers in Nutrition found that Consumption of oat β-glucan may lower cholesterol and risk of cardiovascular disease by altering gut bacteria and their effects on bile acid and cholesterol metabolism. The research paper focused on studying the impact of oat β-glucan on cholesterol levels and cardiovascular disease risk. The methodology revolved around examining how consumption of oat β-glucan might change the gut microbiota, particularly bacterial species that influence bile acid metabolism and the production of short chain fatty acids. These factors are crucial regulators of cholesterol homeostasis in the host body. The research thus looked into the repercussions on bile acid metabolism, reverse cholesterol transport, short-chain fatty acid production, bacterial metabolism of cholesterol, and microbe-host signaling. The researchers found that oat β-glucan appears to have a significant effect on both the host's cholesterol levels and the composition and functionality of their gut microbiota, which in turn impacts bile acid metabolism and cholesterol homeostasis. It creates a potentially beneficial scenario where intestinal cholesterol may be removed for excretion. The results suggest that the benefits attributed to oat β-glucan are multifaceted and likely involve the regulation of complex interactions between microbes and the host at the level of the gastrointestinal interface. These novel insights demonstrate an interesting relationship between diet, gut microbiota, and host cholesterol metabolism.

A Experimental Study published in 2019 in the journal Nature Communications found that Pu-erh tea was found to lower triglyceride and total cholesterol levels more significantly than green, oolong, or black teas. Comparative studies using rodents treated with Pu-erh tea, green tea, and black tea provided supporting evidence that fully fermented Pu-erh tea is more effective in causing hypolipidemic and hypocholesterolemic effects compared to other partially fermented and non-fermented teas.

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