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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Anti-inflammatory and Antioxidant Activity of Cucumis sativus and Citrus macroptera Herbal Formulation: An In-Vitro Study
2024 Jan 07 Cureus Journal of Medical Science Amani T, Surenthar M, Shanmugam R
The combination of cucumber, citrus, and glycerol extract demonstrated significant antioxidant and anti-inflammatory properties, comparable to standard values, as indicated by assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, Hydrogen Peroxide (H2O2), Bovine serum albumin (BSA), and Egg albumin (EA) denaturation assays. The extracts showed appreciable effects at concentrations of 30, 40, and 50 µl, with the maximum concentration of 50 µl exhibiting optimal antioxidant and anti-inflammatory activity.
Experimental Study Antioxidant Cucumber Anti-Inflammatory
Cucumber (Cucumis sativus L.) Fruit and Combination with Losartan Attenuate the Elevation of Blood Pressure in Hypertensive Rats Induced by Angiotensin II
2023 Dec 31 Journal of Pharmacopuncture Hendrayana T, Yoana K, Adnyana IK, Sukandar EY
C. sativus, administered orally at doses of 9, 18, 27, and 36 mg/kg, significantly attenuated angiotensin II-induced hypertension in a dose-dependent manner. The combination of half doses of C. sativus and losartan showed an additive antihypertensive effect, demonstrating blood pressure reduction comparable to a full dose of losartan and better than a full dose of C. sativus alone.
Animal Study Losartan High Blood Pressure Cucumber
Bioactive compounds found in Cucumis sativus demonstrate optimal binding affinity to PTP1B.
2023 Oct 14 IPS Journal of Molecular Docking Simulations Ogunbiyi OE, , Ogunbiyi BT, Adeleke SO, Arietarhire LO, Alege PE, et al.
The analysis revealed that the bioactive compounds isoorientin, chlorogenic acid, isovitexin, caffeic acid, and ferullic acid from Cucumis sativus exhibited inhibitory potential against PTP1B, with scores ranging from -8.60 to -6.44 kcal/mol and MM-GBSA values ranging from -56.46 to -51.13 ΔGbind.
Experimental Study Cucumber
Effectiveness of a Cucumber Extract Supplement on Articular Pain in Patients with Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial
2022 Dec 30 Applied Sciences Pérez-Piñero S, Muñoz-Carrillo JC, Victoria-Montesinos D, García-Muñoz AM, Ávila-Gandía V, López-Román FJ
The study concludes that cucumber extract supplementation leads to a decrease in pain intensity, improvements in physical function, and decreased levels of inflammatory and cartilage degradation biomarkers.
Randomised Controlled Trial Knee Osteoarthritis Cucumber
Plant flavonoids bioavailability in vivo and mechanisms of benefits on chronic kidney disease: a comprehensive review
2022 Sep 22 Phytochemistry Reviews Lin Y, Fang J, Zhang Z, Farag MA, Li Z, Shao P
Plant flavonoids exhibit an alleviating effect on CKD through various mechanisms, including the reduction of oxidative stress, immune modulation, anti-inflammation, inhibition of renal fibrosis, anti-apoptosis, and regulation of gut flora. The study explores how plant flavonoids contribute to the improvement of renal health in CKD patients by regulating the intestinal flora through the gut-kidney axis. Additionally, the review introduces the products and development prospects of plant flavonoids in the context of CKD.
Review Article Chronic Kidney Disease CucumberResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The extract from cucumber, Q-Actin, is effective in reducing moderate knee osteoarthritis related pain and potentially in managing knee pain, stiffness, and physical functions.
2018 Clinical Interventions in Aging Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial Nash RJ, Azantsa BKG, Sharp H, Shanmugham V
Randomised Controlled Trial
In this double-blind, parallel-group clinical trial conducted in three different centres, 122 patients aged between 40 and 75 years with diagnosed moderate knee Osteoarthritis were randomly divided into two groups. Over a 180-day period, one group received the cosmetically prescribed dose of 1,350 mg of glucosamine-chondroitin orally twice daily, and the other group took an orally administered 10 mg of Q-Actin (aqueous extract of cucumber) twice per day.
The results showed a significant decrease in Osteoarthritis Index scores in the group that received the cucumber extract, indicating reduced pain and improved physical function. This trend was observed throughout the trial, and by the 180th day, the extract's effectiveness was substantially higher than that of the traditionally prescribed glucosamine-chondroitin. Notably, no adverse effects from the cucumber extract were reported during the trial period.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Plant flavonoids bioavailability in vivo and mechanisms of benefits on chronic kidney disease: a comprehensive review
2022 Sep 22 Phytochemistry Reviews Lin Y, Fang J, Zhang Z, Farag MA, Li Z, Shao P
Plant flavonoids exhibit an alleviating effect on CKD through various mechanisms, including the reduction of oxidative stress, immune modulation, anti-inflammation, inhibition of renal fibrosis, anti-apoptosis, and regulation of gut flora. The study explores how plant flavonoids contribute to the improvement of renal health in CKD patients by regulating the intestinal flora through the gut-kidney axis. Additionally, the review introduces the products and development prospects of plant flavonoids in the context of CKD.
Review Article Chronic Kidney Disease Cucumber
Antiinflammatory, antimicrobial, and allelopathic activities of some cucurbit seed oils
2022 Jan International Review of Neurobiology Nwaiwu O, Mariod AA
Cucurbit seed oils have been reported to exhibit beneficial antimicrobial and allelopathic effects, supported by empirical data from clinical trials in humans. While some claims are rooted in folklore and preliminary data, the high nutritional value of cucurbit seed oils suggests their suitability for human health needs. This chapter aims to summarize the existing literature on the inflammatory, antimicrobial, and allelopathic activities associated with different types of cucurbit seed oils.
Review Article Antimicrobial CucumberEvaluating the potential benefits of cucumbers for improved health and skin care
2016 Jan Journal of Aging Research and Lifestyle Murad H, Nyc MA
Review Article Skin Care CucumberClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Effectiveness of a Cucumber Extract Supplement on Articular Pain in Patients with Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial
2022 Dec 30 Applied Sciences Pérez-Piñero S, Muñoz-Carrillo JC, Victoria-Montesinos D, García-Muñoz AM, Ávila-Gandía V, López-Román FJ
The study concludes that cucumber extract supplementation leads to a decrease in pain intensity, improvements in physical function, and decreased levels of inflammatory and cartilage degradation biomarkers.
Randomised Controlled Trial Knee Osteoarthritis CucumberEffectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial
2018 Oct Clinical Interventions in Aging Nash RJ, Azantsa BKG, Sharp H, Shanmugham V
Randomised Controlled TrialThe extract from cucumber, Q-Actin, is effective in reducing moderate knee osteoarthritis related pain and potentially in managing knee pain, stiffness, and physical functions.
Presentation Slides
The extract from cucumber, Q-Actin, is effective in reducing moderate knee osteoarthritis related pain and potentially in managing knee pain, stiffness, and physical functions.
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